Abstract：
:This study aimed to investigate the effect of single and repeated administration of fenarimol on murine liver, kidney and lung microsomal CYP-catalyzed drug metabolism. The modulation of the regio- and stereo-selective hydroxylation of testosterone by fenarimol was considered in evaluating cocarcinogenic properties. Induction or suppression of different CYPs was recorded after a single dose of the fungicide. For example, in liver, 6 beta-(mainly associated with CYP3A), 7 alpha- and 2 beta-testosterone hydroxylase (TH) activities were induced up to 4.8-fold (7 alpha-TH) in female mice, at a dose of 150 mg/kg. In contrast, at 150 and 300 mg/kg, 16 alpha-TH (CYP2B9), 17-TH (female) and 6 alpha-TH (CYP2A1 and 2B1, male) activities were appreciably reduced. In extrahepatic tissues, the CYP modulation pattern was different, 16 alpha-TH being the only metabolite decreased (lung, male). In kidney, 16 beta-TH and 17-TH activities were increased up to 5.8-fold in female mice (lowest dose), while in lung 6 alpha-TH and 7 alpha-TH activities were induced up to 6- and 7-fold, respectively (both doses). Repeated treatment (150 mg/kg for 3 days) was able markedly to induce all steroid hydroxylations, up to 78-fold in 2 alpha-TH activity (male liver). In conclusion, fenarimol has a complex pattern of CYP induction or suppression in various tissues of both sexes, suggesting the possible toxic, cotoxic/cocarcinogenic and promoting potential of this fungicide.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Paolini M,Pozzetti L,Mesirca R,Sapone A,Cantelli-Forti Gdoi
10.1007/s002040050298subject
Has Abstractpub_date
1996-01-01 00:00:00pages
451-6issue
7eissn
0340-5761issn
1432-0738journal_volume
70pub_type
杂志文章abstract：:This discussion of the NEL presents some thoughts how toxicologists could be encouraged to use more sophisticated modern techniques for the study of various environmental chemicals. It is proposed to use the concept of the NEL only for data obtained by conventional techniques in routine toxicity experiments. Informati...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00695868
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-015-1538-1
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abstract：:Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01234482
更新日期：1983-12-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02479-6
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100264
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316211
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journal_title：Archives of toxicology
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2334-5
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0620-x
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1688-9
更新日期：2017-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293860
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293807
更新日期：1980-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-011-0659-4
更新日期：2011-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973634
更新日期：1992-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0063-7
更新日期：2006-07-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0644-y
更新日期：2011-07-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050161
更新日期：1995-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00353240
更新日期：1975-02-14 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00570127
更新日期：1988-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00353353
更新日期：1976-12-23 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050613
更新日期：1999-06-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2009-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050281
更新日期：1996-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01971837
更新日期：1990-01-01 00:00:00
abstract：:This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...
journal_title：Archives of toxicology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00204-018-2221-0
更新日期：2018-07-01 00:00:00
abstract：:Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0095-z
更新日期：2006-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0085-1
更新日期：2006-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050345
更新日期：1996-01-01 00:00:00
abstract：:The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December 2015. Drawing on the experience gained ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1421-5
更新日期：2015-01-01 00:00:00
abstract：:During aerobic incubation of trichloroethylene with rabbit liver microsomes and NADPH a difference absorption peak appears at 451-452 nm. Trichloroethylene does not form a ligand absorption spectrum with hepatic microsomes reduced by dithionite, or in anaerobic incubates in the presence of NADPH. Addition of trichloro...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293858
更新日期：1977-06-18 00:00:00
