Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28 days.

abstract：:UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) for various UGT isofo...

journal_title：Archives of toxicology

authors： Kasteel EEJ,Darney K,Kramer NI,Dorne JLCM,Lautz LS

更新日期：2020-08-01 00:00:00

abstract：:People living in damp buildings are typically exposed to spore and mycelial fragments of the fungi that grow on damp building materials. There is experimental evidence that this exposure to triple-helical (1, 3)-β-D glucan and low molecular weight toxins may be associated with non-atopic asthma observed in damp and mo...

journal_title：Archives of toxicology

authors： Rand TG,Robbins C,Rajaraman D,Sun M,Miller JD

更新日期：2013-10-01 00:00:00

abstract：:Cadmium (Cd), a highly toxic heavy metal, is distributed widely in the general environment of today. The characteristic clinical manifestations of chronic Cd intoxication include renal proximal tubular dysfunction, general osteomalacia with severe pains, and anemia. We have recently reported that the serum level of er...

journal_title：Archives of toxicology

authors： Horiguchi H,Sato M,Konno N,Fukushima M

更新日期：1996-01-01 00:00:00

abstract：:The kinetics of vitamin E was followed in serum, liver and kidney of 10- and 55-day-old rats after the administration of a single i.m. dose of 100 mg alpha-tocopherol acetate/100 g body wt. The basal levels without vitamin E administration were significantly higher in serum and liver of 10- than 55-day-old rats. The e...

journal_title：Archives of toxicology

authors： Appenroth D,Fröb S,Kersten L,Splinter FK,Winnefeld K

更新日期：1997-01-01 00:00:00

abstract：:The increasing number of man-made chemicals in the environment that may pose a carcinogenic risk emphasizes the need to develop reliable time- and cost-effective approaches for carcinogen detection. To address this issue, we have investigated the utility of human hepatocytes for the in vitro identification of genotoxi...

journal_title：Archives of toxicology

authors： Tryndyak V,Borowa-Mazgaj B,Beland FA,Pogribny IP

更新日期：2019-11-01 00:00:00

abstract：:Menadione is a naphthoquinone used as a vitamin K source in animal feed that can generate reactive oxygen species (ROS) and cause apoptosis. Here, we examined whether menadione reduces development of preimplantation bovine embryos in a ROS-dependent process and tested the hypothesis that actions of menadione would be ...

journal_title：Archives of toxicology

authors： Moss JI,Pontes E,Hansen PJ

更新日期：2009-11-01 00:00:00

abstract：:Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxicity and prevention. Metabolism and ...

journal_title：Archives of toxicology

authors： Kurebayashi H,Ohno Y

更新日期：2006-12-01 00:00:00

abstract：:The reversibility of quinolone-induced cartilage lesions has not been studied in detail. We treated five groups of five to seven juvenile Wistar rats (male and female; age: 5 weeks) with 2 x 600 mg ofloxacin/kg by gastric intubation on 1 day only (9:00 a.m. and 5:00 p.m.) and studied the knee joints histologically 3 d...

journal_title：Archives of toxicology

authors： Förster C,Kociok K,Shakibaei M,Merker HJ,Stahlmann R

更新日期：1996-01-01 00:00:00

abstract：:Platinum coordination complexes (PtCx) are potent against several types of cancer but are often nephrotoxic. With a view to developing a PtCx nephrotoxicity model, the toxicity of cisplatin (cDDP), transplatin (tDDP) and carboplatin (CBDCA) was studied in primary cultures of rabbit proximal tubule (RPT) cells and in t...

journal_title：Archives of toxicology

authors： Courjault F,Leroy D,Coquery L,Toutain H

更新日期：1993-01-01 00:00:00

abstract：:Teratogenic effects caused by a new nitroimidazopyridazine were examined in Wistar (WU) rats after repeated oral administration of 0, 2.5, 10, and 40 mg/kg, given on days 6-17 post coitum (p.c.) (Day of mating = Day 0) in a regular study on embryo-fetal development according to ICH S5A. At day 20 p.c., fetuses were re...

journal_title：Archives of toxicology

authors： Woehrmann T,Volland J,Tuch K,Bode G,Hübel U

更新日期：2006-07-01 00:00:00

abstract：:The α,β-unsaturated carbonyl group is recognized as alert for mutagenicity, attributed to (1) its direct reaction with DNA, counteractable by glutathione (GSH), and (2) oxidative stress caused indirectly by GSH depletion. Accordingly, the α,β,γ,δ-unsaturated lactone patulin (PAT), a mycotoxin detected in fruits and pr...

