Genetic control of responsiveness of rat liver supernatant aldehyde dehydrogenase to phenobarbital and 3-methylcholanthrene.

abstract：:The activity of 18 vitamin D analogs on soft tissue calcification and growth impairment in neonatal rats and their effect on bone calcium mobilization, intestinal calcium absorption and binding to intestinal 1,25-dihydroxyvitamin D3 receptors in adult rats were compared. Depending on the chemical modification of the v...

journal_title：Archives of toxicology

authors： Kistler A,Galli B,Horst R,Truitt GA,Uskoković MR

更新日期：1989-01-01 00:00:00

abstract：:pp'DDT (600 mg/kg, orally) produced an increase in the level of free ammonia and a decrease of acetylcholine in the corpus striatum of rats. These effects were maximal 5 h after the administration of pp'DDT. The animals showed tremors after 2 h, mild or moderate convulsions after 3.5 h and severe convulsions 5 h after...

journal_title：Archives of toxicology

authors： Matin MA,Jaffery FN,Kar PP

更新日期：1980-05-01 00:00:00

abstract：:Primary human hepatocytes (hHeps) are still gold standard to perform human drug metabolism studies, but their availability is limited by donor organ scarcity. Therefore, hepatoma cell lines are widely used as alternatives, although their phases I and II drug-metabolizing activities are substantially lower compared wit...

journal_title：Archives of toxicology

authors： Lin J,Schyschka L,Mühl-Benninghaus R,Neumann J,Hao L,Nussler N,Dooley S,Liu L,Stöckle U,Nussler AK,Ehnert S

更新日期：2012-01-01 00:00:00

abstract：:The effects of equimolar doses of the triphenylethylene antiestrogens tamoxifen and toremifene on female Sprague-Dawley rat liver were studied in a 52-week toxicity study which included a 13-week recovery period. Liver tumors were found in four out of five rats at the highest dose level of tamoxifen (45 mg/kg per day)...

journal_title：Archives of toxicology

authors： Hirsimäki P,Hirsimäki Y,Nieminen L,Payne BJ

更新日期：1993-01-01 00:00:00

abstract：: ...

journal_title：Archives of toxicology

authors： Murad W,Abbass T,Seddek AL

更新日期：2018-11-01 00:00:00

abstract：:Etoposide (ETP) and anthracyclines are applied for wide anti-cancer treatments. However, the ETP-induced cardiotoxicity remains to be a major safety issue and the underlying cardiotoxic mechanisms are not well understood. This study is aiming to unravel the cardiotoxicity profile of ETP in comparison to anthracyclines...

journal_title：Archives of toxicology

authors： Nemade H,Chaudhari U,Acharya A,Hescheler J,Hengstler JG,Papadopoulos S,Sachinidis A

更新日期：2018-04-01 00:00:00

abstract：:A new strategy for the evaluation of mixtures is presented. The mixture used was the organic extract of diesel exhaust particles (DEP). After extraction with dichloromethane (DCM), the crude extract was fractionated according to polarity into five fractions: aliphatic hydrocarbons, polycyclic aromatic hydrocarbons (PA...

journal_title：Archives of toxicology

authors： Ostby L,Engen S,Melbye A,Eide I

更新日期：1997-01-01 00:00:00

abstract：:Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...

journal_title：Archives of toxicology

authors： Brotzmann K,Wolterbeek A,Kroese D,Braunbeck T

更新日期：2020-10-27 00:00:00

abstract：:Membrane transporters play an important role in the absorption, distribution, metabolism and excretion of drugs. The cellular accumulation of many drugs is the result of the net function of efflux and influx transporters. Efflux transporters such as P-glycoprotein/ABCB1 have been shown to confer multidrug resistance i...

journal_title：Archives of toxicology

authors： Windt T,Tóth S,Patik I,Sessler J,Kucsma N,Szepesi Á,Zdrazil B,Özvegy-Laczka C,Szakács G

更新日期：2019-04-01 00:00:00

abstract：:Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log(10) blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the med...

journal_title：Archives of toxicology

authors： Krieg EF Jr,Chrislip DW,Brightwell WS

更新日期：2008-08-01 00:00:00

abstract：:Airway smooth muscle (ASM) cell phenotypic switching played an important role in airway remodeling in asthma. In vitro platelet-derived growth factor (PDGF) induced ASM cell phenotypic switching from a mature to pro-remodeling phenotype, but the mechanism remained incompletely understood. This study was to explore the...

