Abstract:
:When rats were dosed with 14 microgram/kg 3H-isoproterenol, 3H-radioactivity was measurable in the liver until 48 h. This amount was not different in livers of animals which have been pretreated with diethyl maleate. After exhaustive extraction, a significant amount of 3H-radioactivity from isoproterenol could be detected in the proteins of total liver (homogenate), of cytosol and of microsomes. In the cytosol fraction of diethyl maleate pretreated animals twice the amount of isoproterenol-radioactivity was found in the extracted proteins compared to controls. In the microsomal fraction there was no difference between diethyl maleate pretreated and control animals in the amount of radioactivity incorporated into proteins. In all fractions the radioactivity measurable in the extracted proteins declined with a half life time of about 24 h. The in vivo results on covalent binding of isoproterenol are compared to the irreversible protein binding of ethinyloestradiol in vivo. Quantitatively, these in vivo data are compared to the results on irreversible protein binding obtained during incubations of isoproterenol or ethinyloestradiol with rat liver microsomes.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Remmer H,Scheulen M,Kappus H,Bolt HMdoi
10.1007/BF00343273subject
Has Abstractpub_date
1977-12-30 00:00:00pages
31-9issue
1-2eissn
0340-5761issn
1432-0738journal_volume
39pub_type
杂志文章abstract::The aim of this study was to investigate the genotoxic potential of DNA adducts and to compare DNA adduct levels and patterns in petroleum vacuum distillates, coal tar distillate, bitumen fume condensates, and related substances that have a wide range of boiling temperatures. An in vitro assay was used for DNA adduct ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040000172
更新日期:2001-01-01 00:00:00
abstract::The effects of acetone on liver, kidney, and lung monooxygenases were studied using hamsters administered 8% acetone in drinking water. Binding of aniline to liver microsomes induced a type II difference spectrum, and the spectral binding was enhanced in hamsters pretreated with acetone. Administration of acetone caus...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973502
更新日期:1991-01-01 00:00:00
abstract::Particle-induced carcinogenicity is not well understood, but might involve inflammation. The proinflammatory cytokine tumor necrosis factor (TNF) is considered to be an important mediator in inflammation. We investigated its role in particle-induced inflammation and DNA damage in mice with and without TNF signaling. T...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0613-9
更新日期:2005-03-01 00:00:00
abstract::Cholestasis underlies one of the major manifestations of drug-induced liver injury. Drug-induced cholestatic liver toxicity is a complex process, as it can be triggered by a variety of factors that induce 2 types of biological responses, namely a deteriorative response, caused by bile acid accumulation, and an adaptiv...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-019-02437-2
更新日期:2019-05-01 00:00:00
abstract::The effect of 1-deamino-2-tyr(ethyl) oxytocin (dEtOT) upon peri- and postnatal development of the rat was studied in two experiments when administered between day 15 of pregnancy and the day of parturition. The investigation showed that dEtOT did not affect the pups at birth, that dEtOT caused a dose-related growth re...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00324786
更新日期:1985-09-01 00:00:00
abstract::Chlorpyrifos (CPF) is a widely used organophosphorus pesticide. Earlier work from our laboratory and others has demonstrated that the sensitivity to CPF exposure changes markedly during maturation. A number of studies suggest that in addition to inhibiting acetylcholinesterase (AChE), CPF oxon may also interact direct...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-001-0309-3
更新日期:2002-01-01 00:00:00
abstract::The regional distribution of dopamine, norepinephrine and homovanillic acid was assessed in adult male rabbits exposed to styrene vapours. The turnover of dopamine and norepinephrine was also measured in several brain regions by the decay in endogenous catecholamines after inhibition of tyrosine hydroxylase by alpha-m...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316123
更新日期:1984-09-01 00:00:00
abstract::The present study was designed to evaluate the effects of chronic fluorosis on the dynamics (including fusion and fission proteins), fragmentation, and distribution of mitochondria in the cortical neurons of the rat brain in an attempt to elucidate molecular mechanisms underlying the brain damage associated with exces...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-012-0942-z
更新日期:2013-03-01 00:00:00
abstract::Lead (Pb) exposure of consumers and the environment has been reduced over the past decades. Despite all measures taken, immission of Pb onto agricultural soils still occurs, with fertilizer application, lead shot from hunting activities, and Pb from air deposition representing major sources. Little is known about the ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02762-x
更新日期:2020-07-01 00:00:00
abstract::N-Methyl-2-pyrrolidone (NMP) is a versatile organic solvent frequently used for surface cleaning such as paint stripping or graffiti removal. Liquid NMP is rapidly absorbed through the skin but dermal vapour phase absorption might also play an important role for the uptake of the solvent. This particular aspect was in...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0230-5
更新日期:2008-01-01 00:00:00
abstract::Although carbon nanotubes (CNTs) are promising nanomaterials, their potential carcinogenicity is a major concern. We previously established a genetic method of analyzing genotoxicity of chemical compounds, where we evaluated their cytotoxic effect on the DT40 lymphoid cell line comparing DNA-repair-deficient isogenic ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1084-7
