Abstract：
:To investigate possible persistent nephrotoxic effects of trichloroethylene (TRI), a retrospective study was carried out on 39 workers exposed to high levels of TRI from 1956 to 1975. Total protein levels in urine, as well as serum and urine creatinine and serum urea were unchanged in comparison with the control. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) was applied to differentiate between tubular and/or glomerular dysfunction. Urinary excretion of alpha-1-microglobulin and glutathione transferase (GST) alpha, as markers of proximal tubular damage, were correlated with the SDS-PAGE patterns of urinary proteins both in the TRI exposed and the control group. GST alpha was found in elevated concentrations in the urine of the TRI-exposed workers. No increase of urinary GST alpha was observed in the control group, even when alpha-1-microglobulin was elevated as a result of non-toxic damage. Both in the control and exposed groups, GST pi, a marker of distal tubular damage, was in the normal range. The results show that chronic exposure to high doses of TRI causes persistent changes to the proximal tubular system of the kidney and that GST alpha excretion into the urine is a marker well suited for quantitation of the extent of renal damage.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Brüning T,Sundberg AG,Birner G,Lammert M,Bolt HM,Appelkvist EL,Nilsson R,Dallner Gdoi
10.1007/s002040050613keywords:
subject
Has Abstractpub_date
1999-06-01 00:00:00pages
246-54issue
4-5eissn
0340-5761issn
1432-0738journal_volume
73pub_type
杂志文章abstract：:Insulin-exposed rat mammary cancer cells were flow sorted based on a c-myc reporter plasmid encoding a destabilized green fluorescent protein. Sorted cells exhibited gradual increases in c-myc levels. Cells overexpressing c-myc by only 10% exhibited phenotypic changes attributable to c-myc overexpression, such as cell...
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
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更新日期：2017-01-01 00:00:00
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journal_title：Archives of toxicology
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pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00310329
更新日期：1978-08-09 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316123
更新日期：1984-09-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00317980
更新日期：1983-01-01 00:00:00
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journal_title：Archives of toxicology
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更新日期：2014-06-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00353357
更新日期：1976-12-23 00:00:00
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更新日期：2016-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0255-9
更新日期：2008-06-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/BF02307263
更新日期：1992-01-01 00:00:00
abstract：:The possibility that the exposure of the embryo to certain chemical substances can lead to behavioral disturbances is known from human epidemiological studies, e.g., in chronic poisoning with mercury and ethanol. Therefore, efforts are made to develop toxicological techniques with which new behavioral teratogens can b...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/BF00310480
更新日期：1981-09-01 00:00:00
abstract：:The organophosphorus compound trichlorfon, dimethyl (2,2,2-trichloro-1-hydroxyethyl) phosphonate, was administered by stomach tube (100 mg/kg) to pregnant guinea pigs at two different stages of gestation (days 36, 37, 38 and 51, 52, 53). The pups developed locomotory disturbances, and post mortem examination revealed ...
journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：1986-05-01 00:00:00
abstract：:Cadmium (Cd), a highly toxic heavy metal, is distributed widely in the general environment of today. The characteristic clinical manifestations of chronic Cd intoxication include renal proximal tubular dysfunction, general osteomalacia with severe pains, and anemia. We have recently reported that the serum level of er...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050352
更新日期：1996-01-01 00:00:00
abstract：:Deoxynivalenol (DON) contamination in food is a public health concern; however, the effect of DON exposure on immune disorders including allergies remains unclear. The aim of this study is to elucidate the effect of oral exposure to DON on pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermat...
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pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
abstract：:The rodenticide tetramethylenedisulfotetramine (TETS) is a potent convulsant (lethal dose in humans 7-10 mg) that is listed as a possible threat agent by the United States Department of Homeland Security. TETS has previously been studied in vivo for toxicity and in vitro in binding assays, with the latter demonstratin...
journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
