Mechanisms involved in the transport of mercuric ions in target tissues.

abstract：:Dorsal root ganglia from control and methylmercury (MeHg)-treated rats were incubated in vitro with 35S-methionine ant the proteins synthesized were analyzed by two-dimensional electrophoresis. The double labelling method, in which proteins of control dorsal root ganglia labelled in vitro with 3H-leucine were added to...

journal_title：Archives of toxicology

authors： Kasama H,Itoh K,Omata S,Sugano H

更新日期：1989-01-01 00:00:00

abstract：:The disposition, elimination, and metabolism of 50 mg/kg (1.36 muCi/animal) of tri-o-cresyl [phenyl-U-14C] phosphate after ten daily oral doses was investigated in adult male Fischer 344 rats. Groups of three treated animals were killed at intervals of 24, 48, 72, and 96 h after the last administrations. Generally, th...

journal_title：Archives of toxicology

authors： Somkuti SG,Abou-Donia MB

更新日期：1990-01-01 00:00:00

abstract：:Selenium (Se) is an essential dietary component for animals including humans and is regarded as a protective agent against cancer. Although the mode of anticancer action of Se is not fully understood yet, several mechanisms, such as antioxidant protection by selenoenzymes, specific inhibition of tumor cell growth by S...

journal_title：Archives of toxicology

authors： Brozmanová J,Mániková D,Vlčková V,Chovanec M

更新日期：2010-12-01 00:00:00

abstract：:Etoposide (ETP) and anthracyclines are applied for wide anti-cancer treatments. However, the ETP-induced cardiotoxicity remains to be a major safety issue and the underlying cardiotoxic mechanisms are not well understood. This study is aiming to unravel the cardiotoxicity profile of ETP in comparison to anthracyclines...

journal_title：Archives of toxicology

authors： Nemade H,Chaudhari U,Acharya A,Hescheler J,Hengstler JG,Papadopoulos S,Sachinidis A

更新日期：2018-04-01 00:00:00

abstract：:As part of a study on cadmium nephrotoxicity, we studied the effect of cadmium chloride (CdCl2) in isolated human renal proximal tubules metabolizing the physiological substrate lactate. Dose-effect experiments showed that 10-500 μM CdCl2 reduced lactate removal, glucose production and the cellular levels of ATP, coen...

journal_title：Archives of toxicology

authors： Faiz H,Conjard-Duplany A,Boghossian M,Martin G,Baverel G,Ferrier B

更新日期：2011-09-01 00:00:00

abstract：:Previous studies indicate that benzanthrone, an anthraquinone dye intermediate, caused significant depletion of ascorbic acid (AsA). In this investigation the effect of benzanthrone on the status of different forms of AsA and other bio-antioxidants such as glutathione (GSH) was studied. Oral administration of benzanth...

journal_title：Archives of toxicology

authors： Dwivedi N,Das M,Khanna SK

更新日期：2001-06-01 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) are a family of kinases associated predominantly with cell cycle control, making CDK inhibitors interesting candidates for anti-cancer therapeutics. However, retinal toxicity (loss of photoreceptors) has been associated with CDK inhibitors, including the pan-CDK inhibitor AG-012896. The...

journal_title：Archives of toxicology

authors： Wright P,Kelsall J,Healing G,Sanderson J

更新日期：2019-03-01 00:00:00

abstract：:Experimental and/or epidemiological studies suggest that prenatal exposure to bisphenol A (BPA) may delay fetal lung development and maturation and increase the susceptibility to childhood respiratory disease. However, the underlying mechanisms remain to be elucidated. In our previous study with cultured human fetal l...

journal_title：Archives of toxicology

authors： Mahemuti L,Chen Q,Coughlan MC,Qiao C,Chepelev NL,Florian M,Dong D,Woodworth RG,Yan J,Cao XL,Scoggan KA,Jin X,Willmore WG

更新日期：2018-04-01 00:00:00

abstract：:Betulinic acid (BA), a compound isolated from the bark of white birch (Betula pubescens), was reported to induce apoptosis in many types of cancer through mitochondrial dysfunction with low side effects in normal cells. Because of these features, BA is regarded as a potential anti-cancer agent. However, the effect of ...

journal_title：Archives of toxicology

authors： Gao M,Lau PM,Kong SK

更新日期：2014-03-01 00:00:00

abstract：:The ultimate purpose of the present study was to evaluate correlations between acute in vivo and in vitro toxicity and log P (P is n-octanol-water partition coefficient). The in vitro toxicity to cloned cells (neuroblastoma N18TG-2 and glioma C6) in culture (ED50) and the in vivo toxicity to mice (LD50) of ethylene gl...

