Abstract：
:Many carcinogens and mutagens are electrophilic in nature and will react with nucleophilic sites in protein and nucleic acid. Determination of the extent of formation of these adducts of genotoxic agents with protein provides a practical method of monitoring human exposure and of determining the possible risk associated with the exposure. Proteins are predominantly attacked on the cysteine, histidine and N-terminal amino acids. Hemoglobin is the most suitable protein for dose monitoring due to its ready availability and its long lifetime. Methods have been developed using capillary gas chromatography with mass spectrometry for determining S-methylcysteine, Nr-[2-hydroxyethyl]histidine and Nr-[2-hydroxypropyl]histidine in hemoglobin, allowing the monitoring of in vivo exposure of laboratory animals and humans to methylating agents, ethylene oxide and propylene oxide, respectively. A method for monitoring exposure to acrylamide has also been devised based on the determination by gas chromatography-mass spectrometry of the adduct formed with cysteine residues in hemoglobin. An alternative method of dose monitoring of some methylating agents by the measurement of the urinary N-7-methylated guanine derived from alkylated DNA breakdown products has also been investigated.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Bailey E,Farmer PB,Shuker DEdoi
10.1007/BF00296978subject
Has Abstractpub_date
1987-01-01 00:00:00pages
187-91issue
1-3eissn
0340-5761issn
1432-0738journal_volume
60pub_type
杂志文章abstract：:The effect of acetone pretreatment (5% in drinking water for 10 days on rat liver metabolism and toxicity of thiobenzamide (TB) was investigated. Hepatic microsomes from acetone-pretreated rats showed a significant increase of TB-S-oxidation rate which, on the basis of selective thermal inactivation of FAD-containing ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974397
更新日期：1990-01-01 00:00:00
abstract：:The toxic effect of cadmium varies with sex in experimental animals. Previous studies have demonstrated that pretreatment of male Fischer 344 (F344) rats with the female sex hormone progesterone markedly enhances the susceptibility to cadmium, suggesting a role for progesterone in the sexual dimorphism of cadmium toxi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0844-0
更新日期：2012-09-01 00:00:00
abstract：:Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0095-z
更新日期：2006-10-01 00:00:00
abstract：:Chronic exposure to propiverine, a frequently prescribed pharmaceutical for treatment of overactive bladder and incontinence, provokes massive protein accumulation in the cytosol and nucleus of renal proximal tubule epithelial cells in rats. Previously, the accumulating protein was identified as D-amino acid oxidase (...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1685-z
更新日期：2017-01-01 00:00:00
abstract：:A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). The molecular and cellular events by which PPARα activators induce rodent hepatocarcinogenesis have been extensively studied elucidating a...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-017-2094-7
更新日期：2018-01-01 00:00:00
abstract：:The effect of methantheline, a quaternary ammonium compound, on the reactivation by HI 6 of soman-inhibited human erythrocyte acetylcholinesterase (AChE) was investigated in vitro using purified human erythrocyte AChE or washed human erythrocytes. Methantheline itself was found to be a mixed competitive/non-competitiv...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050243
更新日期：1995-01-01 00:00:00
abstract：:The toxicity of 60 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) given IP in corn oil/5% acetone was examined in male Sprague-Dawley rats adapted to 25 degrees C or 4 degrees C ambient temperature. Cold exposure significantly reduced mean time to death and tended to increase mortality. Body weight at the ti...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290540
更新日期：1986-12-01 00:00:00
abstract：:Reactive oxygen species are generated during ischaemia-reperfusion of tissue. Oxidation of thymidine by hydroxyl radicals (HO) leads to the formation of 5,6-dihydroxy-5,6-dihydrothymidine (thymidine glycol). Thymidine glycol is excreted in urine and can be used as biomarker of oxidative DNA damage. Time dependent chan...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050638
更新日期：1999-11-01 00:00:00
abstract：: ...
