Meso-2,3-dimercaptosuccinic acid and sodium N-benzyl-N-dithiocarboxy-D-glucamine as antagonists for cadmium intoxication.


:Orally administered meso-2,3-dimercaptosuccinic acid (DMSA) is an effective antagonist for acute oral cadmium chloride (1 mmol/kg) intoxication in mice when administered up to 8 h after cadmium ingestion. Administration of sodium N-benzyl-N-dithiocarboxy-D-glucamine (NaB) i.p. along with DMSA p.o. resulted in kidney and liver cadmium levels only marginally smaller than those obtained with DMSA alone. Both chelation treatment regimens permitted survival of 80% or more of the animals, in comparison to a survival rate of 40-50% in untreated animals. Intraperitoneally administered NaB by itself is a very effective antagonist for cadmium chloride administered intraperitoneally in either acute or chronic cadmium intoxication. A dose-response study was made of the mobilization of cadmium from the liver and kidney of cadmium-loaded mice by NaB; this showed that NaB is one of the most effective cadmium mobilizing agents developed to date. We have also confirmed the earlier report of Kojima and his co-workers of the ability of NaB to remove cadmium from animals which have been treated with cadmium over an extended period of time. NaB causes a very large increase in the biliary excretion of cadmium. Nuclear magnetic resonance (NMR) spectra of 113Cd in bile from treated animals and model solutions indicates that such cadmium is undergoing rapid ligand exchange.


Arch Toxicol


Archives of toxicology


Jones MM,Basinger MA,Topping RJ,Gale GR,Jones SG,Holscher MA




Has Abstract


1988-08-01 00:00:00












  • Induction of cytochrome P450 1A1 in multiple organs of minipigs after oral exposure to soils contaminated with polycyclic aromatic hydrocarbons (PAH).

    abstract::We have used the minipig as a prospective animal model for human risk characterization to study primary biochemical alterations upon oral contaminant intake. The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 i...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Roos PH,Tschirbs S,Welge P,Hack A,Theegarten D,Mogilevski G,Wilhelm M

    更新日期:2002-06-01 00:00:00

  • Toluene concentrations in various tissues of rats after inhalation and oral administration.

    abstract::The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhala...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Pyykkö K,Tähti H,Vapaatalo H

    更新日期:1977-09-28 00:00:00

  • Diazinon oxon affects the differentiation of mouse N2a neuroblastoma cells.

    abstract::The aim of this study was to assess the neurotoxicity of diazinon oxon (DZO), a major in vivo metabolite of the phosphorothionate insecticide diazinon (DZ), on differentiating mouse N2a neuroblastoma cells. When used at concentrations of 1, 5 and 10 microM, DZO did not cause cell death but it impaired the outgrowth of...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Sidiropoulou E,Sachana M,Flaskos J,Harris W,Hargreaves AJ,Woldehiwet Z

    更新日期:2009-04-01 00:00:00

  • VEGF isoforms and receptors expression throughout acute acetaminophen-induced liver injury and regeneration.

    abstract::Acetaminophen (APAP) is a widely-used analgesic and a known hepatotoxic agent. Vascular endothelial growth factor (VEGF) is a growth factor with multiple functional roles. VEGF plays an important role in angiogenesis and hepatic regeneration. The aim of this study was to determine the expression of VEGF isoforms and i...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Papastefanou VP,Bozas E,Mykoniatis MG,Grypioti A,Garyfallidis S,Bartsocas CS,Nicolopoulou-Stamati P

    更新日期:2007-10-01 00:00:00

  • Peripheral nerve phospholipids in acrylamide neuropathy.

    abstract::Treatment of cats with acrylamide, either 7.5 or 15 mg/kg IM, once a day for 10 days, resulted in increases of 31 and 47% in the phospholipid content of sciatic nerve, respectively, from a control level of 41.1 +/- 2.7 mg/kg wet weight. Determination of the distribution of individual phospholipids indicated no signifi...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Howland RD,Lowndes HE

    更新日期:1984-09-01 00:00:00

  • Unsaturated compounds induce up-regulation of CD86 on dendritic cells in the in vitro sensitization assay LCSA.

