Transfer of hexachlorobenzene (HCB) from mother to newborn baby through placenta and milk.

abstract：: ...

journal_title：Archives of toxicology

authors： Deng Y,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：:The uncertainties that surround the methods used for risk assessment of exposure to carcinogens have been highlighted by a recent document advocating an approach based on the T25 dose (the dose giving a 25% incidence of cancer in an appropriately designed animal experiment). This method relies on derivation of the T25...

journal_title：Archives of toxicology

authors： Roberts RA,Crump KS,Lutz WK,Wiegand HJ,Williams GM,Harrison PT,Purchase IF

更新日期：2001-11-01 00:00:00

abstract：:The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We s...

journal_title：Archives of toxicology

authors： Yang M,Ryu JH,Jeon R,Kang D,Yoo KY

更新日期：2009-03-01 00:00:00

abstract：:The circadian rhythms of HMG-CoA reductase and cholesterol-7 alpha-hydroxylase (low values, during light, rising in the evening with maximum at 12.00 p.m.) are investigated in rats under diverse conditions. Intragastral administration of cholestyramine (bile acid-absorbing resin) leads to an increased rhythm of both e...

journal_title：Archives of toxicology

authors： Mayer D

更新日期：1976-12-17 00:00:00

abstract：:False-negative judgment due to poor chemical solubility is a problem with in vitro skin sensitisation tests. Water-insoluble chemicals are typically dissolved in DMSO in most sensitisation tests but precipitate when diluted with medium beyond their solubility in water. Such tests lack procedures to rule out false-nega...

journal_title：Archives of toxicology

authors： Kimura Y,Fujimura C,Aiba S

更新日期：2020-10-17 00:00:00

abstract：:Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic to rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibit protein synthesis in vitro and in several in vivo systems. The mechanism whereby this mitogenic activity occurs was previously u...

journal_title：Archives of toxicology

authors： Ennamany R,Kretz O,Creppy EE

更新日期：1995-01-01 00:00:00

abstract：:Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs i...

journal_title：Archives of toxicology

authors： Nurulain SM,Kornelia T,Naqvi SN,Sharma C,Ojha S,Adem A

更新日期：2014-03-01 00:00:00

abstract：:This article is published with the incorrect copyright holder name in the HTML article as "© Springer 2018". The correct copyright line should read "The Author(s) 2018" (as it appears in the article PDF). ...

journal_title：Archives of toxicology

authors： Oesch F,Fabian E,Landsiedel R

更新日期：2018-11-01 00:00:00

abstract：:Environmental tobacco smoke (ETS) is associated with high morbidity and mortality, mainly in children. However, few studies focus on the brain development effects of ETS exposure. Myelination mainly occurs in the early years of life in humans and the first three postnatal weeks in rodents and is sensitive to xenobioti...

journal_title：Archives of toxicology

authors： Torres LH,Annoni R,Balestrin NT,Coleto PL,Duro SO,Garcia RC,Pacheco-Neto M,Mauad T,Camarini R,Britto LR,Marcourakis T

更新日期：2015-11-01 00:00:00

abstract：:3H-soman (specific activity 10 Ci/mMol), a potent irreversible cholinesterase inhibitor, was administered IV to mice in a dose of one LD-50, which corresponds to 0.25 mCi/mouse. Animals were sacrificed at 5 min, 2 h and 24 h, and whole body autoradiography was performed. High levels of radioactivity in lung and skin w...

journal_title：Archives of toxicology

authors： Kadar T,Raveh L,Cohen G,Oz N,Baranes I,Balan A,Ashani Y,Shapira S

更新日期：1985-10-01 00:00:00

abstract：:Labilization of lysosomal enzymes is often associated with the general process of inflammation. The present study investigated the effect of the pneumotoxin cadmium on the release and activity of two lung lysosomal enzymes. Incubation of rat lung lysosomes with cadmium resulted in the release of beta-glucuronidase but...

journal_title：Archives of toxicology

authors： Giri SN,Hollinger MA

更新日期：1995-01-01 00:00:00

abstract：:The aim of this study was to assess the neurotoxicity of diazinon oxon (DZO), a major in vivo metabolite of the phosphorothionate insecticide diazinon (DZ), on differentiating mouse N2a neuroblastoma cells. When used at concentrations of 1, 5 and 10 microM, DZO did not cause cell death but it impaired the outgrowth of...

