Identification and quantitative determination of a carboxylic and a mercapturic acid metabolite of etridiazole in urine of rat and man. Potential tools for biological monitoring.

abstract：:Polymorphisms of the apolipoprotein E (APOE) gene differentially affect neurobiological functions and cognitive performance and confer different vulnerabilities to subclinical exposures to chlorpyrifos (CPF), a pesticide used worldwide. The data reported on this topic suggest a complex interaction between cholinergic ...

journal_title：Archives of toxicology

authors： Basaure P,Guardia-Escote L,Cabré M,Peris-Sampedro F,Sánchez-Santed F,Domingo JL,Colomina MT

更新日期：2019-03-01 00:00:00

abstract：:Rat embryos (9.5-day-old) were cultured for 48 h in the presence of nifedipine (NIF), nimodipine (NIM), nitrendipine (NIT), gallopamil HCl (GAL), verapamil HCl (VER) and diltiazem HCl (DIL). The effects on growth and morphogenetic differentiation in vitro were monitored. Dose-response relationships were evaluated, inc...

journal_title：Archives of toxicology

authors： Stein G,Srivastava MK,Merker HJ,Neubert D

更新日期：1990-01-01 00:00:00

abstract：:The effect of Co(NO3)2, CdSO4, NiSO4, ZnSO4, and HgCl2 (given repeatedly in subtoxic doses in the drinking water for 30 days) on rat liver monooxygenases was studied in experiments on male Wistar rats. The salts of Co, Cd, and Zn increased the activity of benzphetamine-N-demethylase, the content of cytochrome P-450 an...

journal_title：Archives of toxicology

authors： Kadiiska M,Stoytchev T,Serbinova E

更新日期：1985-01-01 00:00:00

abstract：:Cats were given vincristine sulfate (50 micrograms/kg i.v. every 4 days) and studied after 7-29 injections when neurological deficits became evident. The conduction velocity spectrum of individual afferent nerves from soleus muscles was shifted toward slower velocities. Relatively few functional muscle spindles or oth...

journal_title：Archives of toxicology

authors： Goldstein BD,Lowndes HE,Cho E

更新日期：1981-11-01 00:00:00

abstract：:Dibromoacetonitrile (DBAN) is a disinfection byproduct of chlorination of drinking water. Epidemiological studies indicate that it might present a potential hazard to human health. The present work provides evidence for DBAN activation to cyanide (CN(-)) by the hypoxanthine (HX)/xanthine oxidase (XO)/iron (Fe) system ...

journal_title：Archives of toxicology

authors： Mohamadin AM,Abdel-Naim AB

更新日期：2003-02-01 00:00:00

abstract：:In a previous study, we showed that bisphenol A (BPA) had oestrogen-like effects in bird embryos, causing malformations of the oviducts in Japanese quail (Coturnix japonica) and feminisation of the left testis in chicken (Gallus domesticus). In this study, uptake and distribution of BPA and tetrabromobisphenol A (TBBP...

journal_title：Archives of toxicology

authors： Halldin K,Berg C,Bergman A,Brandt I,Brunström B

更新日期：2001-12-01 00:00:00

abstract：:Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...

journal_title：Archives of toxicology

authors： Wolff T,Distlerath LM,Worthington MT,Guengerich FP

更新日期：1987-01-01 00:00:00

abstract：:Previous studies indicate that benzanthrone, an anthraquinone dye intermediate, caused significant depletion of ascorbic acid (AsA). In this investigation the effect of benzanthrone on the status of different forms of AsA and other bio-antioxidants such as glutathione (GSH) was studied. Oral administration of benzanth...

journal_title：Archives of toxicology

authors： Dwivedi N,Das M,Khanna SK

更新日期：2001-06-01 00:00:00

abstract：:Evading apoptosis and chemo-resistance are considered as very important factors which help tumour progression and metastasis. Hence, to overcome chemo-resistance, there is an urgent requirement for emergence of more effective treatment options. Myricetin, a naturally occurring flavonoid, is present in various plant-de...

journal_title：Archives of toxicology

authors： Akhtar S,Najafzadeh M,Isreb M,Newton L,Gopalan RC,Anderson D

更新日期：2021-01-01 00:00:00

abstract：:Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicating factor is that non-genotoxic carcinogens act through several distinctive modes of action, which makes prediction of t...

journal_title：Archives of toxicology

authors： Schaap MM,Wackers PF,Zwart EP,Huijskens I,Jonker MJ,Hendriks G,Breit TM,van Steeg H,van de Water B,Luijten M

