Dual-label time-resolved fluoroimmunoassay for simultaneous detection of aflatoxin B1 and ochratoxin A.

abstract：:Sodium diethyldithiocarbamate (DETC) is the main metabolite of disulfiram. Recently, we reported that mechanism of disulfiram cytotoxicity in V79 cells might be partially connected with thiol redox-state imbalance. Here, we examined the effect of DETC on the level of intracellular glutathione (GSH), protein oxidation ...

journal_title：Archives of toxicology

authors： Rahden-Staroń I,Grosicka-Maciąg E,Kurpios-Piec D,Czeczot H,Grzela T,Szumiło M

更新日期：2012-12-01 00:00:00

abstract：:Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis. ...

journal_title：Archives of toxicology

authors： Giusti GV,Carnevale A

更新日期：1975-10-20 00:00:00

abstract：:MDMA-induced impairments of memory performance have been reported in different human and animal studies. However, the correlation between spatial memory impairment, brain mitochondrial function, and concentrations of MDMA and its metabolites has not yet been investigated despite it being needed for comparison with hum...

journal_title：Archives of toxicology

authors： Taghizadeh G,Mehdizadeh H,Lavasani H,Hosseinzadeh Ardakani Y,Foroumadi A,Halvaei Khankahdani Z,Moshtagh A,Pourahmad J,Sharifzadeh M,Rouini MR

更新日期：2020-03-01 00:00:00

abstract：:Intake of inorganic arsenic is known to cause vascular diseases as well as skin lesions and cancer in humans. We investigated the differences in cytotoxicity, uptake rate of arsenic, and gene expression of antioxidative enzymes between arsenite (As(3+))- and arsenate (As(5+))-exposed rat heart microvessel endothelial ...

journal_title：Archives of toxicology

authors： Hirano S,Cui X,Li S,Kanno S,Kobayashi Y,Hayakawa T,Shraim A

更新日期：2003-06-01 00:00:00

abstract：:During aerobic incubation of trichloroethylene with rabbit liver microsomes and NADPH a difference absorption peak appears at 451-452 nm. Trichloroethylene does not form a ligand absorption spectrum with hepatic microsomes reduced by dithionite, or in anaerobic incubates in the presence of NADPH. Addition of trichloro...

journal_title：Archives of toxicology

authors： Uehleke H,Tabarelli-Poplawski S,Bonse G,Henschler D

更新日期：1977-06-18 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) are a family of kinases associated predominantly with cell cycle control, making CDK inhibitors interesting candidates for anti-cancer therapeutics. However, retinal toxicity (loss of photoreceptors) has been associated with CDK inhibitors, including the pan-CDK inhibitor AG-012896. The...

journal_title：Archives of toxicology

authors： Wright P,Kelsall J,Healing G,Sanderson J

更新日期：2019-03-01 00:00:00

abstract：:The pharmacokinetics of styrene were investigated in male Sprague-Dawley rats and male B6C3F1 mice using the closed chamber technique. Animals were exposed to styrene vapors of initial concentrations ranging from 550 to 5000 ppm, or received intraperitoneal (i.p.) doses of styrene from 20 to 340 mg/kg or oral (p.o.) d...

journal_title：Archives of toxicology

authors： Filser JG,Schwegler U,Csanády GA,Greim H,Kreuzer PE,Kessler W

更新日期：1993-01-01 00:00:00

abstract：:The main purpose of this study was to verify the hypothesis that cognitive dysfunctions induced by arsenic exposure were related to the changes of D-serine metabolism in the hippocampus of offspring mice. Mother mice and their offsprings were exposed to 0, 15, 30 or 60 mg/L sodium arsenite (NaAsO2) through drinking wa...

journal_title：Archives of toxicology

authors： Wang Y,Yang X,Yu H,Wang H,Qi Y,Geng M

更新日期：2020-01-01 00:00:00

abstract：:A histochemical technique for detection of the in vivo induced cellular aldehydes based on the direct Schiff's reaction is reported in this paper. CCl4-intoxicated rat liver was used as an experimental model. Fresh and non-pretreated rat liver cryostat sections fixed in 10% formol calcium solution and washed in distil...

journal_title：Archives of toxicology

authors： Taper HS,Somer MP,Lans M,de Gerlache J,Roberfroid M

更新日期：1988-04-01 00:00:00

abstract：:High-dosage alcohol intoxication (i.e., binge drinking in humans) is an increasingly prevalent problem. Despite the well-known long-term consequences, the acute effects of high-dosage alcohol intoxication on cognitive control processes have not been investigated with respect to neurophysiological changes in humans. We...

