Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent manner.

abstract：:The use of silver nanoparticles is one of the fastest growing product categories in the nanotechnology industry, with a focus on antimicrobial activity. However, thus far, toxicity data for silver nanoparticles are limited. In this study, we investigated the cytotoxic effects of silver nanoparticles (Ag NPs) and the p...

journal_title：Archives of toxicology

authors： Lee YS,Kim DW,Lee YH,Oh JH,Yoon S,Choi MS,Lee SK,Kim JW,Lee K,Song CW

更新日期：2011-12-01 00:00:00

abstract：:The inhibitory effect and mechanism of action of nicotinamide to paraquat toxicity were studied in male Sprague-Dawley rats. Proteins of submitochondrial particles (SMP), especially of mol. wt. 25-30 kDa, in rat lungs were destroyed by paraquat radicals, and aggregated protein bands approximately 100 kDa were observed...

journal_title：Archives of toxicology

authors： Fukushima T,Gao T,Tawara T,Hojo N,Isobe A,Yamane Y

更新日期：1997-01-01 00:00:00

abstract：:Previous rat toxicity studies of alpha-glycosyl isoquercitrin (AGIQ), a water-soluble flavonol glycoside derived from rutin, revealed systemic yellow bone discoloration. This investigative study was conducted to determine the AGIQ metabolite(s) responsible for the discoloration. Female Sprague-Dawley rats were adminis...

journal_title：Archives of toxicology

authors： Davis JP,Koyanagi M,Maronpot RR,Recio L,Hayashi SM

更新日期：2020-07-01 00:00:00

abstract：:Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroetha...

journal_title：Archives of toxicology

authors： Nielsen GD,Abraham MH,Hansen LF,Hammer M,Cooksey CJ,Andonian-Haftvan J,Alarie Y

更新日期：1996-01-01 00:00:00

abstract：:Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. The microsomes themselves were not cytotoxic. P388D1 cells were more sensitive to CPA, ...

journal_title：Archives of toxicology

authors： Gut I,Danielová V,Holubová J,Soucek P,Klucková H

更新日期：2000-10-01 00:00:00

abstract：:Millions of tons of all kind of munitions, including mines, bombs and torpedoes have been dumped after World War II in the marine environment and do now pose a new threat to the seas worldwide. Beside the acute risk of unwanted detonation, there is a chronic risk of contamination, because the metal vessels corrode and...

journal_title：Archives of toxicology

authors： Strehse JS,Brenner M,Kisiela M,Maser E

更新日期：2020-12-01 00:00:00

abstract：:The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological releva...

journal_title：Archives of toxicology

authors： Dragovic S,Vermeulen NP,Gerets HH,Hewitt PG,Ingelman-Sundberg M,Park BK,Juhila S,Snoeys J,Weaver RJ

更新日期：2016-12-01 00:00:00

abstract：:A method is outlined to estimate from hemodialysis or hemoperfusion data, respectively, the rate constants, the distribution volume in the beta-phase, and other pharmacokinetic parameters of toxic substances. All calculations are based on the assumption that the usual linear open two-compartment system is also the app...

journal_title：Archives of toxicology

authors： Wellhöner HH

更新日期：1983-05-01 00:00:00

abstract：:Sulfur mustard (SM) is a highly toxic war chemical that causes significant morbidity and mortality and lacks any effective therapy. Rats exposed to aerosolized CEES (2-chloroethyl ethyl sulfide; 10% in ethanol), an analog of SM, developed acute respiratory distress syndrome (ARDS), which is characterized by increased ...

journal_title：Archives of toxicology

authors： Mariappan N,Husain M,Zafar I,Singh V,Smithson KG,Crowe DR,Pittet JF,Ahmad S,Ahmad A

更新日期：2020-04-01 00:00:00

abstract：:The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhala...

journal_title：Archives of toxicology

authors： Pyykkö K,Tähti H,Vapaatalo H

更新日期：1977-09-28 00:00:00

abstract：:The cholestatic effect of the newly developed oestradiol sulphamate (J995) was compared with that of the natural oestrogen oestradiol (E) and of the cholestatic standard oestrogen ethinyloestradiol (EE). Female ovariectomized rats were orally treated for 7 days with oestrogen doses molar equivalent to 0.01, 0.1, 1, an...

