Expression of Neuropathy Target Esterase in mouse embryonic stem cells during differentiation.

abstract：:The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA) as well as mercuric chloride (HgCl(2)) and methylmercury chloride (MeHgCl) on gluconeogenesis was investigated in isolated rat kidney tubules. From starved rats kidney tubules were prepared and isolat...

journal_title：Archives of toxicology

authors： Reichl FX,Durner J,Mückter H,Elsenhans B,Forth W,Kunzelmann KH,Hickel R,Spahl W,Hume WR,Moes GW

更新日期：1999-09-01 00:00:00

abstract：:The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2...

journal_title：Archives of toxicology

authors： Reichl FX,Hunder G,Liebl B,Fichtl B,Forth W

更新日期：1995-01-01 00:00:00

abstract：:The deleterious effect of lead has been attributed to lead-induced oxidative stress with the consequence of lipid peroxidation. The present study was designed to investigate the combined effect of DL-alpha-lipoic acid (LA) and meso-2,3-dimercaptosuccinic acid (DMSA) on lead-induced peroxidative damages in rat kidney. ...

journal_title：Archives of toxicology

authors： Sivaprasad R,Nagaraj M,Varalakshmi P

更新日期：2002-08-01 00:00:00

abstract：:Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxicity and prevention. Metabolism and ...

journal_title：Archives of toxicology

authors： Kurebayashi H,Ohno Y

更新日期：2006-12-01 00:00:00

abstract：:Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...

journal_title：Archives of toxicology

authors： Aluoch AO,Odman-Ghazi SO,Whalen MM

更新日期：2007-04-01 00:00:00

abstract：:Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services. Standard drug treatment consists of atropine and an oxime as reactivator of OP-inhibited acetylcholinesterase and is virtually unchanged since more...

journal_title：Archives of toxicology

authors： Worek F,Thiermann H,Wille T

更新日期：2020-07-01 00:00:00

abstract：:The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase. In vitro studies have indicated that APAP may also be cooxidized by prostaglandin H synthetase. The present experiments were designed to assess the possible contributio...

journal_title：Archives of toxicology

authors： Ben-Zvi Z,Weissman-Teitellman B,Katz S,Danon A

更新日期：1990-01-01 00:00:00

abstract：:Breast cancer is the most commonly diagnosed malignancy in females, the etiology being multifactorial and includes the role of lifestyle exposure to DNA-damaging chemicals such as dietary carcinogens benzo (a) pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP). Both compounds require cytochrome...

journal_title：Archives of toxicology

authors： Malik DE,David RM,Gooderham NJ

更新日期：2019-10-01 00:00:00

abstract：:Single doses of procarbazine (MIH) were injected IP at 0, 50, 100, 200, and 400 mg/kg body weight to CD-1 male mice. Activities of hyaluronidase, lactate dehydrogenase isoenzyme-X, and the dehydrogenases of sorbitol, alpha-glycerophosphate, glucose-6-phosphate, malate, isocitrate, and glyceraldehyde-3-phosphate in the...

journal_title：Archives of toxicology

authors： Shen RS,Lee IP

更新日期：1984-10-01 00:00:00

abstract：:The binding characteristics of [14C]ortho-toluidine (OT), a suspect human carcinogen, were investigated in male Sprague-Dawley rats. Rats were administered [14C]OT i.p. at 10, 20, 40, 50, or 100 mg/kg body weight, then sacrificed at 2, 4, 8, 18, 24, 48, or 72 h, or 7, 14, or 28 days. Hemoglobin (Hb) and albumin (Alb) ...

journal_title：Archives of toxicology

authors： DeBord DG,Swearengin TF,Cheever KL,Booth-Jones AD,Wissinger LA

更新日期：1992-01-01 00:00:00

abstract：:The EU-EuroMix project adopted the strategy of the European Food Safety Authority (EFSA) for cumulative risk assessment, which limits the number of chemicals to consider in a mixture to those that induce a specific toxicological phenotype. These so-called cumulative assessment groups (CAGs) are refined at several leve...

journal_title：Archives of toxicology

authors： Staal YCM,Meijer J,van der Kris RJC,de Bruijn AC,Boersma AY,Gremmer ER,Zwart EP,Beekhof PK,Slob W,van der Ven LTM

