Electroretinographic assessment of early retinopathy in rats.

abstract：:The effect of intracerebroventricular (i.c.v.) administration of cadmium or magnesium on central calcium-dependent blood pressure regulation was investigated. The systolic blood pressure of spontaneously hypertensive rats (SHR; male, 13 weeks of age) decreased following i.c.v. administration of cadmium chloride (20 nm...

journal_title：Archives of toxicology

authors： Sutoo D,Akiyama K

更新日期：2000-03-01 00:00:00

abstract：:To investigate possible persistent nephrotoxic effects of trichloroethylene (TRI), a retrospective study was carried out on 39 workers exposed to high levels of TRI from 1956 to 1975. Total protein levels in urine, as well as serum and urine creatinine and serum urea were unchanged in comparison with the control. Sodi...

journal_title：Archives of toxicology

authors： Brüning T,Sundberg AG,Birner G,Lammert M,Bolt HM,Appelkvist EL,Nilsson R,Dallner G

更新日期：1999-06-01 00:00:00

abstract：:The mycotoxin ochratoxin A (OTA) and its metabolite ochratoxin alpha (OT-alpha) were investigated, to examine their potency to induce sister chromatid exchanges (SCE) in cultured porcine urinary bladder epithelial cells (PUBEC) (primary culture). Serum-free cultured PUBEC were incubated for 5 h with either OTA or OT-a...

journal_title：Archives of toxicology

authors： Föllmann W,Hillebrand IE,Creppy EE,Bolt HM

更新日期：1995-01-01 00:00:00

abstract：:Current developmental neurotoxicity (DNT) testing in animals faces major limitations, such as high cost and time demands as well as uncertainties in their methodology, evaluation and regulation. Therefore, the use of human-based 3D in vitro systems in combination with high-content image analysis (HCA) might contribute...

journal_title：Archives of toxicology

authors： Schmuck MR,Temme T,Dach K,de Boer D,Barenys M,Bendt F,Mosig A,Fritsche E

更新日期：2017-04-01 00:00:00

abstract：:Sarin, a potent organophosphate cholinesterase inhibitor, induces an array of toxic effects including convulsions. Many antidotal treatments contain anticonvulsants to block seizure activity and the ensuing brain damage. Magnesium sulfate (MGS) is used to suppress eclamptic seizures in pregnant women with hypertension...

journal_title：Archives of toxicology

authors： Katalan S,Lazar S,Brandeis R,Rabinovitz I,Egoz I,Grauer E,Bloch-Shilderman E,Raveh L

更新日期：2013-02-01 00:00:00

abstract：:The in ovo carcinogenicity assessing (IOCA) assay was used to examine the morphological changes in fetal turkey livers caused by the DNA-reactive carcinogen diethylnitrosamine (DEN). Fertilized turkey eggs were allocated into 3 groups: nondosed control (NDC), vehicle (water) control (VC) and DEN-dosed. At day 0, the f...

journal_title：Archives of toxicology

authors： Williams GM,Brunnemann KD,Iatropoulos MJ,Smart DJ,Enzmann HG

更新日期：2011-06-01 00:00:00

abstract：:The implementation of the Chemical Weapon Convention (CWC), prohibiting the development, production, storage and use of chemical weapons by 192 nations and the ban of highly toxic OP pesticides, especially class I pesticides according to the WHO classification, by many countries constitutes a great success of the inte...

journal_title：Archives of toxicology

authors： Worek F,Wille T,Koller M,Thiermann H

更新日期：2016-09-01 00:00:00

abstract：:Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...

journal_title：Archives of toxicology

authors： Barański B,Stetkiewicz I,Sitarek K,Szymczak W

更新日期：1983-12-01 00:00:00

abstract：:Pyrrolizidine alkaloids (PAs) are widely occurring phytotoxins which can induce severe liver damage in humans and other mammalian species by mechanisms that are not fully understood. Therefore, we investigated the development of PA hepatotoxicity in vivo, using an acutely toxic dose of the PA senecionine in mice, in c...

journal_title：Archives of toxicology

authors： Hessel-Pras S,Braeuning A,Guenther G,Adawy A,Enge AM,Ebmeyer J,Henderson CJ,Hengstler JG,Lampen A,Reif R

更新日期：2020-01-01 00:00:00

abstract：:The nephrotoxic action of aristolochic acid (AA) was investigated in female Wistar rats given single doses of 10, 50 or 100 mg/kg by gastric tube. Renal lesions developed within 3 days, the effect being dose-dependent. Histologically, there was evidence of necrosis of the epithelium of the renal tubules, and functiona...

journal_title：Archives of toxicology

authors： Mengs U,Stotzem CD

更新日期：1993-01-01 00:00:00

abstract：:The pregnancy outcomes of 109 women who were intoxicated during pregnancy due to excessive amounts of drugs and other agents were studied. Seventy per cent of the women attempted suicide, and the intoxication in 78% of all cases was caused by drugs. The stillbirth rate (4%) was higher than that in previous and subsequ...

