Abstract：
:Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatments (dithizone, activated charcoal, furosemide, Prussian Blue, and a combination of Prussian Blue and furosemide) were compared with controls for their efficacy in reducing the total thallium body load. In the control group (C,n = 10) of an approximate administered dose of 2 mg, after 8 days 411 micrograms (21%) had been eliminated in the urine and 641 micrograms (32%) in the feces, making a total of 1,052 micrograms (53%). In the treated groups the effects were very significant and in accord with the mode of action of the antidotes: furosemide (a diuretic) only enhanced urinary elimination; activated charcoal and Prussian Blue (unabsorbed adsorbents) only increased fecal elimination; dithizone increased only urinary elimination, whereas combined treatment with Prussian Blue and furosemide increased elimination by both routes. At the end of 8 days the control group had only eliminated 53% of the dose; this was increased to 99% by dithizone, 93% by activated charcoal, 64% by furosemide, 82% by Prussian Blue and 92% by combining furosemide and Prussian Blue. In view of the inherent toxicity of dithizone, it is suggested that treatment with a combination of Prussian Blue-furosemide or with activated charcoal should be adequate.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Lehmann PA,Favari Ldoi
10.1007/BF00286576subject
Has Abstractpub_date
1985-04-01 00:00:00pages
56-60issue
1eissn
0340-5761issn
1432-0738journal_volume
57pub_type
杂志文章abstract：:The effect of N-benzyl-D-glucamine dithiocarbamate (BGD) on the renal toxicity induced by acute exposure to cadmium-metallothionein (Cd-MT) in rats was studied. Rats were injected intraperitoneally with BGD (400 mumol/kg) 6, 12, or 24 h after intraperitoneal injection of Cd-MT (1.78 mumol Cd as Cd-MT/kg) and thereafte...
journal_title：Archives of toxicology
pub_type： 杂志文章
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journal_title：Archives of toxicology
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更新日期：1995-01-01 00:00:00
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更新日期：2018-02-01 00:00:00
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journal_title：Archives of toxicology
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更新日期：2016-09-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
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更新日期：1987-01-01 00:00:00
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更新日期：2016-04-01 00:00:00
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