journal_title：Archives of toxicology
pub_type： 评论,信件
doi：10.1007/s00204-018-2384-8
更新日期：2019-01-01 00:00:00
abstract：:Aciclovir (synonym: acyclovir) causes abnormal thymus development in rats. After treatment on day 10 of gestation a weight reduction of the organ is obvious in 21-day-old fetuses which persists postnatally. Adult male rats exposed in utero to one or three injections of 100 mg aciclovir/kg body wt given to the dam on d...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973385
更新日期：1992-01-01 00:00:00
abstract：:Although carbon nanotubes (CNTs) are promising nanomaterials, their potential carcinogenicity is a major concern. We previously established a genetic method of analyzing genotoxicity of chemical compounds, where we evaluated their cytotoxic effect on the DT40 lymphoid cell line comparing DNA-repair-deficient isogenic ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1084-7
更新日期：2014-01-01 00:00:00
abstract：:The use of nanotechnology is increasing exponentially, whereas the possible adverse health effects of engineered nanoparticles (NPs) are so far less known. Standardized mouse bioassay was used to study sensory and pulmonary irritation, airflow limitation, and inflammation potency of nanosized TiO(2). Single exposure (...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0644-y
更新日期：2011-07-01 00:00:00
abstract：:A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented. In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposu...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050072
更新日期：1994-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050131
更新日期：1994-01-01 00:00:00
abstract：:This study was conducted to determine the functional role of phospholipase D (PLD) involved in testicular Leydig cell damage caused by di (2-ethylhexyl) phthalate (DEHP) in Sprague-Dawley rats. DEHP (500 mg/kg/day) was administered orally to prepubertal rats for 1, 7, 14, 21 or 28 days. After 7 days of exposure, DEHP ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0618-5
更新日期：2011-08-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02547-x
更新日期：2019-10-01 00:00:00
abstract：:Although the tumor-promoting effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), coplanar polychlorinated biphenyls (PCBs), and related compounds in liver tissue are primarily attributed to the activation of the aryl hydrocarbon receptor (AhR), the underlying molecular mechanisms are still unclear. Liver progenitor...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0979-z
更新日期：2013-04-01 00:00:00
abstract：:Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01234482
更新日期：1983-12-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316261
更新日期：1988-08-01 00:00:00
abstract：:The present study was designed to evaluate the possible protective effects of 3,3'-diselenodipropionic acid (DSePA), a potent radioprotector, against oxidative organ damage induced by whole body γ-irradiation and explore its mechanistic effects. The mice were subjected to whole body γ-irradiation at 5 Gy for the detec...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0687-0
更新日期：2011-11-01 00:00:00
abstract：:This study was carried out to investigate the effect of in utero exposure to the cholinotoxicants, nicotine and chlorpyrifos, alone or in combination on neurobehavioral alterations and neuronal morphology latter in adult age. In the present study, 90 days old (corresponding to a human adult age) male and female offspr...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0077-1
更新日期：2006-09-01 00:00:00
abstract：:Pyrrolizidine alkaloids (PAs) are widely occurring phytotoxins which can induce severe liver damage in humans and other mammalian species by mechanisms that are not fully understood. Therefore, we investigated the development of PA hepatotoxicity in vivo, using an acutely toxic dose of the PA senecionine in mice, in c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02582-8
更新日期：2020-01-01 00:00:00
abstract：:Etridiazole, 5-ethoxy-3-trichloromethyl-1,2,4-thiadiazole, was orally administered to rats and human volunteers. Two metabolites of etridiazole were synthesized: 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid (ET-CA) and N-acetyl-S-(5-ethoxy-1,2,4-thiadiazol-3-yl-methyl)-L-cysteine (ET-MA). Selective and sensitive analy...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02098027
更新日期：1991-01-01 00:00:00
abstract：:Fumonisin B1 (FB1) is a well-known inhibitor of de novo sphingolipid biosynthesis, due to its ability to inhibit ceramide synthases (CerS) activity. In mammals, this toxin triggers broad clinical symptoms with multi-organ dysfunction such as hepatotoxicity or pulmonary edema. The molecular mechanism of CerS inhibition...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1323-6
更新日期：2015-09-01 00:00:00
abstract：:It is estimated that only a few marketed drugs are able to directly induce liver steatosis. However, many other drugs may exacerbate or precipitate fatty liver in the presence of other risk factors or in patients prone to non-alcoholic fatty liver disease. On the other hand, current in vitro tests for drug-induced ste...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1197-7
更新日期：2014-04-01 00:00:00
abstract：:Overdose of acetaminophen (APAP) causes necrosis of centrilobular cells of the liver. Accumulating evidence suggests that innate immune system may contribute to APAP-induced hepatotoxicity. Interaction between RANTES and its receptor C-C chemokine receptor (CCR) 5 is related to recruitment of macrophages to sites of i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1253-3
更新日期：2015-02-01 00:00:00
abstract：:The aim of our study was to determine the period of maximum sensitivity for the induction of characteristic malformations with thalidomide (TH) in Himalayan rabbits. TH was administered orally in different doses (50, 100, 150 and 200 mg/kg) four times at 24-h intervals starting at 192 h of gestation. The malformations...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00295758
更新日期：1987-07-01 00:00:00
abstract：:The effects of cadmium exposure during pregnancy (by means of daily subcutaneous injections of 4.4 mumol/kg to the mother) on the neonates were investigated. No effect was observed on fetal or neonatal body weights, nor on neonatal liver weights. These parameters were examined up to 5 weeks after birth. The weight of ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00334632
更新日期：1989-01-01 00:00:00
abstract：:4, 4'-Methylenedianiline (MDA) is used extensively as a curing agent in the production of elastomers and is classified as reasonably anticipated to be a human carcinogen based on sufficient evidence in animal experiments. Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the N-acetylation of aromatic amines and...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02516-4
更新日期：2019-08-01 00:00:00
abstract：:Deoxynivalenol (DON) contamination in food is a public health concern; however, the effect of DON exposure on immune disorders including allergies remains unclear. The aim of this study is to elucidate the effect of oral exposure to DON on pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermat...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02875-3
更新日期：2020-12-01 00:00:00
