Abstract:
:In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark toxicity of the clinically utilized platinum drugs, we used three distinct referent compounds as follows cisplatin for the assessment of in vitro nephrotoxicity, carboplatin in case of cultured bone marrow cells and oxaliplatin for the determination of the in vitro neurotoxicty, respectively. The results obtained indicate that the investigated dinuclear complex is endowed by a lower potential to induce detrimental effects upon these typically susceptible platinum toxicity cellular populations as compared to the corresponding referent drugs. These findings, together with the previously encountered profound cytotoxic efficiency of this dinuclear platinum(II) complex against human tumor cell lines, recall for a further detailed evaluation of BAP as potential antineoplastic agent.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Momekov G,Ferdinandov D,Bakalova A,Zaharieva M,Konstantinov S,Karaivanova Mdoi
10.1007/s00204-006-0078-0keywords:
subject
Has Abstractpub_date
2006-09-01 00:00:00pages
555-60issue
9eissn
0340-5761issn
1432-0738journal_volume
80pub_type
杂志文章abstract::Chalepensin, a furanocoumarin, is present in several medicinal Rutaceae plants and causes a mechanism-based inhibition of human and mouse cytochrome P450 (P450, CYP) 2A in vitro. To address the in vivo effect, we investigated the effects of chalepensin on multiple hepatic P450 enzymes in C57BL/6JNarl mice. Oral admini...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-012-0902-7
更新日期:2012-12-01 00:00:00
abstract::The hepatoproliferative and cytochrome P450 enzyme inducing effects of two antiestrogens, tamoxifen and toremifene, were compared in female Sprague-Dawley rats using immunohistochemical staining methods. Equimolar doses of the antiestrogens (tamoxifen 45 mg/kg and toremifene 48 mg/kg) were given by oral administration...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040000116
更新日期:2000-07-01 00:00:00
abstract::Mouse liver tumors that harbor activating mutations in Ctnnb1, encoding β-catenin, express high levels of various cytochromes P450 (CYP), including CYP2E1 and CYP1A2. Acetaminophen (AAP) is metabolized in hepatocytes by these CYPs to the reactive intermediate N-acetyl-p-benzoquinone-imine, which is toxic to hepatocyte...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1030-8
更新日期:2013-08-01 00:00:00
abstract::The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of t...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00333620
更新日期:1979-12-01 00:00:00
abstract::Unfolded protein response (UPR) and endoplasmic reticulum (ER)-phagy are essential for cell homeostasis. Quantum dots (QDs), which have been widely used for biomedical applications, can accumulate in the kidney tissues and may cause renal dysfunction. However, the molecular mechanism of QDs-induced nephrotoxicity is s...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2169-0
更新日期:2018-04-01 00:00:00
abstract::During aerobic incubation of trichloroethylene with rabbit liver microsomes and NADPH a difference absorption peak appears at 451-452 nm. Trichloroethylene does not form a ligand absorption spectrum with hepatic microsomes reduced by dithionite, or in anaerobic incubates in the presence of NADPH. Addition of trichloro...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00293858
更新日期:1977-06-18 00:00:00
abstract::In the present study, spiking was used as a strategy to evaluate the mutagenicity of individual compounds in a mixture. Mutagenicity of individual polycyclic aromatic hydrocarbons (PAH) was evaluated in an organic extract of diesel exhaust particles (DEP). The particles were extracted with dichloromethane (DCM). After...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050555
更新日期:1998-10-01 00:00:00
abstract::5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1392-6
更新日期:2016-01-01 00:00:00
abstract::The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050237
更新日期:1995-01-01 00:00:00
abstract::Dinitrochlorobenzene (DNCB) absorption through mouse and rat dorsal skin, pig ear skin and human abdominal skin in vitro was determined, and local metabolism to the glutathione conjugate was related to glutathione transferase activities and glutathione status in the skin. Absorption studies were conducted using skin m...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040000123
更新日期:2000-09-01 00:00:00
abstract::Initially, mice were pretreated with atropine (17.4 mg/kg; IP) and the oxime reactivator HI-6 (50 mg/kg; IP) 5 min prior to an injection of soman (287 micrograms/kg, SC); approximately 2.1 x LD50 dose). More than 95% of the mice survived this dose of soman with atropine and HI-6 pretreatment. In these survivors of som...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316438
更新日期:1989-01-01 00:00:00
abstract::This study investigated whether paraquat (Pq)-induced lipidic peroxidation (LP) is accompanied by changes in blood pressure and heart rate (HR) in rats. Groups of adult male Wistar rats were studied 2 and 12 h after Pq (35 mg/kg, i.p.) administration. The LP was evaluated by monitoring thiobarbituric acid reactive sub...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-005-0660-x
更新日期:2005-09-01 00:00:00
abstract::Insulin-exposed rat mammary cancer cells were flow sorted based on a c-myc reporter plasmid encoding a destabilized green fluorescent protein. Sorted cells exhibited gradual increases in c-myc levels. Cells overexpressing c-myc by only 10% exhibited phenotypic changes attributable to c-myc overexpression, such as cell...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0463-6
更新日期:2009-12-01 00:00:00
abstract::Neutrophils infiltrate tissues during inflammation, and when activated, they release β-glucuronidase. Since inflammation is associated with carcinogenesis, we investigated how extracellular β-glucuronidase changed the in vitro cellular response to the chemical carcinogen benzo(a)pyrene (B[a]P). For this we exposed hum...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1593-7
更新日期:2016-09-01 00:00:00
abstract::DW-116, 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-l-piperazinyl)-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride, is a newly developed fluoroquinolone antibacterial. The potential of DW-116 to induce developmental toxicity was, investigated in Sprague-Dawley rats. DW-116 was administered by gavage to pre...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050662
更新日期:2000-04-01 00:00:00
abstract::The trichothecene mycotoxin deoxynivalenol (DON) is produced in wheat, barley and corn following infestation by the fungus Fusarium in the field and during storage. Colloquially known as "vomitoxin" because of its emetic effects in pigs, DON has been associated with human gastroenteritis. Since DON is commonly detecte...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-010-0579-8
更新日期:2010-09-01 00:00:00
abstract::Increasing incidence of multidrug-resistant bacteria presents an imminent risk to global health. Polymyxins are 'last-resort' antibiotics against Gram-negative 'superbugs'; however, nephrotoxicity remains a key impediment in their clinical use. Molecular mechanisms underlying this nephrotoxicity remain poorly defined....
