Correction to: An evidence-based review of the genotoxic and reproductive effects of sulfur mustard.

abstract：:Carbon tetrachloride-induced liver injury is a thoroughly studied model for regeneration and fibrosis in rodents. Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type. To clarify this, we show that collagen type IV+ "streets" and α-SMA+ cells accumulate pericentrally and extend to ne...

journal_title：Archives of toxicology

authors： Hammad S,Braeuning A,Meyer C,Mohamed FEZA,Hengstler JG,Dooley S

更新日期：2017-11-01 00:00:00

abstract：:This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a seco...

journal_title：Archives of toxicology

authors： Godoy P,Hewitt NJ,Albrecht U,Andersen ME,Ansari N,Bhattacharya S,Bode JG,Bolleyn J,Borner C,Böttger J,Braeuning A,Budinsky RA,Burkhardt B,Cameron NR,Camussi G,Cho CS,Choi YJ,Craig Rowlands J,Dahmen U,Damm G,Dirsch

更新日期：2013-08-01 00:00:00

abstract：:Pyrrolizidine alkaloids (PAs) are widely occurring phytotoxins which can induce severe liver damage in humans and other mammalian species by mechanisms that are not fully understood. Therefore, we investigated the development of PA hepatotoxicity in vivo, using an acutely toxic dose of the PA senecionine in mice, in c...

journal_title：Archives of toxicology

authors： Hessel-Pras S,Braeuning A,Guenther G,Adawy A,Enge AM,Ebmeyer J,Henderson CJ,Hengstler JG,Lampen A,Reif R

更新日期：2020-01-01 00:00:00

abstract：:Experimental manganese lymphadenopathy was produced by guinea pigs by intratracheal inoculation of manganese dioxide (50 mg/300 g body weight) and histopathologic changes in the tracheobronchial lymph nodes were studied up to 180 days. There was slow extracellular transport of manganese dust into the nodes, which did ...

journal_title：Archives of toxicology

authors： Shanker R,Dogra RK,Sahu AP,Zaidi SH

更新日期：1976-10-28 00:00:00

abstract：:Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats we...

journal_title：Archives of toxicology

authors： Monteiro JP,Pereira CV,Silva AM,Maciel E,Baldeiras I,Peixoto F,Domingues MR,Jurado AS,Oliveira PJ

更新日期：2013-12-01 00:00:00

abstract：:Doppler and M-mode echocardiography (EC) were used to investigate the effects of minoxidil on the cardiac function of the dog and potentially to clarify the pathogenesis of cardiac lesions, in particular the necrotic lesion in the left ventricle and the haemorrhagic lesion in the right atrium. Groups of three dogs wer...

journal_title：Archives of toxicology

authors： Hanton G,Gautier M,Bonnet P

更新日期：2004-01-01 00:00:00

abstract：:Pregnant C3H mice were exposed to a teratogenic dose of cyclophosphamide (CP, 20 mg/kg body weight) on the 10th day after copulation. Embryos or fetuses were examined 2-9 days later for gross abnormalities, weighed, and assayed for cephalic acetylcholinesterase (EC 3.1.1.7, AChE) activity, and haemoglobin content. In ...

journal_title：Archives of toxicology

authors： Pillans PI,Stephenson BA,Folb PI

更新日期：1988-01-01 00:00:00

abstract：:Mouse liver tumors that harbor activating mutations in Ctnnb1, encoding β-catenin, express high levels of various cytochromes P450 (CYP), including CYP2E1 and CYP1A2. Acetaminophen (AAP) is metabolized in hepatocytes by these CYPs to the reactive intermediate N-acetyl-p-benzoquinone-imine, which is toxic to hepatocyte...

journal_title：Archives of toxicology

authors： Singh Y,Braeuning A,Schmid A,Pichler BJ,Schwarz M

更新日期：2013-08-01 00:00:00

abstract：:Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in drug discovery. Three-dimensional (3D) spheroid hepatic cultures have emerged as pr...

journal_title：Archives of toxicology

authors： Proctor WR,Foster AJ,Vogt J,Summers C,Middleton B,Pilling MA,Shienson D,Kijanska M,Ströbel S,Kelm JM,Morgan P,Messner S,Williams D

更新日期：2017-08-01 00:00:00

abstract：:This study aimed to investigate the effect of single and repeated administration of fenarimol on murine liver, kidney and lung microsomal CYP-catalyzed drug metabolism. The modulation of the regio- and stereo-selective hydroxylation of testosterone by fenarimol was considered in evaluating cocarcinogenic properties. I...

