Abstract:
:Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a central role of mitochondrial dysregulation. The pathological changes in mitochondria in cisplatin nephrotoxicity are mainly triggered by DNA damage response, pro-apoptotic protein attack, disruption of mitochondrial dynamics, and oxidative stress. As such, inhibitory strategies targeting these cytotoxic events may provide renal protection. Nonetheless, ideal approaches for renoprotection should not only protect kidneys but also enhance the anticancer efficacy of cisplatin in chemotherapy.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Yang Y,Liu H,Liu F,Dong Zdoi
10.1007/s00204-014-1239-1subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1249-56issue
6eissn
0340-5761issn
1432-0738journal_volume
88pub_type
杂志文章,评审abstract::Zearalenone, a cereal mycotoxin with mycoestrogen activity and effect on fertility, is known to trigger apoptosis of a variety of nucleated cell types including hematopoietic progenitor cells. In analogy to apoptosis of nucleated cells, eryptosis, the suicidal death of erythrocytes, leads to cell shrinkage and cell me...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1037-1
更新日期:2013-10-01 00:00:00
abstract::Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions. These epoxy FAs comprise epoxyeicosatrienoic acids (EETs) and epoxy-octadeceno...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2060-4
更新日期:2017-11-01 00:00:00
abstract::The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological releva...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1845-1
更新日期:2016-12-01 00:00:00
abstract::The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The calibration curve for morphine in hair showed linear over 0.5-100 ng/mg hair. Though the limit of detection was 0.1 ng/mg hair with an S/N > 3 of the base ion(m/z 429) for morphine, the limit of confirmation by detection of thr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01981507
更新日期:1992-01-01 00:00:00
abstract::Acetaminophen (APAP) overdose is the leading cause of acute liver failure. Yet the mechanisms underlying adaptive tolerance toward APAP-induced liver injury are not fully understood. To better understand molecular mechanisms contributing to adaptive tolerance to APAP is an underpinning foundation for APAP-related prec...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2090-y
更新日期:2018-02-01 00:00:00
abstract::The development and application of high throughput in vitro assays is an important development for risk assessment in the twenty-first century. However, there are still significant challenges to incorporate in vitro assays into routine toxicity testing practices. In this paper, a robust learning approach was developed...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2260-6
更新日期:2018-09-01 00:00:00
abstract::In mutagenicity testing of pharmaceuticals it is advisable, whenever possible, to use in vivo mammalian systems where the pharmacokinetic properties of a drug would be more or less similar to those in man. However, although there are a number of different genetic endpoints which are important in mutagen testing, suffi...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00361248
更新日期:1980-11-01 00:00:00
abstract::Many carcinogens and mutagens are electrophilic in nature and will react with nucleophilic sites in protein and nucleic acid. Determination of the extent of formation of these adducts of genotoxic agents with protein provides a practical method of monitoring human exposure and of determining the possible risk associat...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00296978
更新日期:1987-01-01 00:00:00
abstract::This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a sh...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0255-9
更新日期:2008-06-01 00:00:00
abstract::Chronic exposure to carbon disulfide (CS2) can induce polyneuropathy in occupational worker and experimental animals, but underlying mechanism for CS2 neurotoxicity is currently unknown. In the present study, male Wistar rats were randomly divided into two experimental groups and one control group. The rats in two exp...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0399-2
更新日期:2009-06-01 00:00:00
abstract::In order to study the mechanisms of acute n-hexane intoxication, the effects of n-hexane and its metabolites 2-hexanol, methyl-n-butyl ketone, 2,5-hexanediol and 2,5-hexanedione on the cloned voltage-operated potassium channels Kv1.1, Kv1.4, Kv2.1 and Kv3.4 were investigated with electrophysiological techniques in the...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050382
更新日期:1997-01-01 00:00:00
abstract::In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0078-0
更新日期:2006-09-01 00:00:00
abstract::Exposure to toxic metals is a well-known problem in industrialized countries. Metals interfere with a number of physiological processes, including central nervous system (CNS), haematopoietic, hepatic and renal functions. In the evaluation of the toxicity of a particular metal it is crucial to consider many parameters...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-010-0544-6
更新日期:2010-07-01 00:00:00
abstract::Recently, acutely toxic doses of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been reported to affect the hepatic distribution of essential metals in the rat. However, the reduced food intake by TCDD was not taken into account. Therefore, metal concentrations were determined in different...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02284268
更新日期:1991-01-01 00:00:00
abstract::Neurotoxic properties of acrylamide and seven related compounds in rats were studied with regard to the effects on rotarod performance, morphology of nerves and neurotubulin. Compounds used in the present study were acrylamide, N-hydroxymethylacrylamide, N-isopropylacrylamide, methacrylamide, N-methylacrylamide, croto...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01239204
更新日期:1983-11-01 00:00:00
