In vitro toxicological evaluation of a dinuclear platinum(II) complex with acetate ligands.

Abstract:

:In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark toxicity of the clinically utilized platinum drugs, we used three distinct referent compounds as follows cisplatin for the assessment of in vitro nephrotoxicity, carboplatin in case of cultured bone marrow cells and oxaliplatin for the determination of the in vitro neurotoxicty, respectively. The results obtained indicate that the investigated dinuclear complex is endowed by a lower potential to induce detrimental effects upon these typically susceptible platinum toxicity cellular populations as compared to the corresponding referent drugs. These findings, together with the previously encountered profound cytotoxic efficiency of this dinuclear platinum(II) complex against human tumor cell lines, recall for a further detailed evaluation of BAP as potential antineoplastic agent.

journal_name

Arch Toxicol

journal_title

Archives of toxicology

authors

Momekov G,Ferdinandov D,Bakalova A,Zaharieva M,Konstantinov S,Karaivanova M

doi

10.1007/s00204-006-0078-0

keywords:

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

555-60

issue

9

eissn

0340-5761

issn

1432-0738

journal_volume

80

pub_type

杂志文章
  • A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation.

    abstract::Chalepensin, a furanocoumarin, is present in several medicinal Rutaceae plants and causes a mechanism-based inhibition of human and mouse cytochrome P450 (P450, CYP) 2A in vitro. To address the in vivo effect, we investigated the effects of chalepensin on multiple hepatic P450 enzymes in C57BL/6JNarl mice. Oral admini...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-012-0902-7

    authors: Lo WS,Lim YP,Chen CC,Hsu CC,Souček P,Yun CH,Xie W,Ueng YF

    更新日期:2012-12-01 00:00:00

  • Comparison of the effects of tamoxifen and toremifene on rat hepatocarcinogenesis.

    abstract::The hepatoproliferative and cytochrome P450 enzyme inducing effects of two antiestrogens, tamoxifen and toremifene, were compared in female Sprague-Dawley rats using immunohistochemical staining methods. Equimolar doses of the antiestrogens (tamoxifen 45 mg/kg and toremifene 48 mg/kg) were given by oral administration...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040000116

    authors: Kärki A,Mäntylä E,Hirsimäki Y,Karlsson S,Toikkanen S,Hirsimäki P

    更新日期:2000-07-01 00:00:00

  • Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen.

    abstract::Mouse liver tumors that harbor activating mutations in Ctnnb1, encoding β-catenin, express high levels of various cytochromes P450 (CYP), including CYP2E1 and CYP1A2. Acetaminophen (AAP) is metabolized in hepatocytes by these CYPs to the reactive intermediate N-acetyl-p-benzoquinone-imine, which is toxic to hepatocyte...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-013-1030-8

    authors: Singh Y,Braeuning A,Schmid A,Pichler BJ,Schwarz M

    更新日期:2013-08-01 00:00:00

  • Genetic control of responsiveness of rat liver supernatant aldehyde dehydrogenase to phenobarbital and 3-methylcholanthrene.

    abstract::The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of t...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00333620

    authors: Nakanishi S,Shiohara E,Tsukada M,Yamazaki H,Nishiguchi K,Saladin R

    更新日期:1979-12-01 00:00:00

  • The role of unfolded protein response and ER-phagy in quantum dots-induced nephrotoxicity: an in vitro and in vivo study.

    abstract::Unfolded protein response (UPR) and endoplasmic reticulum (ER)-phagy are essential for cell homeostasis. Quantum dots (QDs), which have been widely used for biomedical applications, can accumulate in the kidney tissues and may cause renal dysfunction. However, the molecular mechanism of QDs-induced nephrotoxicity is s...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-018-2169-0

    authors: Jiang S,Lin Y,Yao H,Yang C,Zhang L,Luo B,Lei Z,Cao L,Lin N,Liu X,Lin Z,He C

    更新日期:2018-04-01 00:00:00

  • Spectral evidence for 2,2,3-trichloro-oxirane formation during microsomal trichloroethylene oxidation.

