Penetration of beta-naphthylamine and o-toluidine through human skin in vitro.

abstract：:Chlorpyrifos (CPF) is a widely used organophosphorus pesticide. Earlier work from our laboratory and others has demonstrated that the sensitivity to CPF exposure changes markedly during maturation. A number of studies suggest that in addition to inhibiting acetylcholinesterase (AChE), CPF oxon may also interact direct...

journal_title：Archives of toxicology

authors： Zhang H,Liu J,Pope CN

更新日期：2002-01-01 00:00:00

abstract：:Rats were exposed to black tea (2.5% w/v) as their sole drinking liquid for either 1 day or 1 month, while controls were maintained on water. After this treatment period, all animals received a single oral dose IQ (2-amino-3-methylimidazo-[4,5-f]quinoline), and urine was collected for 48 h. Mutagenic activity of the u...

journal_title：Archives of toxicology

authors： Yoxall VR,Parker DA,Kentish PA,Ioannides C

更新日期：2004-08-01 00:00:00

abstract：:Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in th...

journal_title：Archives of toxicology

authors： Malhotra KM,Shukla GS,Chandra SV

更新日期：1982-03-01 00:00:00

abstract：:Blooms of cyanobacteria have been documented throughout history, all over the world. Mass populations of these organisms typically present hazards to human health and are known for the production of a wide range of highly toxic metabolites-cyanotoxins, of which among the most common and most investigated are the micro...

journal_title：Archives of toxicology

authors： Svirčev Z,Drobac D,Tokodi N,Mijović B,Codd GA,Meriluoto J

更新日期：2017-02-01 00:00:00

abstract：:Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal methods addressing mechanisms under the first three key events of th...

journal_title：Archives of toxicology

authors： Casati S,Aschberger K,Barroso J,Casey W,Delgado I,Kim TS,Kleinstreuer N,Kojima H,Lee JK,Lowit A,Park HK,Régimbald-Krnel MJ,Strickland J,Whelan M,Yang Y,Zuang V

更新日期：2018-02-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) and non-NMDA receptors were found to be involved in development of functional disorders caused by hexachlorophene. In order to specify the role of glutamate receptors we studied the protective effects of the selective antagonist of the kainate/(+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4...

journal_title：Archives of toxicology

authors： Häntzschel A,Andreas K

更新日期：2000-01-01 00:00:00

abstract：:Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. The microsomes themselves were not cytotoxic. P388D1 cells were more sensitive to CPA, ...

journal_title：Archives of toxicology

authors： Gut I,Danielová V,Holubová J,Soucek P,Klucková H

更新日期：2000-10-01 00:00:00

abstract：:Steatosis, also known as fatty liver disease (FLD), is a disorder in which the lipid metabolism of the liver is disturbed, leading to the abnormal retention of lipids in hepatocytes. FLD can be induced by several drugs, and although it is mostly asymptomatic, it can lead to steatohepatitis, which is associated with li...

journal_title：Archives of toxicology

authors： Rodrigues RM,Branson S,De Boe V,Sachinidis A,Rogiers V,De Kock J,Vanhaecke T

更新日期：2016-03-01 00:00:00

abstract：:The investigation was aimed at providing insight into the side chain metabolism of furazolidone in mice. The agents used in the experiments were furazolidone, 3-amino-2-oxazolidinone, oxazolidinone, nitrofurantoin, 3-aminohydantoin and hydantoin, administered intraperitoneally at five equimolar doses ranging from 0.17...

journal_title：Archives of toxicology

authors： Hunder G,Schmid A,Mayring L

更新日期：1987-12-01 00:00:00

abstract：:Exposure to alkylanilines found in tobacco smoke and indoor air is associated with risk of bladder cancer. Genetic factors significantly influence the metabolism of arylamine carcinogens and the toxicological outcomes that result from exposure. We utilized nucleotide excision repair (NER)-deficient immortalized human ...

journal_title：Archives of toxicology

authors： Leggett CS,Doll MA,States JC,Hein DW

更新日期：2021-01-01 00:00:00

abstract：:Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. The aim of this study was to compare the toxic effects of the two drugs on hepatocytes in primary culture as a function of their metabolism and to explore the variations...

