A novel genotoxicity assay of carbon nanotubes using functional macrophage receptor with collagenous structure (MARCO)-expressing chicken B lymphocytes.

abstract：:Iron (Fe) plays essential roles in biological processes, whereas cadmium (Cd) is a toxic and non-essential metal. Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals. Here, we studied the effect of dietary Fe on the expression ...

journal_title：Archives of toxicology

authors： Kim DW,Kim KY,Choi BS,Youn P,Ryu DY,Klaassen CD,Park JD

更新日期：2007-05-01 00:00:00

abstract：:Pathological changes induced by cadmium aerosol had features common to the changes evoked by oxidants. Female rats were exposed to fumes of lead, antimony, zinc and cadmium (15-100 nmoles/m3). One hour after termination of exposure, superoxide dismutase (SOD) activity in erythrocytes of the exposed rats lowered by 15-...

journal_title：Archives of toxicology

authors： Minami M,Koshi K,Homma K,Suzuki Y

更新日期：1982-03-01 00:00:00

abstract：:The peroxisome proliferator class of non-genotoxic rodent hepatocarcinogens cause hepatocyte DNA synthesis, peroxisome proliferation and liver tumours when administered to rats and mice, but fail to induce S-phase or peroxisome proliferation in hepatocytes from other species including guinea-pigs, dogs, and primates i...

journal_title：Archives of toxicology

authors： Tugwood JD,Holden PR,James NH,Prince RA,Roberts RA

更新日期：1998-02-01 00:00:00

abstract：:Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By cont...

journal_title：Archives of toxicology

authors： Duydu Y,Başaran N,Üstündağ A,Aydın S,Yalçın CÖ,Anlar HG,Bacanlı M,Aydos K,Atabekoğlu CS,Golka K,Ickstadt K,Schwerdtle T,Werner M,Meyer S,Bolt HM

更新日期：2018-08-01 00:00:00

abstract：:Phenobarbital pretreatment (50 mg/kg/day for 3 days orally) of male Wistar rats increased Vmax of benzene in vitro hepatic microsomal biotransformation about 6-fold without changing Km. However, benzene blood levels after oral, intraperitoneal, or subcutaneous benzene administration (3-3.5 mmoles/kg) were not influenc...

journal_title：Archives of toxicology

authors： Gut I

更新日期：1976-06-08 00:00:00

abstract：:5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...

journal_title：Archives of toxicology

authors： Sachse B,Meinl W,Sommer Y,Glatt H,Seidel A,Monien BH

更新日期：2016-01-01 00:00:00

abstract：:Pregnant C3H mice were exposed to a teratogenic dose of cyclophosphamide (CP, 20 mg/kg body weight) on the 10th day after copulation. Embryos or fetuses were examined 2-9 days later for gross abnormalities, weighed, and assayed for cephalic acetylcholinesterase (EC 3.1.1.7, AChE) activity, and haemoglobin content. In ...

journal_title：Archives of toxicology

authors： Pillans PI,Stephenson BA,Folb PI

更新日期：1988-01-01 00:00:00

abstract：:The kinetic analysis of esterase inhibition by acylating compounds (organophosphorus carbamates and sulfonyl fluorides) is sometimes unable to yield consistent results by fitting simple inhibition kinetic models to experimental data of complex systems. In this work, kinetic data were obtained for phenylmethylsulfonyl ...

journal_title：Archives of toxicology

authors： Estévez J,Barril J,Vilanova E

更新日期：2012-05-01 00:00:00

abstract：:Recent work concerned with the mechanism underlying the development of organophosphorous compound-induced delayed neurotoxicity (OPIDN) is reviewed. Topics covered include the prophylaxis of OPIDN by phenylmethylsulfonyl fluoride and other agents, neurotoxic esterase (NTE) as measured using either labelled di-isopropy...

journal_title：Archives of toxicology

authors： Carrington CD

更新日期：1989-01-01 00:00:00

abstract：:Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizol...