abstract::3-Chloro-1,2-propanediol (3-MCPD) fatty acid esters are formed upon thermal processing of fat-containing foods in the presence of chloride ions. Upon hydrolytic cleavage, these substances could release free 3-MCPD. This compound is toxicologically well characterised and displayed cancerogenic potential in rodent model...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-011-0657-6
更新日期:2011-10-01 00:00:00
abstract::Female Wistar rats were treated with various doses of progesterone orally via the diet or via the SC route. Oral treatment resulted in enhanced progesterone levels in the liver as measured by radioimmunoassay. There were up to 3-fold increases in activity of ethylmorphine demethylation by isolated microsomes; metaboli...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316323
更新日期:1986-10-01 00:00:00
abstract::Deoxynivalenol (DON) contamination in food is a public health concern; however, the effect of DON exposure on immune disorders including allergies remains unclear. The aim of this study is to elucidate the effect of oral exposure to DON on pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermat...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02875-3
更新日期:2020-12-01 00:00:00
abstract::Berberine, a main protoberberine component of Coptidis Rhizoma, was studied for the mechanism of its inhibitory effects on the tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity and lipid peroxidation in rat liver. In the preliminary study, berberine expressed an antioxidant property by its capacity for quenching t...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-002-0351-9
更新日期:2002-11-01 00:00:00
abstract::In the isolated liver transient perfusion without calcium results in cholestasis which was characterized by an increased efflux rate across the sinusoidal membrane and inhibition of the concentrative transport of bromosulfophthalein to the canalicular side of the cell. Cholestasis could not be reversed within the usua...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00303180
更新日期:1980-03-01 00:00:00
abstract::Initially, mice were pretreated with atropine (17.4 mg/kg; IP) and the oxime reactivator HI-6 (50 mg/kg; IP) 5 min prior to an injection of soman (287 micrograms/kg, SC); approximately 2.1 x LD50 dose). More than 95% of the mice survived this dose of soman with atropine and HI-6 pretreatment. In these survivors of som...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316438
更新日期:1989-01-01 00:00:00
abstract::Xenobiotic induced liver injury is a leading cause for drug withdrawal and toxicogenomics may help to identify molecular causes. Here we report studies with cultures of human hepatocytes to detect early responses of liver toxicity upon treatment with the hepatotoxin Aroclor 1254. We studied transcript abundance of 302...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0234-1
更新日期:2008-02-01 00:00:00
abstract::A compound was isolated from the urine of workers exposed to carbon disulfide during the production of rayon. The compound was identified as 2-thiothiazolidine-4-carboxylic acid (TTCA) by GC/MS and NMR. A HPLC method for the quantitative determination of TTCA was elaborated and applied to urine samples. The method all...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00297130
更新日期:1981-03-01 00:00:00
abstract::Certain bisphenols (BPs) have been regarded as endocrine-disrupting chemicals due to their structural similarities to bisphenol A (BPA), a well-known weak estrogenic chemical. However, very limited data are currently available on the relationship between estrogenic activity and the structure of BP analogs. Therefore, ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2011-0
更新日期:2017-12-01 00:00:00
abstract::Previous studies in our laboratory identified retinoid-induced defects that are mediated by RAR-RXR heterodimerization using interaction of synthetic ligands selective for the retinoid receptors RAR and RXR in mice (Elmazar et al. 1997, Toxicol Appl Pharmacol 146:21-28; Elmazar et al. 2001, Toxicol Appl Pharmacol 170:...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0586-8
更新日期:2004-11-01 00:00:00
abstract::Sunitinib (SNT) is a multi-targeted receptor tyrosine kinase inhibitor that has been approved by the FDA for cancer therapy. However, its cardiotoxicity has limited the clinical applicability with no effective therapeutic approach available. As a broadband kinase inhibitor, the function of several kinases that are ess...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02448-z
更新日期:2019-06-01 00:00:00
abstract::Bisphenol A (BPA) is a chemical in widespread use that is under scientific discussion due to its endocrine activity. Controversies exist about how to interpret reportedly high blood concentrations measured in uncontrolled situations. Physiologically based pharmaco-/toxicokinetic modelling resulted in 10-100-fold lower...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1022-8
更新日期:2013-07-01 00:00:00
abstract::MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In our study, we investigat...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-012-1004-2
更新日期:2013-05-01 00:00:00
abstract::The inhibitory effect and mechanism of action of nicotinamide to paraquat toxicity were studied in male Sprague-Dawley rats. Proteins of submitochondrial particles (SMP), especially of mol. wt. 25-30 kDa, in rat lungs were destroyed by paraquat radicals, and aggregated protein bands approximately 100 kDa were observed...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050437
更新日期:1997-01-01 00:00:00
abstract::The goal of these studies was to characterize the role played by antigen challenge in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunosuppression. The effects of single exposure to TCDD (4.2, 14, and 42 microg/kg) in B6C3F1 mice on the reverse plaque assay (RPA; no sensitization) and the sheep red blood cell ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050467
更新日期:1997-01-01 00:00:00