Abstract:
:The cadmilm-induced (Cd) damage of mammalian testes is thought to be correlated with an inhibition of carbonic anhydrase (CAH) by Cd. Since Cd causes dose-dependent changes in blood flow of the testes, an inhibition of CAH in the testes could be simulated by a decrease of CAH-rich erythrocytes. Therefore, CAH activities and hemoglobin (Hb) content were determined in blood and testes of untreated and Cd-treated Sprague-Dawley rats as well as in testes perfused via the testicular artery. Cd was intraperitoneally applied as CdCl2 in single doses of 1.5, 3.0, and 5.0 mg Cd2+/kg b.w., respectively. 1. The experiments on perfused testes clearly demonstrated that the CAH activities originate from erythrocytes rather than from a tissue located enzyme. 2. The alterations in blood circulation occurring shortly (0.25-1.0 h) after the Cd administration were characterized by a dose-dependent, transient decrease (1.5 mg Cd2+/kg) as well as an increase (3.0 and 5.0 mg Ck2+, respectively) of the Hb content in the testes. 3. Independent of these minor alterations in a later state (14-24 h after 1.5 mg Ck2+/kg, 7-14 h after 3.0 mg Cd2+/kg, and 1-3 after 5.0 mg Cd2+/kg), Cd induced the well known hemorrhagic alterations of the testes with a high increase of Hb content and CAH activity. 4. By means of the correlations between CAH activities and Hb content in blood and testes an inhibition of the CAH by Cd as the primary cause for the tissue damage of the testes could largely be excluded.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Alsen C,Köpcke C,Ohnesorge FK,Schneider Jdoi
10.1007/BF00353353subject
Has Abstractpub_date
1976-12-23 00:00:00pages
39-46issue
1eissn
0340-5761issn
1432-0738journal_volume
37pub_type
杂志文章abstract::Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0095-z
更新日期:2006-10-01 00:00:00
abstract::Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log(10) blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the med...
journal_title:Archives of toxicology
pub_type: 杂志文章,meta分析
doi:10.1007/s00204-008-0292-z
更新日期:2008-08-01 00:00:00
abstract::Although carbon nanotubes (CNTs) are promising nanomaterials, their potential carcinogenicity is a major concern. We previously established a genetic method of analyzing genotoxicity of chemical compounds, where we evaluated their cytotoxic effect on the DT40 lymphoid cell line comparing DNA-repair-deficient isogenic ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1084-7
更新日期:2014-01-01 00:00:00
abstract::During/after the BP/Deepwater Horizon oil spill, cleanup workers, fisherpersons, SCUBA divers, and coastal residents were exposed to crude oil and dispersants. These people experienced acute physiological and behavioral symptoms and consulted a physician. They were diagnosed with petroleum hydrocarbon poisoning and ha...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1526-5
更新日期:2016-04-01 00:00:00
abstract::The inhibitory effect and mechanism of action of nicotinamide to paraquat toxicity were studied in male Sprague-Dawley rats. Proteins of submitochondrial particles (SMP), especially of mol. wt. 25-30 kDa, in rat lungs were destroyed by paraquat radicals, and aggregated protein bands approximately 100 kDa were observed...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050437
更新日期:1997-01-01 00:00:00
abstract::A paradigm shift is occurring in toxicology following the report of the National Research Council of the USA National Academies entitled "Toxicity testing in the 21st Century: a vision and strategy". This new vision encourages the use of in vitro and in silico models for toxicity testing. In the goal to identify new r...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02520-8
更新日期:2019-09-01 00:00:00
abstract::The comet assay is a versatile, reliable, cost-efficient, and fast technique for detecting DNA damage and repair in any tissue. It is useable in almost any cell type and applicable to both eukaryotic and prokaryotic organisms. Instead of highlighting one of the numerous specific aspects of the comet assay, the present...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1767-y
更新日期:2016-10-01 00:00:00
abstract::Aliphatic nitriles are a class of chemicals used in high volumes in the production of plastics and elastomers, in organic synthesis, and in production of a number of food packaging containers. Toxicity and metabolism of acrylonitrile (AN) are well characterized. On the other hand, minimal information is available on t...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF03208340
更新日期:1994-01-01 00:00:00
abstract::Degradation of neurofilament (NF) proteins by Ca2+-activated neutral protease (CANP) was studied in the nervous system of rats treated with neurotoxic or non-neurotoxic compounds. In the tibial nerve, the degradation of NF 68K was depressed by five neurotoxic compounds: acrylamide, N-hydroxymetylacrylamide, N-isopropy...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316261
更新日期:1988-08-01 00:00:00
abstract::Amoscanate, a substance which damages photoreceptors, was administered orally to Wistar rats in doses of 10, 40, and 125 mg/kg body weight once daily for 3 or 10 days. At both times electroretinographic, ophthalmological, and histopathological examinations of the retina were carried out to compare the sensitivity of c...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973682
更新日期:1993-01-01 00:00:00
abstract::The studies presented were designed to investigate the effects of cytochrome P450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female B6C3F(1) mice. Groups of female B6C3F(1) mice were exposed to dynamic atmospheres containing tetrahydrofuran (THF) concentrations of 0, 5,400 or 15,000 mg/m(3) ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-003-0474-7
更新日期:2003-08-01 00:00:00
abstract::This discussion of the NEL presents some thoughts how toxicologists could be encouraged to use more sophisticated modern techniques for the study of various environmental chemicals. It is proposed to use the concept of the NEL only for data obtained by conventional techniques in routine toxicity experiments. Informati...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00695868
更新日期:1979-10-01 00:00:00
abstract::The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1490-0
更新日期:2016-04-01 00:00:00
abstract::Manufactured nanomaterials (MNMs) selected from a library of over 120 different MNMs with varied compositions, sizes, and surface coatings were tested by four different laboratories for toxicity by high-throughput/-content (HT/C) techniques. The selected particles comprise 14 MNMs composed of CeO2, Ag, TiO2, ZnO and S...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2106-7
更新日期:2018-02-01 00:00:00
abstract::This article is published with the incorrect copyright holder name in the HTML article as "© Springer 2018". The correct copyright line should read "The Author(s) 2018" (as it appears in the article PDF). ...