journal_title：Archives of toxicology

authors： Tanii H,Saito S,Hashimoto K

更新日期：1992-01-01 00:00:00

abstract：:The effects of six iv infusions of an emulsion containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) on the liver and testes were investigated in 40-day-old rats. Groups of five to six animals received the emulsion every other day in doses of 0, 5, 50 or 500 mg DEHP/kg body weight. Liver effects were studied by...

journal_title：Archives of toxicology

authors： Sjöberg P,Lindquist NG,Montin G,Plöen L

更新日期：1985-12-01 00:00:00

abstract：:Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...

journal_title：Archives of toxicology

authors： Aluoch AO,Odman-Ghazi SO,Whalen MM

更新日期：2007-04-01 00:00:00

abstract：:Pregnane X receptor (PXR) is a nuclear receptor that plays a key regulatory role in xenobiotic metabolism in a ligand-dependent manner. Recently, ethanol was reported to be either an inducer or inhibitor of Cytochrome P450 (CYP) 3A expression. According to our recent microarray data, chronic ethanol upregulates the ex...

journal_title：Archives of toxicology

authors： Je YT,Sim WC,Kim DG,Jung BH,Shin HS,Lee BH

更新日期：2015-04-01 00:00:00

abstract：:Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to the shortage of donor organs. Developing renewable sources of human liver tissue is therefore attractive. Pluripotent stem cell-derived liver tissue represents a poten...

journal_title：Archives of toxicology

authors： Rashidi H,Luu NT,Alwahsh SM,Ginai M,Alhaque S,Dong H,Tomaz RA,Vernay B,Vigneswara V,Hallett JM,Chandrashekran A,Dhawan A,Vallier L,Bradley M,Callanan A,Forbes SJ,Newsome PN,Hay DC

更新日期：2018-10-01 00:00:00

abstract：:Epidemiological and experimental studies have demonstrated the atherogenic effects of environmental toxicant arsenic and fluoride. Inflammatory mechanism plays an important role in the pathogenesis of atherosclerosis. The aim of the present study is to determine the effect of chronic exposure to arsenic and fluoride a...

journal_title：Archives of toxicology

authors： Ma Y,Niu R,Sun Z,Wang J,Luo G,Zhang J,Wang J

更新日期：2012-06-01 00:00:00

abstract：:Although polybrominated naphthalenes (PBNs) are contaminants of the commercial fire retardant fireMaster BP-6, the individual PBN isomers have not been identified. In order to study PBNs possessing an analogous level of bromination to those found in fireMaster BP-6, three synthetic PBN mixtures, averaging 5.0, 5.3, an...

journal_title：Archives of toxicology

authors： Robertson LW,Thompson K,Parkinson A

更新日期：1984-07-01 00:00:00

abstract：:Chalepensin, a furanocoumarin, is present in several medicinal Rutaceae plants and causes a mechanism-based inhibition of human and mouse cytochrome P450 (P450, CYP) 2A in vitro. To address the in vivo effect, we investigated the effects of chalepensin on multiple hepatic P450 enzymes in C57BL/6JNarl mice. Oral admini...

journal_title：Archives of toxicology

authors： Lo WS,Lim YP,Chen CC,Hsu CC,Souček P,Yun CH,Xie W,Ueng YF

更新日期：2012-12-01 00:00:00

abstract：:Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxicity and prevention. Metabolism and ...

journal_title：Archives of toxicology

authors： Kurebayashi H,Ohno Y

更新日期：2006-12-01 00:00:00

abstract：:Mouse liver CYP2A5 is induced by several structurally unrelated compounds. In intact mouse liver, pyrazole (PYR) and 4-hydroxypyrazole (4-OH) induce selectively the expression of CYP2A5 while expression of other CYPs is decreased. In this study we exposed mouse primary hepatocytes to PYR, 4-OH, 4-methylpyrazole (4Me; ...

journal_title：Archives of toxicology

authors： Kojo A,Viitala P,Pasanen M,Pelkonen O,Raunio H,Juvonen R

更新日期：1998-05-01 00:00:00

abstract：:The tissue distribution, metabolism and excretion of 14C-2,2',4,4',5-pentachlorodiphenyl ether (PCDE) were studied in the rat. Radioactivity was distributed in all tissues examined, with the highest concentrations being found in the fat followed by the skin, liver, kidney and muscle. Most of the radioactivity found in...