journal_title：Archives of toxicology

authors： Paolini M,Pozzetti L,Mesirca R,Sapone A,Cantelli-Forti G

更新日期：1996-01-01 00:00:00

abstract：:Some nucleoside analogues are used to treat herpes simplex and other viral infections. They are known to impair spermatogenesis, but published data are scarce. We studied the effects of four nucleosides on SerW3 cells, a rat Sertoli cell line. Cells were cultured for 3 days in DMEM supplemented with four different con...

journal_title：Archives of toxicology

authors： Qiu R,Horvath A,Stahlmann R

更新日期：2016-08-01 00:00:00

abstract：:With the development of nanotechnology, myriad types of novel materials have been discovered at the nanoscale, among which the most interesting material is graphene. However, the toxicity data available on graphene are extremely limited. In this study, we explored toxic response of commercially available graphene nano...

journal_title：Archives of toxicology

authors： Park EJ,Lee GH,Han BS,Lee BS,Lee S,Cho MH,Kim JH,Kim DW

更新日期：2015-09-01 00:00:00

abstract：:The effect of pretreatment with SKF-525A, which inhibits hepatic cytochrome P450 enzymes, on metabolism and hepatotoxicity was examined in mice orally administered tributyltin chloride (TBTC) or dibutyltin dichloride (DBTC) at a dose of 180 mumol/kg. Analysis of butyltin compounds showed that the main metabolites in l...

journal_title：Archives of toxicology

authors： Ueno S,Suzuki T,Susa N,Furukawa Y,Sugiyama M

更新日期：1997-01-01 00:00:00

abstract：:The influence of haemoperfusion on some immunological parameters was investigated in a pilot study involving two groups of three patients each. In columns containing cellulose-coated activated charcoal or polystyrene resin a temporary reduction of the total white cell number, particularly involving the segmented and b...

journal_title：Archives of toxicology

authors： Rommes JH,Sangster B,Gmelig Meyling FH,Daha MR,van Heijst AN

更新日期：1983-02-01 00:00:00

abstract：:The binding characteristics of [14C]ortho-toluidine (OT), a suspect human carcinogen, were investigated in male Sprague-Dawley rats. Rats were administered [14C]OT i.p. at 10, 20, 40, 50, or 100 mg/kg body weight, then sacrificed at 2, 4, 8, 18, 24, 48, or 72 h, or 7, 14, or 28 days. Hemoglobin (Hb) and albumin (Alb) ...

journal_title：Archives of toxicology

authors： DeBord DG,Swearengin TF,Cheever KL,Booth-Jones AD,Wissinger LA

更新日期：1992-01-01 00:00:00

abstract：:The first withdrawal of certain polybrominated diphenyl ethers flame retardants from the US market occurred in 2004. Since then, use of brominated non-PBDE compounds such as bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) in commercial formulations has incr...

journal_title：Archives of toxicology

authors： Silva MJ,Hilton D,Furr J,Gray LE,Preau JL,Calafat AM,Ye X

更新日期：2016-03-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) and non-NMDA receptors were found to be involved in development of functional disorders caused by hexachlorophene. In order to specify the role of glutamate receptors we studied the protective effects of the selective antagonist of the kainate/(+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4...

journal_title：Archives of toxicology

authors： Häntzschel A,Andreas K

更新日期：2000-01-01 00:00:00

abstract：:The effect of pretreatment with cadmium (Cd) complexes on the distribution and accumulation of Cd in the liver and kidneys was examined for the Cd complexes that are reabsorbed site-selectively at the renal proximal tubules of rats. Cd was administered simultaneously with excess cysteine or as metallothionein (MT) and...

journal_title：Archives of toxicology

authors： Suzuki KT,Takahara T,Watanabe H,Nishikawa M,Yamamura M,Murakami M

更新日期：1986-04-01 00:00:00

abstract：:The significance of urinary trehalase as a possible early indicator of renal disorder was examined using Cd-treated rabbits, which received 1 mg/kg Cd thrice weekly for 3 months subcutaneously. The results showed that urinary trehalase increased significantly from 1 week after treatment, earlier than LAP, ALP, protein...

journal_title：Archives of toxicology

authors： Nishimura N,Oshima H,Nakano M

更新日期：1986-12-01 00:00:00

abstract：:Retinoids, derivatives of vitamin A, are essential for many vertebrate functions. Furthermore, several drugs of this class of compounds are valuable in the treatment of certain forms of skin disorders and cancer. However, the therapeutic application of retinoids is limited by their teratogenic potency. The limbs are i...

