Abstract：
:Cholestasis underlies one of the major manifestations of drug-induced liver injury. Drug-induced cholestatic liver toxicity is a complex process, as it can be triggered by a variety of factors that induce 2 types of biological responses, namely a deteriorative response, caused by bile acid accumulation, and an adaptive response, aimed at removing the accumulated bile acids. Several key events in both types of responses have been characterized in the past few years. In parallel, many efforts have focused on the development and further optimization of experimental cell culture models to predict the occurrence of drug-induced cholestatic liver toxicity in vivo. In this paper, a state-of-the-art overview of mechanisms and in vitro models of drug-induced cholestatic liver injury is provided.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Gijbels E,Vilas-Boas V,Deferm N,Devisscher L,Jaeschke H,Annaert P,Vinken Mdoi
10.1007/s00204-019-02437-2subject
Has Abstractpub_date
2019-05-01 00:00:00pages
1169-1186issue
5eissn
0340-5761issn
1432-0738pii
10.1007/s00204-019-02437-2journal_volume
93pub_type
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