Mitochondrial dysregulation and protection in cisplatin nephrotoxicity.

Abstract:

:Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a central role of mitochondrial dysregulation. The pathological changes in mitochondria in cisplatin nephrotoxicity are mainly triggered by DNA damage response, pro-apoptotic protein attack, disruption of mitochondrial dynamics, and oxidative stress. As such, inhibitory strategies targeting these cytotoxic events may provide renal protection. Nonetheless, ideal approaches for renoprotection should not only protect kidneys but also enhance the anticancer efficacy of cisplatin in chemotherapy.

journal_name

Arch Toxicol

journal_title

Archives of toxicology

authors

Yang Y,Liu H,Liu F,Dong Z

doi

10.1007/s00204-014-1239-1

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

1249-56

issue

6

eissn

0340-5761

issn

1432-0738

journal_volume

88

pub_type

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