Abstract:
:Thanks to the confluence of genome sequencing and bioinformatics, the number of metabolic databases has expanded from a handful in the mid-1990s to several thousand today. These databases lie within distinct families that have common ancestry and common attributes. The main families are the MetaCyc, KEGG, Reactome, Model SEED, and BiGG families. We survey these database families, as well as important individual metabolic databases, including multiple human metabolic databases. The MetaCyc family is described in particular detail. It contains well over 1,000 databases, including highly curated databases for Escherichia coli, Saccharomyces cerevisiae, Mus musculus, and Arabidopsis thaliana. These databases are available through a number of web sites that offer a range of software tools for querying and visualizing metabolic networks. These web sites also provide multiple tools for analysis of gene expression and metabolomics data, including visualization of those datasets on metabolic network diagrams and over-representation analysis of gene sets and metabolite sets.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Karp PD,Caspi Rdoi
10.1007/s00204-011-0705-2subject
Has Abstractpub_date
2011-09-01 00:00:00pages
1015-33issue
9eissn
0340-5761issn
1432-0738journal_volume
85pub_type
杂志文章,评审abstract::Ziram is a carbamate pesticide, which is widely used throughout the world as a fungicide in agriculture and as an accelerating agent in latex production. In the present study, we investigated the effect of ziram at 0.031-4 μM in vitro on human natural killer (NK) and lymphokine-activated killer (LAK) and murine cytoto...
journal_title:Archives of toxicology
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journal_title:Archives of toxicology
pub_type: 杂志文章,已发布勘误
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
pub_type: 杂志文章
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abstract::Sulfur mustard (SM) is a bifunctional alkylating agent. Its primary toxic consequence is severe skin damage with blisters, occurring after skin contact. These vesicant properties of SM have been linked to cell death of proliferating keratinocytes in the basal layer of the skin. Catalytic activation of the nuclear enzy...
journal_title:Archives of toxicology
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