Abstract：
:The organophosphorus compound trichlorfon, dimethyl (2,2,2-trichloro-1-hydroxyethyl) phosphonate, was administered by stomach tube (100 mg/kg) to pregnant guinea pigs at two different stages of gestation (days 36, 37, 38 and 51, 52, 53). The pups developed locomotory disturbances, and post mortem examination revealed significantly decreased weights of the total brain and the cerebellum, as compared to controls. There was also a significant weight reduction particularly of the medulla oblongata, but also of the hippocampus, the thalamus, and the colliculi. Histological examination of the cerebellum revealed reduction of the external granular layer and the molecular layer, and regional absence of Purkinje cells. The activities of the neurotransmitter enzymes choline acetyltransferase (ChAT), and glutamate decarboxylase (GAD) in cerebellum were reduced as compared to the control values.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Berge GN,Nafstad I,Fonnum Fdoi
10.1007/BF00263954subject
Has Abstractpub_date
1986-05-01 00:00:00pages
30-5issue
1eissn
0340-5761issn
1432-0738journal_volume
59pub_type
杂志文章abstract：:Doppler and M-mode echocardiography (EC) were used to investigate the effects of minoxidil on the cardiac function of the dog and potentially to clarify the pathogenesis of cardiac lesions, in particular the necrotic lesion in the left ventricle and the haemorrhagic lesion in the right atrium. Groups of three dogs wer...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0503-6
更新日期：2004-01-01 00:00:00
abstract：:The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA) as well as mercuric chloride (HgCl(2)) and methylmercury chloride (MeHgCl) on gluconeogenesis was investigated in isolated rat kidney tubules. From starved rats kidney tubules were prepared and isolat...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050677
更新日期：1999-09-01 00:00:00
abstract：:This study was performed to assess the relation between occupational exposure to N,N-dimethylformamide after an 8 h work shift in the acrylic fibre industry and its three biological markers N-methylformamide (NMFtotal), N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC), and N-methylcarbamoyl adduct at haemoglobin (MCVal)....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2219-7
更新日期：2018-07-01 00:00:00
abstract：:The effect of various hepatotoxicants on urinary taurine and urinary creatine has been studied in the rat. Several hepatotoxic agents, carbon tetrachloride, thioacetamide, galactosamine and allyl alcohol which all caused hepatic necrosis (sometimes accompanied by steatosis), resulted in a rise in urinary taurine and i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974343
更新日期：1993-01-01 00:00:00
abstract：:Using human neuroblastoma SH-SY5Y cells, effects of acrylamide on p53 protein and intracellular signal transducting pathways were examined. Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2). The phosphorylation of p53 was specific for the Ser15 site. Among mitogen-a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0022-8
更新日期：2006-03-01 00:00:00
abstract：:Orally administered meso-2,3-dimercaptosuccinic acid (DMSA) is an effective antagonist for acute oral cadmium chloride (1 mmol/kg) intoxication in mice when administered up to 8 h after cadmium ingestion. Administration of sodium N-benzyl-N-dithiocarboxy-D-glucamine (NaB) i.p. along with DMSA p.o. resulted in kidney a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316253
更新日期：1988-08-01 00:00:00
abstract：:The toxicity of amphetamines is conditioned by a complex array of mechanisms, involving the increase of neurotransmission (e.g. leading to hyperthermia) and enzymatic and non-enzymatic oxidation of amphetamines and biogenic amines. Considering that all these processes may increase the generation of hydrogen peroxide (...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100264
更新日期：2001-10-01 00:00:00
abstract：:O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050212
更新日期：1995-01-01 00:00:00
abstract：:Using male ICR mice, the LC50 and acute and subacute inhalation toxicity of dichlorosilane (SiH2Cl2, DCS) and the fate of DCS released into the air were investigated. DCS resolved and minute particles including silicon and chloride were observed, when DCS was released into the air. Most particles were under 1 micron i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050263
更新日期：1996-01-01 00:00:00
abstract：:The consumption of plants containing the diterpenoid atractyloside (ATR) causes selective proximal tubule injury, renal failure and death in humans. We have compared the effects of ATR in freshly isolated renal proximal tubules and glomeruli from rat and also in cell lines: NRK, derived from the proximal tubules, and ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050362
更新日期：1996-01-01 00:00:00
abstract：:Iron (Fe) plays essential roles in biological processes, whereas cadmium (Cd) is a toxic and non-essential metal. Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals. Here, we studied the effect of dietary Fe on the expression ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0160-7
更新日期：2007-05-01 00:00:00
abstract：:The aim of this study was to investigate the electrophilic tissue burden (ETB) formation, assessed as covalent binding of the ultimate carcinogen benzo( a)pyrene diolepoxide (BaPDE) with cellular proteins, in liver, lung and heart, as well as with haemoglobin (Hb) following repeated exposure to binary mixtures of benz...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0518-z
更新日期：2004-02-01 00:00:00
abstract：:A dual-label time-resolved fluoroimmunoassay (TRFIA) for simultaneous quantification of aflatoxin B1 (AFB1) and ochratoxin A (OTA) is described. For this, microtitration wells were coated with AFB1-horse radish peroxidase (HRP) and OTA-bovine serum albumin. The standards and samples were loaded on the coated plates, a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-009-0410-6
更新日期：2009-06-01 00:00:00
abstract：:Gebel (In Arch Toxicol 87(5):923-924, 2013) replied to my Letter to the Editor (Morfeld in Arch Toxicol 87(5):921, 2013) in which I criticized the quantitative review of inhalation rat studies on the association of granular biopersistent dust exposures and lung cancer risk (Gebel in Arch Toxicol 86(7):995-1007, 2012)....