journal_title:Archives of toxicology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00204-018-2301-1
更新日期:2018-11-01 00:00:00
abstract::The antidepressants, imipramine and mianserin, have been reported to cause liver damage. We investigated a role of cytochrome P450 (CYP)-mediated formation of a reactive metabolite in antidepressant-induced acute cell injury using hepatocytes isolated from male and female Wistar rats, and male Dark Agouti rats, which ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050599
更新日期:1999-04-01 00:00:00
abstract::Reactive oxygen species are generated during ischaemia-reperfusion of tissue. Oxidation of thymidine by hydroxyl radicals (HO) leads to the formation of 5,6-dihydroxy-5,6-dihydrothymidine (thymidine glycol). Thymidine glycol is excreted in urine and can be used as biomarker of oxidative DNA damage. Time dependent chan...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050638
更新日期:1999-11-01 00:00:00
abstract::Pentachlorophenol (PCP) and Dichlorodiphenyltrichloroethane (DDT) are environmental contaminants found in human blood. Previous studies have shown that PCP and DDT inhibit the lytic function of highly purified human natural killer (NK) lymphocytes and decrease the expression of several surface proteins on NK cells. In...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1829-1
更新日期:2017-04-01 00:00:00
abstract::Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis. ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00353318
更新日期:1975-10-20 00:00:00
abstract::Hydrogen sulfide (H2S), the third gasotransmitter, has been shown to act as a neuroprotective factor in numerous pathological processes; however, its underlying mechanism(s) of action remain unclear. It is widely accepted that activation of moderate autophagy and the Nrf2/ARE signaling pathway play important roles in ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2208-x
更新日期:2018-06-01 00:00:00
abstract::This study aimed to investigate the effect of single and repeated administration of fenarimol on murine liver, kidney and lung microsomal CYP-catalyzed drug metabolism. The modulation of the regio- and stereo-selective hydroxylation of testosterone by fenarimol was considered in evaluating cocarcinogenic properties. I...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050298
更新日期:1996-01-01 00:00:00
abstract::Inhibition mechanism(s) of protein kinase B/Akt1 and its consequences on related cell signaling were investigated in human neuroblastoma SH-SY5Y cells exposed to 4-hydroxy-trans-2-nonenal (4-HNE), one of the most reactive aldehyde by-products of lipid peroxidation. In silico data indicate that 4-HNE interacts with kin...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1260-4
更新日期:2015-02-01 00:00:00
abstract::Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in th...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00347881
更新日期:1982-03-01 00:00:00
abstract::A single dose of 10 mg methylmercury chloride per kg body weight was given to 30 days old rats and to adult rats (180-200g)(. This resulted in brain levels of 1.4-2.2 micrograms Hg/g wet weight. In the young rats electron microscopic morphometry showed swelling of the granule cells. The extent of changes was more pron...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00332352
更新日期:1981-04-01 00:00:00
abstract::203Pb(NO3)2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01261379
更新日期:1983-10-01 00:00:00
abstract::The possibility that the exposure of the embryo to certain chemical substances can lead to behavioral disturbances is known from human epidemiological studies, e.g., in chronic poisoning with mercury and ethanol. Therefore, efforts are made to develop toxicological techniques with which new behavioral teratogens can b...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/BF00310480
更新日期:1981-09-01 00:00:00
abstract::The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined. Exposure of cultured mouse hepatocytes to DDC, EDDC or griseofulvin resulted in a marked ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01974011
更新日期:1992-01-01 00:00:00
abstract::Pyrrolizidine alkaloids (PAs) are widely occurring phytotoxins which can induce severe liver damage in humans and other mammalian species by mechanisms that are not fully understood. Therefore, we investigated the development of PA hepatotoxicity in vivo, using an acutely toxic dose of the PA senecionine in mice, in c...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02582-8
更新日期:2020-01-01 00:00:00
abstract::Occupational exposure to benzene has been associated with leukemia, anemia, leukopenia, and thrombocytopenia. Genetic susceptibility to benzene toxicity in humans may be related to variations in benzene metabolizing genes. The main objective of this study was to ascertain whether polymorphism of GSTP1, GSTM1, GSTT1 an...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2104-9
更新日期:2018-06-01 00:00:00
abstract::Due to its unique physical structure and chemical properties, graphene family nanomaterials (GFNs) and derived commodities have been widely used in commercial products, particularly biomedical applications, which has significantly increased the risk of human exposure. There exists significant evidence that GFNs are ac...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-020-02717-2
更新日期:2020-06-01 00:00:00