Abstract:
:Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mortality due to a lethal dose of manganese chloride. However, a few common drugs which could be used in high dosage or for longer duration in manganese intoxication without serious side effects, appear promising.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Tandon SK,Khandelwal Sdoi
10.1007/BF00569233subject
Has Abstractpub_date
1982-05-01 00:00:00pages
19-25issue
1eissn
0340-5761issn
1432-0738journal_volume
50pub_type
杂志文章abstract::A set of biomedically relevant iron oxide nanoparticles with systematically modified polymer surfaces was investigated regarding their interaction with the first contact partners after systemic administration such as blood cells, blood proteins, and the endothelial blood vessels, to establish structure-activity relati...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-1968-z
更新日期:2017-10-01 00:00:00
abstract::2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) is known to influence vitamin A homeostasis. In order to investigate the mechanism behind this retinoid disruption, male Sprague-Dawley rats were exposed to TCDD at doses ranging from 0.1 to 100 micro g/kg body weight, and were killed 3 days after exposure. Additional groups...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-003-0457-8
更新日期:2003-07-01 00:00:00
abstract::The effects of acetone on liver, kidney, and lung monooxygenases were studied using hamsters administered 8% acetone in drinking water. Binding of aniline to liver microsomes induced a type II difference spectrum, and the spectral binding was enhanced in hamsters pretreated with acetone. Administration of acetone caus...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973502
更新日期:1991-01-01 00:00:00
abstract::Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs i...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-013-1160-z
更新日期:2014-03-01 00:00:00
abstract::The reduction of 20 microM hexavalent chromium [chromium(VI)] by L-ascorbic acid (AsA) (0.06-2 mM) and/or glutathione (GSH) (2-15 mM) in buffer solutions, cell-free bronchoalveolar lavage fluids or soluble fractions of rat lungs was investigated at physiological pH (37 degrees C). The reduction in AsA solution was pse...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02010721
更新日期:1990-01-01 00:00:00
abstract::The evaluation of developmental and reproductive toxicity of food contact materials (FCMs) is an important task for food safety. Since traditional experiments are both time-consuming and labor-intensive, only a small number of FCMs have sufficient toxicological data for evaluating their effects on human health. While ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02641-0
更新日期:2020-02-01 00:00:00
abstract::The disposition, elimination, and metabolism of 50 mg/kg (1.36 muCi/animal) of tri-o-cresyl [phenyl-U-14C] phosphate after ten daily oral doses was investigated in adult male Fischer 344 rats. Groups of three treated animals were killed at intervals of 24, 48, 72, and 96 h after the last administrations. Generally, th...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01971837
更新日期:1990-01-01 00:00:00
abstract::Vitamin E acetate (VEA) has come under significant scrutiny due to its association with e-cigarette, or vaping, product use-associated lung injury (EVALI). In 1965, Sir Austin Bradford Hill proposed a set of criteria used to critically assess an association for causality. In this article, we apply the Bradford Hill ca...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-020-02770-x
更新日期:2020-06-01 00:00:00
abstract::Groups of adult male Sprague-Dawley rats were treated i.p. with 0, 0.3 and 0.5 mmole bromobenzene (BB)/kg per day in corn oil, 5 days a week for 4 weeks. Thereafter, one half of each of these groups was treated i.p. with a single acute toxic dose of 2.5 mmole BB/kg. Urines were then collected for 24 h and the animals ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02098037
更新日期:1991-01-01 00:00:00
abstract::Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00296955
更新日期:1987-01-01 00:00:00
abstract::As previously demonstrated, chronic administration of phenobarbital (0.05% in the drinking water) and of nafenopin (0.1% in the diet) increases the incidence and the kinetics of appearance of liver cancers. If bile acids play a key role in liver carcinogenesis, it might thus be expected that treatments like phenobarbi...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050087
更新日期:1994-01-01 00:00:00
abstract::This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a sh...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0255-9
更新日期:2008-06-01 00:00:00
abstract::Sulfur dioxide (SO2) is a common air pollutant, and inhaled SO2 in airway epithelium easily forms its soluble derivatives in vivo (bisulfite and sulfite), which are toxic to the respiratory system and related to the exacerbation of asthma. To investigate the effects of SO2 derivatives on the expressions of asthma rela...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0212-7
更新日期:2007-12-01 00:00:00
abstract::In the present study, spiking was used as a strategy to evaluate the mutagenicity of individual compounds in a mixture. Mutagenicity of individual polycyclic aromatic hydrocarbons (PAH) was evaluated in an organic extract of diesel exhaust particles (DEP). The particles were extracted with dichloromethane (DCM). After...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050555
更新日期:1998-10-01 00:00:00