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2192-1
更新日期:2018-07-01 00:00:00
abstract::As previously demonstrated, chronic administration of phenobarbital (0.05% in the drinking water) and of nafenopin (0.1% in the diet) increases the incidence and the kinetics of appearance of liver cancers. If bile acids play a key role in liver carcinogenesis, it might thus be expected that treatments like phenobarbi...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050087
更新日期:1994-01-01 00:00:00
abstract::The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The calibration curve for morphine in hair showed linear over 0.5-100 ng/mg hair. Though the limit of detection was 0.1 ng/mg hair with an S/N > 3 of the base ion(m/z 429) for morphine, the limit of confirmation by detection of thr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01981507
更新日期:1992-01-01 00:00:00
abstract::Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log(10) blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the med...
journal_title:Archives of toxicology
pub_type: 杂志文章,meta分析
doi:10.1007/s00204-008-0292-z
更新日期:2008-08-01 00:00:00
abstract::The studies presented were designed to investigate the effects of cytochrome P450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female B6C3F(1) mice. Groups of female B6C3F(1) mice were exposed to dynamic atmospheres containing tetrahydrofuran (THF) concentrations of 0, 5,400 or 15,000 mg/m(3) ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-003-0474-7
更新日期:2003-08-01 00:00:00
abstract::Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the effects of two AsH...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2194-z
更新日期:2018-05-01 00:00:00
abstract::Pathological changes induced by cadmium aerosol had features common to the changes evoked by oxidants. Female rats were exposed to fumes of lead, antimony, zinc and cadmium (15-100 nmoles/m3). One hour after termination of exposure, superoxide dismutase (SOD) activity in erythrocytes of the exposed rats lowered by 15-...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00347869
更新日期:1982-03-01 00:00:00
abstract::O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050212
更新日期:1995-01-01 00:00:00
abstract::2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) is known to influence vitamin A homeostasis. In order to investigate the mechanism behind this retinoid disruption, male Sprague-Dawley rats were exposed to TCDD at doses ranging from 0.1 to 100 micro g/kg body weight, and were killed 3 days after exposure. Additional groups...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-003-0457-8
更新日期:2003-07-01 00:00:00
abstract::Levels of glutathione and activity of glutamine synthetase were assayed in organs of rats following inhalation of a heterogeneous solvent mixture containing both aliphatic and aromatic hydrocarbons. This mixture was administered for 3 weeks (6 h daily) at two levels in the inhaled air (400 and 800 ppm) to young adult ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050192
更新日期:1995-01-01 00:00:00
abstract::Darbepoetin (DPO), an erythropoietin (EPO) derivative, was licensed in 2002 to treat patients with solid tumors suffering from chemotherapy-dependent anemia, although various tumors express EPO to improve vascularization, thus favoring tumor growth and spreading. Therefore, we wanted to investigate direct effects of D...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1094-5
更新日期:2014-01-01 00:00:00
abstract::This discussion of the NEL presents some thoughts how toxicologists could be encouraged to use more sophisticated modern techniques for the study of various environmental chemicals. It is proposed to use the concept of the NEL only for data obtained by conventional techniques in routine toxicity experiments. Informati...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00695868
更新日期:1979-10-01 00:00:00
abstract::UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) for various UGT isofo...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02765-8
更新日期:2020-08-01 00:00:00
abstract::The in ovo carcinogenicity assessing (IOCA) assay was used to examine the morphological changes in fetal turkey livers caused by the DNA-reactive carcinogen diethylnitrosamine (DEN). Fertilized turkey eggs were allocated into 3 groups: nondosed control (NDC), vehicle (water) control (VC) and DEN-dosed. At day 0, the f...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0603-z
更新日期:2011-06-01 00:00:00