Overdose toxicity studies versus threshold: elements of biology must be incorporated into risk assessment.

abstract：:The current management of rodent pest populations is based on second-generation anticoagulant rodenticides (SGAR). These molecules, of which difethialone is part, are much more efficient than the first generation. Nevertheless, this efficiency comes with a major drawback, SGARs are tissue persistent that increases the...

journal_title：Archives of toxicology

authors： Lefebvre S,Fourel I,Chatron N,Caruel H,Benoit E,Lattard V

更新日期：2020-03-01 00:00:00

abstract：:Previous studies have shown the antidotal efficacy of topical iodine at 15 and 30 min post-exposure to sulfur mustard (SM). Here we demonstrate efficacy at longer intervals (20, 30, 45, and 60 min, respectively, for data) using an improved topical povidone-iodine preparation termed N66, which contains steroidal and no...

journal_title：Archives of toxicology

authors： Wormser U,Sintov A,Brodsky B,Casillas RP,Nyska A

更新日期：2004-03-01 00:00:00

abstract：:Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are t...

journal_title：Archives of toxicology

authors： Bridges CC,Zalups RK

更新日期：2017-01-01 00:00:00

abstract：:Intermittent inhalation of 300 ppm of xylene vapour 6 h daily for 2 weeks caused a marked accumulation of the solvent in the perirenal fat. Simultaneous ethanol ingestion reduced the solvent load significantly although the perirenal xylene concentration increased in both test groups between the first and second week o...

journal_title：Archives of toxicology

authors： Savolainen H,Vainio H,Helojoki M,Elovaara E

更新日期：1978-12-28 00:00:00

abstract：:Chronic exposure to inorganic arsenic (As) [As(III) + As(V)], which affects millions of people, increases the incidence of some kinds of cancer and other non-carcinogenic pathologies. Although the oral pathway is the main form of exposure, in vivo studies have not been conducted to verify the intestinal toxicity of th...

journal_title：Archives of toxicology

authors： Chiocchetti GM,Domene A,Kühl AA,Zúñiga M,Vélez D,Devesa V,Monedero V

更新日期：2019-08-01 00:00:00

abstract：:This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...

journal_title：Archives of toxicology

authors： Khan F,Niaz K,Ismail Hassan F,Abdollahi M

更新日期：2018-07-01 00:00:00

abstract：:Mice in experimental delay of implantation were injected intravenously with 75 micrograms.g-1 body weight of lead chloride, corresponding to a dose of lead of about 56 micrograms.g-1 body weight. Delay of implantation was obtained by ovariectomy 3 days after mating followed by a depot dose of progesterone every fifth ...

journal_title：Archives of toxicology

authors： Nilsson BO,Ljung L,Wide M

更新日期：1991-01-01 00:00:00

abstract：:The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The calibration curve for morphine in hair showed linear over 0.5-100 ng/mg hair. Though the limit of detection was 0.1 ng/mg hair with an S/N > 3 of the base ion(m/z 429) for morphine, the limit of confirmation by detection of thr...

journal_title：Archives of toxicology

authors： Nakahara Y,Takahashi K,Shimamine M,Saitoh A

更新日期：1992-01-01 00:00:00

abstract：:To evaluate the developmental neurotoxicity of arsenic in offspring rats by transplacental and early life exposure to sodium arsenite in drinking water, the pregnant rats or lactating dams, and weaned pups were given free access to drinking water, which contained arsenic at concentrations of 0, 10, 50, 100 mg/L from G...

journal_title：Archives of toxicology

authors： Xi S,Sun W,Wang F,Jin Y,Sun G

更新日期：2009-06-01 00:00:00

abstract：:Pyrrolizidine alkaloids (PAs) are widely occurring phytotoxins which can induce severe liver damage in humans and other mammalian species by mechanisms that are not fully understood. Therefore, we investigated the development of PA hepatotoxicity in vivo, using an acutely toxic dose of the PA senecionine in mice, in c...

journal_title：Archives of toxicology

authors： Hessel-Pras S,Braeuning A,Guenther G,Adawy A,Enge AM,Ebmeyer J,Henderson CJ,Hengstler JG,Lampen A,Reif R

更新日期：2020-01-01 00:00:00

abstract：:Exposure to toxic metals is a well-known problem in industrialized countries. Metals interfere with a number of physiological processes, including central nervous system (CNS), haematopoietic, hepatic and renal functions. In the evaluation of the toxicity of a particular metal it is crucial to consider many parameters...