journal_title：Archives of toxicology

authors： Stock AK,Blaszkewicz M,Beste C

更新日期：2014-02-01 00:00:00

abstract：:3H-soman (specific activity 10 Ci/mMol), a potent irreversible cholinesterase inhibitor, was administered IV to mice in a dose of one LD-50, which corresponds to 0.25 mCi/mouse. Animals were sacrificed at 5 min, 2 h and 24 h, and whole body autoradiography was performed. High levels of radioactivity in lung and skin w...

journal_title：Archives of toxicology

authors： Kadar T,Raveh L,Cohen G,Oz N,Baranes I,Balan A,Ashani Y,Shapira S

更新日期：1985-10-01 00:00:00

abstract：:Treatment of cats with acrylamide, either 7.5 or 15 mg/kg IM, once a day for 10 days, resulted in increases of 31 and 47% in the phospholipid content of sciatic nerve, respectively, from a control level of 41.1 +/- 2.7 mg/kg wet weight. Determination of the distribution of individual phospholipids indicated no signifi...

journal_title：Archives of toxicology

authors： Howland RD,Lowndes HE

更新日期：1984-09-01 00:00:00

abstract：:Quercetin (QC), a polyphenolic compound widely distributed in fruits and vegetables has recently gained interest due to its cisplatin (CP) sensitizing properties in cancer cells. It is currently unknown, whether quercetin also increases the susceptibility of the kidneys to cisplatin toxicity. We studied the effects of...

journal_title：Archives of toxicology

authors： Kuhlmann MK,Horsch E,Burkhardt G,Wagner M,Köhler H

更新日期：1998-07-01 00:00:00

abstract：:Vitamin E acetate (VEA) has come under significant scrutiny due to its association with e-cigarette, or vaping, product use-associated lung injury (EVALI). In 1965, Sir Austin Bradford Hill proposed a set of criteria used to critically assess an association for causality. In this article, we apply the Bradford Hill ca...

journal_title：Archives of toxicology

authors： Feldman R,Meiman J,Stanton M,Gummin DD

更新日期：2020-06-01 00:00:00

abstract：:In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca2+-binding proteins and/or Ca2+ pumps. The plasma membrane calcium pump (PMCA) maintains Ca2+ homeosta...

journal_title：Archives of toxicology

authors： Ferreira-Gomes MS,Mangialavori IC,Ontiveros MQ,Rinaldi DE,Martiarena J,Verstraeten SV,Rossi JPFC

更新日期：2018-01-01 00:00:00

abstract：:Increasing incidence of multidrug-resistant bacteria presents an imminent risk to global health. Polymyxins are 'last-resort' antibiotics against Gram-negative 'superbugs'; however, nephrotoxicity remains a key impediment in their clinical use. Molecular mechanisms underlying this nephrotoxicity remain poorly defined....

journal_title：Archives of toxicology

authors： Yun B,Zhang T,Azad MAK,Wang J,Nowell CJ,Kalitsis P,Velkov T,Hudson DF,Li J

更新日期：2018-07-01 00:00:00

abstract：:Glyphosate (G) is the largest selling herbicide worldwide; the most common formulations (Roundup, R) contain polyoxyethyleneamine as main surfactant. Recent findings indicate that G exposure may cause DNA damage and cancer in humans. Aim of this investigation was to study the cytotoxic and genotoxic properties of G an...

journal_title：Archives of toxicology

authors： Koller VJ,Fürhacker M,Nersesyan A,Mišík M,Eisenbauer M,Knasmueller S

更新日期：2012-05-01 00:00:00

abstract：:Sulfites whether ingested or produced through the sulfur-containing amino acids metabolism of the animal are very active molecules and can cause cellular toxicity. Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabol...

journal_title：Archives of toxicology

authors： Oztürk OH,Küçükatay V,Yönden Z,Ağar A,Bağci H,Delibaş N

更新日期：2006-10-01 00:00:00

abstract：:The neurological effects of four synthetic pyrethroids resmethrin, permethrin, cypermethrin, and deltamethrin have been investigated in the rat to establish whether there is a correlation between the clinical-functional status of the animal and peripheral nerve damage as measured biochemically. Neuromuscular dysfuncti...

journal_title：Archives of toxicology

authors： Rose GP,Dewar AJ

更新日期：1983-08-01 00:00:00

abstract：:The effect of culture medium on glutathione (GSH) dependent detoxification defence system of primary cultured hepatocyte from either male or female rats was studied. Intracellular reduced (GSH) and oxidized glutathione (GSSG), and six GSH-related enzyme activities, including GSH peroxidase (GSH Px), GSH reductase (GSH...