abstract::Di-n-butylin dichloride (DBTCl), which is commonly used as heat and light stabilizer for polyvinyl chloride (PVC) plastics, is a teratogen in vivo. In the present study, the toxic effects were investigated of DBTCl on cultured rat embryos during three different stages of organogenesis. Rat embryos explanted on gestati...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050335
更新日期:1996-01-01 00:00:00
abstract::Rodents are relatively insensitive to the neurotoxic effects of various organophosphorus compounds. The purpose of this investigation was to determine if differences in inactivation of CBDP could explain the strain differences in the sensitivity to neurotoxicity following administration of TOCP (tri-o-cresyl phosphate...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973466
更新日期:1990-01-01 00:00:00
abstract::Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatm...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00286576
更新日期:1985-04-01 00:00:00
abstract::The goal of the present study was to obtain an in vivo relevant prioritization method for the endocrine potencies of different polycarbonate monomers, by combining in vitro bioassay data with physiologically based kinetic (PBK) modelling. PBK models were developed for a selection of monomers, including bisphenol A (BP...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02479-6
更新日期:2019-07-01 00:00:00
abstract::Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2259-z
更新日期:2018-09-01 00:00:00
abstract::The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050237
更新日期:1995-01-01 00:00:00
abstract::DNA damage induced by methylmethane sulfonate, cyclophosphamide, doxorubicin and procarbazine in male germ cells was assessed in rabbits by the demonstration of unscheduled DNA synthesis (UDS), in meiotic and postmeiotic phases of maturation. Immediately after treatment by the intravenous route tritiated thymidine was...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00361252
更新日期:1980-11-01 00:00:00
abstract::The toxic effect of cyclophosphamide on the proliferative cell population of hair follicles plucked from the human scalp was examined by the in vivo nuclear aberration assay. Patients participating in an independent clinical trial received oral low dose cyclophosphamide, intravenous high dose cyclophosphamide or oral ...
journal_title:Archives of toxicology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01974396
更新日期:1990-01-01 00:00:00
abstract::The effects of equimolar doses of the triphenylethylene antiestrogens tamoxifen and toremifene on female Sprague-Dawley rat liver were studied in a 52-week toxicity study which included a 13-week recovery period. Liver tumors were found in four out of five rats at the highest dose level of tamoxifen (45 mg/kg per day)...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02072035
更新日期:1993-01-01 00:00:00
abstract::The involvement of oxidative stress has been suggested as a mechanism for neurotoxicity caused by methylmercury (MeHg), but the mechanism for MeHg selective toxicity in the central nervous system is still unclear. In this research, to clarify the mechanism of selective neurotoxicity caused by MeHg, the oxygen consumpt...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0209-2
更新日期:2007-11-01 00:00:00
abstract::Although shorter chain homologues and other types of fluorinated chemicals are currently used as alternatives to long-chain perfluoroalkyl substances (PFASs), their safety information remains unclear and urgently needed. Here, the cytotoxicity of several fluorinated alternatives (i.e., 6:2 fluorotelomer carboxylic aci...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2055-1
更新日期:2018-01-01 00:00:00
abstract::The effects of six iv infusions of an emulsion containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) on the liver and testes were investigated in 40-day-old rats. Groups of five to six animals received the emulsion every other day in doses of 0, 5, 50 or 500 mg DEHP/kg body weight. Liver effects were studied by...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00348313
更新日期:1985-12-01 00:00:00
abstract::Engineered amorphous silica nanoparticles (nanosilica) are widely used in industry yet can induce adverse effects, which might be classified according to the oxidative stress model. However, the underlying mechanisms as well as the potential interactions of the three postulated different tiers of toxicity-i.e. oxidati...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2223-y
更新日期:2018-07-01 00:00:00
abstract::Aciclovir (synonym: acyclovir) causes abnormal thymus development in rats. After treatment on day 10 of gestation a weight reduction of the organ is obvious in 21-day-old fetuses which persists postnatally. Adult male rats exposed in utero to one or three injections of 100 mg aciclovir/kg body wt given to the dam on d...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973385
更新日期:1992-01-01 00:00:00
abstract::Recently, acutely toxic doses of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been reported to affect the hepatic distribution of essential metals in the rat. However, the reduced food intake by TCDD was not taken into account. Therefore, metal concentrations were determined in different...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02284268
更新日期:1991-01-01 00:00:00
abstract::The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We s...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0364-0
更新日期:2009-03-01 00:00:00