Abstract:
:Treatment of cats with acrylamide, either 7.5 or 15 mg/kg IM, once a day for 10 days, resulted in increases of 31 and 47% in the phospholipid content of sciatic nerve, respectively, from a control level of 41.1 +/- 2.7 mg/kg wet weight. Determination of the distribution of individual phospholipids indicated no significant differences between control cats and those receiving a cumulative dose of 150 mg/kg acrylamide. In a separate experiment, cats were treated with the 150 mg/kg dose of acrylamide and the sciatic nerve was divided into proximal and distal portions at the level of the triceps surae nerve. Significant increases in phospholipid content were observed in both the proximal and distal portions of peripheral nerve of the acrylamide-intoxicated cats. This effect was present even when the phospholipid content was expressed in terms of total protein, dry weight or total lipid. Total weight of nerve segments, however, was significantly decreased in the neuropathic animals. The data are consistent with a focal degeneration of axons with relative sparing of phospholipids.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Howland RD,Lowndes HEdoi
10.1007/BF00316124subject
Has Abstractpub_date
1984-09-01 00:00:00pages
178-81issue
3eissn
0340-5761issn
1432-0738journal_volume
55pub_type
杂志文章abstract::The effects of diabetes on cytochrome P450 (CYP)-dependent drug metabolizing enzymes are yet to be clarified. The most widely used animals in these studies have been rats, and information on the effects of diabetes on rabbit liver drug metabolizing enzymes have been unavailable until now. In this study, for the first ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-005-0654-8
更新日期:2005-08-01 00:00:00
abstract::The toxic effect of cyclophosphamide on the proliferative cell population of hair follicles plucked from the human scalp was examined by the in vivo nuclear aberration assay. Patients participating in an independent clinical trial received oral low dose cyclophosphamide, intravenous high dose cyclophosphamide or oral ...
journal_title:Archives of toxicology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01974396
更新日期:1990-01-01 00:00:00
abstract::In case of mycotoxin contaminations, food and feedstuff are usually contaminated by more than one toxin. However toxicological data concerning the effects of mycotoxin combinations are sparse. The intestinal epithelium is the first barrier against food contaminants and this constantly renewing organ is particularly se...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1309-4
更新日期:2015-08-01 00:00:00
abstract::The "closed chamber technique" (CCT) is presented. It allows investigation of pharmacokinetics of volatile substances in vivo in animals and in man and in vitro using tissue fractions. During the exposure period only the atmospheric concentrations of the substance are measured. The concentration-time data obtained are...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/BF02307263
更新日期:1992-01-01 00:00:00
abstract::The implementation of the Chemical Weapon Convention (CWC), prohibiting the development, production, storage and use of chemical weapons by 192 nations and the ban of highly toxic OP pesticides, especially class I pesticides according to the WHO classification, by many countries constitutes a great success of the inte...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1772-1
更新日期:2016-09-01 00:00:00
abstract::Renal papillary necrosis (RPN) was induced in Fischer 344 (F344) rats (n = 4) using 2-bromoethanamine hydrobromide (BEA) dosed at 150 mg/kg, and in multimammate desert mice (Mastomys natalensis) at 150 and 250 mg/kg (n = 4 per group). Control rats and Mastomys were dosed with 0.9% saline (n = 4 per group). Urine was c...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02733668
更新日期:1995-01-01 00:00:00
abstract::Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0095-z
更新日期:2006-10-01 00:00:00
abstract::Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). The presently available oximes, obidoxime and pralidoxime (2-PAM), are considered to be insufficient for highly toxic OPs, e.g. sari...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-002-0375-1
更新日期:2002-09-01 00:00:00
abstract::Xenobiotic induced liver injury is a leading cause for drug withdrawal and toxicogenomics may help to identify molecular causes. Here we report studies with cultures of human hepatocytes to detect early responses of liver toxicity upon treatment with the hepatotoxin Aroclor 1254. We studied transcript abundance of 302...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0234-1
更新日期:2008-02-01 00:00:00
abstract::Liquorice [main ingredient, glycyrrhizin (GL)] is widely used as a food sweetener and herbal medicine. Occasionally, liquorice consumption causes pseudoaldosteronism as a side effect which causes oedema, hypokalaemia, and hypertension due to hyperactivity of mineral corticoid receptor. We aimed to detect GL metabolite...
journal_title:Archives of toxicology
pub_type: 杂志文章,meta分析
doi:10.1007/s00204-019-02588-2
更新日期:2019-11-01 00:00:00
abstract::Using male ICR mice, the LC50 and acute and subacute inhalation toxicity of dichlorosilane (SiH2Cl2, DCS) and the fate of DCS released into the air were investigated. DCS resolved and minute particles including silicon and chloride were observed, when DCS was released into the air. Most particles were under 1 micron i...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050263
更新日期:1996-01-01 00:00:00
abstract::This study was performed to assess the relation between occupational exposure to N,N-dimethylformamide after an 8 h work shift in the acrylic fibre industry and its three biological markers N-methylformamide (NMFtotal), N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC), and N-methylcarbamoyl adduct at haemoglobin (MCVal)....
