Abstract：
:The present study was designed to evaluate the possible protective effects of 3,3'-diselenodipropionic acid (DSePA), a potent radioprotector, against oxidative organ damage induced by whole body γ-irradiation and explore its mechanistic effects. The mice were subjected to whole body γ-irradiation at 5 Gy for the detection of oxidative stress, apoptosis, and proliferation in the intestinal (jejunum) tissue and at 7 Gy for the examination of intestinal inflammation and immune imbalance. Groups of mice received intraperitoneal injections of DSePA (2 mg/kg/day) or vehicle (phosphate-buffered saline) for 5 consecutive days prior to irradiation. The whole body γ-irradiation of mice led to the induction of oxidative stress and apoptosis in the intestinal tissue, and pretreatment with DSePA significantly reduced both these parameters. It was also found to abrogate the radiation-induced intestinal inflammatory response and augment the proliferation of intestinal cells. Additionally, irradiation-induced polarization of Th1/Th2 immune balance toward the Th2-dominant direction and pretreatment with DSePA ameliorated this shift, which may be beneficial for the recovery from radiation injury. In conclusion, pretreatment with DSePA prevented radiation-induced oxidative damage in small intestine and the underlying mechanisms responsible for this could be attributed to inhibition of oxidative stress, apoptosis, and inflammation.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Kunwar A,Bag PP,Chattopadhyay S,Jain VK,Priyadarsini KIdoi
10.1007/s00204-011-0687-0subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1395-405issue
11eissn
0340-5761issn
1432-0738journal_volume
85pub_type
杂志文章abstract：:Hydrogen sulfide (H2S), the third gasotransmitter, has been shown to act as a neuroprotective factor in numerous pathological processes; however, its underlying mechanism(s) of action remain unclear. It is widely accepted that activation of moderate autophagy and the Nrf2/ARE signaling pathway play important roles in ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2208-x
更新日期：2018-06-01 00:00:00
abstract：:The effect of ethanol on metabolism of 20 nitriles was studied in vivo and in vitro in mice. The hepatic microsomal metabolizing activity for nitriles was at a maximum 13 h after ethanol dosing (4.0 g/kg). Using microsomes from mice pretreated with ethanol under the above conditions, enhancement of the in vitro metabo...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00340977
更新日期：1986-02-01 00:00:00
abstract：: ...
journal_title：Archives of toxicology
pub_type： 评论,信件
doi：10.1007/s00204-018-2384-8
更新日期：2019-01-01 00:00:00
abstract：:Neutrophils infiltrate tissues during inflammation, and when activated, they release β-glucuronidase. Since inflammation is associated with carcinogenesis, we investigated how extracellular β-glucuronidase changed the in vitro cellular response to the chemical carcinogen benzo(a)pyrene (B[a]P). For this we exposed hum...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1593-7
更新日期：2016-09-01 00:00:00
abstract：:In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca2+-binding proteins and/or Ca2+ pumps. The plasma membrane calcium pump (PMCA) maintains Ca2+ homeosta...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2031-9
更新日期：2018-01-01 00:00:00
abstract：:Menadione is a naphthoquinone used as a vitamin K source in animal feed that can generate reactive oxygen species (ROS) and cause apoptosis. Here, we examined whether menadione reduces development of preimplantation bovine embryos in a ROS-dependent process and tested the hypothesis that actions of menadione would be ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-009-0458-3
更新日期：2009-11-01 00:00:00
abstract：:Quinolone-induced arthropathy is probably caused by a lack of functionally available magnesium in immature joint cartilage. We used an in vitro assay to study the effects of fluoroquinolones on cartilage formation in mouse limb buds from 12-day-old mouse embryos in regular and in magnesium-deficient medium. Omission o...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050521
更新日期：1998-06-01 00:00:00
abstract：:Reduced gluconeogenesis due to decreased activity of key gluconeogenic enzymes in liver, together with feed refusal, has been suggested to play an important role in 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced lethality in rats. This study was carried out to further analyse the toxicological significance of red...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050626
更新日期：1999-08-01 00:00:00
abstract：:Sunitinib (SNT) is a multi-targeted receptor tyrosine kinase inhibitor that has been approved by the FDA for cancer therapy. However, its cardiotoxicity has limited the clinical applicability with no effective therapeutic approach available. As a broadband kinase inhibitor, the function of several kinases that are ess...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02448-z
更新日期：2019-06-01 00:00:00
abstract：:The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined. Exposure of cultured mouse hepatocytes to DDC, EDDC or griseofulvin resulted in a marked ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974011
更新日期：1992-01-01 00:00:00
abstract：:Xenobiotic induced liver injury is a leading cause for drug withdrawal and toxicogenomics may help to identify molecular causes. Here we report studies with cultures of human hepatocytes to detect early responses of liver toxicity upon treatment with the hepatotoxin Aroclor 1254. We studied transcript abundance of 302...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0234-1
更新日期：2008-02-01 00:00:00
abstract：:The development of metabolically competent in vitro models is of utmost importance for predicting adverse drug reactions, thereby preventing attrition-related economical and clinical burdens. Using the antiretroviral drug nevirapine (NVP) as a model, this work aimed to validate rat hepatocyte 3D spheroid cultures as c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1792-x
更新日期：2017-03-01 00:00:00
