Abstract:
:Pathological changes induced by cadmium aerosol had features common to the changes evoked by oxidants. Female rats were exposed to fumes of lead, antimony, zinc and cadmium (15-100 nmoles/m3). One hour after termination of exposure, superoxide dismutase (SOD) activity in erythrocytes of the exposed rats lowered by 15-40%. SOD activity of lung lavage fluid also lowered by 20-35% and the 2nd day after the exposure. The inverse value of SOD activity (l/SOD) in erythrocytes and of lung lavage fluid were proportional to the molar exposure level adjusted by the particle size (Dixon plot), irrespective of the difference of the exposed substance. The ratio of dry weight to wet weight of the lung was 4.3-26% lower than the control value on the later period after the exposure. With the heavy metal exposure, the uptake of the exposed metal was found to be proportional to the endogenous zinc concentration, which was correlated well with the change of SOD in the lung and in erythrocytes. Cadmium decreased the zinc concentration after the exposure.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Minami M,Koshi K,Homma K,Suzuki Ydoi
10.1007/BF00347869subject
Has Abstractpub_date
1982-03-01 00:00:00pages
215-25issue
3-4eissn
0340-5761issn
1432-0738journal_volume
49pub_type
杂志文章abstract::Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions. These epoxy FAs comprise epoxyeicosatrienoic acids (EETs) and epoxy-octadeceno...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2060-4
更新日期:2017-11-01 00:00:00
abstract::It is estimated that only a few marketed drugs are able to directly induce liver steatosis. However, many other drugs may exacerbate or precipitate fatty liver in the presence of other risk factors or in patients prone to non-alcoholic fatty liver disease. On the other hand, current in vitro tests for drug-induced ste...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1197-7
更新日期:2014-04-01 00:00:00
abstract::Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotectiv...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-015-1538-1
更新日期:2015-10-01 00:00:00
abstract::Deoxynivalenol (DON) contamination in food is a public health concern; however, the effect of DON exposure on immune disorders including allergies remains unclear. The aim of this study is to elucidate the effect of oral exposure to DON on pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermat...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02875-3
更新日期:2020-12-01 00:00:00
abstract::Increasing evidence suggests that free radical-mediated oxidation of biological substrates is a key feature of Alzheimer's disease (AD) pathogenesis. While it has long been established that biomarkers of lipid peroxidation (LPO) are elevated in AD brain as well as ventricular CSF postmortem, more recent studies have d...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-015-1517-6
更新日期:2015-07-01 00:00:00
abstract::The effect of Co(NO3)2, CdSO4, NiSO4, ZnSO4, and HgCl2 (given repeatedly in subtoxic doses in the drinking water for 30 days) on rat liver monooxygenases was studied in experiments on male Wistar rats. The salts of Co, Cd, and Zn increased the activity of benzphetamine-N-demethylase, the content of cytochrome P-450 an...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00333421
更新日期:1985-01-01 00:00:00
abstract::Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA lesions from the genomes of organisms across the evolutionary scale, from bacteria to humans. The serial steps in NER involve recognition of lesions, adducts or structures that disrupt the DNA double helix, removal of a short oli...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1820-x
更新日期:2016-11-01 00:00:00
abstract::Engineered amorphous silica nanoparticles (nanosilica) are widely used in industry yet can induce adverse effects, which might be classified according to the oxidative stress model. However, the underlying mechanisms as well as the potential interactions of the three postulated different tiers of toxicity-i.e. oxidati...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2223-y
更新日期:2018-07-01 00:00:00
abstract::To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the l...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01969922
更新日期:1993-01-01 00:00:00
abstract::The hypothesis that methylmercury (MeHg) potently induces formation of reactive oxygen species (ROS) in the brain is supported by observations on the neuroprotective effects of various classes of antioxidants. Flavonoids have been reported to possess divalent metal chelating properties, antioxidant activities and to r...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0482-3
更新日期:2010-02-01 00:00:00
abstract::The hepatoproliferative and cytochrome P450 enzyme inducing effects of two antiestrogens, tamoxifen and toremifene, were compared in female Sprague-Dawley rats using immunohistochemical staining methods. Equimolar doses of the antiestrogens (tamoxifen 45 mg/kg and toremifene 48 mg/kg) were given by oral administration...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040000116
更新日期:2000-07-01 00:00:00
abstract::We studied the incorporation of cocaine (COC), benzoylecgonine (BE) and ecgonine methyl ester (EME) into hair from blood. At first, the time courses of three drugs in rat plasma following i.p. administration of cocaine were investigated over 360 min. AUCs of COC, BE and EME in plasma were 14.2, 60.7 and 53.4 microgram...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02035137
更新日期:1992-01-01 00:00:00
abstract::The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-015-1470-4
更新日期:2015-05-01 00:00:00
abstract::Cats were given vincristine sulfate (50 micrograms/kg i.v. every 4 days) and studied after 7-29 injections when neurological deficits became evident. The conduction velocity spectrum of individual afferent nerves from soleus muscles was shifted toward slower velocities. Relatively few functional muscle spindles or oth...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00319653
