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NF-κB in cancer therapy.

Abstract：

:The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regulated genes have been linked to malignant transformation, tumor cell proliferation, survival, angiogenesis, invasion/metastasis, and therapeutic resistance. In this review, we highlight the diverse molecular mechanism(s) by which the NF-κB pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. Additionally, various pharmacological approaches employed to target the deregulated NF-κB signaling pathway, and their possible therapeutic potential in cancer therapy is also discussed briefly.

journal_name

Arch Toxicol

journal_title

Archives of toxicology

authors

Li F,Zhang J,Arfuso F,Chinnathambi A,Zayed ME,Alharbi SA,Kumar AP,Ahn KS,Sethi G

doi

10.1007/s00204-015-1470-4

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

711-31

issue

5

eissn

0340-5761

issn

1432-0738

journal_volume

89

pub_type

杂志文章,评审

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