abstract：:Chondrotoxicity is a rare toxicological finding which is observed in dogs after administration of quinolone antibacterials. To study this effect chondrocytes from articular cartilage of dogs were isolated, and incubated with quinolone derivatives. The effects on cell viability, mitochondrial dehydrogenase, and proteog...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01977402
更新日期：1993-01-01 00:00:00
abstract：:Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic to rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibit protein synthesis in vitro and in several in vivo systems. The mechanism whereby this mitogenic activity occurs was previously u...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050223
更新日期：1995-01-01 00:00:00
abstract：:The current management of rodent pest populations is based on second-generation anticoagulant rodenticides (SGAR). These molecules, of which difethialone is part, are much more efficient than the first generation. Nevertheless, this efficiency comes with a major drawback, SGARs are tissue persistent that increases the...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02662-0
更新日期：2020-03-01 00:00:00
abstract：:To investigate possible persistent nephrotoxic effects of trichloroethylene (TRI), a retrospective study was carried out on 39 workers exposed to high levels of TRI from 1956 to 1975. Total protein levels in urine, as well as serum and urine creatinine and serum urea were unchanged in comparison with the control. Sodi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050613
更新日期：1999-06-01 00:00:00
abstract：:Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01234482
更新日期：1983-12-01 00:00:00
abstract：:pp'DDT (600 mg/kg, orally) produced an increase in the level of free ammonia and a decrease of acetylcholine in the corpus striatum of rats. These effects were maximal 5 h after the administration of pp'DDT. The animals showed tremors after 2 h, mild or moderate convulsions after 3.5 h and severe convulsions 5 h after...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303292
更新日期：1980-05-01 00:00:00
abstract：:Ochratoxin A (OTA) is a toxin produced by fungi such as Aspergillus spp. and Penicillium spp. The key target organ of OTA toxicity is the kidney, and it is known that epithelial-to-mesenchymal transition (EMT) leading to fibrosis is enhanced after long-term exposure of the kidney to OTA. However, the mechanisms respon...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02829-9
更新日期：2020-09-01 00:00:00
abstract：:Bisphenol A (BPA) is a chemical in widespread use that is under scientific discussion due to its endocrine activity. Controversies exist about how to interpret reportedly high blood concentrations measured in uncontrolled situations. Physiologically based pharmaco-/toxicokinetic modelling resulted in 10-100-fold lower...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1022-8
更新日期：2013-07-01 00:00:00
abstract：:Tea (Camellia sinensis, Theaceace), a popular beverage consumed world-wide, has been studied for its preventive effects against cancer as well as cardiovascular, neurodegenerative, and other diseases. Most of the proposed beneficial effects have been attributed to the polyphenolic compounds in tea, but the nature of t...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-008-0372-0
更新日期：2009-01-01 00:00:00
abstract：:2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) has been developed as a substitute for ozone-depleting chlorofluorocarbons (CFCs). It is a structural analogue of halothane and similarities in the metabolic pathways and liver toxicity of both compounds have been described. The present study was initiated after an acciden...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100237
更新日期：2001-07-01 00:00:00
abstract：:Cocaine is an intrinsic hepatotoxin in laboratory animals, and there is growing evidence that high doses of cocaine can precipitate hepatic necrosis in humans. The rodent model of cocaine hepatotoxicity is commensurate with the concept that a multistep mainly cytochrome P-450 dependent N-oxidative pathway is responsib...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/BF02284256
更新日期：1991-01-01 00:00:00
abstract：:This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a sh...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0255-9
更新日期：2008-06-01 00:00:00
abstract：:The in ovo carcinogenicity assessing (IOCA) assay was used to examine the morphological changes in fetal turkey livers caused by the DNA-reactive carcinogen diethylnitrosamine (DEN). Fertilized turkey eggs were allocated into 3 groups: nondosed control (NDC), vehicle (water) control (VC) and DEN-dosed. At day 0, the f...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0603-z
更新日期：2011-06-01 00:00:00
abstract：:As Drosophila melanogaster occupies an important position within the test battery for mutagens and carcinogens, it is of interest to study the xenobiotics metabolism of this insect. Likewise, the genetic control of these important enzyme systems falls within this interest. Our attempt was to get new strains, which sho...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316345
更新日期：1984-11-01 00:00:00
abstract：:Pregnant mice administered per os during the days 1--3 (plug day = day 0) post conception (p.c.) with 375 mg 2,2'-dichlorobiphenyl/kilograms/day revealed on day 18 p.c. increased number of resorptions and doses up from 500 milligrams/kilograms/day led to a substantial retardation of the prenatal development. Based on ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00310329
更新日期：1978-08-09 00:00:00
abstract：:Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. The aim of this study was to compare the toxic effects of the two drugs on hepatocytes in primary culture as a function of their metabolism and to explore the variations...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050499
更新日期：1998-04-01 00:00:00
abstract：:The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of adm...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00288341
更新日期：1988-01-01 00:00:00
abstract：:The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhala...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293651
更新日期：1977-09-28 00:00:00
