Detrimental effects of prenatal exposure to filtered diesel exhaust on mouse spermatogenesis.

abstract：:The peroxisome proliferator class of non-genotoxic rodent hepatocarcinogens cause hepatocyte DNA synthesis, peroxisome proliferation and liver tumours when administered to rats and mice, but fail to induce S-phase or peroxisome proliferation in hepatocytes from other species including guinea-pigs, dogs, and primates i...

journal_title：Archives of toxicology

authors： Tugwood JD,Holden PR,James NH,Prince RA,Roberts RA

更新日期：1998-02-01 00:00:00

abstract：:The genotoxicity of the sensory irritant 2-chlorobenzylidene malonitrile (CS) to V79 Chinese hamster cells was investigated using the induction of gene mutations, micronuclei and DNA repair synthesis as biological endpoints. CS efficiently induced micronuclei and mutants resistant to 6-thioguanine in these cells, but ...

journal_title：Archives of toxicology

authors： Ziegler-Skylakakis K,Summer KH,Andrae U

更新日期：1989-01-01 00:00:00

abstract：:In the isolated liver transient perfusion without calcium results in cholestasis which was characterized by an increased efflux rate across the sinusoidal membrane and inhibition of the concentrative transport of bromosulfophthalein to the canalicular side of the cell. Cholestasis could not be reversed within the usua...

journal_title：Archives of toxicology

authors： Höke H,Krell H,Pfaff E

更新日期：1980-03-01 00:00:00

abstract：:Sulfites whether ingested or produced through the sulfur-containing amino acids metabolism of the animal are very active molecules and can cause cellular toxicity. Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabol...

journal_title：Archives of toxicology

authors： Oztürk OH,Küçükatay V,Yönden Z,Ağar A,Bağci H,Delibaş N

更新日期：2006-10-01 00:00:00

abstract：:Spin trapping in vivo was first achieved in the author's laboratory and is shown to be a feasible method for demonstrating that highly reactive free radical intermediates are generated in the tissues of intact animals as a result of the exposure to certain toxic compounds and to ionizing radiation. The method is based...

journal_title：Archives of toxicology

authors： McCay PB

更新日期：1987-01-01 00:00:00

abstract：:Zearalenone, a cereal mycotoxin with mycoestrogen activity and effect on fertility, is known to trigger apoptosis of a variety of nucleated cell types including hematopoietic progenitor cells. In analogy to apoptosis of nucleated cells, eryptosis, the suicidal death of erythrocytes, leads to cell shrinkage and cell me...

journal_title：Archives of toxicology

authors： Jilani K,Lang F

更新日期：2013-10-01 00:00:00

abstract：:In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark ...

journal_title：Archives of toxicology

authors： Momekov G,Ferdinandov D,Bakalova A,Zaharieva M,Konstantinov S,Karaivanova M

更新日期：2006-09-01 00:00:00

abstract：:When rats were dosed with 14 microgram/kg 3H-isoproterenol, 3H-radioactivity was measurable in the liver until 48 h. This amount was not different in livers of animals which have been pretreated with diethyl maleate. After exhaustive extraction, a significant amount of 3H-radioactivity from isoproterenol could be dete...

journal_title：Archives of toxicology

authors： Remmer H,Scheulen M,Kappus H,Bolt HM

更新日期：1977-12-30 00:00:00

abstract：:The influence of haemoperfusion on some immunological parameters was investigated in a pilot study involving two groups of three patients each. In columns containing cellulose-coated activated charcoal or polystyrene resin a temporary reduction of the total white cell number, particularly involving the segmented and b...

journal_title：Archives of toxicology

authors： Rommes JH,Sangster B,Gmelig Meyling FH,Daha MR,van Heijst AN

更新日期：1983-02-01 00:00:00

abstract：:A new strategy for the evaluation of mixtures is presented. The mixture used was the organic extract of diesel exhaust particles (DEP). After extraction with dichloromethane (DCM), the crude extract was fractionated according to polarity into five fractions: aliphatic hydrocarbons, polycyclic aromatic hydrocarbons (PA...