journal_title：Archives of toxicology

authors： Vanparys P,Fabry L,Léonard A,Marsboom R

更新日期：1982-07-01 00:00:00

abstract：:Bisphenol A (BPA) is a chemical in widespread use that is under scientific discussion due to its endocrine activity. Controversies exist about how to interpret reportedly high blood concentrations measured in uncontrolled situations. Physiologically based pharmaco-/toxicokinetic modelling resulted in 10-100-fold lower...

journal_title：Archives of toxicology

authors： Partosch F,Mielke H,Gundert-Remy U

更新日期：2013-07-01 00:00:00

abstract：:Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340 mumol/kg/h for rats and 560 mumol/kg/h for mice. The atmospheric concentration at which Vmax/2 is reached is 1200 ppm for rats and 1800 pp...

journal_title：Archives of toxicology

authors： Csanády GA,Freise D,Denk B,Filser JG,Cornet M,Rogiers V,Laib RJ

更新日期：1991-01-01 00:00:00

abstract：:With the development of nanotechnology, myriad types of novel materials have been discovered at the nanoscale, among which the most interesting material is graphene. However, the toxicity data available on graphene are extremely limited. In this study, we explored toxic response of commercially available graphene nano...

journal_title：Archives of toxicology

authors： Park EJ,Lee GH,Han BS,Lee BS,Lee S,Cho MH,Kim JH,Kim DW

更新日期：2015-09-01 00:00:00

abstract：:The goal of the present study was to obtain an in vivo relevant prioritization method for the endocrine potencies of different polycarbonate monomers, by combining in vitro bioassay data with physiologically based kinetic (PBK) modelling. PBK models were developed for a selection of monomers, including bisphenol A (BP...

journal_title：Archives of toxicology

authors： Punt A,Aartse A,Bovee TFH,Gerssen A,van Leeuwen SPJ,Hoogenboom RLAP,Peijnenburg AACM

更新日期：2019-07-01 00:00:00

abstract：:We investigated the hepatotoxicity induced by AQ using a glutathione (GSH)-depleted mice model. Although sole administration of either AQ or L-buthionine-S,R-sulfoxinine (BSO), a well-known GSH synthesis inhibitor, produced no significant hepatotoxicity, combined administration of AQ with BSO induced hepatotoxicity ch...

journal_title：Archives of toxicology

authors： Shimizu S,Atsumi R,Itokawa K,Iwasaki M,Aoki T,Ono C,Izumi T,Sudo K,Okazaki O

更新日期：2009-07-01 00:00:00

abstract：:Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...

journal_title：Archives of toxicology

authors： Wolff T,Distlerath LM,Worthington MT,Guengerich FP

更新日期：1987-01-01 00:00:00

abstract：:Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic to rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibit protein synthesis in vitro and in several in vivo systems. The mechanism whereby this mitogenic activity occurs was previously u...

journal_title：Archives of toxicology

authors： Ennamany R,Kretz O,Creppy EE

更新日期：1995-01-01 00:00:00

abstract：:Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. One of the most frequent manifestations of chemical allergy is contact hypersensitivity, which can have serious impact on quality of life. Allergic contact dermatitis is a predominantly CD8 + T cell-mediated immune d...

journal_title：Archives of toxicology

authors： Corsini E,Engin AB,Neagu M,Galbiati V,Nikitovic D,Tzanakakis G,Tsatsakis AM

更新日期：2018-10-01 00:00:00

abstract：:Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydro...

journal_title：Archives of toxicology

authors： Oishi S

更新日期：1986-12-01 00:00:00

abstract：:The "closed chamber technique" (CCT) is presented. It allows investigation of pharmacokinetics of volatile substances in vivo in animals and in man and in vitro using tissue fractions. During the exposure period only the atmospheric concentrations of the substance are measured. The concentration-time data obtained are...