journal_title：Archives of toxicology

authors： Sinicropi MS,Amantea D,Caruso A,Saturnino C

更新日期：2010-07-01 00:00:00

abstract：:The "closed chamber technique" (CCT) is presented. It allows investigation of pharmacokinetics of volatile substances in vivo in animals and in man and in vitro using tissue fractions. During the exposure period only the atmospheric concentrations of the substance are measured. The concentration-time data obtained are...

journal_title：Archives of toxicology

authors： Filser JG

更新日期：1992-01-01 00:00:00

abstract：:Millions of tons of all kind of munitions, including mines, bombs and torpedoes have been dumped after World War II in the marine environment and do now pose a new threat to the seas worldwide. Beside the acute risk of unwanted detonation, there is a chronic risk of contamination, because the metal vessels corrode and...

journal_title：Archives of toxicology

authors： Strehse JS,Brenner M,Kisiela M,Maser E

更新日期：2020-12-01 00:00:00

abstract：:Cholestasis underlies one of the major manifestations of drug-induced liver injury. Drug-induced cholestatic liver toxicity is a complex process, as it can be triggered by a variety of factors that induce 2 types of biological responses, namely a deteriorative response, caused by bile acid accumulation, and an adaptiv...

journal_title：Archives of toxicology

authors： Gijbels E,Vilas-Boas V,Deferm N,Devisscher L,Jaeschke H,Annaert P,Vinken M

更新日期：2019-05-01 00:00:00

abstract：:Metabolism of carbaryl by rat liver and skin post-mitochondrial fraction has been measured in the presence and absence of cofactors to promote different metabolic pathways. The metabolic capacity was compared with the metabolism of carbaryl during percutaneous absorption in a static skin diffusion system using a varie...

journal_title：Archives of toxicology

authors： MacPherson SE,Scott RC,Williams FM

更新日期：1991-01-01 00:00:00

abstract：:False-negative judgment due to poor chemical solubility is a problem with in vitro skin sensitisation tests. Water-insoluble chemicals are typically dissolved in DMSO in most sensitisation tests but precipitate when diluted with medium beyond their solubility in water. Such tests lack procedures to rule out false-nega...

journal_title：Archives of toxicology

authors： Kimura Y,Fujimura C,Aiba S

更新日期：2020-10-17 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) are a family of kinases associated predominantly with cell cycle control, making CDK inhibitors interesting candidates for anti-cancer therapeutics. However, retinal toxicity (loss of photoreceptors) has been associated with CDK inhibitors, including the pan-CDK inhibitor AG-012896. The...

journal_title：Archives of toxicology

authors： Wright P,Kelsall J,Healing G,Sanderson J

更新日期：2019-03-01 00:00:00

abstract：:The binding characteristics of [14C]ortho-toluidine (OT), a suspect human carcinogen, were investigated in male Sprague-Dawley rats. Rats were administered [14C]OT i.p. at 10, 20, 40, 50, or 100 mg/kg body weight, then sacrificed at 2, 4, 8, 18, 24, 48, or 72 h, or 7, 14, or 28 days. Hemoglobin (Hb) and albumin (Alb) ...

journal_title：Archives of toxicology

authors： DeBord DG,Swearengin TF,Cheever KL,Booth-Jones AD,Wissinger LA

更新日期：1992-01-01 00:00:00

abstract：:The acute toxicity of cyanide is determined by its peak levels reached in the body. Compared to the ingestion of free cyanide, lower peak levels may be expected after consumption of foods containing cyanogenic glycosides with the same equivalent dose of cyanide. This is due to possible delayed and/or incomplete releas...

journal_title：Archives of toxicology

authors： Abraham K,Buhrke T,Lampen A

更新日期：2016-03-01 00:00:00

abstract：:Current developmental neurotoxicity (DNT) testing in animals faces major limitations, such as high cost and time demands as well as uncertainties in their methodology, evaluation and regulation. Therefore, the use of human-based 3D in vitro systems in combination with high-content image analysis (HCA) might contribute...

journal_title：Archives of toxicology

authors： Schmuck MR,Temme T,Dach K,de Boer D,Barenys M,Bendt F,Mosig A,Fritsche E