更新日期：2015-12-01 00:00:00

abstract：:With the development of nanotechnologies, the potential adverse effects of nanomaterials such as multi-walled carbon nanotubes (MWCNT) on the respiratory tract of asthmatics are questioned. Furthermore, investigations are necessary to understand how these effects might arise. In the present study, we hypothesized that...

journal_title：Archives of toxicology

authors： Ronzani C,Casset A,Pons F

更新日期：2014-02-01 00:00:00

abstract：:Etoposide (ETP) and anthracyclines are applied for wide anti-cancer treatments. However, the ETP-induced cardiotoxicity remains to be a major safety issue and the underlying cardiotoxic mechanisms are not well understood. This study is aiming to unravel the cardiotoxicity profile of ETP in comparison to anthracyclines...

journal_title：Archives of toxicology

authors： Nemade H,Chaudhari U,Acharya A,Hescheler J,Hengstler JG,Papadopoulos S,Sachinidis A

更新日期：2018-04-01 00:00:00

abstract：:The ethylene oxide adduct formed on the N-terminal valine in haemoglobin was investigated as a biological monitor of tobacco smoke intake. The modified method developed for the determination of the hydroxyethylvaline adduct (HOEtVal) involved reaction of globin with pentafluorophenyl isothiocyanate, extraction of the ...

journal_title：Archives of toxicology

authors： Bailey E,Brooks AG,Dollery CT,Farmer PB,Passingham BJ,Sleightholm MA,Yates DW

更新日期：1988-01-01 00:00:00

abstract：:The mechanical properties of the bones of young, adult and old rats administered various concentrations of cadmium were measured to prove the direct effect of cadmium on the bones of young rats. The young rats were divided into three subgroups, which were administered 0 (control), 5 and 10 ppm cadmium, respectively. T...

journal_title：Archives of toxicology

authors： Ogoshi K,Moriyama T,Nanzai Y

更新日期：1989-01-01 00:00:00

abstract：:Aliphatic nitriles are a class of chemicals used in high volumes in the production of plastics and elastomers, in organic synthesis, and in production of a number of food packaging containers. Toxicity and metabolism of acrylonitrile (AN) are well characterized. On the other hand, minimal information is available on t...

journal_title：Archives of toxicology

authors： Burka LT,Sanchez IM,Ahmed AE,Ghanayem BI

更新日期：1994-01-01 00:00:00

abstract：:Melanin is a polyanionic pigment that colors, e.g., the hair, skin and eyes. The pigment neuromelanin is closely related to melanin and is mainly produced in specific neurons of the substantia nigra. Certain drugs and chemicals bind to melanin/neuromelanin and are retained in pigment cells for long periods. This speci...

journal_title：Archives of toxicology

authors： Karlsson O,Lindquist NG

更新日期：2016-08-01 00:00:00

abstract：:The influence of haemoperfusion on some immunological parameters was investigated in a pilot study involving two groups of three patients each. In columns containing cellulose-coated activated charcoal or polystyrene resin a temporary reduction of the total white cell number, particularly involving the segmented and b...

journal_title：Archives of toxicology

authors： Rommes JH,Sangster B,Gmelig Meyling FH,Daha MR,van Heijst AN

更新日期：1983-02-01 00:00:00

abstract：:In vivo screening methods for detection of thyroid function modulators are now under development in many research laboratories. We assessed the applicability of the Hershberger assay protocol to screen for thyroid function modulators. In experiment 1, castrated male BrlHan WIST@Jcl (GALAS) rats were administered a pot...

journal_title：Archives of toxicology

authors： Noda S,Muroi T,Takakura S,Sakamoto S,Takatsuki M,Yamasaki K,Tateyama S,Yamaguchi R

更新日期：2005-11-01 00:00:00

abstract：:The implementation of the Chemical Weapon Convention (CWC), prohibiting the development, production, storage and use of chemical weapons by 192 nations and the ban of highly toxic OP pesticides, especially class I pesticides according to the WHO classification, by many countries constitutes a great success of the inte...

journal_title：Archives of toxicology

authors： Worek F,Wille T,Koller M,Thiermann H

更新日期：2016-09-01 00:00:00

abstract：:The EU-EuroMix project adopted the strategy of the European Food Safety Authority (EFSA) for cumulative risk assessment, which limits the number of chemicals to consider in a mixture to those that induce a specific toxicological phenotype. These so-called cumulative assessment groups (CAGs) are refined at several leve...

