Abstract:
:Aciclovir (synonym: acyclovir) causes abnormal thymus development in rats. After treatment on day 10 of gestation a weight reduction of the organ is obvious in 21-day-old fetuses which persists postnatally. Adult male rats exposed in utero to one or three injections of 100 mg aciclovir/kg body wt given to the dam on day 10 of pregnancy showed a reduction of the thymus weight to 333 +/- 158 mg and 276 +/- 61 mg (control: 428 +/- 92 mg; n = 10). Corresponding alterations were detectable in female offspring. Liver weight was also decreased and spleen weight (in relation to body wt) was significantly increased in the offspring after the three exposures. In a host resistance model with Trichinella spiralis the function of the immune system of rats prenatally exposed to aciclovir was examined. Six weeks postnatally 10-12 randomly selected male rat offspring of one control and two treatment groups (1 or 3 injections of 100 mg aciclovir/kg body wt on day 10 of gestation) were infected orally with 500 Trichinella spiralis muscle larvae. Before and several times after the infection blood was taken from a tail vein or obtained by decapitation for examination of the antibody titers (IgM, IgG, IgA, IgE) to antigens of T. spiralis. Six weeks after the infection the weight of relevant organs was determined and tongue preparations were used for T. spiralis muscle larvae counting. Aciclovir exposed animals showed a different immune response than control rats. IgM titers in both treatment groups were higher than in controls two weeks after the infection but not different by the end of the experiment.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Stahlmann R,Korte M,Van Loveren H,Vos JG,Thiel R,Neubert Ddoi
10.1007/BF01973385keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
551-9issue
8eissn
0340-5761issn
1432-0738journal_volume
66pub_type
杂志文章abstract::The activity of 18 vitamin D analogs on soft tissue calcification and growth impairment in neonatal rats and their effect on bone calcium mobilization, intestinal calcium absorption and binding to intestinal 1,25-dihydroxyvitamin D3 receptors in adult rats were compared. Depending on the chemical modification of the v...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00303129
更新日期:1989-01-01 00:00:00
abstract::The effect of culture medium on glutathione (GSH) dependent detoxification defence system of primary cultured hepatocyte from either male or female rats was studied. Intracellular reduced (GSH) and oxidized glutathione (GSSG), and six GSH-related enzyme activities, including GSH peroxidase (GSH Px), GSH reductase (GSH...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050345
更新日期:1996-01-01 00:00:00
abstract::Pulmonary fibrosis is a poorly understood pathologic condition. Carbon nanotubes (CNTs) are nanomaterials with potentials for broad applications. CNTs can induce pulmonary fibrosis in animals, a cause for concern for exposed workers and consumers. Given the large number of CNTs available on the market and the seemingl...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2306-9
更新日期:2018-11-01 00:00:00
abstract::Interactions between chemicals in a mixture and interactions of mixture components with the skin can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous disposition of a topically applied chemical. The predictive ability of dermal absorption models, and consequently the dermal ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040100242
更新日期:2001-08-01 00:00:00
abstract::Inhibition mechanism(s) of protein kinase B/Akt1 and its consequences on related cell signaling were investigated in human neuroblastoma SH-SY5Y cells exposed to 4-hydroxy-trans-2-nonenal (4-HNE), one of the most reactive aldehyde by-products of lipid peroxidation. In silico data indicate that 4-HNE interacts with kin...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1260-4
更新日期:2015-02-01 00:00:00
abstract::Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs i...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-013-1160-z
更新日期:2014-03-01 00:00:00
abstract::Sulfur dioxide (SO2) is a common air pollutant, and inhaled SO2 in airway epithelium easily forms its soluble derivatives in vivo (bisulfite and sulfite), which are toxic to the respiratory system and related to the exacerbation of asthma. To investigate the effects of SO2 derivatives on the expressions of asthma rela...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0212-7
更新日期:2007-12-01 00:00:00
abstract::Phytoestrogens have been described as weak estrogens, selective estrogen receptor mediators (SERMs) or to exhibit antiestrogenic properties. However, information about their activity in combination with xenoestrogens and 17beta-estradiol in vivo, is limited. Therefore, the combinatory activity of the phytoestrogen gen...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0102-4
更新日期:2006-12-01 00:00:00
abstract::Treatment of tuberculosis (TB) has been a therapeutic challenge because of not only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also the newly acquired mutations that confer further resistance. Currently standardized regimens require patients to daily ingest up to four drugs un...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1727-6
更新日期:2016-07-01 00:00:00
abstract::Reduced gluconeogenesis due to decreased activity of key gluconeogenic enzymes in liver, together with feed refusal, has been suggested to play an important role in 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced lethality in rats. This study was carried out to further analyse the toxicological significance of red...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050626
更新日期:1999-08-01 00:00:00
abstract::Tea (Camellia sinensis, Theaceace), a popular beverage consumed world-wide, has been studied for its preventive effects against cancer as well as cardiovascular, neurodegenerative, and other diseases. Most of the proposed beneficial effects have been attributed to the polyphenolic compounds in tea, but the nature of t...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-008-0372-0
更新日期:2009-01-01 00:00:00
abstract::Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are t...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1803-y
更新日期:2017-01-01 00:00:00
abstract::The routinely used analytical method for detecting the abuse of anabolic steroids only allows the detection of molecules with known analytical properties. In our supplementary approach to structure-independent detection, substances are identified by their biological activity. In the present study, urines excreted afte...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0590-0