journal_title：Archives of toxicology

authors： Filser JG

更新日期：1992-01-01 00:00:00

abstract：:The goal of these studies was to characterize the role played by antigen challenge in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunosuppression. The effects of single exposure to TCDD (4.2, 14, and 42 microg/kg) in B6C3F1 mice on the reverse plaque assay (RPA; no sensitization) and the sheep red blood cell ...

journal_title：Archives of toxicology

authors： Matulka RA,Morris DL,Wood SW,Kaminski NE,Holsapple MP

更新日期：1997-01-01 00:00:00

abstract：:A single dose of 10 mg methylmercury chloride per kg body weight was given to 30 days old rats and to adult rats (180-200g)(. This resulted in brain levels of 1.4-2.2 micrograms Hg/g wet weight. In the young rats electron microscopic morphometry showed swelling of the granule cells. The extent of changes was more pron...

journal_title：Archives of toxicology

authors： Syversen TL,Totland G,Flood PR

更新日期：1981-04-01 00:00:00

abstract：:To investigate possible persistent nephrotoxic effects of trichloroethylene (TRI), a retrospective study was carried out on 39 workers exposed to high levels of TRI from 1956 to 1975. Total protein levels in urine, as well as serum and urine creatinine and serum urea were unchanged in comparison with the control. Sodi...

journal_title：Archives of toxicology

authors： Brüning T,Sundberg AG,Birner G,Lammert M,Bolt HM,Appelkvist EL,Nilsson R,Dallner G

更新日期：1999-06-01 00:00:00

abstract：:Etridiazole, 5-ethoxy-3-trichloromethyl-1,2,4-thiadiazole, was orally administered to rats and human volunteers. Two metabolites of etridiazole were synthesized: 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid (ET-CA) and N-acetyl-S-(5-ethoxy-1,2,4-thiadiazol-3-yl-methyl)-L-cysteine (ET-MA). Selective and sensitive analy...

journal_title：Archives of toxicology

authors： van Welie RT,Mensert R,Van Duyn P,Vermeulen NP

更新日期：1991-01-01 00:00:00

abstract：:The amphetamine-derived designer drugs have been illegally used worldwide as recreational drugs, some of which are known to be hepatotoxic in humans. To compare their cytotoxic effects, 3,4-methylenedioxy-N-methamphetamine (MDMA) and its related analogues, N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), 3,4...

journal_title：Archives of toxicology

authors： Nakagawa Y,Suzuki T,Tayama S,Ishii H,Ogata A

更新日期：2009-01-01 00:00:00

abstract：:Organophosphate-induced delayed polyneuropathy (OPIDP) is initiated by inhibition/aging of more than 70-75% of neuropathy target esterase (NTE). Di-n-butyl-2,2-dichlorovinyl phosphate (DBDCVP) (1 mg/kg s.c.) inhibited 96%, 86% and 83% of NTE in brain, spinal cord and peripheral nerve, respectively, and induced a typic...

journal_title：Archives of toxicology

authors： Moretto A,Lotti M,Spencer PS

更新日期：1989-01-01 00:00:00

abstract：:Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg ...

journal_title：Archives of toxicology

authors： Wakui S,Muto T,Suzuki Y,Takahashi H,Hano H

更新日期：2012-01-01 00:00:00

abstract：:Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of...

journal_title：Archives of toxicology

authors： El-Sherbeni AA,El-Kadi AO

更新日期：2014-11-01 00:00:00

abstract：:Evading apoptosis and chemo-resistance are considered as very important factors which help tumour progression and metastasis. Hence, to overcome chemo-resistance, there is an urgent requirement for emergence of more effective treatment options. Myricetin, a naturally occurring flavonoid, is present in various plant-de...

journal_title：Archives of toxicology

authors： Akhtar S,Najafzadeh M,Isreb M,Newton L,Gopalan RC,Anderson D

更新日期：2021-01-01 00:00:00

abstract：:The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December 2015. Drawing on the experience gained ...

journal_title：Archives of toxicology

authors： Daston G,Knight DJ,Schwarz M,Gocht T,Thomas RS,Mahony C,Whelan M

更新日期：2015-01-01 00:00:00