Abstract：
:The effect of acetone pretreatment (5% in drinking water for 10 days on rat liver metabolism and toxicity of thiobenzamide (TB) was investigated. Hepatic microsomes from acetone-pretreated rats showed a significant increase of TB-S-oxidation rate which, on the basis of selective thermal inactivation of FAD-containing monooxygenase (FADM), appeared dependent only on cytochrome P-450. Furthermore, TB was able to competitively inhibit acetone hydroxylase (AcH), an enzymatic reaction highly specific for the P-450IIE1 isozyme. Acetone pretreatment of rats also produced an exacerbation of liver damage induced by acute administration of TB (150 mg/kg), as judged by the extent of liver necrosis and serum alanine-amino transferase (ALAT) activities. Coadministration of acetone with TB reduced on the other hand the extent of liver damage. The findings suggest that P-450 species induced by acetone, and in particular the P-450IIE1 isozyme, could be involved in the biotransformation of TB.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Chieli E,Saviozzi M,Puccini P,Longo V,Gervasi PGdoi
10.1007/BF01974397subject
Has Abstractpub_date
1990-01-01 00:00:00pages
122-7issue
2eissn
0340-5761issn
1432-0738journal_volume
64pub_type
杂志文章abstract：:The uncertainties that surround the methods used for risk assessment of exposure to carcinogens have been highlighted by a recent document advocating an approach based on the T25 dose (the dose giving a 25% incidence of cancer in an appropriately designed animal experiment). This method relies on derivation of the T25...
journal_title：Archives of toxicology
pub_type：
doi：10.1007/s002040100271
更新日期：2001-11-01 00:00:00
abstract：:Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. The microsomes themselves were not cytotoxic. P388D1 cells were more sensitive to CPA, ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000141
更新日期：2000-10-01 00:00:00
abstract：:The effect of lindane and heptachlor on haem metabolism was studied with the aim to elucidate the mechanism of their porphyrinogenic action. The effects of these compounds on delta-aminolaevulinate synthase (ALA-S) and ferrochelatase were evaluated and the mechanism of increase of ALA-S activity was especially studied...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050566
更新日期：1998-11-01 00:00:00
abstract：:The involvement of oxidative stress has been suggested as a mechanism for neurotoxicity caused by methylmercury (MeHg), but the mechanism for MeHg selective toxicity in the central nervous system is still unclear. In this research, to clarify the mechanism of selective neurotoxicity caused by MeHg, the oxygen consumpt...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0209-2
更新日期：2007-11-01 00:00:00
abstract：:The results from a survey of the expert information that is publicly accessible on the use of the dog as test species during the regulatory evaluation of agricultural chemicals and pesticides are reported. Methods that are being used or considered in order to reduce the number of dogs used for this purpose are describ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0678-0
更新日期：2005-11-01 00:00:00
abstract：:The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of adm...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00288341
更新日期：1988-01-01 00:00:00
abstract：:Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. One of the most frequent manifestations of chemical allergy is contact hypersensitivity, which can have serious impact on quality of life. Allergic contact dermatitis is a predominantly CD8 + T cell-mediated immune d...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-018-2283-z
更新日期：2018-10-01 00:00:00
abstract：:The aim of this study was to assess the neurotoxicity of diazinon oxon (DZO), a major in vivo metabolite of the phosphorothionate insecticide diazinon (DZ), on differentiating mouse N2a neuroblastoma cells. When used at concentrations of 1, 5 and 10 microM, DZO did not cause cell death but it impaired the outgrowth of...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0339-1
更新日期：2009-04-01 00:00:00
abstract：:In the isolated liver transient perfusion without calcium results in cholestasis which was characterized by an increased efflux rate across the sinusoidal membrane and inhibition of the concentrative transport of bromosulfophthalein to the canalicular side of the cell. Cholestasis could not be reversed within the usua...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303180
更新日期：1980-03-01 00:00:00
abstract：:The consumption of plants containing the diterpenoid atractyloside (ATR) causes selective proximal tubule injury, renal failure and death in humans. We have compared the effects of ATR in freshly isolated renal proximal tubules and glomeruli from rat and also in cell lines: NRK, derived from the proximal tubules, and ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050362
更新日期：1996-01-01 00:00:00
abstract：:This study was carried out to investigate the effect of in utero exposure to the cholinotoxicants, nicotine and chlorpyrifos, alone or in combination on neurobehavioral alterations and neuronal morphology latter in adult age. In the present study, 90 days old (corresponding to a human adult age) male and female offspr...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0077-1
更新日期：2006-09-01 00:00:00
abstract：:Age-related macular degeneration (AMD) is a late-onset retinal disease and the leading cause of central vision loss in the elderly. Degeneration of retinal pigment epithelial cells (RPE) is a crucial contributing factor responsible for the onset and progression of AMD. The toxic fluorophore N-retinyl-N-retinylidene et...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02637-w
更新日期：2020-02-01 00:00:00
abstract：:The organophosphorus compound trichlorfon, dimethyl (2,2,2-trichloro-1-hydroxyethyl) phosphonate, was administered by stomach tube (100 mg/kg) to pregnant guinea pigs at two different stages of gestation (days 36, 37, 38 and 51, 52, 53). The pups developed locomotory disturbances, and post mortem examination revealed ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00263954
更新日期：1986-05-01 00:00:00
abstract：:Labilization of lysosomal enzymes is often associated with the general process of inflammation. The present study investigated the effect of the pneumotoxin cadmium on the release and activity of two lung lysosomal enzymes. Incubation of rat lung lysosomes with cadmium resulted in the release of beta-glucuronidase but...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050181
