Abstract:
:The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We studied potential associations between BPA exposure and breast cancer risks in Korean women by performing biomonitoring of BPA among breast cancer patients and controls (N = 167). Blood samples were collected between 1994 and 1997 and kept over 10 years in a freezer under well controlled conditions. The blood BPA levels determined by HPLC/FD, ranged between LOD (0.012 microg/L) and 13.87 microg/L (mean +/- SD, 1.69 +/- 2.57 microg/L; median, 0.043 microg/L). In age-matched subjects (N = 152), there were some associations between BPA levels and risks of breast cancer, such as age at first birth and null parity. However, there were no significant differences in blood BPA levels between the cases and the controls (P = 0.42). Considering interactions between BPA exposure and risks of breast cancer, we suggest further enlarged biomonitoring studies of BPA to provide effective prevention against breast cancer.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Yang M,Ryu JH,Jeon R,Kang D,Yoo KYdoi
10.1007/s00204-008-0364-0subject
Has Abstractpub_date
2009-03-01 00:00:00pages
281-5issue
3eissn
0340-5761issn
1432-0738journal_volume
83pub_type
杂志文章abstract::High-dosage alcohol intoxication (i.e., binge drinking in humans) is an increasingly prevalent problem. Despite the well-known long-term consequences, the acute effects of high-dosage alcohol intoxication on cognitive control processes have not been investigated with respect to neurophysiological changes in humans. We...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1109-2
更新日期:2014-02-01 00:00:00
abstract::Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01234482
更新日期:1983-12-01 00:00:00
abstract::Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02928-7
更新日期:2020-10-27 00:00:00
abstract::Intravenous administration of lead acetate to rabbits for 10 weeks at 2 week intervals resulted in significantly elevated blood lead levels, slight anemia with marked microspherocytosis and moderate basophilic stippling, and marked depression of red cell delta-aminolevulinic acid (ALA) dehydratase activity. However th...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00695874
更新日期:1979-10-01 00:00:00
abstract::The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of adm...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00288341
更新日期:1988-01-01 00:00:00
abstract::Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in th...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00347881
更新日期:1982-03-01 00:00:00
abstract::Acetaminophen (APAP) is a widely-used analgesic and a known hepatotoxic agent. Vascular endothelial growth factor (VEGF) is a growth factor with multiple functional roles. VEGF plays an important role in angiogenesis and hepatic regeneration. The aim of this study was to determine the expression of VEGF isoforms and i...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0201-x
更新日期:2007-10-01 00:00:00
abstract::The tissue distribution, metabolism and excretion of 14C-2,2',4,4',5-pentachlorodiphenyl ether (PCDE) were studied in the rat. Radioactivity was distributed in all tissues examined, with the highest concentrations being found in the fat followed by the skin, liver, kidney and muscle. Most of the radioactivity found in...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00332484
更新日期:1988-01-01 00:00:00
abstract::DNA damage induced by methylmethane sulfonate, cyclophosphamide, doxorubicin and procarbazine in male germ cells was assessed in rabbits by the demonstration of unscheduled DNA synthesis (UDS), in meiotic and postmeiotic phases of maturation. Immediately after treatment by the intravenous route tritiated thymidine was...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00361252
更新日期:1980-11-01 00:00:00
abstract::Amanita phalloides is responsible for more than 90 % of mushroom-related fatalities, and no effective antidote is available. α-Amanitin, the main toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and kidney failure. In silico studies included docking and molecular dynamics simulation couple...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1582-x
更新日期:2015-12-01 00:00:00
abstract::Fifteen patients who were severely poisoned with either hypnotic drugs or salicylate were treated by charcoal haemoperfusion. The device contained 100g of activated charcoal immobilised by fixation to a polyester film. Two patients showed no response and eventually died. The remainder showed marked lightening of coma ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01270911
更新日期:1980-07-01 00:00:00
abstract::This study was performed to assess the relation between occupational exposure to N,N-dimethylformamide after an 8 h work shift in the acrylic fibre industry and its three biological markers N-methylformamide (NMFtotal), N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC), and N-methylcarbamoyl adduct at haemoglobin (MCVal)....