journal_title：Archives of toxicology

authors： Pfenning C,Esch HL,Fliege R,Lehmann L

更新日期：2016-02-01 00:00:00

abstract：: ...

journal_title：Archives of toxicology

authors： Murad W,Abbass T,Seddek AL

更新日期：2018-11-01 00:00:00

abstract：:The development of metabolically competent in vitro models is of utmost importance for predicting adverse drug reactions, thereby preventing attrition-related economical and clinical burdens. Using the antiretroviral drug nevirapine (NVP) as a model, this work aimed to validate rat hepatocyte 3D spheroid cultures as c...

journal_title：Archives of toxicology

authors： Pinheiro PF,Pereira SA,Harjivan SG,Martins IL,Marinho AT,Cipriano M,Jacob CC,Oliveira NG,Castro MF,Marques MM,Antunes AMM,Miranda JP

更新日期：2017-03-01 00:00:00

abstract：:The nephrotoxicity of 4-amino-3-S-glutathionylphenol (PAP-GSH), a known metabolite of 4-amino-phenol (PAP), was determined in male Fischer 344 rats. Administration of a single dose of 40 or 60 mumol kg-1 caused a marked elevation in blood urea nitrogen and an increase in the urinary excretion of glucose, protein and g...

journal_title：Archives of toxicology

authors： Fowler LM,Foster JR,Lock EA

更新日期：1994-01-01 00:00:00

abstract：:In mutagenicity testing of pharmaceuticals it is advisable, whenever possible, to use in vivo mammalian systems where the pharmacokinetic properties of a drug would be more or less similar to those in man. However, although there are a number of different genetic endpoints which are important in mutagen testing, suffi...

journal_title：Archives of toxicology

authors： Matter BE,Tsuchimoto T

更新日期：1980-11-01 00:00:00

abstract：:To examine the demethylation reaction of methylmercury (MeHg) in rat liver, slices prepared from MeHg-treated rats were incubated in L-15 medium under 95% O2/5% CO2 atmosphere. During the incubation, the amount of inorganic Hg in the slices markedly increased in a time-dependent manner, although the concentration of t...

journal_title：Archives of toxicology

authors： Yasutake A,Hirayama K

更新日期：2001-09-01 00:00:00

abstract：:A recent intervention study demonstrated the occurrence of irilone as second most abundant isoflavone next to daidzein in human plasma after consumption of a red clover-based dietary supplement (RCDS) containing predominately formononetin ≫ biochanin A > irilone (12 % of these isoflavones). To elucidate the relevance ...

journal_title：Archives of toxicology

authors： Lutter S,Schmalbach K,Esch HL,Lehmann L

更新日期：2014-02-01 00:00:00

abstract：:Male F344/DuCrj (Fischer) rats were given bisphenol A (BPA) in the diet at levels of 0 (control), 0.25, 0.50 and 1.00%, equivalent to 0, 235, 466 and 950 mg/kg per day, respectively, for 44 days. Body weight gains were depressed dose-dependently in BPA-treated rats, and those of 0.50 and 1.00% groups were significant....

journal_title：Archives of toxicology

authors： Takahashi O,Oishi S

更新日期：2001-03-01 00:00:00

abstract：:In a previous study, we showed that bisphenol A (BPA) had oestrogen-like effects in bird embryos, causing malformations of the oviducts in Japanese quail (Coturnix japonica) and feminisation of the left testis in chicken (Gallus domesticus). In this study, uptake and distribution of BPA and tetrabromobisphenol A (TBBP...

journal_title：Archives of toxicology

authors： Halldin K,Berg C,Bergman A,Brandt I,Brunström B

更新日期：2001-12-01 00:00:00

abstract：:Chronic ciprofibrate administration resulted in distinct differences in hepatic responses between the two species examined. In the rat, hepatomegaly was observed with the coordinate induction of carnitine acetyltransferase, peroxisomal beta-oxidation and cytochrome P450IVA1 activities. The latter induction of cytochro...