更新日期：1995-01-01 00:00:00
abstract：:Berberine, a main protoberberine component of Coptidis Rhizoma, was studied for the mechanism of its inhibitory effects on the tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity and lipid peroxidation in rat liver. In the preliminary study, berberine expressed an antioxidant property by its capacity for quenching t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0351-9
更新日期：2002-11-01 00:00:00
abstract：:Sulfur dioxide (SO2) is a common air pollutant, and inhaled SO2 in airway epithelium easily forms its soluble derivatives in vivo (bisulfite and sulfite), which are toxic to the respiratory system and related to the exacerbation of asthma. To investigate the effects of SO2 derivatives on the expressions of asthma rela...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0212-7
更新日期：2007-12-01 00:00:00
abstract：:Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal methods addressing mechanisms under the first three key events of th...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2097-4
更新日期：2018-02-01 00:00:00
abstract：:We analyzed adverse events in a clinical phase I trial to assess dose-dependent metabolic effects of St. John's wort co-administered with rifampicin in 12 healthy volunteers. Within 3-6 days after increasing the St. John's wort dose from 300 to 600 mg TID, five of six female participants developed ambient temperature-...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1532-7
更新日期：2016-04-01 00:00:00
abstract：:To cope with the rapid onset of the life-threatening cholinergic crisis after poisoning with organophosphorus compounds, atropine-oxime preparations should be available in autoinjectors allowing i.m. administration also in the absence of a physician. Such a scenario is conceivable in the battlefield, when nerve agents...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050276
更新日期：1996-01-01 00:00:00
abstract：:The pregnancy outcomes of 109 women who were intoxicated during pregnancy due to excessive amounts of drugs and other agents were studied. Seventy per cent of the women attempted suicide, and the intoxication in 78% of all cases was caused by drugs. The stillbirth rate (4%) was higher than that in previous and subsequ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316249
更新日期：1988-08-01 00:00:00
abstract：:Carbromal is metabolized extensively in humans. The major metabolites known to date are bromoethylbutyramide, ethylbutyrylurea and inorganic bromide. After ingestion of a therapeutic dose of 1.0 g carbromal (4.2 mmoles) by four healthy volunteers highest concentrations in serum were found to be for carbromal 30 mumole...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00364653
更新日期：1978-06-16 00:00:00
abstract：:Etridiazole, 5-ethoxy-3-trichloromethyl-1,2,4-thiadiazole, was orally administered to rats and human volunteers. Two metabolites of etridiazole were synthesized: 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid (ET-CA) and N-acetyl-S-(5-ethoxy-1,2,4-thiadiazol-3-yl-methyl)-L-cysteine (ET-MA). Selective and sensitive analy...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02098027
更新日期：1991-01-01 00:00:00
abstract：:The present study was designed to compare the nephrotoxicity induced by the three platinum compounds cisplatin (CDDP), carboplatin (CBDCA) and transplatin (TDDP) in vitro and to obtain information to elucidate the mechanism of platinum compound-induced nephrotoxicity. Rat or rabbit renal cortical slices were incubated...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973462
更新日期：1990-01-01 00:00:00
abstract：:Environmental tobacco smoke (ETS) is associated with high morbidity and mortality, mainly in children. However, few studies focus on the brain development effects of ETS exposure. Myelination mainly occurs in the early years of life in humans and the first three postnatal weeks in rodents and is sensitive to xenobioti...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1343-2
更新日期：2015-11-01 00:00:00
abstract：:The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental animals are still inconclusive. Here, we investigated the association of personal exposure to metals in respirable welding fumes during a working shift with oxi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1319-2
更新日期：2015-08-01 00:00:00
abstract：:The effect of intracerebroventricular (i.c.v.) administration of cadmium or magnesium on central calcium-dependent blood pressure regulation was investigated. The systolic blood pressure of spontaneously hypertensive rats (SHR; male, 13 weeks of age) decreased following i.c.v. administration of cadmium chloride (20 nm...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050644
更新日期：2000-03-01 00:00:00
abstract：:The mycotoxin ochratoxin A (OTA) and its metabolite ochratoxin alpha (OT-alpha) were investigated, to examine their potency to induce sister chromatid exchanges (SCE) in cultured porcine urinary bladder epithelial cells (PUBEC) (primary culture). Serum-free cultured PUBEC were incubated for 5 h with either OTA or OT-a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050171
更新日期：1995-01-01 00:00:00
abstract：:The treatment of poisoning by highly toxic organophosphorus compounds (nerve agents) is unsatisfactory. Until now, the efficacy of new potential antidotes has primarily been evaluated in animals. However, the extrapolation of these results to humans is hampered by species differences. Since oximes are believed to act ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050495
更新日期：1998-03-01 00:00:00
abstract：:Zearalenone, a cereal mycotoxin with mycoestrogen activity and effect on fertility, is known to trigger apoptosis of a variety of nucleated cell types including hematopoietic progenitor cells. In analogy to apoptosis of nucleated cells, eryptosis, the suicidal death of erythrocytes, leads to cell shrinkage and cell me...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1037-1
更新日期：2013-10-01 00:00:00
abstract：:The mycotoxins altertoxin I and II (ATX I and II) are secondary metabolites produced by Alternaria alternata fungi and may occur as food and feed contaminants, especially after long storage periods. Although the toxic potential of altertoxins has been previously investigated, little is known about the pathways that pl...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1726-7
更新日期：2017-01-01 00:00:00