更新日期：2017-04-01 00:00:00

abstract：:Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...

journal_title：Archives of toxicology

authors： Brotzmann K,Wolterbeek A,Kroese D,Braunbeck T

更新日期：2020-10-27 00:00:00

abstract：:Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340 mumol/kg/h for rats and 560 mumol/kg/h for mice. The atmospheric concentration at which Vmax/2 is reached is 1200 ppm for rats and 1800 pp...

journal_title：Archives of toxicology

authors： Csanády GA,Freise D,Denk B,Filser JG,Cornet M,Rogiers V,Laib RJ

更新日期：1991-01-01 00:00:00

abstract：:Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in drug discovery. Three-dimensional (3D) spheroid hepatic cultures have emerged as pr...

journal_title：Archives of toxicology

authors： Proctor WR,Foster AJ,Vogt J,Summers C,Middleton B,Pilling MA,Shienson D,Kijanska M,Ströbel S,Kelm JM,Morgan P,Messner S,Williams D

更新日期：2017-08-01 00:00:00

abstract：:Female Wistar rats were treated with various doses of progesterone orally via the diet or via the SC route. Oral treatment resulted in enhanced progesterone levels in the liver as measured by radioimmunoassay. There were up to 3-fold increases in activity of ethylmorphine demethylation by isolated microsomes; metaboli...

journal_title：Archives of toxicology

authors： Ochs H,Düsterberg B,Schulte-Hermann R

更新日期：1986-10-01 00:00:00

abstract：:Exposure to high-dose benzene leads to the inhibition of erythroid differentiation. However, whether lower doses of benzene exposure resemble high-dose effects in erythroid differentiation, as well as the underlying mechanisms, remains largely unknown. To identify the microRNAs (miRNAs) specifically responsible for be...

journal_title：Archives of toxicology

authors： Liang B,Chen Y,Yuan W,Qin F,Zhang Q,Deng N,Liu X,Ma X,Zhang X,Zhang B,Deng Q,Huang M,Tang H,Liu L,Chen W,Xiao Y

更新日期：2018-01-01 00:00:00

abstract：:Okadaic acid (OA) is produced by several types of dinoflagellates (marine plankton) and has been implicated as the causative agent of diarrhetic shellfish syndrome. Previous studies have shown that okadaic acid is a tumor promoter and a specific potent inhibitor of protein phosphatases and protein synthesis. These eff...

journal_title：Archives of toxicology

authors： Traoré A,Baudrimont I,Dano S,Sanni A,Larondelle Y,Schneider YJ,Creppy EE

更新日期：2003-11-01 00:00:00

abstract：:This article is published with the incorrect copyright holder name in the HTML article as "© Springer 2018". The correct copyright line should read "The Author(s) 2018" (as it appears in the article PDF). ...

journal_title：Archives of toxicology

authors： Oesch F,Fabian E,Landsiedel R

更新日期：2018-11-01 00:00:00

abstract：:The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman was analysed in cerebrospinal fluid (CSF) and blood in anaesthetized, spontaneously breathing pigs during a 90-min period after injection of soman. The pigs were challenged with different intravenous (i.v.) doses of C(+/-)P(+/-)-soman c...

journal_title：Archives of toxicology

authors： Göransson-Nyberg A,Fredriksson SA,Karlsson B,Lundström M,Cassel G

更新日期：1998-07-01 00:00:00

abstract：:Dulcin (DL), now banned, was once a widely used artificial sweetener. DL possesses an ureido group that is metabolized by direct glucuronidation in rabbit liver microsomes. Dulcin N-glucuronide (DNG) is the only type of ureido N-glucuronide known to date; ureido glucuronidation in humans has not been previously report...

journal_title：Archives of toxicology

authors： Uesawa Y,Staines AG,Lockley D,Mohri K,Burchell B

更新日期：2007-03-01 00:00:00

abstract：:The pregnancy outcomes of 109 women who were intoxicated during pregnancy due to excessive amounts of drugs and other agents were studied. Seventy per cent of the women attempted suicide, and the intoxication in 78% of all cases was caused by drugs. The stillbirth rate (4%) was higher than that in previous and subsequ...

journal_title：Archives of toxicology

authors： Czeizel A,Szentesi I,Szekeres I,Molnár G,Glauber A,Bucski P

更新日期：1988-08-01 00:00:00