journal_title：Archives of toxicology

authors： Czeizel A,Szentesi I,Szekeres I,Molnár G,Glauber A,Bucski P

更新日期：1988-08-01 00:00:00

abstract：:The nephrotoxicity of 4-amino-3-S-glutathionylphenol (PAP-GSH), a known metabolite of 4-amino-phenol (PAP), was determined in male Fischer 344 rats. Administration of a single dose of 40 or 60 mumol kg-1 caused a marked elevation in blood urea nitrogen and an increase in the urinary excretion of glucose, protein and g...

journal_title：Archives of toxicology

authors： Fowler LM,Foster JR,Lock EA

更新日期：1994-01-01 00:00:00

abstract：:Thanks to the confluence of genome sequencing and bioinformatics, the number of metabolic databases has expanded from a handful in the mid-1990s to several thousand today. These databases lie within distinct families that have common ancestry and common attributes. The main families are the MetaCyc, KEGG, Reactome, Mo...

journal_title：Archives of toxicology

authors： Karp PD,Caspi R

更新日期：2011-09-01 00:00:00

abstract：:Neutrophils infiltrate tissues during inflammation, and when activated, they release β-glucuronidase. Since inflammation is associated with carcinogenesis, we investigated how extracellular β-glucuronidase changed the in vitro cellular response to the chemical carcinogen benzo(a)pyrene (B[a]P). For this we exposed hum...

journal_title：Archives of toxicology

authors： Shi Q,Haenen GR,Maas L,Arlt VM,Spina D,Vasquez YR,Moonen E,Veith C,Van Schooten FJ,Godschalk RWL

更新日期：2016-09-01 00:00:00

abstract：:Metabolic activation of the heterocyclic amine 3-amino -1,4-dimethyl-5 H-pyrido[4,3-b]indole (Trp-P-1) and 7-ethoxyresorufin O-deethylase (EROD) activity were examined in the chorioallantoic membrane (CAM) of 15-day-old chicken and 18-day-old eider duck embryos. The embryos were pretreated with an Ah receptor agonist,...

journal_title：Archives of toxicology

authors： Annas A,Brunström B,Brittebo EB

更新日期：2000-08-01 00:00:00

abstract：:A histochemical technique for detection of the in vivo induced cellular aldehydes based on the direct Schiff's reaction is reported in this paper. CCl4-intoxicated rat liver was used as an experimental model. Fresh and non-pretreated rat liver cryostat sections fixed in 10% formol calcium solution and washed in distil...

journal_title：Archives of toxicology

authors： Taper HS,Somer MP,Lans M,de Gerlache J,Roberfroid M

更新日期：1988-04-01 00:00:00

abstract：:Exposure to bisphenolic chemicals during pregnancy occurs in > 90% of pregnancies. Bisphenolic compounds can cross the placental barrier reaching fetal circulation. However, the effects of emerging bisphenolic compounds, such as bisphenol S (BPS), on placental function remain untested. The aim was to determine if bisp...

journal_title：Archives of toxicology

authors： Gingrich J,Pu Y,Roberts J,Karthikraj R,Kannan K,Ehrhardt R,Veiga-Lopez A

更新日期：2018-05-01 00:00:00

abstract：:Although shorter chain homologues and other types of fluorinated chemicals are currently used as alternatives to long-chain perfluoroalkyl substances (PFASs), their safety information remains unclear and urgently needed. Here, the cytotoxicity of several fluorinated alternatives (i.e., 6:2 fluorotelomer carboxylic aci...

journal_title：Archives of toxicology

authors： Sheng N,Cui R,Wang J,Guo Y,Wang J,Dai J

更新日期：2018-01-01 00:00:00

abstract：:The metabolic fate of 2-ethylhexyl diphenyl phosphate (EHDPP) was studied in male rats. Orally administered 14C-EHDPP was rapidly absorbed and about 80% of the radioactivity was excreted in the urine and feces in the first 24 h. By 7 days, 48% and 52% of the radioactivity was recovered in urine and feces, respectively...

journal_title：Archives of toxicology

authors： Nishimaki-Mogami T,Minegishi K,Tanaka A,Sato M

更新日期：1988-01-01 00:00:00

abstract：:The effect of acute and chronic cadmium administration on hepatic drug metabolism was investigated in the male rat. 3 days after the acute administration of cadmium by either the intraperitoneal (0.84 mg Cd/kg) or the oral (greater than 80 mg Cd/kg) route, there was a significant potentiation in duration of hexobarbit...

journal_title：Archives of toxicology

authors： Schnell RC,Yuhas EM,Pence DH,Means JR,Roberts SA,Yau ET,Miya TS,Mennear JH