更新日期：2018-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In our study, we investigat...

journal_title：Archives of toxicology

authors： Ma L,Zhu L,Gu D,Chu H,Tong N,Chen J,Zhang Z,Wang M

更新日期：2013-05-01 00:00:00

abstract：:Tea (Camellia sinensis, Theaceace), a popular beverage consumed world-wide, has been studied for its preventive effects against cancer as well as cardiovascular, neurodegenerative, and other diseases. Most of the proposed beneficial effects have been attributed to the polyphenolic compounds in tea, but the nature of t...

journal_title：Archives of toxicology

authors： Yang CS,Lambert JD,Sang S

更新日期：2009-01-01 00:00:00

abstract：:A single dose of 10 mg methylmercury chloride per kg body weight was given to 30 days old rats and to adult rats (180-200g)(. This resulted in brain levels of 1.4-2.2 micrograms Hg/g wet weight. In the young rats electron microscopic morphometry showed swelling of the granule cells. The extent of changes was more pron...

journal_title：Archives of toxicology

authors： Syversen TL,Totland G,Flood PR

更新日期：1981-04-01 00:00:00

abstract：:In anaesthetized and artificially ventilated rabbits an intravenous infusion of paraoxon (0.8 mg/kg) was given over 30 min. The effects on cardiac output, blood flow to various vascular beds, and on the mass discharge of the postganglionic sympathetic efferents to the spleen and kidney were monitored. Immediately foll...

journal_title：Archives of toxicology

authors： Kullmann R,Reinsberg J,Amirmanssouri M

更新日期：1982-09-01 00:00:00

abstract：:Aluminum phosphide (AlP), one of the most commonly used pesticides worldwide, has been the leading cause of self-poisoning mortalities among many Asian countries. The heart is the main organ affected in AlP poisoning. Melatonin has been previously shown to be beneficial in reversing toxic changes in the heart. The pre...

journal_title：Archives of toxicology

authors： Asghari MH,Moloudizargari M,Baeeri M,Baghaei A,Rahimifard M,Solgi R,Jafari A,Aminjan HH,Hassani S,Moghadamnia AA,Ostad SN,Abdollahi M

更新日期：2017-09-01 00:00:00

abstract：:Chronic exposure to inorganic arsenic (As) [As(III) + As(V)], which affects millions of people, increases the incidence of some kinds of cancer and other non-carcinogenic pathologies. Although the oral pathway is the main form of exposure, in vivo studies have not been conducted to verify the intestinal toxicity of th...

journal_title：Archives of toxicology

authors： Chiocchetti GM,Domene A,Kühl AA,Zúñiga M,Vélez D,Devesa V,Monedero V

更新日期：2019-08-01 00:00:00

abstract：:Millions of tons of all kind of munitions, including mines, bombs and torpedoes have been dumped after World War II in the marine environment and do now pose a new threat to the seas worldwide. Beside the acute risk of unwanted detonation, there is a chronic risk of contamination, because the metal vessels corrode and...

journal_title：Archives of toxicology

authors： Strehse JS,Brenner M,Kisiela M,Maser E

更新日期：2020-12-01 00:00:00

abstract：:The toxic effect of cadmium varies with sex in experimental animals. Previous studies have demonstrated that pretreatment of male Fischer 344 (F344) rats with the female sex hormone progesterone markedly enhances the susceptibility to cadmium, suggesting a role for progesterone in the sexual dimorphism of cadmium toxi...

journal_title：Archives of toxicology

authors： Shimada H,Hashiguchi T,Yasutake A,Waalkes MP,Imamura Y

更新日期：2012-09-01 00:00:00

abstract：:Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-...

journal_title：Archives of toxicology

authors： Longhin E,Camatini M,Bersaas A,Mantecca P,Mollerup S

更新日期：2018-09-01 00:00:00

abstract：:The activity of 18 vitamin D analogs on soft tissue calcification and growth impairment in neonatal rats and their effect on bone calcium mobilization, intestinal calcium absorption and binding to intestinal 1,25-dihydroxyvitamin D3 receptors in adult rats were compared. Depending on the chemical modification of the v...