journal_title：Archives of toxicology

authors： Ostby L,Engen S,Melbye A,Eide I

更新日期：1997-01-01 00:00:00

abstract：:The role of the functional substituents on the pyridinium ring of bisquaternary pyridinium compounds, mostly oximes, in exerting reversible and irreversible inhibition of binding of [3H]-N-methyl-4-piperidyl benzilate [( 3H]-4NMPB) to rat brain stem muscarinic receptors was studied. The drugs tested, i.e. HGG-42, HGG-...

journal_title：Archives of toxicology

authors： Kloog Y,Galron R,Balderman D,Sokolovsky M

更新日期：1985-10-01 00:00:00

abstract：:The results from a survey of the expert information that is publicly accessible on the use of the dog as test species during the regulatory evaluation of agricultural chemicals and pesticides are reported. Methods that are being used or considered in order to reduce the number of dogs used for this purpose are describ...

journal_title：Archives of toxicology

authors： Box RJ,Spielmann H

更新日期：2005-11-01 00:00:00

abstract：:Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mo...

journal_title：Archives of toxicology

authors： Tandon SK,Khandelwal S

更新日期：1982-05-01 00:00:00

abstract：:Sulfur mustard (SM) is a bifunctional alkylating agent. Its primary toxic consequence is severe skin damage with blisters, occurring after skin contact. These vesicant properties of SM have been linked to cell death of proliferating keratinocytes in the basal layer of the skin. Catalytic activation of the nuclear enzy...

journal_title：Archives of toxicology

authors： Kehe K,Raithel K,Kreppel H,Jochum M,Worek F,Thiermann H

更新日期：2008-07-01 00:00:00

abstract：:To reveal the molecular mechanism of deficit in learning and memory induced by chronic fluorosis, the expression of muscarinic acetylcholine receptors (mAChRs) and oxidative stress were investigated. Sixty Sprague-Dawley (SD) rats were divided randomly into two groups (30 cases in each), i.e., the control group (<0.5 ...

journal_title：Archives of toxicology

authors： Dong YT,Wang Y,Wei N,Zhang QF,Guan ZZ

更新日期：2015-11-01 00:00:00

abstract：:Contents of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and of 16 further congeners--polychlorinated dibenzodioxins and dibenzofuranes (PCDD/PCDF)--were determined in lipids of adipose tissue and of livers of 3 stillborns and of 17 infants (0.43-44 weeks old) who died from sudden infant death syndrome. International to...

journal_title：Archives of toxicology

authors： Kreuzer PE,Csanády GA,Baur C,Kessler W,Päpke O,Greim H,Filser JG

更新日期：1997-01-01 00:00:00

abstract：:In order to study the mechanisms of acute n-hexane intoxication, the effects of n-hexane and its metabolites 2-hexanol, methyl-n-butyl ketone, 2,5-hexanediol and 2,5-hexanedione on the cloned voltage-operated potassium channels Kv1.1, Kv1.4, Kv2.1 and Kv3.4 were investigated with electrophysiological techniques in the...

journal_title：Archives of toxicology

authors： Madeja M,Binding N,Musshoff U,Witting U,Speckmann EJ

更新日期：1997-01-01 00:00:00

abstract：:To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the l...

journal_title：Archives of toxicology

authors： Kudo Y,Egashira T,Takayama F,Yamanaka Y,Shimada T

更新日期：1993-01-01 00:00:00

abstract：:Targeted therapies against cancer have improved both survival and quality of life of patients. However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic mightiness. Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many...

journal_title：Archives of toxicology

authors： Matés JM,Campos-Sandoval JA,de Los Santos-Jiménez J,Márquez J

更新日期：2020-08-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent tumor promoter ever tested in rodents. Although it is known that most of the effects of TCDD are mediated by binding to the aryl hydrocarbon receptor (AhR), the mechanisms leading to tumor promotion still remain to be elucidated. Loss of contact inhibition ...

journal_title：Archives of toxicology

authors： Hoelper P,Faust D,Oesch F,Dietrich C

更新日期：2005-01-01 00:00:00

abstract：:Purified phenobarbital-induced rat liver cytochrome P-450 was incorporated in a reconstituted system containing NADPH-cytochrome P-450 reductase, dilauroyl phosphatidyl choline and sodium cholate. This system was added to organ cultures of limb buds from mouse embryos on day 11 of gestation. Cyclophosphamide (100 micr...