journal_title：Archives of toxicology

authors： Ning Y,Huang H,Dong Y,Sun Q,Zhang W,Xu W,Li Q

更新日期：2013-05-01 00:00:00

abstract：:Second order rate constants for the initial reaction of 12 mammalian oxyhemoglobins (Hb) with equimolar phenylhydrazine (PHZ), a compound inducing Heinz body hemolytic anemia, were determined by recording continuous changes in absorbance with time at 577 nm. The rate constants were varied in a range from 43 m-1.s-1 wi...

journal_title：Archives of toxicology

authors： Kinuta M,Matteson JL,Itano HA

更新日期：1995-01-01 00:00:00

abstract：:Although polybrominated naphthalenes (PBNs) are contaminants of the commercial fire retardant fireMaster BP-6, the individual PBN isomers have not been identified. In order to study PBNs possessing an analogous level of bromination to those found in fireMaster BP-6, three synthetic PBN mixtures, averaging 5.0, 5.3, an...

journal_title：Archives of toxicology

authors： Robertson LW,Thompson K,Parkinson A

更新日期：1984-07-01 00:00:00

abstract：:To reveal the molecular mechanism of deficit in learning and memory induced by chronic fluorosis, the expression of muscarinic acetylcholine receptors (mAChRs) and oxidative stress were investigated. Sixty Sprague-Dawley (SD) rats were divided randomly into two groups (30 cases in each), i.e., the control group (<0.5 ...

journal_title：Archives of toxicology

authors： Dong YT,Wang Y,Wei N,Zhang QF,Guan ZZ

更新日期：2015-11-01 00:00:00

abstract：:Previous studies in our laboratory identified retinoid-induced defects that are mediated by RAR-RXR heterodimerization using interaction of synthetic ligands selective for the retinoid receptors RAR and RXR in mice (Elmazar et al. 1997, Toxicol Appl Pharmacol 146:21-28; Elmazar et al. 2001, Toxicol Appl Pharmacol 170:...

journal_title：Archives of toxicology

authors： Elmazar MM,Nau H

更新日期：2004-11-01 00:00:00

abstract：:Environmental carcinogens-induced lung cancer and potential mechanisms have attracted widespread attention. Currently, microRNAs (miRNAs) have been recognized as key players in development of cancer, among which guide strand of miRNA has been well documented rather than its passenger strand (miRNA*). Our previous stud...

journal_title：Archives of toxicology

authors： Wang Y,Zhang Z,Wang H,Zhang Y,Ji M,Xu H,Wang C,Sun Z,Gao W,Wang SL

更新日期：2016-05-01 00:00:00

abstract：:Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address. Specifically, this study investigated the cytoto...

journal_title：Archives of toxicology

authors： Tomiyama KI,Funada M

更新日期：2020-11-10 00:00:00

abstract：:Cocaine is an intrinsic hepatotoxin in laboratory animals, and there is growing evidence that high doses of cocaine can precipitate hepatic necrosis in humans. The rodent model of cocaine hepatotoxicity is commensurate with the concept that a multistep mainly cytochrome P-450 dependent N-oxidative pathway is responsib...

journal_title：Archives of toxicology

authors： Boelsterli UA,Göldlin C

更新日期：1991-01-01 00:00:00

abstract：:Aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, has been studied extensively in carcinogenesis through the genomic pathway. In recent years, AHR has also been reported to exert positive or negative effects on epithelial-mesenchymal transition (EMT), the crucial step in tumor malignant progres...

journal_title：Archives of toxicology

authors： Li CH,Liu CW,Tsai CH,Peng YJ,Yang YH,Liao PL,Lee CC,Cheng YW,Kang JJ

更新日期：2017-05-01 00:00:00

abstract：:Cyclic AMP (c-AMP), added on its own to rat hepatocyte cultures, caused a marked accumulation of coproporphyrin III. The results obtained by comparing the effect of c-AMP to that of exogenous 5-aminolevulinate (ALA), and from adding c-AMP and ALA together, indicated that the coproporphyrinogen III metabolism was block...

journal_title：Archives of toxicology

authors： De Matteis F,Harvey C

更新日期：2005-07-01 00:00:00

abstract：:Treatment of cats with acrylamide, either 7.5 or 15 mg/kg IM, once a day for 10 days, resulted in increases of 31 and 47% in the phospholipid content of sciatic nerve, respectively, from a control level of 41.1 +/- 2.7 mg/kg wet weight. Determination of the distribution of individual phospholipids indicated no signifi...