journal_title：Archives of toxicology

authors： Ellouk-Achard S,Martin C,Duc HT,Dutertre-Catella H,Thevenin M,Warnet JM,Claude JR

更新日期：1998-04-01 00:00:00

abstract：:The significance of elevated excretion of metallothionein in urine of women living in cadmium-polluted areas of Japan was studied with respect to renal dysfunction. The relationships between the concentrations of metallothionein in urine and those of other non-specific urinary indices of renal dysfunction, i.e., total...

journal_title：Archives of toxicology

authors： Tohyama C,Shaikh ZA,Nogawa K,Kobayashi E,Honda R

更新日期：1982-07-01 00:00:00

abstract：:DNA binding in vivo: [6,7-3H]beta-trenbolone (beta-TBOH) was administered p.o. and i.p. to rats. After 8 or 16 h, DNA was isolated from the livers and purified to constant specific radioactivity. Enzymatic digestion to deoxyribonucleotides and separation by HPLC revealed about 90% of the DNA radioactivity eluting in t...

journal_title：Archives of toxicology

authors： Lutz WK,Deuber R,Caviezel M,Sagelsdorff P,Friederich U,Schlatter C

更新日期：1988-01-01 00:00:00

abstract：:Vitamin E acetate (VEA) has come under significant scrutiny due to its association with e-cigarette, or vaping, product use-associated lung injury (EVALI). In 1965, Sir Austin Bradford Hill proposed a set of criteria used to critically assess an association for causality. In this article, we apply the Bradford Hill ca...

journal_title：Archives of toxicology

authors： Feldman R,Meiman J,Stanton M,Gummin DD

更新日期：2020-06-01 00:00:00

abstract：:Knowledge about established breast carcinogens can support improved and modernized toxicological testing methods by identifying key mechanistic events. Ionizing radiation (IR) increases the risk of breast cancer, especially for women and for exposure at younger ages, and evidence overall supports a linear dose-respons...

journal_title：Archives of toxicology

authors： Helm JS,Rudel RA

更新日期：2020-05-01 00:00:00

abstract：:The metabolism of 74As-arsenate (As V, 0.4 mg As/kg body weight, IV) in marmoset monkeys (two males and two females) was studied. Unlike all other animal species studied so far, the marmoset was found to be unable to metabolize the arsenate to dimethylarsinic acid. Most of the absorbed arsenate was reduced to arsenite...

journal_title：Archives of toxicology

authors： Vahter M,Marafante E

更新日期：1985-06-01 00:00:00

abstract：:Female wistar rats, conventional albino mice, and Chinese hamsters were given a single dose of acrylonitrile, 0.5 or 0.75 mM/kg body weight. The elimination in the urine of thiocyanate, which is the main metabolite of acrylonitrile, indicated a decreasing proportion of biotransformation after oral (over 20%), intraper...

journal_title：Archives of toxicology

authors： Gut I,Nerudová J,Kopecký J,Holecek V

更新日期：1975-02-14 00:00:00

abstract：:The effect of intracerebroventricular (i.c.v.) administration of cadmium or magnesium on central calcium-dependent blood pressure regulation was investigated. The systolic blood pressure of spontaneously hypertensive rats (SHR; male, 13 weeks of age) decreased following i.c.v. administration of cadmium chloride (20 nm...

journal_title：Archives of toxicology

authors： Sutoo D,Akiyama K

更新日期：2000-03-01 00:00:00

abstract：:In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his N...

journal_title：Archives of toxicology

authors： Calabrese EJ

更新日期：2011-12-01 00:00:00

abstract：:During/after the BP/Deepwater Horizon oil spill, cleanup workers, fisherpersons, SCUBA divers, and coastal residents were exposed to crude oil and dispersants. These people experienced acute physiological and behavioral symptoms and consulted a physician. They were diagnosed with petroleum hydrocarbon poisoning and ha...