journal_title：Archives of toxicology
pub_type： 评论,信件
doi：10.1007/s00204-013-1138-x
更新日期：2013-11-01 00:00:00
abstract：:Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). The presently available oximes, obidoxime and pralidoxime (2-PAM), are considered to be insufficient for highly toxic OPs, e.g. sari...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0375-1
更新日期：2002-09-01 00:00:00
abstract：:Chronic exposure to carbon disulfide (CS2) can induce polyneuropathy in occupational worker and experimental animals, but underlying mechanism for CS2 neurotoxicity is currently unknown. In the present study, male Wistar rats were randomly divided into two experimental groups and one control group. The rats in two exp...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0399-2
更新日期：2009-06-01 00:00:00
abstract：:The effect of intracerebroventricular (i.c.v.) administration of cadmium or magnesium on central calcium-dependent blood pressure regulation was investigated. The systolic blood pressure of spontaneously hypertensive rats (SHR; male, 13 weeks of age) decreased following i.c.v. administration of cadmium chloride (20 nm...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050644
更新日期：2000-03-01 00:00:00
abstract：:Berberine, a main protoberberine component of Coptidis Rhizoma, was studied for the mechanism of its inhibitory effects on the tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity and lipid peroxidation in rat liver. In the preliminary study, berberine expressed an antioxidant property by its capacity for quenching t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0351-9
更新日期：2002-11-01 00:00:00
abstract：:Previous studies indicate that benzanthrone, an anthraquinone dye intermediate, caused significant depletion of ascorbic acid (AsA). In this investigation the effect of benzanthrone on the status of different forms of AsA and other bio-antioxidants such as glutathione (GSH) was studied. Oral administration of benzanth...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100222
更新日期：2001-06-01 00:00:00
abstract：:The excretion and biotransformation of [14C] 1,1-dichloroethylene (vinylidene chloride, VDC) after administration of a single oral dose has been investigated in female rats. Seventy-two hours after a dose of 0.5, 5.0, and 50.0 mg/kg, 1.26, 9.70, 16.47%, respectively, are exhaled as unchanged VDC, and 13.64, 11.35, 6.1...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00353707
更新日期：1979-07-11 00:00:00
abstract：:The flavonol quercetin shows a wide range of effects in biological systems. We investigated whether quercetin exerts its proposed antioxidant properties via the antioxidant enzyme system. Quercetin in a concentration range from 5 to 100 microM decreased manganese superoxide dismutase, glutathione peroxidase, and coppe...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0482-7
更新日期：2003-09-01 00:00:00
abstract：:Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. The microsomes themselves were not cytotoxic. P388D1 cells were more sensitive to CPA, ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000141
更新日期：2000-10-01 00:00:00
abstract：:Using isolated rat hepatocytes the biochemical effects of hydrazine have been investigated using both conventional assay techniques and high resolution proton NMR. High resolution proton NMR revealed that hydrazine caused a significant increase in alanine and lactate levels in the incubation buffer, whereas levels of ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01981506
更新日期：1992-01-01 00:00:00
abstract：:Reduced gluconeogenesis due to decreased activity of key gluconeogenic enzymes in liver, together with feed refusal, has been suggested to play an important role in 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced lethality in rats. This study was carried out to further analyse the toxicological significance of red...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050626
更新日期：1999-08-01 00:00:00
abstract：:Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydro...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290553
更新日期：1986-12-01 00:00:00
abstract：:Quinacrine hydrochloride is toxic for the heart of F-344 rats. Rats treated with 500 ppm quinacrine hydrochloride in the diet all developed a high incidence of left atrial thrombosis. The lesion was associated with cardiac hypertrophy and dilatation and focal myocardial degeneration. Rats died from cardiac hypertrophy...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316350
更新日期：1984-11-01 00:00:00
abstract：:This discussion of the NEL presents some thoughts how toxicologists could be encouraged to use more sophisticated modern techniques for the study of various environmental chemicals. It is proposed to use the concept of the NEL only for data obtained by conventional techniques in routine toxicity experiments. Informati...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00695868
更新日期：1979-10-01 00:00:00
abstract：:HCB was detected in all preparations of human placenta, maternal blood, milk, and cord blood. It was confirmed that HCB transferred from mother to fetus through the placenta. A significant linear correlation exists between the HCB concentration in placenta and that in cord blood. Therefore, the placental concentration...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00333426
更新日期：1985-01-01 00:00:00
abstract：:The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-015-1470-4
更新日期：2015-05-01 00:00:00
abstract：:A new strategy for the evaluation of mixtures is presented. The mixture used was the organic extract of diesel exhaust particles (DEP). After extraction with dichloromethane (DCM), the crude extract was fractionated according to polarity into five fractions: aliphatic hydrocarbons, polycyclic aromatic hydrocarbons (PA...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050392
更新日期：1997-01-01 00:00:00