journal_title：Archives of toxicology

authors： Staal YCM,Meijer J,van der Kris RJC,de Bruijn AC,Boersma AY,Gremmer ER,Zwart EP,Beekhof PK,Slob W,van der Ven LTM

更新日期：2018-12-01 00:00:00

abstract：:Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in th...

journal_title：Archives of toxicology

authors： Malhotra KM,Shukla GS,Chandra SV

更新日期：1982-03-01 00:00:00

abstract：:To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the l...

journal_title：Archives of toxicology

authors： Kudo Y,Egashira T,Takayama F,Yamanaka Y,Shimada T

更新日期：1993-01-01 00:00:00

abstract：:The main purpose of this study was to verify the hypothesis that cognitive dysfunctions induced by arsenic exposure were related to the changes of D-serine metabolism in the hippocampus of offspring mice. Mother mice and their offsprings were exposed to 0, 15, 30 or 60 mg/L sodium arsenite (NaAsO2) through drinking wa...

journal_title：Archives of toxicology

authors： Wang Y,Yang X,Yu H,Wang H,Qi Y,Geng M

更新日期：2020-01-01 00:00:00

abstract：:A rapid gas-chromatographic method for the qualitative and quantitative measurement of various drugs in human plasma and other body fluids has been developed. The extraction procedure is done within 5 min, and gas-chromatographic measurement carried out on 2 diverse columns with detection by flame ionisation detectors...

journal_title：Archives of toxicology

authors： Pentz R,Schütt A

更新日期：1978-01-25 00:00:00

abstract：:2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) has been developed as a substitute for ozone-depleting chlorofluorocarbons (CFCs). It is a structural analogue of halothane and similarities in the metabolic pathways and liver toxicity of both compounds have been described. The present study was initiated after an acciden...

journal_title：Archives of toxicology

authors： Hoet P,Buchet JP,Sempoux C,Nomiyama T,Rahier J,Lison D

更新日期：2001-07-01 00:00:00

abstract：:A series of experiments was set up to elucidate the effects of pollution on marine and estuarine fish health, since the European flounder (Platichthys flesus) has shown a relatively high prevalence of (pre)neoplastic liver lesions and lymphocystis virus disease in Dutch coastal and estuarine waters. The hypothesis of ...

journal_title：Archives of toxicology

authors： Grinwis GC,van den Brandhof EJ,Engelsma MY,Kuiper RV,Vaal MA,Vethaak AD,Wester PW,Vos JG

更新日期：2001-04-01 00:00:00

abstract：:Carcinogenic risk and molecular mechanisms underlying the liver tumor-promoting activity of copper gluconate, an additive of functional foods, were investigated using a rat medium-term liver carcinogenicity bioassay protocol (Ito test) and a 2-week short-term administration experiment. In the medium-term liver bioassa...

journal_title：Archives of toxicology

authors： Abe M,Usuda K,Hayashi S,Ogawa I,Furukawa S,Igarashi M,Nakae D

更新日期：2008-08-01 00:00:00

abstract：:Heat shock proteins (HSPs) are a group of proteins that are rapidly induced in response to physiological stress, including hyperthermia and exposure to toxicants. Thus they may provide a useful index of toxicity in in vitro systems for screening for toxicity. We have recently developed a rat nasal explant system for i...

journal_title：Archives of toxicology

authors： Simpson SA,Alexander DJ,Reed CJ

更新日期：2004-06-01 00:00:00

abstract：:Exposure to high-dose benzene leads to the inhibition of erythroid differentiation. However, whether lower doses of benzene exposure resemble high-dose effects in erythroid differentiation, as well as the underlying mechanisms, remains largely unknown. To identify the microRNAs (miRNAs) specifically responsible for be...

journal_title：Archives of toxicology

authors： Liang B,Chen Y,Yuan W,Qin F,Zhang Q,Deng N,Liu X,Ma X,Zhang X,Zhang B,Deng Q,Huang M,Tang H,Liu L,Chen W,Xiao Y

更新日期：2018-01-01 00:00:00

abstract：:Monolayers of L6 rat skeletal myoblast cells formed surface binding isotherms with the purified tobacco leaf glycoprotein TGP1 and the enriched cigarette tar glycoprotein TGP2. Scatchard analysis showed that the binding in the range of the limited concentrations tested was to a single class molecule and the calculated...

journal_title：Archives of toxicology

authors： Santos-Buch CA,Hall HR,Farfan F,Orlow I,Firpo A,von Kreuter BF,Becker CG

更新日期：1995-01-01 00:00:00