journal_title：Archives of toxicology

authors： Sidiropoulou E,Sachana M,Flaskos J,Harris W,Hargreaves AJ,Woldehiwet Z

更新日期：2009-04-01 00:00:00

abstract：:Cannabis use has become a hot topic in several countries due to the debate about its legalization for medical purposes. However, data are limited regarding adverse events, safety and potential impact on reproductive health. Cannabis consumption during pregnancy has been associated with gestational disorders such as pr...

journal_title：Archives of toxicology

authors： Maia J,Midão L,Cunha SC,Almada M,Fonseca BM,Braga J,Gonçalves D,Teixeira N,Correia-da-Silva G

更新日期：2019-03-01 00:00:00

abstract：:Current developmental neurotoxicity (DNT) testing in animals faces major limitations, such as high cost and time demands as well as uncertainties in their methodology, evaluation and regulation. Therefore, the use of human-based 3D in vitro systems in combination with high-content image analysis (HCA) might contribute...

journal_title：Archives of toxicology

authors： Schmuck MR,Temme T,Dach K,de Boer D,Barenys M,Bendt F,Mosig A,Fritsche E

更新日期：2017-04-01 00:00:00

abstract：:Exposure to alkylanilines found in tobacco smoke and indoor air is associated with risk of bladder cancer. Genetic factors significantly influence the metabolism of arylamine carcinogens and the toxicological outcomes that result from exposure. We utilized nucleotide excision repair (NER)-deficient immortalized human ...

journal_title：Archives of toxicology

authors： Leggett CS,Doll MA,States JC,Hein DW

更新日期：2021-01-01 00:00:00

abstract：:The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological releva...

journal_title：Archives of toxicology

authors： Dragovic S,Vermeulen NP,Gerets HH,Hewitt PG,Ingelman-Sundberg M,Park BK,Juhila S,Snoeys J,Weaver RJ

更新日期：2016-12-01 00:00:00

abstract：:With the development of nanotechnologies, the potential adverse effects of nanomaterials such as multi-walled carbon nanotubes (MWCNT) on the respiratory tract of asthmatics are questioned. Furthermore, investigations are necessary to understand how these effects might arise. In the present study, we hypothesized that...

journal_title：Archives of toxicology

authors： Ronzani C,Casset A,Pons F

更新日期：2014-02-01 00:00:00

abstract：:Concerning molecular and cellular mechanisms of aluminum toxicity, recent studies support the hypothesis that interactions of aluminum ions with elements of signal transduction pathways are apparently primary events in cells. In the case of the phosphoinositide-associated signalling pathway of neuroblastoma cells, gua...

journal_title：Archives of toxicology

authors： Haug A,Shi B,Vitorello V

更新日期：1994-01-01 00:00:00

abstract：:Adverse outcome pathways (AOPs) have been recently introduced as tools to map the mechanisms underlying toxic events relevant for chemical risk assessment. AOPs particularly depict the linkage between a molecular initiating event and an adverse outcome through a number of intermediate key events. An AOP has been previ...

journal_title：Archives of toxicology

authors： Gijbels E,Vilas-Boas V,Annaert P,Vanhaecke T,Devisscher L,Vinken M

更新日期：2020-04-01 00:00:00

abstract：:Reduced gluconeogenesis due to decreased activity of key gluconeogenic enzymes in liver, together with feed refusal, has been suggested to play an important role in 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced lethality in rats. This study was carried out to further analyse the toxicological significance of red...

journal_title：Archives of toxicology

authors： Viluksela M,Unkila M,Pohjanvirta R,Tuomisto JT,Stahl BU,Rozman KK,Tuomisto J

更新日期：1999-08-01 00:00:00

abstract：:Primary hepatocytes are a widely used cell model to analyse the expression and regulation of hepatic cytochrome P450 (CYP) isoenzymes. Transforming growth factor-beta1 (TGF-beta1) was previously shown to inhibit constitutive and induced CYP1 expression in human cell lines and primary hepatocytes but not in rat cells. ...