    abstract::During aerobic incubation of trichloroethylene with rabbit liver microsomes and NADPH a difference absorption peak appears at 451-452 nm. Trichloroethylene does not form a ligand absorption spectrum with hepatic microsomes reduced by dithionite, or in anaerobic incubates in the presence of NADPH. Addition of trichloro...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00293858

    authors: Uehleke H,Tabarelli-Poplawski S,Bonse G,Henschler D

    更新日期:1977-06-18 00:00:00

  • Mutagenicity testing of organic extracts of diesel exhaust particles after spiking with polycyclic aromatic hydrocarbons (PAH).

    abstract::In the present study, spiking was used as a strategy to evaluate the mutagenicity of individual compounds in a mixture. Mutagenicity of individual polycyclic aromatic hydrocarbons (PAH) was evaluated in an organic extract of diesel exhaust particles (DEP). The particles were extracted with dichloromethane (DCM). After...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050555

    authors: Bostrøm E,Engen S,Eide I

    更新日期:1998-10-01 00:00:00

  • Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.

    abstract::5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-014-1392-6

    authors: Sachse B,Meinl W,Sommer Y,Glatt H,Seidel A,Monien BH

    更新日期:2016-01-01 00:00:00

  • Effect of DMPS and various adsorbents on the arsenic excretion in guinea-pigs after injection with As2O3.

    abstract::The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050237

    authors: Reichl FX,Hunder G,Liebl B,Fichtl B,Forth W

    更新日期:1995-01-01 00:00:00

  • Percutaneous absorption and metabolism of dinitrochlorobenzene in vitro.

    abstract::Dinitrochlorobenzene (DNCB) absorption through mouse and rat dorsal skin, pig ear skin and human abdominal skin in vitro was determined, and local metabolism to the glutathione conjugate was related to glutathione transferase activities and glutathione status in the skin. Absorption studies were conducted using skin m...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040000123

    authors: Jewell C,Heylings J,Clowes HM,Williams FM

    更新日期:2000-09-01 00:00:00

  • Survivors of soman poisoning: recovery of the soman LD50 to control value in the presence of extensive acetylcholinesterase inhibition.

    abstract::Initially, mice were pretreated with atropine (17.4 mg/kg; IP) and the oxime reactivator HI-6 (50 mg/kg; IP) 5 min prior to an injection of soman (287 micrograms/kg, SC); approximately 2.1 x LD50 dose). More than 95% of the mice survived this dose of soman with atropine and HI-6 pretreatment. In these survivors of som...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00316438

    authors: Clement JG

    更新日期:1989-01-01 00:00:00

  • High blood pressure is one of the symptoms of paraquat-induced toxicity in rats.

    abstract::This study investigated whether paraquat (Pq)-induced lipidic peroxidation (LP) is accompanied by changes in blood pressure and heart rate (HR) in rats. Groups of adult male Wistar rats were studied 2 and 12 h after Pq (35 mg/kg, i.p.) administration. The LP was evaluated by monitoring thiobarbituric acid reactive sub...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-005-0660-x

    authors: Oliveira MV,Albuquerque JA,Paixão AD,Guedes LS,Cabral AM

    更新日期:2005-09-01 00:00:00

  • Driving gradual endogenous c-myc overexpression by flow-sorting: intracellular signaling and tumor cell phenotype correlate with oncogene expression.

    abstract::Insulin-exposed rat mammary cancer cells were flow sorted based on a c-myc reporter plasmid encoding a destabilized green fluorescent protein. Sorted cells exhibited gradual increases in c-myc levels. Cells overexpressing c-myc by only 10% exhibited phenotypic changes attributable to c-myc overexpression, such as cell...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-009-0463-6

    authors: Knudsen KJ,Nelander Holm GM,Krabbe JS,Listov-Saabye N,Kiehr B,Dufva M,Svendsen JE,Oleksiewicz MB

    更新日期:2009-12-01 00:00:00

  • Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene.