    abstract::Unsaturated compounds are known to cause false-positive reactions in the local lymph node assay (LLNA) but not in the guinea pig maximization test. We have tested a panel of substances (succinic acid, undecylenic acid, 1-octyn-3-ol, fumaric acid, maleic acid, linoleic acid, oleic acid, alpha-linolenic acid, squalene, ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Frohwein TA,Sonnenburg A,Zuberbier T,Stahlmann R,Schreiner M

    更新日期:2016-04-01 00:00:00

  • High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver.

    abstract::Perfluorooctanoic acid (PFOA) has been shown to cause hepatotoxicity and other toxicological effects. Though PPARα activation by PFOA in the liver has been well accepted as an important mechanism of PFOA-induced hepatotoxicity, several pieces of evidence have shown that the hepatotoxic effects of PFOA may not be fully...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Yan S,Zhang H,Guo X,Wang J,Dai J

    更新日期:2017-01-01 00:00:00

  • Testicular toxicity of dietary 2,2-bis(4-hydroxyphenyl)propane (bisphenol A) in F344 rats.

    abstract::Male F344/DuCrj (Fischer) rats were given bisphenol A (BPA) in the diet at levels of 0 (control), 0.25, 0.50 and 1.00%, equivalent to 0, 235, 466 and 950 mg/kg per day, respectively, for 44 days. Body weight gains were depressed dose-dependently in BPA-treated rats, and those of 0.50 and 1.00% groups were significant....

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Takahashi O,Oishi S

    更新日期:2001-03-01 00:00:00

  • Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells.

    abstract::Intake of inorganic arsenic is known to cause vascular diseases as well as skin lesions and cancer in humans. We investigated the differences in cytotoxicity, uptake rate of arsenic, and gene expression of antioxidative enzymes between arsenite (As(3+))- and arsenate (As(5+))-exposed rat heart microvessel endothelial ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hirano S,Cui X,Li S,Kanno S,Kobayashi Y,Hayakawa T,Shraim A

    更新日期:2003-06-01 00:00:00

  • Urinary trehalase as an early indicator of cadmium-induced renal tubular damage in rabbit.

    abstract::The significance of urinary trehalase as a possible early indicator of renal disorder was examined using Cd-treated rabbits, which received 1 mg/kg Cd thrice weekly for 3 months subcutaneously. The results showed that urinary trehalase increased significantly from 1 week after treatment, earlier than LAP, ALP, protein...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nishimura N,Oshima H,Nakano M

    更新日期:1986-12-01 00:00:00

  • Phagocytes render chemicals immunogenic: oxidation of gold(I) to the T cell-sensitizing gold(III) metabolite generated by mononuclear phagocytes.

    abstract::The oxidizing capacity of phagocytic cells is suspected to play a major role in the generation of immunogenic drug metabolites, in particular those that cause extrahepatic immunopathological lesions. In the case of the antirheumatic drug gold(I) disodium thiomalate (Na2Au(I)TM), oxidation of the Au(I) ion to Au(III) a...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Goebel C,Kubicka-Muranyi M,Tonn T,Gonzalez J,Gleichmann E

    更新日期:1995-01-01 00:00:00

  • Disposition, elimination, and metabolism of tri-o-cresyl phosphate following daily oral administration in Fischer 344 male rats.

    abstract::The disposition, elimination, and metabolism of 50 mg/kg (1.36 muCi/animal) of tri-o-cresyl [phenyl-U-14C] phosphate after ten daily oral doses was investigated in adult male Fischer 344 rats. Groups of three treated animals were killed at intervals of 24, 48, 72, and 96 h after the last administrations. Generally, th...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Somkuti SG,Abou-Donia MB

    更新日期:1990-01-01 00:00:00

  • Hashish smoking and T-lymphocytes.

    abstract::To investigate the effect of long term hashish use on T-lymphocytes we have measured the incorporation of 14C-thymidine by peripheral blood lymphocytes, unstimulated and stimulated by phytohemagglutinin, as well as the proportion and number of E-rosettes in 12 healthy male chronic users of the drug before and after a ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Kaklamani E,Trichopoulos D,Koutselinis A,Drouga M,Karalis D