journal_title：Archives of toxicology

authors： Howland RD,Lowndes HE

更新日期：1984-09-01 00:00:00

abstract：:Previously we reported that exposure of mouse and human mast cells to aryl hydrocarbon receptor (AhR) ligands resulted in reactive oxygen species (ROS)- and calcium (Ca2+)-dependent activation of mast cells in vitro and in vivo. However, the mechanisms through which the AhR-ligand axis mediates stress response, Ca2+ s...

journal_title：Archives of toxicology

authors： Wang HC,Zhou Y,Huang SK

更新日期：2017-04-01 00:00:00

abstract：:Many carcinogens and mutagens are electrophilic in nature and will react with nucleophilic sites in protein and nucleic acid. Determination of the extent of formation of these adducts of genotoxic agents with protein provides a practical method of monitoring human exposure and of determining the possible risk associat...

journal_title：Archives of toxicology

authors： Bailey E,Farmer PB,Shuker DE

更新日期：1987-01-01 00:00:00

abstract：:The neurological effects of four synthetic pyrethroids resmethrin, permethrin, cypermethrin, and deltamethrin have been investigated in the rat to establish whether there is a correlation between the clinical-functional status of the animal and peripheral nerve damage as measured biochemically. Neuromuscular dysfuncti...

journal_title：Archives of toxicology

authors： Rose GP,Dewar AJ

更新日期：1983-08-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) is known to influence vitamin A homeostasis. In order to investigate the mechanism behind this retinoid disruption, male Sprague-Dawley rats were exposed to TCDD at doses ranging from 0.1 to 100 micro g/kg body weight, and were killed 3 days after exposure. Additional groups...

journal_title：Archives of toxicology

authors： Schmidt CK,Hoegberg P,Fletcher N,Nilsson CB,Trossvik C,Håkansson H,Nau H

更新日期：2003-07-01 00:00:00

abstract：:This review provides a compendium of the results of genotoxicity and carcinogenicity assays performed on marketed antihistamines. Of the 70 drugs examined, 29 (41.4%) have at least one genotoxicity and/or carcinogenicity test result: 12 tested positive in at least one genotoxicity assay, six in at least one carcinogen...

journal_title：Archives of toxicology

authors： Brambilla G,Mattioli F,Robbiano L,Martelli A

更新日期：2011-10-01 00:00:00

abstract：:The binding characteristics of [14C]ortho-toluidine (OT), a suspect human carcinogen, were investigated in male Sprague-Dawley rats. Rats were administered [14C]OT i.p. at 10, 20, 40, 50, or 100 mg/kg body weight, then sacrificed at 2, 4, 8, 18, 24, 48, or 72 h, or 7, 14, or 28 days. Hemoglobin (Hb) and albumin (Alb) ...

journal_title：Archives of toxicology

authors： DeBord DG,Swearengin TF,Cheever KL,Booth-Jones AD,Wissinger LA

更新日期：1992-01-01 00:00:00

abstract：:Nine bispyridinium oximes containing two pyridinium rings linked by dimethylether were synthesised. Each compound had on one of the pyridinium rings a hydroxyiminomethyl group in position 2 or 4, while the other ring was unsubstituted or had a methyl or a hydroxyiminomethyl group in position 2 or 4. The reactivating p...

journal_title：Archives of toxicology

authors： Simeon V,Wilhelm K,Granov A,Besarović-Lazarev S,Buntić A,Fajdetić A,Binenfeld Z

更新日期：1979-02-23 00:00:00

abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...

journal_title：Archives of toxicology

authors： Nordgren I,Bergström M,Holmstedt B,Sandoz M

更新日期：1978-10-13 00:00:00

abstract：:The asexual freshwater planarian Dugesia japonica has emerged as a medium-throughput alternative animal model for neurotoxicology. We have previously shown that D. japonica are sensitive to organophosphorus pesticides (OPs) and characterized the in vitro inhibition profile of planarian cholinesterase (DjChE) activity ...

journal_title：Archives of toxicology

authors： Hagstrom D,Zhang S,Ho A,Tsai ES,Radić Z,Jahromi A,Kaj KJ,He Y,Taylor P,Collins ES

更新日期：2018-03-01 00:00:00