    abstract::Neutrophils infiltrate tissues during inflammation, and when activated, they release β-glucuronidase. Since inflammation is associated with carcinogenesis, we investigated how extracellular β-glucuronidase changed the in vitro cellular response to the chemical carcinogen benzo(a)pyrene (B[a]P). For this we exposed hum...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-015-1593-7

    authors: Shi Q,Haenen GR,Maas L,Arlt VM,Spina D,Vasquez YR,Moonen E,Veith C,Van Schooten FJ,Godschalk RWL

    更新日期:2016-09-01 00:00:00

  • Embryo lethality and teratogenicity of a new fluoroquinolone antibacterial DW-116 in rats.

    abstract::DW-116, 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-l-piperazinyl)-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride, is a newly developed fluoroquinolone antibacterial. The potential of DW-116 to induce developmental toxicity was, investigated in Sprague-Dawley rats. DW-116 was administered by gavage to pre...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050662

    authors: Kim JC,Yun HI,Shin HC,Han SS,Chung MK

    更新日期:2000-04-01 00:00:00

  • Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance.

    abstract::The trichothecene mycotoxin deoxynivalenol (DON) is produced in wheat, barley and corn following infestation by the fungus Fusarium in the field and during storage. Colloquially known as "vomitoxin" because of its emetic effects in pigs, DON has been associated with human gastroenteritis. Since DON is commonly detecte...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-010-0579-8

    authors: Pestka JJ

    更新日期:2010-09-01 00:00:00

  • Polymyxin B causes DNA damage in HK-2 cells and mice.

    abstract::Increasing incidence of multidrug-resistant bacteria presents an imminent risk to global health. Polymyxins are 'last-resort' antibiotics against Gram-negative 'superbugs'; however, nephrotoxicity remains a key impediment in their clinical use. Molecular mechanisms underlying this nephrotoxicity remain poorly defined....

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-018-2192-1

    authors: Yun B,Zhang T,Azad MAK,Wang J,Nowell CJ,Kalitsis P,Velkov T,Hudson DF,Li J

    更新日期:2018-07-01 00:00:00

  • Modifications of liver bile acids pool during modulation of rat hepatocarcinogenesis by phenobarbital and nafenopin.

    abstract::As previously demonstrated, chronic administration of phenobarbital (0.05% in the drinking water) and of nafenopin (0.1% in the diet) increases the incidence and the kinetics of appearance of liver cancers. If bile acids play a key role in liver carcinogenesis, it might thus be expected that treatments like phenobarbi...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050087

    authors: Delzenne NM,Taper HS,Roberfroid M

    更新日期:1994-01-01 00:00:00

  • Hair analysis for drugs of abuse. IV. Determination of total morphine and confirmation of 6-acetylmorphine in monkey and human hair by GC/MS.

    abstract::The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The calibration curve for morphine in hair showed linear over 0.5-100 ng/mg hair. Though the limit of detection was 0.1 ng/mg hair with an S/N > 3 of the base ion(m/z 429) for morphine, the limit of confirmation by detection of thr...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF01981507

    authors: Nakahara Y,Takahashi K,Shimamine M,Saitoh A

    更新日期:1992-01-01 00:00:00

  • A meta-analysis of studies investigating the effects of lead exposure on nerve conduction.

    abstract::Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log(10) blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the med...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00204-008-0292-z

    authors: Krieg EF Jr,Chrislip DW,Brightwell WS

    更新日期:2008-08-01 00:00:00

  • Effect of cytochrome P-450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female mice.

    abstract::The studies presented were designed to investigate the effects of cytochrome P450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female B6C3F(1) mice. Groups of female B6C3F(1) mice were exposed to dynamic atmospheres containing tetrahydrofuran (THF) concentrations of 0, 5,400 or 15,000 mg/m(3) ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-003-0474-7

    authors: van Ravenzwaay B,Gamer AO,Leibold E,Kaufmann W

    更新日期:2003-08-01 00:00:00

  • Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells.

    abstract::Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the effects of two AsH...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-018-2194-z

    authors: Müller SM,Finke H,Ebert F,Kopp JF,Schumacher F,Kleuser B,Francesconi KA,Raber G,Schwerdtle T