journal_title：Archives of toxicology

authors： Sass JO,Zimmermann B,Rühl R,Nau H

更新日期：1997-01-01 00:00:00

abstract：:O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...

journal_title：Archives of toxicology

authors： Ohtaka K,Hamade N,Yamazaki Y,Suzuki M,Koizumi A

更新日期：1995-01-01 00:00:00

abstract：:A study was conducted to determine the levels of cis-diamminedichloroplatinum (II) (cisplatin) in plasma proteins and hemoglobin of cancer patients after cisplatin chemotherapy. Thirty-seven cancer patients with different type of cancers (lung, esophageal, urinary tract, and testicular cancer, melanoma, osteosarcoma e...

journal_title：Archives of toxicology

authors： Mustonen R,Hietanen P,Leppälä S,Takala M,Hemminki K

更新日期：1989-01-01 00:00:00

abstract：:Polymorphisms of the apolipoprotein E (APOE) gene differentially affect neurobiological functions and cognitive performance and confer different vulnerabilities to subclinical exposures to chlorpyrifos (CPF), a pesticide used worldwide. The data reported on this topic suggest a complex interaction between cholinergic ...

journal_title：Archives of toxicology

authors： Basaure P,Guardia-Escote L,Cabré M,Peris-Sampedro F,Sánchez-Santed F,Domingo JL,Colomina MT

更新日期：2019-03-01 00:00:00

abstract：:The effects of acetaldehyde (ACD) on dopamine (DA) and DA-derived salsolinol (SAL) levels were investigated in the striatum of freely moving rats. Dialysate levels of DA and SAL were determined using in vivo reverse microdialysis coupled with high-performance liquid chromatography with an electrochemical detector. Per...

journal_title：Archives of toxicology

authors： Wang W,Ameno K,Jamal M,Kumihashi M,Uekita I,Ameno S,Ijiri I

更新日期：2007-02-01 00:00:00

abstract：: ...

journal_title：Archives of toxicology

authors： Murad W,Abbass T,Seddek AL

更新日期：2018-11-01 00:00:00

abstract：:Perfluoroalkyl acids are widely used in numerous industrial and commercial applications due to their unique physical and chemical characteristics. Although perfluorooctanoic acid (PFOA) is associated with hepatomegaly through peroxisome proliferator-activated receptor α (PPARα) activation, liver fat accumulation and c...

journal_title：Archives of toxicology

authors： Yan S,Wang J,Dai J

更新日期：2015-09-01 00:00:00

abstract：:A histochemical technique for detection of the in vivo induced cellular aldehydes based on the direct Schiff's reaction is reported in this paper. CCl4-intoxicated rat liver was used as an experimental model. Fresh and non-pretreated rat liver cryostat sections fixed in 10% formol calcium solution and washed in distil...

journal_title：Archives of toxicology

authors： Taper HS,Somer MP,Lans M,de Gerlache J,Roberfroid M

更新日期：1988-04-01 00:00:00

abstract：:The oxidizing capacity of phagocytic cells is suspected to play a major role in the generation of immunogenic drug metabolites, in particular those that cause extrahepatic immunopathological lesions. In the case of the antirheumatic drug gold(I) disodium thiomalate (Na2Au(I)TM), oxidation of the Au(I) ion to Au(III) a...

journal_title：Archives of toxicology

authors： Goebel C,Kubicka-Muranyi M,Tonn T,Gonzalez J,Gleichmann E

更新日期：1995-01-01 00:00:00

abstract：:The covalent binding of 14C-1,1,2-trichloroethylene (14C-TRI) metabolites to calf thymus DNA in vitro and to RNA and DNA of mouse brain, lung, liver, kidney, spleen, pancreas, and testis after repeated i.p. injections has been studied. Hydrolysates of DNA reacted with 14C-TRI in vitro and hydrolysates of RNA and DNA f...

journal_title：Archives of toxicology

authors： Bergman K

更新日期：1983-11-01 00:00:00

abstract：:Since tattoos became overwhelmingly fashionable worldwide, the demand for removal has proportionally increased, Nd:YAG Q-switch laser being the most commonly used tool for the purpose. In this framework we investigated the composition and products of laser treatment of green tattoo ink, the Green Concentrate from Eter...

journal_title：Archives of toxicology

authors： Bauer EM,Scibetta EV,Cecchetti D,Piccirillo S,Antonaroli S,Sennato S,Cerasa M,Tagliatesta P,Carbone M

更新日期：2020-07-01 00:00:00