更新日期：1978-08-09 00:00:00

abstract：:The mycotoxin deoxynivalenol (DON) has a high global prevalence in grain-based products. Biomarkers of exposure are detectable in most humans and farm animals. Considering the acute emetic and chronic anorexigenic toxicity of DON, maximum levels for food and feed have been implemented by food authorities. The tolerabl...

journal_title：Archives of toxicology

authors： Faeste CK,Pierre F,Ivanova L,Sayyari A,Massotte D

更新日期：2019-07-01 00:00:00

abstract：:Using human neuroblastoma SH-SY5Y cells, effects of acrylamide on p53 protein and intracellular signal transducting pathways were examined. Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2). The phosphorylation of p53 was specific for the Ser15 site. Among mitogen-a...

journal_title：Archives of toxicology

authors： Okuno T,Matsuoka M,Sumizawa T,Igisu H

更新日期：2006-03-01 00:00:00

abstract：:Certain esterase inhibitors such as O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate (KBR-2822) and phenylmethanesulfonyl fluoride (PMSF) cause exacerbation (promotion) of toxic and traumatic axonopathies. Although these chemicals are capable of inhibiting neuropathy target esterase (NTE), whic...

journal_title：Archives of toxicology

authors： Jokanovic M,Moretto A,Lotti M

更新日期：1998-01-01 00:00:00

abstract：:The EU-EuroMix project adopted the strategy of the European Food Safety Authority (EFSA) for cumulative risk assessment, which limits the number of chemicals to consider in a mixture to those that induce a specific toxicological phenotype. These so-called cumulative assessment groups (CAGs) are refined at several leve...

journal_title：Archives of toxicology

authors： Staal YCM,Meijer J,van der Kris RJC,de Bruijn AC,Boersma AY,Gremmer ER,Zwart EP,Beekhof PK,Slob W,van der Ven LTM

更新日期：2018-12-01 00:00:00

abstract：:The toxic effect of cadmium varies with sex in experimental animals. Previous studies have demonstrated that pretreatment of male Fischer 344 (F344) rats with the female sex hormone progesterone markedly enhances the susceptibility to cadmium, suggesting a role for progesterone in the sexual dimorphism of cadmium toxi...

journal_title：Archives of toxicology

authors： Shimada H,Hashiguchi T,Yasutake A,Waalkes MP,Imamura Y

更新日期：2012-09-01 00:00:00

abstract：:The present study was designed to evaluate the possible protective effects of 3,3'-diselenodipropionic acid (DSePA), a potent radioprotector, against oxidative organ damage induced by whole body γ-irradiation and explore its mechanistic effects. The mice were subjected to whole body γ-irradiation at 5 Gy for the detec...

journal_title：Archives of toxicology

authors： Kunwar A,Bag PP,Chattopadhyay S,Jain VK,Priyadarsini KI

更新日期：2011-11-01 00:00:00

abstract：:Contents of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and of 16 further congeners--polychlorinated dibenzodioxins and dibenzofuranes (PCDD/PCDF)--were determined in lipids of adipose tissue and of livers of 3 stillborns and of 17 infants (0.43-44 weeks old) who died from sudden infant death syndrome. International to...

journal_title：Archives of toxicology

authors： Kreuzer PE,Csanády GA,Baur C,Kessler W,Päpke O,Greim H,Filser JG

更新日期：1997-01-01 00:00:00

abstract：:The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts as a 5-hydroxyindoleacetic acid (5-HT) receptor agonist, but little is known about its pharmacological effects...

journal_title：Archives of toxicology

authors： Hur KH,Kim SE,Lee BR,Ko YH,Seo JY,Kim SK,Ma SX,Kim YJ,Jeong Y,Pham DT,Trinh QD,Shin EJ,Kim HC,Lee YS,Lee SY,Jang CG

更新日期：2020-07-01 00:00:00

abstract：:Assay conditions in determining total cytochrome P-450 in four laboratories were compared. Although the determination was derived from the original Omura and Sato method in each laboratory, the four standard protocols differed slightly, resulting in considerable differences in the results. Since the cytochrome P-450 c...

journal_title：Archives of toxicology

authors： Rutten AA,Falke HE,Catsburg JF,Topp R,Blaauboer BJ,van Holsteijn I,Doorn L,van Leeuwen FX

更新日期：1987-01-01 00:00:00

abstract：:In female rats, the lethality and hepatotoxicity of cerous chloride (CeCl3) were significantly altered by pretreatment with steroidal and nonsteroidal compounds (pregnenolone-16alpha-carbonitrile "PCN", dexamethasone, spironolactone, phenobarbital) that stimulate hepatic drug-metabolizine enzyme activity and by estrad...

journal_title：Archives of toxicology

authors： Salas M,Tuchweber B

更新日期：1976-03-11 00:00:00