    更新日期:1978-04-27 00:00:00

  • 1,3-Bispyridinium-dimethylether mono- and dioximes: synthesis, reactivating potency and therapeutic effect in experimental poisoning by organophosphorus compounds.

    abstract::Nine bispyridinium oximes containing two pyridinium rings linked by dimethylether were synthesised. Each compound had on one of the pyridinium rings a hydroxyiminomethyl group in position 2 or 4, while the other ring was unsubstituted or had a methyl or a hydroxyiminomethyl group in position 2 or 4. The reactivating p...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Simeon V,Wilhelm K,Granov A,Besarović-Lazarev S,Buntić A,Fajdetić A,Binenfeld Z

    更新日期:1979-02-23 00:00:00

  • SEURAT: Safety Evaluation Ultimately Replacing Animal Testing--recommendations for future research in the field of predictive toxicology.

    abstract::The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December 2015. Drawing on the experience gained ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Daston G,Knight DJ,Schwarz M,Gocht T,Thomas RS,Mahony C,Whelan M

    更新日期:2015-01-01 00:00:00

  • A sensitive mouse lymph node assay with two application phases for detection of contact allergens.

    abstract::A predictive test using mice for the identification of contact sensitizing chemicals was developed. Contact sensitizing activity is measured as a function of draining lymph node activation following application of test chemical. Experimental conditions for assessment of induced lymph node cell (LNC) responses have bee...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Ikarashi Y,Tsuchiya T,Nakamura A

    更新日期:1993-01-01 00:00:00

  • Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?

    abstract::The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase. In vitro studies have indicated that APAP may also be cooxidized by prostaglandin H synthetase. The present experiments were designed to assess the possible contributio...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Ben-Zvi Z,Weissman-Teitellman B,Katz S,Danon A

    更新日期:1990-01-01 00:00:00

  • Transcription-coupled repair: an update.

    abstract::Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA lesions from the genomes of organisms across the evolutionary scale, from bacteria to humans. The serial steps in NER involve recognition of lesions, adducts or structures that disrupt the DNA double helix, removal of a short oli...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Spivak G

    更新日期:2016-11-01 00:00:00

  • Correction to: An evidence-based review of the genotoxic and reproductive effects of sulfur mustard.

    abstract::This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,已发布勘误


    authors: Khan F,Niaz K,Ismail Hassan F,Abdollahi M

    更新日期:2018-07-01 00:00:00

  • Effect of N-benzyl-D-glucamine dithiocarbamate on renal toxicity induced by cadmium-metallothionein in rats.

    abstract::The effect of N-benzyl-D-glucamine dithiocarbamate (BGD) on the renal toxicity induced by acute exposure to cadmium-metallothionein (Cd-MT) in rats was studied. Rats were injected intraperitoneally with BGD (400 mumol/kg) 6, 12, or 24 h after intraperitoneal injection of Cd-MT (1.78 mumol Cd as Cd-MT/kg) and thereafte...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Kojima S,Ono H,Furukawa A,Kiyozumi M

    更新日期:1990-01-01 00:00:00

  • Human liver debrisoquine 4-hydroxylase: test for specificity toward various monooxygenase substrates and model of the active site.

    abstract::Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Wolff T,Distlerath LM,Worthington MT,Guengerich FP

    更新日期:1987-01-01 00:00:00

  • Validity of different biomonitoring parameters for the assessment of occupational exposure to N,N-dimethylformamide (DMF).

    abstract::This study was performed to assess the relation between occupational exposure to N,N-dimethylformamide after an 8 h work shift in the acrylic fibre industry and its three biological markers N-methylformamide (NMFtotal), N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC), and N-methylcarbamoyl adduct at haemoglobin (MCVal)....

