Abstract：
:This review provides a compendium of the results of genotoxicity and carcinogenicity assays performed on marketed antihistamines. Of the 70 drugs examined, 29 (41.4%) have at least one genotoxicity and/or carcinogenicity test result: 12 tested positive in at least one genotoxicity assay, six in at least one carcinogenicity assay, and four gave a positive response in both at least one genotoxicity assay and at least one carcinogenicity assay. Of 19 drugs with both genotoxicity and carcinogenicity data, eight were neither genotoxic nor carcinogenic, two were carcinogenic in at least one sex of mice or rats but tested negative in genotoxicity assays, five tested positive in at least one genotoxicity assay but were non-carcinogenic, and four gave a positive response in at least one genotoxicity assay and in at least one carcinogenicity assay. Only 12 (17.1%) of the 70 drugs examined have all data required by present guidelines for testing of pharmaceuticals, but it should be considered that a large fraction of them were developed and marketed prior the present regulatory climate.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Brambilla G,Mattioli F,Robbiano L,Martelli Adoi
10.1007/s00204-011-0659-4subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1173-87issue
10eissn
0340-5761issn
1432-0738journal_volume
85pub_type
杂志文章,评审abstract：:The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime whi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02342509
更新日期：1992-01-01 00:00:00
abstract：:The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-015-1470-4
更新日期：2015-05-01 00:00:00
abstract：:In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his N...
journal_title：Archives of toxicology
pub_type： 历史文章,杂志文章
doi：10.1007/s00204-011-0728-8
更新日期：2011-12-01 00:00:00
abstract：:The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts as a 5-hydroxyindoleacetic acid (5-HT) receptor agonist, but little is known about its pharmacological effects...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02740-3
更新日期：2020-07-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-017-2094-7
更新日期：2018-01-01 00:00:00
abstract：:The flavonol quercetin shows a wide range of effects in biological systems. We investigated whether quercetin exerts its proposed antioxidant properties via the antioxidant enzyme system. Quercetin in a concentration range from 5 to 100 microM decreased manganese superoxide dismutase, glutathione peroxidase, and coppe...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0482-7
更新日期：2003-09-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973712
更新日期：1991-01-01 00:00:00
abstract：:2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) is known to influence vitamin A homeostasis. In order to investigate the mechanism behind this retinoid disruption, male Sprague-Dawley rats were exposed to TCDD at doses ranging from 0.1 to 100 micro g/kg body weight, and were killed 3 days after exposure. Additional groups...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0457-8
更新日期：2003-07-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2306-9
更新日期：2018-11-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1743-6
更新日期：2016-08-01 00:00:00
abstract：:The excretion and biotransformation of [14C] 1,1-dichloroethylene (vinylidene chloride, VDC) after administration of a single oral dose has been investigated in female rats. Seventy-two hours after a dose of 0.5, 5.0, and 50.0 mg/kg, 1.26, 9.70, 16.47%, respectively, are exhaled as unchanged VDC, and 13.64, 11.35, 6.1...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00353707
更新日期：1979-07-11 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01270911
更新日期：1980-07-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2192-1
更新日期：2018-07-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/BF02284256
更新日期：1991-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0771-5
更新日期：2012-03-01 00:00:00
abstract：:The toxicity of 60 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) given IP in corn oil/5% acetone was examined in male Sprague-Dawley rats adapted to 25 degrees C or 4 degrees C ambient temperature. Cold exposure significantly reduced mean time to death and tended to increase mortality. Body weight at the ti...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290540
更新日期：1986-12-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-009-0463-6
更新日期：2009-12-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290882
更新日期：1985-08-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303124
更新日期：1989-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF03208340
更新日期：1994-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
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更新日期：1989-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2247-3
更新日期：2018-08-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050499
更新日期：1998-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-017-2024-8
更新日期：2017-09-01 00:00:00
abstract：:Experimental and/or epidemiological studies suggest that prenatal exposure to bisphenol A (BPA) may delay fetal lung development and maturation and increase the susceptibility to childhood respiratory disease. However, the underlying mechanisms remain to be elucidated. In our previous study with cultured human fetal l...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2150-3
更新日期：2018-04-01 00:00:00
abstract：:Environmental carcinogens-induced lung cancer and potential mechanisms have attracted widespread attention. Currently, microRNAs (miRNAs) have been recognized as key players in development of cancer, among which guide strand of miRNA has been well documented rather than its passenger strand (miRNA*). Our previous stud...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1551-4
更新日期：2016-05-01 00:00:00
abstract：:Most dietary flavonoids have antioxidant activity in vitro however, secondary mechanisms such as the ability to influence gene expression with the consequent modulation of specific enzymatic activities involved in the intracellular response against oxidative stress, are being realized. In the following study, we exami...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0210-9
更新日期：2007-11-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02934-9
更新日期：2020-10-17 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973682
更新日期：1993-01-01 00:00:00
abstract：:Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0788-9
更新日期：2012-04-01 00:00:00