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2219-7
更新日期:2018-07-01 00:00:00
abstract::The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicin-induced histopathologic changes in renal tissue were examine in rats. Gentamicin (30, 60, 120, 160 mg/kg) was administered s.c. for 10 consecutive days with or without isosorbide pretreatment. Osmotic diuresis with ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02419001
更新日期:1980-09-01 00:00:00
abstract::The nephrotoxicity of 4-amino-3-S-glutathionylphenol (PAP-GSH), a known metabolite of 4-amino-phenol (PAP), was determined in male Fischer 344 rats. Administration of a single dose of 40 or 60 mumol kg-1 caused a marked elevation in blood urea nitrogen and an increase in the urinary excretion of glucose, protein and g...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF03035706
更新日期:1994-01-01 00:00:00
abstract::Darbepoetin (DPO), an erythropoietin (EPO) derivative, was licensed in 2002 to treat patients with solid tumors suffering from chemotherapy-dependent anemia, although various tumors express EPO to improve vascularization, thus favoring tumor growth and spreading. Therefore, we wanted to investigate direct effects of D...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1094-5
更新日期:2014-01-01 00:00:00
abstract::A recent study reported that exposure of student embalmers in Cincinnati to high concentrations of formaldehyde (2 mg/m3) reduced the activity of the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT). Reduction in a DNA repair enzyme may strongly increase the cancer risk not only with respect to the rep...
journal_title:Archives of toxicology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s002040050581
更新日期:1999-02-01 00:00:00
abstract::Liver microsomes were prepared from Wistar rat by the Ca2+ aggregation method. Under various conditions, ethyl mercury chloride (EtHgCl) or methyl mercury chloride (MeHgCl) was incubated with the microsomal preparations. After the incubation, the amounts of inorganic Hg and hydroxyl radical (.OH) in the preparations w...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02035129
更新日期:1992-01-01 00:00:00
abstract::Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions. These epoxy FAs comprise epoxyeicosatrienoic acids (EETs) and epoxy-octadeceno...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2060-4
更新日期:2017-11-01 00:00:00
abstract::MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In our study, we investigat...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-012-1004-2
更新日期:2013-05-01 00:00:00
abstract::Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biologica...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02746-x
更新日期:2020-06-01 00:00:00
abstract::Cholestasis underlies one of the major manifestations of drug-induced liver injury. Drug-induced cholestatic liver toxicity is a complex process, as it can be triggered by a variety of factors that induce 2 types of biological responses, namely a deteriorative response, caused by bile acid accumulation, and an adaptiv...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-019-02437-2
更新日期:2019-05-01 00:00:00
abstract::The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined. Exposure of cultured mouse hepatocytes to DDC, EDDC or griseofulvin resulted in a marked ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01974011
更新日期:1992-01-01 00:00:00
abstract::Perfluorocarboxylic acids (PFCAs) including perfluorooctanoic acid (PFOA) are environmental pollutants showing high accumulation, thermochemical stability and hepatocarcinogenicity. Peroxisome proliferator-activated receptor α is suggested to mediate their toxicities, but the precise mechanism remains unclear. Previou...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1888-3
更新日期:2017-06-01 00:00:00
abstract::The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-015-1470-4
更新日期:2015-05-01 00:00:00
abstract::The cadmilm-induced (Cd) damage of mammalian testes is thought to be correlated with an inhibition of carbonic anhydrase (CAH) by Cd. Since Cd causes dose-dependent changes in blood flow of the testes, an inhibition of CAH in the testes could be simulated by a decrease of CAH-rich erythrocytes. Therefore, CAH activiti...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00353353
更新日期:1976-12-23 00:00:00
abstract::Treatment of tuberculosis (TB) has been a therapeutic challenge because of not only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also the newly acquired mutations that confer further resistance. Currently standardized regimens require patients to daily ingest up to four drugs un...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1727-6
更新日期:2016-07-01 00:00:00
abstract::Carcinogenic risk and molecular mechanisms underlying the liver tumor-promoting activity of copper gluconate, an additive of functional foods, were investigated using a rat medium-term liver carcinogenicity bioassay protocol (Ito test) and a 2-week short-term administration experiment. In the medium-term liver bioassa...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0294-x
更新日期:2008-08-01 00:00:00
abstract::Previous histomorphometric studies led us to hypothesize that suppression of hepatocellular regeneration and the repair of the hepatolobular architecture was involved besides bioactivation phenomenon in the progressive and irreversible phase of toxicity resulting from CD + CCl4 interaction. We have recently observed s...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00303125
更新日期:1989-01-01 00:00:00
abstract::Increasing incidence of multidrug-resistant bacteria presents an imminent risk to global health. Polymyxins are 'last-resort' antibiotics against Gram-negative 'superbugs'; however, nephrotoxicity remains a key impediment in their clinical use. Molecular mechanisms underlying this nephrotoxicity remain poorly defined....
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2192-1
更新日期:2018-07-01 00:00:00
abstract::This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a seco...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-013-1078-5
更新日期:2013-08-01 00:00:00