Human CYP2E1 mediates the formation of glycidamide from acrylamide.

abstract：:The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA) as well as mercuric chloride (HgCl(2)) and methylmercury chloride (MeHgCl) on gluconeogenesis was investigated in isolated rat kidney tubules. From starved rats kidney tubules were prepared and isolat...

journal_title：Archives of toxicology

authors： Reichl FX,Durner J,Mückter H,Elsenhans B,Forth W,Kunzelmann KH,Hickel R,Spahl W,Hume WR,Moes GW

更新日期：1999-09-01 00:00:00

abstract：:Selenium (Se) is an essential dietary component for animals including humans and is regarded as a protective agent against cancer. Although the mode of anticancer action of Se is not fully understood yet, several mechanisms, such as antioxidant protection by selenoenzymes, specific inhibition of tumor cell growth by S...

journal_title：Archives of toxicology

authors： Brozmanová J,Mániková D,Vlčková V,Chovanec M

更新日期：2010-12-01 00:00:00

abstract：:Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic to rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibit protein synthesis in vitro and in several in vivo systems. The mechanism whereby this mitogenic activity occurs was previously u...

journal_title：Archives of toxicology

authors： Ennamany R,Kretz O,Creppy EE

更新日期：1995-01-01 00:00:00

abstract：:A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. ...

journal_title：Archives of toxicology

authors： de Groot G,Maes RA,Lemmens HH

更新日期：1976-06-08 00:00:00

abstract：:Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a centr...

journal_title：Archives of toxicology

authors： Yang Y,Liu H,Liu F,Dong Z

更新日期：2014-06-01 00:00:00

abstract：:The mechanical properties of the bones of young, adult and old rats administered various concentrations of cadmium were measured to prove the direct effect of cadmium on the bones of young rats. The young rats were divided into three subgroups, which were administered 0 (control), 5 and 10 ppm cadmium, respectively. T...

journal_title：Archives of toxicology

authors： Ogoshi K,Moriyama T,Nanzai Y

更新日期：1989-01-01 00:00:00

abstract：:The in ovo carcinogenicity assessing (IOCA) assay was used to examine the morphological changes in fetal turkey livers caused by the DNA-reactive carcinogen diethylnitrosamine (DEN). Fertilized turkey eggs were allocated into 3 groups: nondosed control (NDC), vehicle (water) control (VC) and DEN-dosed. At day 0, the f...

journal_title：Archives of toxicology

authors： Williams GM,Brunnemann KD,Iatropoulos MJ,Smart DJ,Enzmann HG

更新日期：2011-06-01 00:00:00

abstract：:The neurological effects of four synthetic pyrethroids resmethrin, permethrin, cypermethrin, and deltamethrin have been investigated in the rat to establish whether there is a correlation between the clinical-functional status of the animal and peripheral nerve damage as measured biochemically. Neuromuscular dysfuncti...

journal_title：Archives of toxicology

authors： Rose GP,Dewar AJ

更新日期：1983-08-01 00:00:00

abstract：:This study examined the effect of tamoxifen, an anti-breast cancer drug, on Ca2+ handling in bladder female transitional cancer cells. Changes in cytosolic free Ca2+ levels were recorded by using the Ca2+-sensitive dye fura-2. In a dose-dependent manner, tamoxifen induced intracellular free Ca2+ concentrations ([Ca2+]...

journal_title：Archives of toxicology

authors： Chang HT,Huang JK,Wang JL,Cheng JS,Lee KC,Lo YK,Lin MC,Tang KY,Jan CR

更新日期：2001-05-01 00:00:00

abstract：:Chronic exposure to inorganic arsenic (As) [As(III) + As(V)], which affects millions of people, increases the incidence of some kinds of cancer and other non-carcinogenic pathologies. Although the oral pathway is the main form of exposure, in vivo studies have not been conducted to verify the intestinal toxicity of th...

journal_title：Archives of toxicology

authors： Chiocchetti GM,Domene A,Kühl AA,Zúñiga M,Vélez D,Devesa V,Monedero V

更新日期：2019-08-01 00:00:00

abstract：:The toxic effect of cyclophosphamide on the proliferative cell population of hair follicles plucked from the human scalp was examined by the in vivo nuclear aberration assay. Patients participating in an independent clinical trial received oral low dose cyclophosphamide, intravenous high dose cyclophosphamide or oral ...

