Neurofilament degradation in the nervous system of rats intoxicated with acrylamide, related compounds or 2,5-hexanedione.

abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...

journal_title：Archives of toxicology

authors： Nordgren I,Bergström M,Holmstedt B,Sandoz M

更新日期：1978-10-13 00:00:00

abstract：:Intermittent inhalation of 300 ppm of xylene vapour 6 h daily for 2 weeks caused a marked accumulation of the solvent in the perirenal fat. Simultaneous ethanol ingestion reduced the solvent load significantly although the perirenal xylene concentration increased in both test groups between the first and second week o...

journal_title：Archives of toxicology

authors： Savolainen H,Vainio H,Helojoki M,Elovaara E

更新日期：1978-12-28 00:00:00

abstract：:Aciclovir (synonym: acyclovir) causes abnormal thymus development in rats. After treatment on day 10 of gestation a weight reduction of the organ is obvious in 21-day-old fetuses which persists postnatally. Adult male rats exposed in utero to one or three injections of 100 mg aciclovir/kg body wt given to the dam on d...

journal_title：Archives of toxicology

authors： Stahlmann R,Korte M,Van Loveren H,Vos JG,Thiel R,Neubert D

更新日期：1992-01-01 00:00:00

abstract：:5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...

journal_title：Archives of toxicology

authors： Sachse B,Meinl W,Sommer Y,Glatt H,Seidel A,Monien BH

更新日期：2016-01-01 00:00:00

abstract：:The present study was performed to investigate the potential toxic effects of prenatal exposure to 4-tert-octylphenol (OP) on liver, kidney, spleen, and hematologic parameters of male and female rats in adult life. The rats were treated with OP subcutaneously in utero at doses of control (vehicle, corn oil), 100 or 25...

journal_title：Archives of toxicology

authors： Barlas N,Aydoğan M

更新日期：2009-04-01 00:00:00

abstract：:Assay conditions in determining total cytochrome P-450 in four laboratories were compared. Although the determination was derived from the original Omura and Sato method in each laboratory, the four standard protocols differed slightly, resulting in considerable differences in the results. Since the cytochrome P-450 c...

journal_title：Archives of toxicology

authors： Rutten AA,Falke HE,Catsburg JF,Topp R,Blaauboer BJ,van Holsteijn I,Doorn L,van Leeuwen FX

更新日期：1987-01-01 00:00:00

abstract：:We recently showed that prenatal exposure to diesel exhaust (DE) disrupts spermatogenesis in mouse offspring. This study was undertaken to determine whether filtered DE in which 99.97% of diesel exhaust particles >0.3 microm in diameter were removed affects spermatogenesis in growing mice. After prenatal exposure to f...

journal_title：Archives of toxicology

authors： Ono N,Oshio S,Niwata Y,Yoshida S,Tsukue N,Sugawara I,Takano H,Takeda K

更新日期：2008-11-01 00:00:00

abstract：:The immunotoxic potential of many classes of environmental contaminants has been well established in laboratory studies, with much attention being focussed on aryl hydrocarbon (Ah)-receptor binding polychlorinated biphenyl (PCB), polychlorinated dibenzo-p-dioxin (PCDD), and polychlorinated dibenzofuran (PCDF) congener...

journal_title：Archives of toxicology

authors： Ross PS,Van Loveren H,de Swart RL,van der Vliet H,de Klerk A,Timmerman HH,van Binnendijk R,Brouwer A,Vos JG,Osterhaus AD

更新日期：1996-01-01 00:00:00

abstract：:Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxicity and prevention. Metabolism and ...

journal_title：Archives of toxicology

authors： Kurebayashi H,Ohno Y

更新日期：2006-12-01 00:00:00

abstract：:Nanoparticles (NP) have a tendency to agglomerate after dispersion in physiological media, which can be prevented by the addition of serum. This may however result in modification of the toxic potential of particles due to the formation of protein corona. Our study aimed to analyze the role of serum that is added to i...

journal_title：Archives of toxicology

authors： Vranic S,Gosens I,Jacobsen NR,Jensen KA,Bokkers B,Kermanizadeh A,Stone V,Baeza-Squiban A,Cassee FR,Tran L,Boland S

更新日期：2017-01-01 00:00:00

abstract：:Berberine, a main protoberberine component of Coptidis Rhizoma, was studied for the mechanism of its inhibitory effects on the tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity and lipid peroxidation in rat liver. In the preliminary study, berberine expressed an antioxidant property by its capacity for quenching t...