journal_title：Archives of toxicology

authors： Sammarco PW,Kolian SR,Warby RA,Bouldin JL,Subra WA,Porter SA

更新日期：2016-04-01 00:00:00

abstract：:Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in drug discovery. Three-dimensional (3D) spheroid hepatic cultures have emerged as pr...

journal_title：Archives of toxicology

authors： Proctor WR,Foster AJ,Vogt J,Summers C,Middleton B,Pilling MA,Shienson D,Kijanska M,Ströbel S,Kelm JM,Morgan P,Messner S,Williams D

更新日期：2017-08-01 00:00:00

abstract：:In case of mycotoxin contaminations, food and feedstuff are usually contaminated by more than one toxin. However toxicological data concerning the effects of mycotoxin combinations are sparse. The intestinal epithelium is the first barrier against food contaminants and this constantly renewing organ is particularly se...

journal_title：Archives of toxicology

authors： Alassane-Kpembi I,Puel O,Oswald IP

更新日期：2015-08-01 00:00:00

abstract：:Di(2-ethylhexyl)phthalate (DEHP) and mono-(2-ethylhexyl)phthalate (MEHP) were administered PO or IP to pregnant ICR mice at varying doses on days 7, 8, and 9 of gestation. In groups given DEHP orally, resorptions and malformed fetuses increased significantly at 1,000 mg/kg. Fetal weights were also significantly suppre...

journal_title：Archives of toxicology

authors： Shiota K,Mima S

更新日期：1985-02-01 00:00:00

abstract：:Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicating factor is that non-genotoxic carcinogens act through several distinctive modes of action, which makes prediction of t...

journal_title：Archives of toxicology

authors： Schaap MM,Wackers PF,Zwart EP,Huijskens I,Jonker MJ,Hendriks G,Breit TM,van Steeg H,van de Water B,Luijten M

更新日期：2015-12-01 00:00:00

abstract：:As previously demonstrated, chronic administration of phenobarbital (0.05% in the drinking water) and of nafenopin (0.1% in the diet) increases the incidence and the kinetics of appearance of liver cancers. If bile acids play a key role in liver carcinogenesis, it might thus be expected that treatments like phenobarbi...

journal_title：Archives of toxicology

authors： Delzenne NM,Taper HS,Roberfroid M

更新日期：1994-01-01 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) has been shown to cause hepatotoxicity and other toxicological effects. Though PPARα activation by PFOA in the liver has been well accepted as an important mechanism of PFOA-induced hepatotoxicity, several pieces of evidence have shown that the hepatotoxic effects of PFOA may not be fully...

journal_title：Archives of toxicology

authors： Yan S,Zhang H,Guo X,Wang J,Dai J

更新日期：2017-01-01 00:00:00

abstract：:High-dosage alcohol intoxication (i.e., binge drinking in humans) is an increasingly prevalent problem. Despite the well-known long-term consequences, the acute effects of high-dosage alcohol intoxication on cognitive control processes have not been investigated with respect to neurophysiological changes in humans. We...

journal_title：Archives of toxicology

authors： Stock AK,Blaszkewicz M,Beste C

更新日期：2014-02-01 00:00:00

abstract：:Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg ...

journal_title：Archives of toxicology

authors： Wakui S,Muto T,Suzuki Y,Takahashi H,Hano H

更新日期：2012-01-01 00:00:00

abstract：:In vivo screening methods for detection of thyroid function modulators are now under development in many research laboratories. We assessed the applicability of the Hershberger assay protocol to screen for thyroid function modulators. In experiment 1, castrated male BrlHan WIST@Jcl (GALAS) rats were administered a pot...

journal_title：Archives of toxicology

authors： Noda S,Muroi T,Takakura S,Sakamoto S,Takatsuki M,Yamasaki K,Tateyama S,Yamaguchi R

更新日期：2005-11-01 00:00:00

abstract：:We have used the minipig as a prospective animal model for human risk characterization to study primary biochemical alterations upon oral contaminant intake. The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 i...

journal_title：Archives of toxicology

authors： Roos PH,Tschirbs S,Welge P,Hack A,Theegarten D,Mogilevski G,Wilhelm M

更新日期：2002-06-01 00:00:00