journal_title：Archives of toxicology

authors： Makowska JM,Bonner FW,Gibson GG

更新日期：1991-01-01 00:00:00

abstract：:This study examined the effect of tamoxifen, an anti-breast cancer drug, on Ca2+ handling in bladder female transitional cancer cells. Changes in cytosolic free Ca2+ levels were recorded by using the Ca2+-sensitive dye fura-2. In a dose-dependent manner, tamoxifen induced intracellular free Ca2+ concentrations ([Ca2+]...

journal_title：Archives of toxicology

authors： Chang HT,Huang JK,Wang JL,Cheng JS,Lee KC,Lo YK,Lin MC,Tang KY,Jan CR

更新日期：2001-05-01 00:00:00

abstract：:The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of t...

journal_title：Archives of toxicology

authors： Nakanishi S,Shiohara E,Tsukada M,Yamazaki H,Nishiguchi K,Saladin R

更新日期：1979-12-01 00:00:00

abstract：:Although polybrominated naphthalenes (PBNs) are contaminants of the commercial fire retardant fireMaster BP-6, the individual PBN isomers have not been identified. In order to study PBNs possessing an analogous level of bromination to those found in fireMaster BP-6, three synthetic PBN mixtures, averaging 5.0, 5.3, an...

journal_title：Archives of toxicology

authors： Robertson LW,Thompson K,Parkinson A

更新日期：1984-07-01 00:00:00

abstract：:Cyclohexylmethylphosphonofluoridate (cyclosarin) is a highly toxic organophosphate, which was shown to be rather resistant to conventional oxime therapy. To give more insight into the inhibition, reactivation and aging kinetics, human acetyl-(AChE) and butyrylcholinesterase (BChE) were inhibited by cyclosarin (k2 of 7...

journal_title：Archives of toxicology

authors： Worek F,Eyer P,Szinicz L

更新日期：1998-09-01 00:00:00

abstract：:Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. The aim of this study was to compare the toxic effects of the two drugs on hepatocytes in primary culture as a function of their metabolism and to explore the variations...

journal_title：Archives of toxicology

authors： Ellouk-Achard S,Martin C,Duc HT,Dutertre-Catella H,Thevenin M,Warnet JM,Claude JR

更新日期：1998-04-01 00:00:00

abstract：:A histochemical technique for detection of the in vivo induced cellular aldehydes based on the direct Schiff's reaction is reported in this paper. CCl4-intoxicated rat liver was used as an experimental model. Fresh and non-pretreated rat liver cryostat sections fixed in 10% formol calcium solution and washed in distil...

journal_title：Archives of toxicology

authors： Taper HS,Somer MP,Lans M,de Gerlache J,Roberfroid M

更新日期：1988-04-01 00:00:00

abstract：:Glucose is a major energy source for the entire body, while fructose metabolism occurs mainly in the liver. Fructose consumption has increased over the last decade globally and is suspected to contribute to the increased incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD is a manifestation of metabolic synd...

journal_title：Archives of toxicology

authors： Alwahsh SM,Gebhardt R

更新日期：2017-04-01 00:00:00

abstract：:Gebel (In Arch Toxicol 87(5):923-924, 2013) replied to my Letter to the Editor (Morfeld in Arch Toxicol 87(5):921, 2013) in which I criticized the quantitative review of inhalation rat studies on the association of granular biopersistent dust exposures and lung cancer risk (Gebel in Arch Toxicol 86(7):995-1007, 2012)....

journal_title：Archives of toxicology

authors： Morfeld P

更新日期：2013-11-01 00:00:00

abstract：:Carbon tetrachloride (CCl4) caused a dose-dependent increase in urinary taurine which correlated with both the histological and biochemical assessment of liver damage. The peak elevation in urinary taurine occurred within the first 48 h after dosing but there was still significant taurinuria 72 and 96 h after the inte...

journal_title：Archives of toxicology

authors： Waterfield CJ,Turton JA,Scales MD,Timbrell JA

更新日期：1991-01-01 00:00:00

abstract：:Female C57/BL/6 x DBA/2 hybrid mice were exposed to two concentrations (270 and 135 ppm) of tetrachloroethylene (PER) in inhalation chambers for 6 h/day, 5 days per week, up to 11.5 weeks (270 ppm) and 7.5 weeks (135 ppm), respectively, followed by a 3-week exposure-free period. In the peripheral blood a reduction of ...

journal_title：Archives of toxicology

authors： Seidel HJ,Weber L,Barthel E

更新日期：1992-01-01 00:00:00