journal_title：Archives of toxicology

authors： Hwang JM,Wang CJ,Chou FP,Tseng TH,Hsieh YS,Lin WL,Chu CY

更新日期：2002-11-01 00:00:00

abstract：:Genistein and daidzein are the main isoflavones in soy. Their potential beneficial or adverse effects in males like the prevention of prostate cancer or the impact on reproductive functions are controversially discussed. Major determinants of their bioactivity are the absorption and biotransformation of isoflavones. I...

journal_title：Archives of toxicology

authors： Soukup ST,Müller DR,Kurrat A,Diel P,Kulling SE

更新日期：2017-04-01 00:00:00

abstract：:This study was carried out to investigate the effect of in utero exposure to the cholinotoxicants, nicotine and chlorpyrifos, alone or in combination on neurobehavioral alterations and neuronal morphology latter in adult age. In the present study, 90 days old (corresponding to a human adult age) male and female offspr...

journal_title：Archives of toxicology

authors： Abou-Donia MB,Khan WA,Dechkovskaia AM,Goldstein LB,Bullman SL,Abdel-Rahman A

更新日期：2006-09-01 00:00:00

abstract：:The acute toxicity of cyanide is determined by its peak levels reached in the body. Compared to the ingestion of free cyanide, lower peak levels may be expected after consumption of foods containing cyanogenic glycosides with the same equivalent dose of cyanide. This is due to possible delayed and/or incomplete releas...

journal_title：Archives of toxicology

authors： Abraham K,Buhrke T,Lampen A

更新日期：2016-03-01 00:00:00

abstract：:Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydro...

journal_title：Archives of toxicology

authors： Oishi S

更新日期：1986-12-01 00:00:00

abstract：:We recently reported that doxorubicin decreased the expression of calpain-1/2, while inhibition of calpain activity promoted doxorubicin-induced cardiac injury in mice. In this study, we investigated whether and how elevation of calpain-2 could affect doxorubicin-triggered cardiac injury. Transgenic mice with inducibl...

journal_title：Archives of toxicology

authors： Zheng D,Su Z,Zhang Y,Ni R,Fan GC,Robbins J,Song LS,Li J,Peng T

更新日期：2019-04-01 00:00:00

abstract：:Thanks to the confluence of genome sequencing and bioinformatics, the number of metabolic databases has expanded from a handful in the mid-1990s to several thousand today. These databases lie within distinct families that have common ancestry and common attributes. The main families are the MetaCyc, KEGG, Reactome, Mo...

journal_title：Archives of toxicology

authors： Karp PD,Caspi R

更新日期：2011-09-01 00:00:00

abstract：:In order to clarify the possible mechanism of hepatocarcinogenesis induced by piperonyl butoxide, we attempted to identify the transcription factor activated by piperonyl butoxide in the male ICR mouse liver. Administration of 0.6% piperonyl butoxide for 24 h elevated the level of liver nuclear proteins that bind to a...

journal_title：Archives of toxicology

authors： Muguruma M,Arai K,Moto M,Nishimura J,Dewa Y,Mitsumori K

更新日期：2008-10-01 00:00:00

abstract：:A recent intervention study demonstrated the occurrence of irilone as second most abundant isoflavone next to daidzein in human plasma after consumption of a red clover-based dietary supplement (RCDS) containing predominately formononetin ≫ biochanin A > irilone (12 % of these isoflavones). To elucidate the relevance ...

journal_title：Archives of toxicology

authors： Lutter S,Schmalbach K,Esch HL,Lehmann L

更新日期：2014-02-01 00:00:00

abstract：:This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a sh...

journal_title：Archives of toxicology

authors： Chuu JJ,Huang ZN,Yu HH,Chang LH,Lin-Shiau SY

更新日期：2008-06-01 00:00:00

abstract：:Levels of glutathione and activity of glutamine synthetase were assayed in organs of rats following inhalation of a heterogeneous solvent mixture containing both aliphatic and aromatic hydrocarbons. This mixture was administered for 3 weeks (6 h daily) at two levels in the inhaled air (400 and 800 ppm) to young adult ...