更新日期:2014-01-01 00:00:00
abstract::Single doses of procarbazine (MIH) were injected IP at 0, 50, 100, 200, and 400 mg/kg body weight to CD-1 male mice. Activities of hyaluronidase, lactate dehydrogenase isoenzyme-X, and the dehydrogenases of sorbitol, alpha-glycerophosphate, glucose-6-phosphate, malate, isocitrate, and glyceraldehyde-3-phosphate in the...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00341017
更新日期:1984-10-01 00:00:00
abstract::Acetaminophen (APAP) overdose is the leading cause of acute liver failure. Yet the mechanisms underlying adaptive tolerance toward APAP-induced liver injury are not fully understood. To better understand molecular mechanisms contributing to adaptive tolerance to APAP is an underpinning foundation for APAP-related prec...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2090-y
更新日期:2018-02-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1532-7
更新日期:2016-04-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050529
更新日期:1998-07-01 00:00:00
abstract::In female rats dosed orally with 14C-hexachlorobenzene the extent of intestinal absorption of carbon-14 has been found to be dependent on the form of application. When the substance was given as a solution in oil about 80% of the dose administered was absorbed, but when given as an aqueous suspension only 6%. In anima...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00353283
更新日期:1975-11-20 00:00:00
abstract::The development and application of high throughput in vitro assays is an important development for risk assessment in the twenty-first century. However, there are still significant challenges to incorporate in vitro assays into routine toxicity testing practices. In this paper, a robust learning approach was developed...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2260-6
更新日期:2018-09-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2320-y
更新日期:2018-12-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01270911
更新日期:1980-07-01 00:00:00
abstract::Initially, mice were pretreated with atropine (17.4 mg/kg; IP) and the oxime reactivator HI-6 (50 mg/kg; IP) 5 min prior to an injection of soman (287 micrograms/kg, SC); approximately 2.1 x LD50 dose). More than 95% of the mice survived this dose of soman with atropine and HI-6 pretreatment. In these survivors of som...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316438
更新日期:1989-01-01 00:00:00
abstract::Early hepatocyte death occurs in most liver injury cases and triggers liver inflammation, which in combination with other risk factors leads to the development of liver disease. However, the pathogenesis of early phase hepatocyte death remains poorly understood. Here, C57BL/6J mice were treated with the hepatotoxic dr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02454-1
更新日期:2019-06-01 00:00:00
abstract::Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-011-0736-8
更新日期:2012-01-01 00:00:00
abstract::Experimental and/or epidemiological studies suggest that prenatal exposure to bisphenol A (BPA) may delay fetal lung development and maturation and increase the susceptibility to childhood respiratory disease. However, the underlying mechanisms remain to be elucidated. In our previous study with cultured human fetal l...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2150-3
更新日期:2018-04-01 00:00:00
abstract::The tissue distribution, metabolism and excretion of 14C-2,2',4,4',5-pentachlorodiphenyl ether (PCDE) were studied in the rat. Radioactivity was distributed in all tissues examined, with the highest concentrations being found in the fat followed by the skin, liver, kidney and muscle. Most of the radioactivity found in...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00332484
更新日期:1988-01-01 00:00:00
abstract::Quinacrine hydrochloride is toxic for the heart of F-344 rats. Rats treated with 500 ppm quinacrine hydrochloride in the diet all developed a high incidence of left atrial thrombosis. The lesion was associated with cardiac hypertrophy and dilatation and focal myocardial degeneration. Rats died from cardiac hypertrophy...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316350
更新日期:1984-11-01 00:00:00
abstract::Regarding the potential impact of traffic-born air pollutants on public health, in recent years attention has increasingly been focused on the possible effects on the cardiovascular system. In order to investigate this problem further, the influence of long-term exhaust gas exposure on rats has been studied. One hundr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00332390
更新日期:1981-07-01 00:00:00
abstract::The neurological effects of four synthetic pyrethroids resmethrin, permethrin, cypermethrin, and deltamethrin have been investigated in the rat to establish whether there is a correlation between the clinical-functional status of the animal and peripheral nerve damage as measured biochemically. Neuromuscular dysfuncti...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00294995
更新日期:1983-08-01 00:00:00
abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent tumor promoter ever tested in rodents. Although it is known that most of the effects of TCDD are mediated by binding to the aryl hydrocarbon receptor (AhR), the mechanisms leading to tumor promotion still remain to be elucidated. Loss of contact inhibition ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0601-0
更新日期:2005-01-01 00:00:00
abstract::In a previous study, we showed that bisphenol A (BPA) had oestrogen-like effects in bird embryos, causing malformations of the oviducts in Japanese quail (Coturnix japonica) and feminisation of the left testis in chicken (Gallus domesticus). In this study, uptake and distribution of BPA and tetrabromobisphenol A (TBBP...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040100277
更新日期:2001-12-01 00:00:00
abstract::Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroetha...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050281
更新日期:1996-01-01 00:00:00