更新日期:1981-11-01 00:00:00
abstract::The organophosphorus (OP) pesticide malathion is a neurotoxic compound whose acute toxicity is primarily caused by the inhibition of acetylcholinesterase (AChE), leading to cholinergic syndrome-related symptoms. Some lines of evidence indicate that long-term exposure to low levels of OP may produce neuropsychiatric an...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1466-0
更新日期:2016-03-01 00:00:00
abstract::To investigate the effect of long term hashish use on T-lymphocytes we have measured the incorporation of 14C-thymidine by peripheral blood lymphocytes, unstimulated and stimulated by phytohemagglutinin, as well as the proportion and number of E-rosettes in 12 healthy male chronic users of the drug before and after a ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01891963
更新日期:1978-04-27 00:00:00
abstract::Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01234482
更新日期:1983-12-01 00:00:00
abstract::The acute toxicity of cyanide is determined by its peak levels reached in the body. Compared to the ingestion of free cyanide, lower peak levels may be expected after consumption of foods containing cyanogenic glycosides with the same equivalent dose of cyanide. This is due to possible delayed and/or incomplete releas...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1479-8
更新日期:2016-03-01 00:00:00
abstract::The effect of acetone pretreatment (5% in drinking water for 10 days on rat liver metabolism and toxicity of thiobenzamide (TB) was investigated. Hepatic microsomes from acetone-pretreated rats showed a significant increase of TB-S-oxidation rate which, on the basis of selective thermal inactivation of FAD-containing ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01974397
更新日期:1990-01-01 00:00:00
abstract::203Pb(NO3)2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01261379
更新日期:1983-10-01 00:00:00
abstract::Ethylenediaminetetraacetic acid (EDTA) is widely used in food and other industries to sequester metal ions and to prevent their disadvantageous effects. The objective of the current study was to evaluate the protective effect of Panax ginseng extract standardized with ginsenoside Rg3 (ginsenoside Rg3 content was 3.6% ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0237-y
更新日期:2008-03-01 00:00:00
abstract::Sarin, a potent organophosphate cholinesterase inhibitor, induces an array of toxic effects including convulsions. Many antidotal treatments contain anticonvulsants to block seizure activity and the ensuing brain damage. Magnesium sulfate (MGS) is used to suppress eclamptic seizures in pregnant women with hypertension...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-012-0916-1
更新日期:2013-02-01 00:00:00
abstract::The activity of 18 vitamin D analogs on soft tissue calcification and growth impairment in neonatal rats and their effect on bone calcium mobilization, intestinal calcium absorption and binding to intestinal 1,25-dihydroxyvitamin D3 receptors in adult rats were compared. Depending on the chemical modification of the v...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00303129
更新日期:1989-01-01 00:00:00
abstract::In case of mycotoxin contaminations, food and feedstuff are usually contaminated by more than one toxin. However toxicological data concerning the effects of mycotoxin combinations are sparse. The intestinal epithelium is the first barrier against food contaminants and this constantly renewing organ is particularly se...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1309-4
更新日期:2015-08-01 00:00:00
abstract::The α,β-unsaturated carbonyl group is recognized as alert for mutagenicity, attributed to (1) its direct reaction with DNA, counteractable by glutathione (GSH), and (2) oxidative stress caused indirectly by GSH depletion. Accordingly, the α,β,γ,δ-unsaturated lactone patulin (PAT), a mycotoxin detected in fruits and pr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1443-z
更新日期:2016-02-01 00:00:00
abstract::The antidepressants, imipramine and mianserin, have been reported to cause liver damage. We investigated a role of cytochrome P450 (CYP)-mediated formation of a reactive metabolite in antidepressant-induced acute cell injury using hepatocytes isolated from male and female Wistar rats, and male Dark Agouti rats, which ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050599
更新日期:1999-04-01 00:00:00
abstract::Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0095-z
更新日期:2006-10-01 00:00:00
abstract::The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicin-induced histopathologic changes in renal tissue were examine in rats. Gentamicin (30, 60, 120, 160 mg/kg) was administered s.c. for 10 consecutive days with or without isosorbide pretreatment. Osmotic diuresis with ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02419001
更新日期:1980-09-01 00:00:00
abstract::Perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA), which are classified as perfluoroalkyl and polyfluoroalkyl substances (PFASs), have been widely used in industrial applications as a surface protectant. PFASs have been detected in wildlife and in humans around the globe. The purposes of this study are t...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2365-y
更新日期:2019-02-01 00:00:00
abstract::Particle-induced carcinogenicity is not well understood, but might involve inflammation. The proinflammatory cytokine tumor necrosis factor (TNF) is considered to be an important mediator in inflammation. We investigated its role in particle-induced inflammation and DNA damage in mice with and without TNF signaling. T...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0613-9
更新日期:2005-03-01 00:00:00