journal_title：Archives of toxicology

authors： Barth A,Elger W,Schneider B,Schwarz S

更新日期：1997-01-01 00:00:00

abstract：:In vitro assays are often used for the hazard characterisation of compounds, but their application for quantitative risk assessment purposes is limited. This is because in vitro assays cannot provide a complete in vivo dose-response curve from which a point of departure (PoD) for risk assessment can be derived, like t...

journal_title：Archives of toxicology

authors： Strikwold M,Spenkelink B,Woutersen RA,Rietjens IM,Punt A

更新日期：2013-09-01 00:00:00

abstract：:Heat shock proteins (HSPs) are a group of proteins that are rapidly induced in response to physiological stress, including hyperthermia and exposure to toxicants. Thus they may provide a useful index of toxicity in in vitro systems for screening for toxicity. We have recently developed a rat nasal explant system for i...

journal_title：Archives of toxicology

authors： Simpson SA,Alexander DJ,Reed CJ

更新日期：2004-06-01 00:00:00

abstract：:Garenoxacin is a des-F(6)-quinolone with a broad antibacterial spectrum, which has previously been shown to exhibit low chondrotoxicity in juvenile dogs compared with several other quinolones. A study was performed to determine whether the low chondrotoxicity observed in immature rats following garenoxacin treatment c...

journal_title：Archives of toxicology

authors： Kastner M,Rahm U,Baumann-Wilschke I,Bello A,Stahlmann R

更新日期：2004-02-01 00:00:00

abstract：:Interactions between chemicals in a mixture and interactions of mixture components with the skin can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous disposition of a topically applied chemical. The predictive ability of dermal absorption models, and consequently the dermal ...

journal_title：Archives of toxicology

authors： Riviere JE,Qiao G,Baynes RE,Brooks JD,Mumtaz M

更新日期：2001-08-01 00:00:00

abstract：:Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...

journal_title：Archives of toxicology

authors： Lüersen L,Wellner T,Koch HM,Angerer J,Drexler H,Korinth G

更新日期：2006-10-01 00:00:00

abstract：:The significance of elevated excretion of metallothionein in urine of women living in cadmium-polluted areas of Japan was studied with respect to renal dysfunction. The relationships between the concentrations of metallothionein in urine and those of other non-specific urinary indices of renal dysfunction, i.e., total...

journal_title：Archives of toxicology

authors： Tohyama C,Shaikh ZA,Nogawa K,Kobayashi E,Honda R

更新日期：1982-07-01 00:00:00

abstract：:The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman was analysed in cerebrospinal fluid (CSF) and blood in anaesthetized, spontaneously breathing pigs during a 90-min period after injection of soman. The pigs were challenged with different intravenous (i.v.) doses of C(+/-)P(+/-)-soman c...

journal_title：Archives of toxicology

authors： Göransson-Nyberg A,Fredriksson SA,Karlsson B,Lundström M,Cassel G

更新日期：1998-07-01 00:00:00

abstract：:Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA lesions from the genomes of organisms across the evolutionary scale, from bacteria to humans. The serial steps in NER involve recognition of lesions, adducts or structures that disrupt the DNA double helix, removal of a short oli...

journal_title：Archives of toxicology

authors： Spivak G

更新日期：2016-11-01 00:00:00

abstract：:Gene expression analysis has been established as a tool for the characterization of genotoxic mechanisms of chemical mutagens. It has been suggested that expression analysis is capable of distinguishing compounds that cause DNA damage from those that interfere with mitotic spindle function. Formaldehyde (FA) is known ...

journal_title：Archives of toxicology

authors： Kuehner S,Holzmann K,Speit G

更新日期：2013-11-01 00:00:00

abstract：:Cytokeratins (CK) constitute a family of cytoskeletal intermediate filament proteins that are typically expressed in epithelial cells. An abnormal structure and function are effects that are clearly related to liver diseases as non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma. We have previously o...