journal_title：Archives of toxicology

authors： Kistler A,Galli B,Horst R,Truitt GA,Uskoković MR

更新日期：1989-01-01 00:00:00

abstract：:Exposure to toxic metals is a well-known problem in industrialized countries. Metals interfere with a number of physiological processes, including central nervous system (CNS), haematopoietic, hepatic and renal functions. In the evaluation of the toxicity of a particular metal it is crucial to consider many parameters...

journal_title：Archives of toxicology

authors： Sinicropi MS,Amantea D,Caruso A,Saturnino C

更新日期：2010-07-01 00:00:00

abstract：:Fumonisin B1 (FB1) is a well-known inhibitor of de novo sphingolipid biosynthesis, due to its ability to inhibit ceramide synthases (CerS) activity. In mammals, this toxin triggers broad clinical symptoms with multi-organ dysfunction such as hepatotoxicity or pulmonary edema. The molecular mechanism of CerS inhibition...

journal_title：Archives of toxicology

authors： Loiseau N,Polizzi A,Dupuy A,Therville N,Rakotonirainy M,Loy J,Viadere JL,Cossalter AM,Bailly JD,Puel O,Kolf-Clauw M,Bertrand-Michel J,Levade T,Guillou H,Oswald IP

更新日期：2015-09-01 00:00:00

abstract：:A new strategy for the evaluation of mixtures is presented. The mixture used was the organic extract of diesel exhaust particles (DEP). After extraction with dichloromethane (DCM), the crude extract was fractionated according to polarity into five fractions: aliphatic hydrocarbons, polycyclic aromatic hydrocarbons (PA...

journal_title：Archives of toxicology

authors： Ostby L,Engen S,Melbye A,Eide I

更新日期：1997-01-01 00:00:00

abstract：:Ochratoxin A (OTA) is a toxin produced by fungi such as Aspergillus spp. and Penicillium spp. The key target organ of OTA toxicity is the kidney, and it is known that epithelial-to-mesenchymal transition (EMT) leading to fibrosis is enhanced after long-term exposure of the kidney to OTA. However, the mechanisms respon...

journal_title：Archives of toxicology

authors： Pyo MC,Chae SA,Yoo HJ,Lee KW

更新日期：2020-09-01 00:00:00

abstract：:Mycotoxins are the most frequently occurring natural contaminants in human and animal diet. Among them, deoxynivalenol (DON), produced by Fusarium, is one of the most prevalent and thus represents an important health risk. Recent detection methods revealed new mycotoxins and new molecules derivated from the "native" m...

journal_title：Archives of toxicology

authors： Payros D,Alassane-Kpembi I,Pierron A,Loiseau N,Pinton P,Oswald IP

更新日期：2016-12-01 00:00:00

abstract：:For ethical and regulatory reasons, in vitro tests for scoring potential toxicities of cosmetics are essential. A test strategy for investigating potential skin sensitization using two human keratinocytic and two human dendritic cell lines has been developed (Mehling et al. Arch Toxicol 86:1273–1295, 2012). Since proh...

journal_title：Archives of toxicology

authors： Fabian E,Vogel D,Blatz V,Ramirez T,Kolle S,Eltze T,van Ravenzwaay B,Oesch F,Landsiedel R

更新日期：2013-09-01 00:00:00

abstract：:Organotin compounds such as tributyltin (TBT) and triphenyltin can induce diabetes and insulin resistance. However, the development of diabetes caused by organotins and its underlying mechanisms remain unclear. In the present study, male KM mice were orally administered with TBT (0.5, 5, and 50 μg/kg) once every 3 day...

journal_title：Archives of toxicology

authors： Li B,Guo J,Xi Z,Xu J,Zuo Z,Wang C

更新日期：2017-10-01 00:00:00

abstract：:The involvement of oxidative stress has been suggested as a mechanism for neurotoxicity caused by methylmercury (MeHg), but the mechanism for MeHg selective toxicity in the central nervous system is still unclear. In this research, to clarify the mechanism of selective neurotoxicity caused by MeHg, the oxygen consumpt...

journal_title：Archives of toxicology

authors： Mori N,Yasutake A,Hirayama K

更新日期：2007-11-01 00:00:00

abstract：:Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biologica...

journal_title：Archives of toxicology

authors： Aichinger G,Dellafiora L,Pantazi F,Del Favero G,Galaverna G,Dall'Asta C,Marko D

更新日期：2020-06-01 00:00:00