journal_title：Archives of toxicology

authors： Lii CK,Wang ST,Chen HW,Sheen LY

更新日期：1996-01-01 00:00:00

abstract：:Amanita phalloides is responsible for more than 90 % of mushroom-related fatalities, and no effective antidote is available. α-Amanitin, the main toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and kidney failure. In silico studies included docking and molecular dynamics simulation couple...

journal_title：Archives of toxicology

authors： Garcia J,Costa VM,Carvalho AT,Silvestre R,Duarte JA,Dourado DF,Arbo MD,Baltazar T,Dinis-Oliveira RJ,Baptista P,de Lourdes Bastos M,Carvalho F

更新日期：2015-12-01 00:00:00

abstract：:Interactions between chemicals in a mixture and interactions of mixture components with the skin can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous disposition of a topically applied chemical. The predictive ability of dermal absorption models, and consequently the dermal ...

journal_title：Archives of toxicology

authors： Riviere JE,Qiao G,Baynes RE,Brooks JD,Mumtaz M

更新日期：2001-08-01 00:00:00

abstract：:Organotin compounds such as tributyltin (TBT) and triphenyltin can induce diabetes and insulin resistance. However, the development of diabetes caused by organotins and its underlying mechanisms remain unclear. In the present study, male KM mice were orally administered with TBT (0.5, 5, and 50 μg/kg) once every 3 day...

journal_title：Archives of toxicology

authors： Li B,Guo J,Xi Z,Xu J,Zuo Z,Wang C

更新日期：2017-10-01 00:00:00

abstract：:Shaking behavior, so-called wet dog shakes (WDS), in rats is characteristic behavior indicating morphine abstinence in morphine-dependence and central excitation in relation to seizures elicited by chemicals or electrical stimulation. We have found that paraquat (PQ), a nonselective herbicide, administered systemicall...

journal_title：Archives of toxicology

authors： Hara S,Mukai T,Kurosaki K,Kuriiwa F,Yanase T,Kano S,Endo T

更新日期：2001-02-01 00:00:00

abstract：:Aspergillus versicolor and A. flavus are primary colonizers in damp dwellings, and they produce sterigmatocystin (ST) and aflatoxin B1 (AFB(1)), respectively. These hepatotoxic and carcinogenic mycotoxins and their precursors and derivates possess a furofuran ring, which has proven responsible for their toxicity. The ...

journal_title：Archives of toxicology

authors： Jakšić D,Puel O,Canlet C,Kopjar N,Kosalec I,Klarić MŠ

更新日期：2012-10-01 00:00:00

abstract：:The aim of this study was to investigate the genotoxic potential of DNA adducts and to compare DNA adduct levels and patterns in petroleum vacuum distillates, coal tar distillate, bitumen fume condensates, and related substances that have a wide range of boiling temperatures. An in vitro assay was used for DNA adduct ...

journal_title：Archives of toxicology

authors： Akkineni LK,Zeisig M,Baranczewski P,Ekström LG,Möller L

更新日期：2001-01-01 00:00:00

abstract：:Cadmium (Cd), a highly toxic heavy metal, is distributed widely in the general environment of today. The characteristic clinical manifestations of chronic Cd intoxication include renal proximal tubular dysfunction, general osteomalacia with severe pains, and anemia. We have recently reported that the serum level of er...

journal_title：Archives of toxicology

authors： Horiguchi H,Sato M,Konno N,Fukushima M

更新日期：1996-01-01 00:00:00

abstract：:Changes in the urinary excretion of hippuric acid (HIA) and phenaceturic acid (PUA) as well as their metabolic precursors, i.e. benzoic (BA) and phenylacetic acid (PAA), in rats housed in glass metabolic cages for 4 days were monitored using gas-liquid chromatography. The amount of HIA excreted was 128 +/- 63 mumol/kg...

journal_title：Archives of toxicology

authors： Linhart I,Smejkal J

更新日期：1987-01-01 00:00:00

abstract：:Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydro...

journal_title：Archives of toxicology

authors： Oishi S

更新日期：1986-12-01 00:00:00

abstract：:The assay of neurotoxic esterase (NTE) in brains taken from dosed hens enables potential neurotoxicity of organophosphate pesticides, plasticers, etc. to be assessed. The original assay [Johnson, M.K. Biochem. J. 114, 711-717 (1969)] has been simplified to eliminate centrifugation and transfer steps and both the selec...

journal_title：Archives of toxicology

authors： Johnson MK

更新日期：1977-06-18 00:00:00