Abstract：
:Neurotoxic properties of acrylamide and seven related compounds in rats were studied with regard to the effects on rotarod performance, morphology of nerves and neurotubulin. Compounds used in the present study were acrylamide, N-hydroxymethylacrylamide, N-isopropylacrylamide, methacrylamide, N-methylacrylamide, crotonamide, diacetone acrylamide, and N-tert-butylacrylamide. Animals were given chemicals in their drinking water for 90 days. Deficit of rotarod performance was produced by five compounds; acrylamide, N-hydroxymethylacrylamide, N-isopropylacrylamide, methacrylamide, and N-methylacrylamide. Morphological changes in tibial and sural nerves, such as shrinkage and loss of myelinated fibres, myelin retraction, and corrugated myelin sheaths, were observed after treatment with these five compounds. Depression of the [3H]colchicine-binding to neurotubulin (the soluble protein) of sciatic nerves was detected after giving these five compounds. After acrylamide dosing, the depression progressed with time. A significant reduction of the colchicine-binding to neurotubulin was also detected in the spinal cord of both the cervical and the lumbar regions, but neither in the brain nor the cerebellum.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Tanii H,Hashimoto Kdoi
10.1007/BF01239204subject
Has Abstractpub_date
1983-11-01 00:00:00pages
203-13issue
3eissn
0340-5761issn
1432-0738journal_volume
54pub_type
杂志文章abstract：:Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are t...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1803-y
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abstract：:The antidepressants, imipramine and mianserin, have been reported to cause liver damage. We investigated a role of cytochrome P450 (CYP)-mediated formation of a reactive metabolite in antidepressant-induced acute cell injury using hepatocytes isolated from male and female Wistar rats, and male Dark Agouti rats, which ...
journal_title：Archives of toxicology
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abstract：:The pregnancy outcomes of 109 women who were intoxicated during pregnancy due to excessive amounts of drugs and other agents were studied. Seventy per cent of the women attempted suicide, and the intoxication in 78% of all cases was caused by drugs. The stillbirth rate (4%) was higher than that in previous and subsequ...
journal_title：Archives of toxicology
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doi：10.1007/BF00316249
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00351968
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1727-6
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journal_title：Archives of toxicology
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doi：10.1007/BF01974070
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journal_title：Archives of toxicology
pub_type： 杂志文章
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050298
更新日期：1996-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00353240
更新日期：1975-02-14 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02934-9
更新日期：2020-10-17 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050276
更新日期：1996-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316373
更新日期：1989-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050001
更新日期：2000-01-01 00:00:00
abstract：:In order to clarify the possible mechanism of hepatocarcinogenesis induced by piperonyl butoxide, we attempted to identify the transcription factor activated by piperonyl butoxide in the male ICR mouse liver. Administration of 0.6% piperonyl butoxide for 24 h elevated the level of liver nuclear proteins that bind to a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0283-0
更新日期：2008-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02875-3
更新日期：2020-12-01 00:00:00
abstract：:Pregnane X receptor (PXR) is a nuclear receptor that plays a key regulatory role in xenobiotic metabolism in a ligand-dependent manner. Recently, ethanol was reported to be either an inducer or inhibitor of Cytochrome P450 (CYP) 3A expression. According to our recent microarray data, chronic ethanol upregulates the ex...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1268-9
更新日期：2015-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2009-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：Archives of toxicology
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更新日期：1994-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973502
更新日期：1991-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01972990
更新日期：1990-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1084-7
更新日期：2014-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303292
更新日期：1980-05-01 00:00:00
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更新日期：2007-11-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1693-z
更新日期：2017-01-01 00:00:00
abstract：:The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental animals are still inconclusive. Here, we investigated the association of personal exposure to metals in respirable welding fumes during a working shift with oxi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1319-2
更新日期：2015-08-01 00:00:00