journal_title：Archives of toxicology

authors： Müller GF,Döhr O,El-Bahay C,Kahl R,Abel J

更新日期：2000-05-01 00:00:00

abstract：:Di-n-butylin dichloride (DBTCl), which is commonly used as heat and light stabilizer for polyvinyl chloride (PVC) plastics, is a teratogen in vivo. In the present study, the toxic effects were investigated of DBTCl on cultured rat embryos during three different stages of organogenesis. Rat embryos explanted on gestati...

journal_title：Archives of toxicology

authors： Ema M,Iwase T,Iwase Y,Ohyama N,Ogawa Y

更新日期：1996-01-01 00:00:00

abstract：:This review provides a compendium of the results of genotoxicity and carcinogenicity assays performed on marketed antihistamines. Of the 70 drugs examined, 29 (41.4%) have at least one genotoxicity and/or carcinogenicity test result: 12 tested positive in at least one genotoxicity assay, six in at least one carcinogen...

journal_title：Archives of toxicology

authors： Brambilla G,Mattioli F,Robbiano L,Martelli A

更新日期：2011-10-01 00:00:00

abstract：:For ethical and regulatory reasons, in vitro tests for scoring potential toxicities of cosmetics are essential. A test strategy for investigating potential skin sensitization using two human keratinocytic and two human dendritic cell lines has been developed (Mehling et al. Arch Toxicol 86:1273–1295, 2012). Since proh...

journal_title：Archives of toxicology

authors： Fabian E,Vogel D,Blatz V,Ramirez T,Kolle S,Eltze T,van Ravenzwaay B,Oesch F,Landsiedel R

更新日期：2013-09-01 00:00:00

abstract：:Oxidative stress is discussed as a possible hepatocarcinogenic mechanism of peroxisome proliferators (PP) in rodents and is suggested to result from the induction of peroxisomal beta-oxidation (PBOX) by PP. The induced PBOX is assumed to produce excessive H2O2 from the degradation of fatty acids, ultimately leading to...

journal_title：Archives of toxicology

authors： Huber WW,Grasl-Kraupp B,Stekel H,Gschwentner C,Lang H,Schulte-Hermann R

更新日期：1997-01-01 00:00:00

abstract：:The mechanical properties of the bones of young, adult and old rats administered various concentrations of cadmium were measured to prove the direct effect of cadmium on the bones of young rats. The young rats were divided into three subgroups, which were administered 0 (control), 5 and 10 ppm cadmium, respectively. T...

journal_title：Archives of toxicology

authors： Ogoshi K,Moriyama T,Nanzai Y

更新日期：1989-01-01 00:00:00

abstract：:The effect of methantheline, a quaternary ammonium compound, on the reactivation by HI 6 of soman-inhibited human erythrocyte acetylcholinesterase (AChE) was investigated in vitro using purified human erythrocyte AChE or washed human erythrocytes. Methantheline itself was found to be a mixed competitive/non-competitiv...

journal_title：Archives of toxicology

authors： Hallek M,Szinicz L

更新日期：1995-01-01 00:00:00

abstract：:Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...

journal_title：Archives of toxicology

authors： Aluoch AO,Odman-Ghazi SO,Whalen MM

更新日期：2007-04-01 00:00:00

abstract：:To investigate the mechanism on photosensitive dermatitis caused by ketoprofen (KP) in humans, the following experiments were performed by topical application on guinea pigs. The phototoxicity study involving treatment with 10% solution of KP, its enantiomers (R-KP and S-KP), loxoprofen, and flurbiprofen revealed no p...

journal_title：Archives of toxicology

authors： Nakazawa T,Shimo T,Chikamatsu N,Igarashi T,Nagata O,Yamamoto M

更新日期：2006-07-01 00:00:00

abstract：:Sulfur mustard (SM) is a bifunctional alkylating agent. Its primary toxic consequence is severe skin damage with blisters, occurring after skin contact. These vesicant properties of SM have been linked to cell death of proliferating keratinocytes in the basal layer of the skin. Catalytic activation of the nuclear enzy...

journal_title：Archives of toxicology

authors： Kehe K,Raithel K,Kreppel H,Jochum M,Worek F,Thiermann H

更新日期：2008-07-01 00:00:00