更新日期:2011-04-01 00:00:00
abstract::Dose-dependent excretion of p,p'DDE in rats was investigated. p,p'DDE itself was the major excreta in rats. But some o,p'isomer of DDE was detected in feces by GC-MS analysis. The excretion of p,p'DDE after a single administration was modified by its dose level. The time pattern of p,p'DDE excretion agrees well with t...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00332361
更新日期:1982-01-01 00:00:00
abstract::In case of mycotoxin contaminations, food and feedstuff are usually contaminated by more than one toxin. However toxicological data concerning the effects of mycotoxin combinations are sparse. The intestinal epithelium is the first barrier against food contaminants and this constantly renewing organ is particularly se...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1309-4
更新日期:2015-08-01 00:00:00
abstract::The implementation of the Chemical Weapon Convention (CWC), prohibiting the development, production, storage and use of chemical weapons by 192 nations and the ban of highly toxic OP pesticides, especially class I pesticides according to the WHO classification, by many countries constitutes a great success of the inte...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1772-1
更新日期:2016-09-01 00:00:00
abstract::Breast cancer is the most commonly diagnosed malignancy in females, the etiology being multifactorial and includes the role of lifestyle exposure to DNA-damaging chemicals such as dietary carcinogens benzo (a) pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP). Both compounds require cytochrome...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02558-8
更新日期:2019-10-01 00:00:00
abstract::Previous rat toxicity studies of alpha-glycosyl isoquercitrin (AGIQ), a water-soluble flavonol glycoside derived from rutin, revealed systemic yellow bone discoloration. This investigative study was conducted to determine the AGIQ metabolite(s) responsible for the discoloration. Female Sprague-Dawley rats were adminis...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02760-z
更新日期:2020-07-01 00:00:00
abstract::Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroetha...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050281
更新日期:1996-01-01 00:00:00
abstract::Changes in the urinary excretion of hippuric acid (HIA) and phenaceturic acid (PUA) as well as their metabolic precursors, i.e. benzoic (BA) and phenylacetic acid (PAA), in rats housed in glass metabolic cages for 4 days were monitored using gas-liquid chromatography. The amount of HIA excreted was 128 +/- 63 mumol/kg...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00324554
更新日期:1987-01-01 00:00:00
abstract::The present study was designed to compare the nephrotoxicity induced by the three platinum compounds cisplatin (CDDP), carboplatin (CBDCA) and transplatin (TDDP) in vitro and to obtain information to elucidate the mechanism of platinum compound-induced nephrotoxicity. Rat or rabbit renal cortical slices were incubated...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973462
更新日期:1990-01-01 00:00:00
abstract::In a previous study, we showed that bisphenol A (BPA) had oestrogen-like effects in bird embryos, causing malformations of the oviducts in Japanese quail (Coturnix japonica) and feminisation of the left testis in chicken (Gallus domesticus). In this study, uptake and distribution of BPA and tetrabromobisphenol A (TBBP...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040100277
更新日期:2001-12-01 00:00:00
abstract::N-Methyl-2-pyrrolidone (NMP) is a versatile organic solvent frequently used for surface cleaning such as paint stripping or graffiti removal. Liquid NMP is rapidly absorbed through the skin but dermal vapour phase absorption might also play an important role for the uptake of the solvent. This particular aspect was in...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0230-5
更新日期:2008-01-01 00:00:00
abstract::Perfluoroalkyl acids are widely used in numerous industrial and commercial applications due to their unique physical and chemical characteristics. Although perfluorooctanoic acid (PFOA) is associated with hepatomegaly through peroxisome proliferator-activated receptor α (PPARα) activation, liver fat accumulation and c...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1322-7
更新日期:2015-09-01 00:00:00
abstract::Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-011-0788-9
更新日期:2012-04-01 00:00:00
abstract::The purpose of the present study was to investigate the effect of perfusion with a medium containing 12 or 24 micrograms Cadmium (as CdCl2) per ml on this metal's accumulation, transfer rate and metallothionein (MT) level. The experiments were performed with an isolated lobule of a dually-perfused human term placenta....
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01968966
更新日期:1991-01-01 00:00:00
abstract::Female C57/BL/6 x DBA/2 hybrid mice were exposed to two concentrations (270 and 135 ppm) of tetrachloroethylene (PER) in inhalation chambers for 6 h/day, 5 days per week, up to 11.5 weeks (270 ppm) and 7.5 weeks (135 ppm), respectively, followed by a 3-week exposure-free period. In the peripheral blood a reduction of ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01974021
更新日期:1992-01-01 00:00:00
abstract::The mechanical properties of the bones of young, adult and old rats administered various concentrations of cadmium were measured to prove the direct effect of cadmium on the bones of young rats. The young rats were divided into three subgroups, which were administered 0 (control), 5 and 10 ppm cadmium, respectively. T...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00278646
更新日期:1989-01-01 00:00:00
abstract::Certain esterase inhibitors such as O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate (KBR-2822) and phenylmethanesulfonyl fluoride (PMSF) cause exacerbation (promotion) of toxic and traumatic axonopathies. Although these chemicals are capable of inhibiting neuropathy target esterase (NTE), whic...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050473
更新日期:1998-01-01 00:00:00
abstract::The present study was designed to evaluate the possible protective effects of 3,3'-diselenodipropionic acid (DSePA), a potent radioprotector, against oxidative organ damage induced by whole body γ-irradiation and explore its mechanistic effects. The mice were subjected to whole body γ-irradiation at 5 Gy for the detec...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-011-0687-0
更新日期:2011-11-01 00:00:00