journal_title：Archives of toxicology

authors： Goldberg MT,Tackaberry LE,Hardy MH,Noseworthy JH

更新日期：1990-01-01 00:00:00

abstract：:Quercetin (QC), a polyphenolic compound widely distributed in fruits and vegetables has recently gained interest due to its cisplatin (CP) sensitizing properties in cancer cells. It is currently unknown, whether quercetin also increases the susceptibility of the kidneys to cisplatin toxicity. We studied the effects of...

journal_title：Archives of toxicology

authors： Kuhlmann MK,Horsch E,Burkhardt G,Wagner M,Köhler H

更新日期：1998-07-01 00:00:00

abstract：:Clark 1 (diphenylarsine chloride) and Clark 2 (diphenylarsine cyanide) were used as chemical weapon agents (CWA), and the soil contamination by these CWA and their degraded products, diphenyl and phenyl arsenicals, has been one of the most serious environmental issues. In a series of comparisons in toxicity between tr...

journal_title：Archives of toxicology

authors： Hirano S,Kobayashi Y,Hayakawa T,Cui X,Yamamoto M,Kanno S,Shraim A

更新日期：2005-01-01 00:00:00

abstract：:Hydroxysteroid sulfotransferase 2B1b (SULT2B1b) sulfates cholesterol and oxysterols. Hepatic oval cells (HOCs), thought to be progenitor cells, can be triggered in chemically injured livers. The present study focused on the role of SULT2B1b in HOC proliferation after liver injury. Our experiments revealed that the exp...

journal_title：Archives of toxicology

authors： Wang Z,Yang X,Chen L,Zhi X,Lu H,Ning Y,Yeong J,Chen S,Yin L,Wang X,Li X

更新日期：2017-01-01 00:00:00

abstract：:False-negative judgment due to poor chemical solubility is a problem with in vitro skin sensitisation tests. Water-insoluble chemicals are typically dissolved in DMSO in most sensitisation tests but precipitate when diluted with medium beyond their solubility in water. Such tests lack procedures to rule out false-nega...

journal_title：Archives of toxicology

authors： Kimura Y,Fujimura C,Aiba S

更新日期：2020-10-17 00:00:00

abstract：:Two Ceria nanomaterials (NM-211 and NM-212) were tested for inhalation toxicity and organ burdens in order to design a chronic and carcinogenicity inhalation study (OECD TG No. 453). Rats inhaled aerosol concentrations of 0.5, 5, and 25 mg/m(3) by whole-body exposure for 6 h/day on 5 consecutive days for 1 or 4 weeks ...

journal_title：Archives of toxicology

authors： Keller J,Wohlleben W,Ma-Hock L,Strauss V,Gröters S,Küttler K,Wiench K,Herden C,Oberdörster G,van Ravenzwaay B,Landsiedel R

更新日期：2014-11-01 00:00:00

abstract：:Exposure to high-dose benzene leads to the inhibition of erythroid differentiation. However, whether lower doses of benzene exposure resemble high-dose effects in erythroid differentiation, as well as the underlying mechanisms, remains largely unknown. To identify the microRNAs (miRNAs) specifically responsible for be...

journal_title：Archives of toxicology

authors： Liang B,Chen Y,Yuan W,Qin F,Zhang Q,Deng N,Liu X,Ma X,Zhang X,Zhang B,Deng Q,Huang M,Tang H,Liu L,Chen W,Xiao Y

更新日期：2018-01-01 00:00:00

abstract：:Dorsal root ganglia from control and methylmercury (MeHg)-treated rats were incubated in vitro with 35S-methionine ant the proteins synthesized were analyzed by two-dimensional electrophoresis. The double labelling method, in which proteins of control dorsal root ganglia labelled in vitro with 3H-leucine were added to...

journal_title：Archives of toxicology

authors： Kasama H,Itoh K,Omata S,Sugano H

更新日期：1989-01-01 00:00:00

abstract：:Liquorice [main ingredient, glycyrrhizin (GL)] is widely used as a food sweetener and herbal medicine. Occasionally, liquorice consumption causes pseudoaldosteronism as a side effect which causes oedema, hypokalaemia, and hypertension due to hyperactivity of mineral corticoid receptor. We aimed to detect GL metabolite...

journal_title：Archives of toxicology

authors： Takahashi K,Yoshino T,Maki Y,Ishiuchi K,Namiki T,Ogawa-Ochiai K,Minamizawa K,Makino T,Nakamura T,Mimura M,Watanabe K

