Abstract：
:The ethylene oxide adduct formed on the N-terminal valine in haemoglobin was investigated as a biological monitor of tobacco smoke intake. The modified method developed for the determination of the hydroxyethylvaline adduct (HOEtVal) involved reaction of globin with pentafluorophenyl isothiocyanate, extraction of the HOEtVal thiohydantoin product, derivatization of this by trimethylsilylation and quantitation by capillary gas chromatography with selective ion monitoring mass spectrometry using a tetradeuterated internal standard. The method was applied to globin samples from 26 habitual cigarette smokers and 24 non-smokers. There was a significant correlation between cigarette smoke intake as measured by the average number of cigarettes smoked per day and HOEtVal levels (r = 0.537, p less than 0.01). Background levels were found in non-smokers (mean 49.9 pmol/g Hb, range 22-106 pmol/g Hb). Smoking increased these levels by 71 pmol/g Hb/10 cigarettes per day. Cotinine levels in plasma of the smokers were determined by GC-NPD using 2-methyl-4-nitroaniline as internal standard. For non-smokers cotinine was determined by GC-MS selective ion monitoring using d3-methylcotinine as internal standard. There was no correlation between number of cigarettes smoked per day and cotinine levels (r = 0.297, p greater than 0.05) although cotinine was correlated with HOEtVal (r = 0.43, p less than 0.01). The HOEtVal adduct levels thus appear to be a suitable biomonitor for exposure to hydroxyethylating agents in cigarette smoke, reflecting an integrated dose over the erythrocyte lifetime. This is in contrast to plasma cotinine determinations which reflect only the previous day's exposure to nicotine in smoke.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Bailey E,Brooks AG,Dollery CT,Farmer PB,Passingham BJ,Sleightholm MA,Yates DWdoi
10.1007/BF00332482subject
Has Abstractpub_date
1988-01-01 00:00:00pages
247-53issue
4eissn
0340-5761issn
1432-0738journal_volume
62pub_type
杂志文章abstract：:203Pb(NO3)2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01261379
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abstract：:A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented. In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposu...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050072
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journal_title：Archives of toxicology
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00292614
更新日期：1985-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332484
更新日期：1988-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00204-012-0870-y
更新日期：2012-10-01 00:00:00
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journal_title：Archives of toxicology
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更新日期：2001-10-01 00:00:00
abstract：:In a two-step study on exposure control method for occupational handling of permethrin was developed. Air sampling on a filter can be used in case of exposure to permethrin in powder form. The detection limit is 0.001 mg/m3. If biological sampling is used, the acid metabolite moiety in the urine must be monitored. How...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00569234
更新日期：1982-05-01 00:00:00
abstract：:Natural and synthetic chemicals are often used in the fragrance industry. A toxicological profile of the synthetic fragrance booster, 4-cycloocten-1-carbaldehyde, was generated using a test program including the following methods: acute oral toxicity, acute dermal toxicity, acute skin and eye irritation, skin sensitiz...
journal_title：Archives of toxicology
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更新日期：2004-12-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050146
更新日期：1994-01-01 00:00:00
abstract：:Chondrotoxicity is a rare toxicological finding which is observed in dogs after administration of quinolone antibacterials. To study this effect chondrocytes from articular cartilage of dogs were isolated, and incubated with quinolone derivatives. The effects on cell viability, mitochondrial dehydrogenase, and proteog...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01977402
更新日期：1993-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1114-5
更新日期：2014-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0016-6
更新日期：2006-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050392
更新日期：1997-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
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更新日期：2020-08-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00286576
更新日期：1985-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0296-8
更新日期：2008-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-1008-y
更新日期：2013-05-01 00:00:00
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journal_title：Archives of toxicology
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doi：10.1007/s00204-010-0518-8
更新日期：2010-06-01 00:00:00
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journal_title：Archives of toxicology
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doi：10.1007/s00204-017-2055-1
更新日期：2018-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974397
更新日期：1990-01-01 00:00:00
abstract：:The US Environmental Protection Agency's ToxCast program has generated toxicity data for thousands of chemicals but does not adequately assess potential neurotoxicity. Networks of neurons grown on microelectrode arrays (MEAs) offer an efficient approach to screen compounds for neuroactivity and distinguish between com...
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pub_type： 杂志文章
doi：10.1007/s00204-019-02636-x
更新日期：2020-02-01 00:00:00
abstract：:The significance of urinary trehalase as a possible early indicator of renal disorder was examined using Cd-treated rabbits, which received 1 mg/kg Cd thrice weekly for 3 months subcutaneously. The results showed that urinary trehalase increased significantly from 1 week after treatment, earlier than LAP, ALP, protein...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290547
更新日期：1986-12-01 00:00:00
abstract：:The studies presented were designed to investigate the effects of cytochrome P450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female B6C3F(1) mice. Groups of female B6C3F(1) mice were exposed to dynamic atmospheres containing tetrahydrofuran (THF) concentrations of 0, 5,400 or 15,000 mg/m(3) ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0474-7
更新日期：2003-08-01 00:00:00
abstract：:The first step in the oxidative metabolism of cocaine is N-demethylation to norcocaine, which is further N-hydroxylated to more toxic N-hydroxynorcocaine. In this study we examined the kinetics of norcocaine N-hydroxylation mediated by cytochrome P450 (CYP) in mouse and human liver microsomes. N-hydroxynorcocaine was ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000154
更新日期：2000-11-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-001-0301-y
更新日期：2002-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316261
更新日期：1988-08-01 00:00:00
abstract：:Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis. ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00353318
更新日期：1975-10-20 00:00:00
abstract：:Cadmium-induced metallothionein (MT) synthesis was investigated in male rats of three ages, 3, 12 and 24 months. Physiological levels of MT in kidney, liver and lung measured simultaneously in untreated animals were found to be within the same range in all three age groups. Following 3-day treatment with CdCl2 equival...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293629
更新日期：1988-01-01 00:00:00
abstract：:Rats were exposed to nickel sulfate (NiSO4) either by intratracheal (IT) instillation or by acute aerosol inhalation, and pulmonary clearance of Ni and pulmonary inflammatory responses were studied. The half-time of Ni in the lung (initial lung burden = 50 micrograms Ni/rat) was about 32 h in both the IT instillation ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050112
更新日期：1994-01-01 00:00:00