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2219-7
更新日期:2018-07-01 00:00:00
abstract::The protective effects of various chelating agents such as D-penicillamine (D-PEN), 2,3-dimercaptosuccinic acid (DMSA), 2,3-dimercaptopropane sulphonate (DMPS), and N-(2-mercapto-2-methylpropanoyl)-L-cysteine (bucillamine), on the renal damage induced by gold sodium thiomalate (AuTM) in rats were studied. Rats were in...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973712
更新日期:1991-01-01 00:00:00
abstract::To clarify whether oxidative stress is involved in the development of hepatocellular preneoplastic foci induced by fenofibrate (FF), a peroxisome proliferator-activated receptor alpha agonist, male F344/N rats were fed a diet containing 6,000, 3,000, or 0 ppm of FF for 13 weeks after N-diethylnitrosamine initiation. T...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0278-2
更新日期:2008-09-01 00:00:00
abstract::The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime whi...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02342509
更新日期:1992-01-01 00:00:00
abstract::Experimental and/or epidemiological studies suggest that prenatal exposure to bisphenol A (BPA) may delay fetal lung development and maturation and increase the susceptibility to childhood respiratory disease. However, the underlying mechanisms remain to be elucidated. In our previous study with cultured human fetal l...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2150-3
更新日期:2018-04-01 00:00:00
abstract::Chronic exposure to propiverine, a frequently prescribed pharmaceutical for treatment of overactive bladder and incontinence, provokes massive protein accumulation in the cytosol and nucleus of renal proximal tubule epithelial cells in rats. Previously, the accumulating protein was identified as D-amino acid oxidase (...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1685-z
更新日期:2017-01-01 00:00:00
abstract::A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). The molecular and cellular events by which PPARα activators induce rodent hepatocarcinogenesis have been extensively studied elucidating a...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-017-2094-7
更新日期:2018-01-01 00:00:00
abstract::Concerning molecular and cellular mechanisms of aluminum toxicity, recent studies support the hypothesis that interactions of aluminum ions with elements of signal transduction pathways are apparently primary events in cells. In the case of the phosphoinositide-associated signalling pathway of neuroblastoma cells, gua...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s002040050023
更新日期:1994-01-01 00:00:00
abstract::Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the effects of two AsH...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2194-z
更新日期:2018-05-01 00:00:00
abstract::The effects of intravenously (i.v.) administered or inhaled amyl nitrite (AN) were followed under chloralose anaesthesia in intact and cyanide-poisoned, spontaneously breathing beagles. The i.v. doses of AN were 0.03 and 0.15 mmol/kg and the i.v. dose of KCN was 0.06 mmol/kg. AN was inhaled in a closed system at 0.15 ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00570134
更新日期:1988-01-01 00:00:00
abstract::4-Nonylphenol (para-nonylphenol, 4-NP), metabolites including linear and branched isoforms of nonylphenol (n-NP and t-NP, respectively), has been considered an endocrine disrupting substance resulting in reproductive dysfunction and increasing reactive oxygen species production in testis, liver, kidney, and brain. How...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0447-6
更新日期:2009-10-01 00:00:00
abstract::The effects of diabetes on cytochrome P450 (CYP)-dependent drug metabolizing enzymes are yet to be clarified. The most widely used animals in these studies have been rats, and information on the effects of diabetes on rabbit liver drug metabolizing enzymes have been unavailable until now. In this study, for the first ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-005-0654-8
更新日期:2005-08-01 00:00:00
abstract::Environmental tobacco smoke (ETS) is associated with high morbidity and mortality, mainly in children. However, few studies focus on the brain development effects of ETS exposure. Myelination mainly occurs in the early years of life in humans and the first three postnatal weeks in rodents and is sensitive to xenobioti...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1343-2
更新日期:2015-11-01 00:00:00
abstract::Regarding the cancer risk assessment of acrylamide (AA) it is of basic interest to know, as to what amount of the absorbed AA is metabolized to glycidamide (GA) in humans, compared to what has been observed in laboratory animals. GA is suspected of being the ultimate carcinogenic metabolite of AA. From experiments wit...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0296-8
更新日期:2008-10-01 00:00:00
abstract::Sulfites whether ingested or produced through the sulfur-containing amino acids metabolism of the animal are very active molecules and can cause cellular toxicity. Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabol...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0125-x
更新日期:2006-10-01 00:00:00
abstract::Environmental carcinogens-induced lung cancer and potential mechanisms have attracted widespread attention. Currently, microRNAs (miRNAs) have been recognized as key players in development of cancer, among which guide strand of miRNA has been well documented rather than its passenger strand (miRNA*). Our previous stud...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1551-4
更新日期:2016-05-01 00:00:00
abstract::Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00351767
更新日期:1978-10-13 00:00:00
abstract::In order to clarify the possible mechanism of hepatocarcinogenesis induced by piperonyl butoxide, we attempted to identify the transcription factor activated by piperonyl butoxide in the male ICR mouse liver. Administration of 0.6% piperonyl butoxide for 24 h elevated the level of liver nuclear proteins that bind to a...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0283-0
更新日期:2008-10-01 00:00:00
abstract::A series of experiments was set up to elucidate the effects of pollution on marine and estuarine fish health, since the European flounder (Platichthys flesus) has shown a relatively high prevalence of (pre)neoplastic liver lesions and lymphocystis virus disease in Dutch coastal and estuarine waters. The hypothesis of ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040100213
更新日期:2001-04-01 00:00:00