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Seitz M,Kilo S,Eckert E,Müller J,Drexler H,Göen T

    更新日期:2018-07-01 00:00:00

  • Comparative biological properties of the four stereoisomers of difethialone, a second-generation anticoagulant rodenticide, in rats: development of a model allowing to choose the appropriate stereoisomeric ratio.

    abstract::The current management of rodent pest populations is based on second-generation anticoagulant rodenticides (SGAR). These molecules, of which difethialone is part, are much more efficient than the first generation. Nevertheless, this efficiency comes with a major drawback, SGARs are tissue persistent that increases the...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Lefebvre S,Fourel I,Chatron N,Caruel H,Benoit E,Lattard V

    更新日期:2020-03-01 00:00:00

  • Spectral evidence for 2,2,3-trichloro-oxirane formation during microsomal trichloroethylene oxidation.

    abstract::During aerobic incubation of trichloroethylene with rabbit liver microsomes and NADPH a difference absorption peak appears at 451-452 nm. Trichloroethylene does not form a ligand absorption spectrum with hepatic microsomes reduced by dithionite, or in anaerobic incubates in the presence of NADPH. Addition of trichloro...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Uehleke H,Tabarelli-Poplawski S,Bonse G,Henschler D

    更新日期:1977-06-18 00:00:00

  • Contact allergens and irritants show discrete differences in the activation of human monocyte-derived dendritic cells: consequences for in vitro detection of contact allergens.

    abstract::In recent years test systems have been described that may be applied routinely to discriminate between contact allergens and irritants in vitro. Using human monocyte-derived dendritic cells (MoDC), this study was designed to refine the settings of a potential routine screening protocol for contact allergens and to inv...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Straube F,Grenet O,Bruegger P,Ulrich P

    更新日期:2005-01-01 00:00:00

  • Determination of urinary thymidine glycol using affinity chromatography, HPLC and post-column reaction detection: a biomarker of oxidative DNA damage upon kidney transplantation.

    abstract::Reactive oxygen species are generated during ischaemia-reperfusion of tissue. Oxidation of thymidine by hydroxyl radicals (HO) leads to the formation of 5,6-dihydroxy-5,6-dihydrothymidine (thymidine glycol). Thymidine glycol is excreted in urine and can be used as biomarker of oxidative DNA damage. Time dependent chan...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Thier R,Brüning T,Kocher K,Blaszkewicz M,Makropoulos V,Sundberg A,Bolt HM

    更新日期:1999-11-01 00:00:00

  • Induction of Dectin-1 and asthma-associated signal transduction pathways in RAW 264.7 cells by a triple-helical (1, 3)-β-D glucan, curdlan.

    abstract::People living in damp buildings are typically exposed to spore and mycelial fragments of the fungi that grow on damp building materials. There is experimental evidence that this exposure to triple-helical (1, 3)-β-D glucan and low molecular weight toxins may be associated with non-atopic asthma observed in damp and mo...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Rand TG,Robbins C,Rajaraman D,Sun M,Miller JD

    更新日期:2013-10-01 00:00:00

  • Hematological toxicity of tetrachloroethylene in mice.

    abstract::Female C57/BL/6 x DBA/2 hybrid mice were exposed to two concentrations (270 and 135 ppm) of tetrachloroethylene (PER) in inhalation chambers for 6 h/day, 5 days per week, up to 11.5 weeks (270 ppm) and 7.5 weeks (135 ppm), respectively, followed by a 3-week exposure-free period. In the peripheral blood a reduction of ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Seidel HJ,Weber L,Barthel E

    更新日期:1992-01-01 00:00:00

  • Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney.

    abstract::The deleterious effect of lead has been attributed to lead-induced oxidative stress with the consequence of lipid peroxidation. The present study was designed to investigate the combined effect of DL-alpha-lipoic acid (LA) and meso-2,3-dimercaptosuccinic acid (DMSA) on lead-induced peroxidative damages in rat kidney. ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Sivaprasad R,Nagaraj M,Varalakshmi P

    更新日期:2002-08-01 00:00:00

  • Dose-response of promotion by polychlorinated biphenyls and chloroform in rat liver foci bioassay.

    abstract::Using the rat liver foci bioassay a dose-response relationship was evaluated for the promoting activity of the ubiquitous and persistent environmental pollutants polychlorinated biphenyls (PCBs) and chloroform. Initiation of liver foci was performed by oral administration of a single dose of 8 mg/kg body wt of diethyl...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Deml E,Oesterle D

    更新日期:1987-01-01 00:00:00