journal_title：Archives of toxicology

authors： Bondy SC,Lam HR,Ostergaard G,Guo SX,Ladefoged O

更新日期：1995-01-01 00:00:00

abstract：:Contents of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and of 16 further congeners--polychlorinated dibenzodioxins and dibenzofuranes (PCDD/PCDF)--were determined in lipids of adipose tissue and of livers of 3 stillborns and of 17 infants (0.43-44 weeks old) who died from sudden infant death syndrome. International to...

journal_title：Archives of toxicology

authors： Kreuzer PE,Csanády GA,Baur C,Kessler W,Päpke O,Greim H,Filser JG

更新日期：1997-01-01 00:00:00

abstract：:In case of mycotoxin contaminations, food and feedstuff are usually contaminated by more than one toxin. However toxicological data concerning the effects of mycotoxin combinations are sparse. The intestinal epithelium is the first barrier against food contaminants and this constantly renewing organ is particularly se...

journal_title：Archives of toxicology

authors： Alassane-Kpembi I,Puel O,Oswald IP

更新日期：2015-08-01 00:00:00

abstract：:The disposition, elimination, and metabolism of 50 mg/kg (1.36 muCi/animal) of tri-o-cresyl [phenyl-U-14C] phosphate after ten daily oral doses was investigated in adult male Fischer 344 rats. Groups of three treated animals were killed at intervals of 24, 48, 72, and 96 h after the last administrations. Generally, th...

journal_title：Archives of toxicology

authors： Somkuti SG,Abou-Donia MB

更新日期：1990-01-01 00:00:00

abstract：:The effect of N-benzyl-D-glucamine dithiocarbamate (BGD) on the renal toxicity induced by acute exposure to cadmium-metallothionein (Cd-MT) in rats was studied. Rats were injected intraperitoneally with BGD (400 mumol/kg) 6, 12, or 24 h after intraperitoneal injection of Cd-MT (1.78 mumol Cd as Cd-MT/kg) and thereafte...

journal_title：Archives of toxicology

authors： Kojima S,Ono H,Furukawa A,Kiyozumi M

更新日期：1990-01-01 00:00:00

abstract：:This study examined the effect of tamoxifen, an anti-breast cancer drug, on Ca2+ handling in bladder female transitional cancer cells. Changes in cytosolic free Ca2+ levels were recorded by using the Ca2+-sensitive dye fura-2. In a dose-dependent manner, tamoxifen induced intracellular free Ca2+ concentrations ([Ca2+]...

journal_title：Archives of toxicology

authors： Chang HT,Huang JK,Wang JL,Cheng JS,Lee KC,Lo YK,Lin MC,Tang KY,Jan CR

更新日期：2001-05-01 00:00:00

abstract：:Cannabis use has become a hot topic in several countries due to the debate about its legalization for medical purposes. However, data are limited regarding adverse events, safety and potential impact on reproductive health. Cannabis consumption during pregnancy has been associated with gestational disorders such as pr...

journal_title：Archives of toxicology

authors： Maia J,Midão L,Cunha SC,Almada M,Fonseca BM,Braga J,Gonçalves D,Teixeira N,Correia-da-Silva G

更新日期：2019-03-01 00:00:00

abstract：:The goal of these studies was to characterize the role played by antigen challenge in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunosuppression. The effects of single exposure to TCDD (4.2, 14, and 42 microg/kg) in B6C3F1 mice on the reverse plaque assay (RPA; no sensitization) and the sheep red blood cell ...

journal_title：Archives of toxicology

authors： Matulka RA,Morris DL,Wood SW,Kaminski NE,Holsapple MP

更新日期：1997-01-01 00:00:00

abstract：:The purpose of the present study was to investigate the effect of perfusion with a medium containing 12 or 24 micrograms Cadmium (as CdCl2) per ml on this metal's accumulation, transfer rate and metallothionein (MT) level. The experiments were performed with an isolated lobule of a dually-perfused human term placenta....

journal_title：Archives of toxicology

authors： Boadi WY,Yannai S,Urbach J,Brandes JM,Summer KH

更新日期：1991-01-01 00:00:00

abstract：:Unsaturated compounds are known to cause false-positive reactions in the local lymph node assay (LLNA) but not in the guinea pig maximization test. We have tested a panel of substances (succinic acid, undecylenic acid, 1-octyn-3-ol, fumaric acid, maleic acid, linoleic acid, oleic acid, alpha-linolenic acid, squalene, ...

journal_title：Archives of toxicology

authors： Frohwein TA,Sonnenburg A,Zuberbier T,Stahlmann R,Schreiner M

更新日期：2016-04-01 00:00:00