    更新日期:2018-05-01 00:00:00

  • Changes of the activities of superoxide dismutase after exposure to the fume of heavy metals and the significance of zinc in the tissue.

    abstract::Pathological changes induced by cadmium aerosol had features common to the changes evoked by oxidants. Female rats were exposed to fumes of lead, antimony, zinc and cadmium (15-100 nmoles/m3). One hour after termination of exposure, superoxide dismutase (SOD) activity in erythrocytes of the exposed rats lowered by 15-...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00347869

    authors: Minami M,Koshi K,Homma K,Suzuki Y

    更新日期:1982-03-01 00:00:00

  • A direct involvement of the central nervous system in hypophagia and inhibition of respiratory rate in rats after treatment with O,O,S-trimethyl phosphorothioate.

    abstract::O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050212

    authors: Ohtaka K,Hamade N,Yamazaki Y,Suzuki M,Koizumi A

    更新日期:1995-01-01 00:00:00

  • 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the endogenous metabolism of all-trans-retinoic acid in the rat.

    abstract::2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) is known to influence vitamin A homeostasis. In order to investigate the mechanism behind this retinoid disruption, male Sprague-Dawley rats were exposed to TCDD at doses ranging from 0.1 to 100 micro g/kg body weight, and were killed 3 days after exposure. Additional groups...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-003-0457-8

    authors: Schmidt CK,Hoegberg P,Fletcher N,Nilsson CB,Trossvik C,Håkansson H,Nau H

    更新日期:2003-07-01 00:00:00

  • Changes in markers of oxidative status in brain, liver and kidney of young and aged rats following exposure to aromatic white spirit.

    abstract::Levels of glutathione and activity of glutamine synthetase were assayed in organs of rats following inhalation of a heterogeneous solvent mixture containing both aliphatic and aromatic hydrocarbons. This mixture was administered for 3 weeks (6 h daily) at two levels in the inhaled air (400 and 800 ppm) to young adult ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050192

    authors: Bondy SC,Lam HR,Ostergaard G,Guo SX,Ladefoged O

    更新日期:1995-01-01 00:00:00

  • Darbepoetin inhibits proliferation of hepatic cancer cells in the presence of TGF-β.

    abstract::Darbepoetin (DPO), an erythropoietin (EPO) derivative, was licensed in 2002 to treat patients with solid tumors suffering from chemotherapy-dependent anemia, although various tumors express EPO to improve vascularization, thus favoring tumor growth and spreading. Therefore, we wanted to investigate direct effects of D...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-013-1094-5

    authors: Ehnert S,Freude T,Eicher C,Burkhardt B,Martínez Sánchez JJ,Neumann J,Mühl-Benninghaus R,Dooley S,Pscherer S,Nussler AK

    更新日期:2014-01-01 00:00:00

  • The no-effect level, an old bone of contention in toxicology.

    abstract::This discussion of the NEL presents some thoughts how toxicologists could be encouraged to use more sophisticated modern techniques for the study of various environmental chemicals. It is proposed to use the concept of the NEL only for data obtained by conventional techniques in routine toxicity experiments. Informati...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00695868

    authors: Zbinden G

    更新日期:1979-10-01 00:00:00

  • Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors.

    abstract::UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) for various UGT isofo...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02765-8

    authors: Kasteel EEJ,Darney K,Kramer NI,Dorne JLCM,Lautz LS

    更新日期:2020-08-01 00:00:00

  • Production of liver preneoplasia and gallbladder agenesis in turkey fetuses administered diethylnitrosamine.

    abstract::The in ovo carcinogenicity assessing (IOCA) assay was used to examine the morphological changes in fetal turkey livers caused by the DNA-reactive carcinogen diethylnitrosamine (DEN). Fertilized turkey eggs were allocated into 3 groups: nondosed control (NDC), vehicle (water) control (VC) and DEN-dosed. At day 0, the f...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-010-0603-z

    authors: Williams GM,Brunnemann KD,Iatropoulos MJ,Smart DJ,Enzmann HG

    更新日期:2011-06-01 00:00:00