journal_title：Archives of toxicology

authors： Kastner M,Blankenburg G,Schulz T,Schack G,Neubert D

更新日期：1988-01-01 00:00:00

abstract：:The cardiovascular effects were investigated after acute and subacute treatment with chlorodibromomethane (CDBM; 0.4 to 3.2 mmol/kg p.o.), trichloromethane (TCM; 0.31 and 1.25 mmol/kg p.o.) and mixtures of CDBM and TCM (acute, 0.8 mmol CDBM/kg + 1.25 mmol TCM/kg p.o.; subacute, 0.4 mmol CDBM/kg + 0.31 mmol TCM/kg p.o....

journal_title：Archives of toxicology

authors： Müller SP,Wolna P,Wünscher U,Pankow D

更新日期：1997-01-01 00:00:00

abstract：:In vitro assays are often used for the hazard characterisation of compounds, but their application for quantitative risk assessment purposes is limited. This is because in vitro assays cannot provide a complete in vivo dose-response curve from which a point of departure (PoD) for risk assessment can be derived, like t...

journal_title：Archives of toxicology

authors： Strikwold M,Spenkelink B,Woutersen RA,Rietjens IM,Punt A

更新日期：2013-09-01 00:00:00

abstract：:We studied the incorporation of cocaine (COC), benzoylecgonine (BE) and ecgonine methyl ester (EME) into hair from blood. At first, the time courses of three drugs in rat plasma following i.p. administration of cocaine were investigated over 360 min. AUCs of COC, BE and EME in plasma were 14.2, 60.7 and 53.4 microgram...

journal_title：Archives of toxicology

authors： Nakahara Y,Ochiai T,Kikura R

更新日期：1992-01-01 00:00:00

abstract：:In a two-step study on exposure control method for occupational handling of permethrin was developed. Air sampling on a filter can be used in case of exposure to permethrin in powder form. The detection limit is 0.001 mg/m3. If biological sampling is used, the acid metabolite moiety in the urine must be monitored. How...

journal_title：Archives of toxicology

authors： Kolmodin-Hedman B,Swensson A,Akerblom M

更新日期：1982-05-01 00:00:00

abstract：:Natural and synthetic chemicals are often used in the fragrance industry. A toxicological profile of the synthetic fragrance booster, 4-cycloocten-1-carbaldehyde, was generated using a test program including the following methods: acute oral toxicity, acute dermal toxicity, acute skin and eye irritation, skin sensitiz...

journal_title：Archives of toxicology

authors： Messinger H,Kleber M,Aulmann W

更新日期：2004-12-01 00:00:00

abstract：:The aim of our study was to determine the period of maximum sensitivity for the induction of characteristic malformations with thalidomide (TH) in Himalayan rabbits. TH was administered orally in different doses (50, 100, 150 and 200 mg/kg) four times at 24-h intervals starting at 192 h of gestation. The malformations...

journal_title：Archives of toxicology

authors： Sterz H,Nothdurft H,Lexa P,Ockenfels H

更新日期：1987-07-01 00:00:00

abstract：:The effects of equimolar doses of the triphenylethylene antiestrogens tamoxifen and toremifene on female Sprague-Dawley rat liver were studied in a 52-week toxicity study which included a 13-week recovery period. Liver tumors were found in four out of five rats at the highest dose level of tamoxifen (45 mg/kg per day)...

journal_title：Archives of toxicology

authors： Hirsimäki P,Hirsimäki Y,Nieminen L,Payne BJ

更新日期：1993-01-01 00:00:00

abstract：:3-(Phenylamino)alanine (PAA), a contaminant found in L-tryptophan tablets, has been discussed as a possible cause of eosinophilia-myalgia syndrome (EMS). We administered PAA (100 mg/kg) by gastric gavage to Wistar rats to determine its distribution and metabolism. We developed a purification procedure, using Bond Elut...

journal_title：Archives of toxicology

authors： Adachi J,Mio T,Ueno Y,Naito T,Nishimura A,Fujiwara S,Sumino K,Tatsuno Y

更新日期：1994-01-01 00:00:00

abstract：:Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in drug discovery. Three-dimensional (3D) spheroid hepatic cultures have emerged as pr...

journal_title：Archives of toxicology

authors： Proctor WR,Foster AJ,Vogt J,Summers C,Middleton B,Pilling MA,Shienson D,Kijanska M,Ströbel S,Kelm JM,Morgan P,Messner S,Williams D

更新日期：2017-08-01 00:00:00