journal_title：Archives of toxicology

authors： Komsta E,Chu I,Villeneuve DC,Benoit FM,Murdoch D

更新日期：1988-01-01 00:00:00

abstract：:The US Environmental Protection Agency's ToxCast program has generated toxicity data for thousands of chemicals but does not adequately assess potential neurotoxicity. Networks of neurons grown on microelectrode arrays (MEAs) offer an efficient approach to screen compounds for neuroactivity and distinguish between com...

journal_title：Archives of toxicology

authors： Kosnik MB,Strickland JD,Marvel SW,Wallis DJ,Wallace K,Richard AM,Reif DM,Shafer TJ

更新日期：2020-02-01 00:00:00

abstract：:Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node ass...

journal_title：Archives of toxicology

authors： van der Veen JW,Gremmer ER,Vermeulen JP,van Loveren H,Ezendam J

更新日期：2013-04-01 00:00:00

abstract：:A dual-label time-resolved fluoroimmunoassay (TRFIA) for simultaneous quantification of aflatoxin B1 (AFB1) and ochratoxin A (OTA) is described. For this, microtitration wells were coated with AFB1-horse radish peroxidase (HRP) and OTA-bovine serum albumin. The standards and samples were loaded on the coated plates, a...

journal_title：Archives of toxicology

authors： Huang B,Xiao H,Zhang J,Zhang L,Yang H,Zhang Y,Jin J

更新日期：2009-06-01 00:00:00

abstract：:The routinely used analytical method for detecting the abuse of anabolic steroids only allows the detection of molecules with known analytical properties. In our supplementary approach to structure-independent detection, substances are identified by their biological activity. In the present study, urines excreted afte...

journal_title：Archives of toxicology

authors： Wolf S,Diel P,Parr MK,Rataj F,Schänzer W,Vollmer G,Zierau O

更新日期：2011-04-01 00:00:00

abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...

journal_title：Archives of toxicology

authors： Nordgren I,Bergström M,Holmstedt B,Sandoz M

更新日期：1978-10-13 00:00:00

abstract：:The effect of N-benzyl-D-glucamine dithiocarbamate (BGD) on the renal toxicity induced by acute exposure to cadmium-metallothionein (Cd-MT) in rats was studied. Rats were injected intraperitoneally with BGD (400 mumol/kg) 6, 12, or 24 h after intraperitoneal injection of Cd-MT (1.78 mumol Cd as Cd-MT/kg) and thereafte...

journal_title：Archives of toxicology

authors： Kojima S,Ono H,Furukawa A,Kiyozumi M

更新日期：1990-01-01 00:00:00

abstract：:Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal methods addressing mechanisms under the first three key events of th...

journal_title：Archives of toxicology

authors： Casati S,Aschberger K,Barroso J,Casey W,Delgado I,Kim TS,Kleinstreuer N,Kojima H,Lee JK,Lowit A,Park HK,Régimbald-Krnel MJ,Strickland J,Whelan M,Yang Y,Zuang V

更新日期：2018-02-01 00:00:00

abstract：:Intake of inorganic arsenic is known to cause vascular diseases as well as skin lesions and cancer in humans. We investigated the differences in cytotoxicity, uptake rate of arsenic, and gene expression of antioxidative enzymes between arsenite (As(3+))- and arsenate (As(5+))-exposed rat heart microvessel endothelial ...

journal_title：Archives of toxicology

authors： Hirano S,Cui X,Li S,Kanno S,Kobayashi Y,Hayakawa T,Shraim A

更新日期：2003-06-01 00:00:00

abstract：:The OECD has developed an "enhanced Test Guideline 407" (TG 407) protocol for detecting endocrine effects during the course of a 28-day testing scheme. This protocol has gone through a validation process with (anti)estrogenic and (anti)androgenic compounds and substances that affect the thyroid (thyroxine and propylth...

journal_title：Archives of toxicology

authors： Cunha GC,van Ravenzwaay B

更新日期：2005-07-01 00:00:00

abstract：:The results from a survey of the expert information that is publicly accessible on the use of the dog as test species during the regulatory evaluation of agricultural chemicals and pesticides are reported. Methods that are being used or considered in order to reduce the number of dogs used for this purpose are describ...

journal_title：Archives of toxicology

authors： Box RJ,Spielmann H

更新日期：2005-11-01 00:00:00