journal_title：Archives of toxicology

authors： Gonsebatt ME,Del Razo LM,Cerbon MA,Zúñiga O,Sanchez-Peña LC,Ramírez P

更新日期：2007-09-01 00:00:00

abstract：:The cytotoxicity of trivalent and pentavalent inorganic arsenic salts was determined in mouse fibroblasts in vitro. Concentrations of As (III) in the microM range led to a reduction of proliferation and viability with a concomitant increase in LDH release and stimulation of lactic acid production. Similar effects were...

journal_title：Archives of toxicology

authors： Fischer AB,Buchet JP,Lauwerys RR

更新日期：1985-08-01 00:00:00

abstract：:N-methylformamide (NMF) produced dose-dependent zone 3 haemorrhagic necrosis in mice; the threshold dose was 100-200 mg/kg. In rats a dose of 1000 mg/kg caused hepatic damage in some animals and slight elevations of plasma transaminases. A species difference in susceptibility to NMF-induced hepatotoxicity is clearly i...

journal_title：Archives of toxicology

authors： Tulip K,Timbrell JA

更新日期：1988-01-01 00:00:00

abstract：:Mice in experimental delay of implantation were injected intravenously with 75 micrograms.g-1 body weight of lead chloride, corresponding to a dose of lead of about 56 micrograms.g-1 body weight. Delay of implantation was obtained by ovariectomy 3 days after mating followed by a depot dose of progesterone every fifth ...

journal_title：Archives of toxicology

authors： Nilsson BO,Ljung L,Wide M

更新日期：1991-01-01 00:00:00

abstract：:203Pb(NO3)2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. ...

journal_title：Archives of toxicology

authors： Danielsson BR,Dencker L,Lindgren A

更新日期：1983-10-01 00:00:00

abstract：:Regarding the cancer risk assessment of acrylamide (AA) it is of basic interest to know, as to what amount of the absorbed AA is metabolized to glycidamide (GA) in humans, compared to what has been observed in laboratory animals. GA is suspected of being the ultimate carcinogenic metabolite of AA. From experiments wit...

journal_title：Archives of toxicology

authors： Settels E,Bernauer U,Palavinskas R,Klaffke HS,Gundert-Remy U,Appel KE

更新日期：2008-10-01 00:00:00

abstract：:During/after the BP/Deepwater Horizon oil spill, cleanup workers, fisherpersons, SCUBA divers, and coastal residents were exposed to crude oil and dispersants. These people experienced acute physiological and behavioral symptoms and consulted a physician. They were diagnosed with petroleum hydrocarbon poisoning and ha...

journal_title：Archives of toxicology

authors： Sammarco PW,Kolian SR,Warby RA,Bouldin JL,Subra WA,Porter SA

更新日期：2016-04-01 00:00:00

abstract：:The in ovo carcinogenicity assessing (IOCA) assay was used to examine the morphological changes in fetal turkey livers caused by the DNA-reactive carcinogen diethylnitrosamine (DEN). Fertilized turkey eggs were allocated into 3 groups: nondosed control (NDC), vehicle (water) control (VC) and DEN-dosed. At day 0, the f...

journal_title：Archives of toxicology

authors： Williams GM,Brunnemann KD,Iatropoulos MJ,Smart DJ,Enzmann HG

更新日期：2011-06-01 00:00:00

abstract：:Purified phenobarbital-induced rat liver cytochrome P-450 was incorporated in a reconstituted system containing NADPH-cytochrome P-450 reductase, dilauroyl phosphatidyl choline and sodium cholate. This system was added to organ cultures of limb buds from mouse embryos on day 11 of gestation. Cyclophosphamide (100 micr...

journal_title：Archives of toxicology

authors： Kastner M,Blankenburg G,Schulz T,Schack G,Neubert D

更新日期：1988-01-01 00:00:00

abstract：:In order to study the mechanisms of acute n-hexane intoxication, the effects of n-hexane and its metabolites 2-hexanol, methyl-n-butyl ketone, 2,5-hexanediol and 2,5-hexanedione on the cloned voltage-operated potassium channels Kv1.1, Kv1.4, Kv2.1 and Kv3.4 were investigated with electrophysiological techniques in the...

journal_title：Archives of toxicology

authors： Madeja M,Binding N,Musshoff U,Witting U,Speckmann EJ

更新日期：1997-01-01 00:00:00