更新日期：2019-11-01 00:00:00

abstract：:Shaking behavior, so-called wet dog shakes (WDS), in rats is characteristic behavior indicating morphine abstinence in morphine-dependence and central excitation in relation to seizures elicited by chemicals or electrical stimulation. We have found that paraquat (PQ), a nonselective herbicide, administered systemicall...

journal_title：Archives of toxicology

authors： Hara S,Mukai T,Kurosaki K,Kuriiwa F,Yanase T,Kano S,Endo T

更新日期：2001-02-01 00:00:00

abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...

journal_title：Archives of toxicology

authors： Nordgren I,Bergström M,Holmstedt B,Sandoz M

更新日期：1978-10-13 00:00:00

abstract：:Many in the welding industry suffer from bronchitis, lung function changes, metal fume fever, and diseases related to respiratory damage. These phenomena are associated with welding fumes; however, the mechanism behind these findings remains to be elucidated. In this study, the lungs of cynomolgus monkeys were exposed...

journal_title：Archives of toxicology

authors： Heo JD,Oh JH,Lee K,Kim CY,Song CW,Yoon S,Han JS,Yu IJ

更新日期：2010-03-01 00:00:00

abstract：:The metabolism of arsenic is generally accepted to proceed by repetitive reduction and oxidative methylation; the latter is mediated by arsenic methyltransferase (Cyt19). In human urine, the major metabolites of inorganic arsenicals such as arsenite (iAsIII) and arsenate (iAsV) are monomethylarsonic acid (MMA(V)) and ...

journal_title：Archives of toxicology

authors： Hayakawa T,Kobayashi Y,Cui X,Hirano S

更新日期：2005-04-01 00:00:00

abstract：:The effects of diabetes on cytochrome P450 (CYP)-dependent drug metabolizing enzymes are yet to be clarified. The most widely used animals in these studies have been rats, and information on the effects of diabetes on rabbit liver drug metabolizing enzymes have been unavailable until now. In this study, for the first ...

journal_title：Archives of toxicology

authors： Arinç E,Arslan S,Adali O

更新日期：2005-08-01 00:00:00

abstract：:MDMA-induced impairments of memory performance have been reported in different human and animal studies. However, the correlation between spatial memory impairment, brain mitochondrial function, and concentrations of MDMA and its metabolites has not yet been investigated despite it being needed for comparison with hum...

journal_title：Archives of toxicology

authors： Taghizadeh G,Mehdizadeh H,Lavasani H,Hosseinzadeh Ardakani Y,Foroumadi A,Halvaei Khankahdani Z,Moshtagh A,Pourahmad J,Sharifzadeh M,Rouini MR

更新日期：2020-03-01 00:00:00

abstract：:A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). The molecular and cellular events by which PPARα activators induce rodent hepatocarcinogenesis have been extensively studied elucidating a...

journal_title：Archives of toxicology

authors： Corton JC,Peters JM,Klaunig JE

更新日期：2018-01-01 00:00:00

abstract：:Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-...

journal_title：Archives of toxicology

authors： Longhin E,Camatini M,Bersaas A,Mantecca P,Mollerup S

更新日期：2018-09-01 00:00:00

abstract：:5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...

journal_title：Archives of toxicology

authors： Sachse B,Meinl W,Sommer Y,Glatt H,Seidel A,Monien BH

更新日期：2016-01-01 00:00:00

abstract：:Teratogenic effects caused by a new nitroimidazopyridazine were examined in Wistar (WU) rats after repeated oral administration of 0, 2.5, 10, and 40 mg/kg, given on days 6-17 post coitum (p.c.) (Day of mating = Day 0) in a regular study on embryo-fetal development according to ICH S5A. At day 20 p.c., fetuses were re...

journal_title：Archives of toxicology

authors： Woehrmann T,Volland J,Tuch K,Bode G,Hübel U

更新日期：2006-07-01 00:00:00

abstract：:The ethylene oxide adduct formed on the N-terminal valine in haemoglobin was investigated as a biological monitor of tobacco smoke intake. The modified method developed for the determination of the hydroxyethylvaline adduct (HOEtVal) involved reaction of globin with pentafluorophenyl isothiocyanate, extraction of the ...

journal_title：Archives of toxicology

authors： Bailey E,Brooks AG,Dollery CT,Farmer PB,Passingham BJ,Sleightholm MA,Yates DW

更新日期：1988-01-01 00:00:00