Abstract：
:The neurological effects of four synthetic pyrethroids resmethrin, permethrin, cypermethrin, and deltamethrin have been investigated in the rat to establish whether there is a correlation between the clinical-functional status of the animal and peripheral nerve damage as measured biochemically. Neuromuscular dysfunction was assessed by means of the inclined plane test and peripheral nerve damage by reference to beta-glucuronidase and beta-galactosidase activity increases in nerve tissue homogenates from treated and control animals. A transient functional impairment was found in animals treated with any one of the four pyrethroids tested and in all cases this was maximal at the end of the 7 day subacute dosing regimen. Significant increases in beta-glucuronidase and beta-galactosidase were found 3-4 weeks after the start of dosing in the distal portion of the sciatic/posterior tibial nerves from permethrin, cypermethrin, and deltamethrin treated animal; but no changes were found in remesthrin-dosed animals. It is concluded therefore, that there is no direct correlation between the time-course of the neuromuscular dysfunction and the neurobiochemical changes. This suggests that these pyrethroids have at least two distinct actions--a short-term pharmacological effect and at near-lethal dose levels a more chronic neurotoxic effect that results in sparse axonal nerve damage.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Rose GP,Dewar AJdoi
10.1007/BF00294995subject
Has Abstractpub_date
1983-08-01 00:00:00pages
297-316issue
4eissn
0340-5761issn
1432-0738journal_volume
53pub_type
杂志文章abstract：:Between 0.25-25 micrograms of an aqueous solution of either mercuric chloride or methyl mercuric acetate was injected directly into the sciatic nerve of 28 adult Wistar rats. The resultant pathological changes in the nerve were examined by teasing individual fibres and by light and electron microscopy. In most respect...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00310442
更新日期：1980-12-01 00:00:00
abstract：:Tea (Camellia sinensis, Theaceace), a popular beverage consumed world-wide, has been studied for its preventive effects against cancer as well as cardiovascular, neurodegenerative, and other diseases. Most of the proposed beneficial effects have been attributed to the polyphenolic compounds in tea, but the nature of t...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-008-0372-0
更新日期：2009-01-01 00:00:00
abstract：:This study investigated whether paraquat (Pq)-induced lipidic peroxidation (LP) is accompanied by changes in blood pressure and heart rate (HR) in rats. Groups of adult male Wistar rats were studied 2 and 12 h after Pq (35 mg/kg, i.p.) administration. The LP was evaluated by monitoring thiobarbituric acid reactive sub...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0660-x
更新日期：2005-09-01 00:00:00
abstract：:A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented. In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposu...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050072
更新日期：1994-01-01 00:00:00
abstract：:The genotoxicity of the sensory irritant 2-chlorobenzylidene malonitrile (CS) to V79 Chinese hamster cells was investigated using the induction of gene mutations, micronuclei and DNA repair synthesis as biological endpoints. CS efficiently induced micronuclei and mutants resistant to 6-thioguanine in these cells, but ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00278645
更新日期：1989-01-01 00:00:00
abstract：:Previous studies in our laboratory identified retinoid-induced defects that are mediated by RAR-RXR heterodimerization using interaction of synthetic ligands selective for the retinoid receptors RAR and RXR in mice (Elmazar et al. 1997, Toxicol Appl Pharmacol 146:21-28; Elmazar et al. 2001, Toxicol Appl Pharmacol 170:...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0586-8
更新日期：2004-11-01 00:00:00
abstract：:Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicating factor is that non-genotoxic carcinogens act through several distinctive modes of action, which makes prediction of t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1368-6
更新日期：2015-12-01 00:00:00
abstract：:Quinacrine hydrochloride is toxic for the heart of F-344 rats. Rats treated with 500 ppm quinacrine hydrochloride in the diet all developed a high incidence of left atrial thrombosis. The lesion was associated with cardiac hypertrophy and dilatation and focal myocardial degeneration. Rats died from cardiac hypertrophy...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316350
更新日期：1984-11-01 00:00:00
abstract：:Berberine, a main protoberberine component of Coptidis Rhizoma, was studied for the mechanism of its inhibitory effects on the tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity and lipid peroxidation in rat liver. In the preliminary study, berberine expressed an antioxidant property by its capacity for quenching t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0351-9
更新日期：2002-11-01 00:00:00
abstract：:Clinical and electrophysiological examinations were performed on 12 patients with toxic neuropathy following accidental ingestion of alcohol polluted by triorthocresyl phosphate (TOCP). Concurrent PNS and CNS lesions were found in all patients. Two to three months after ingestion, five of them showed prevalent signs o...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00366186
更新日期：1980-02-01 00:00:00
abstract：:This article is published with the incorrect copyright holder name in the HTML article as "© Springer 2018". The correct copyright line should read "The Author(s) 2018" (as it appears in the article PDF). ...
journal_title：Archives of toxicology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00204-018-2301-1
更新日期：2018-11-01 00:00:00
abstract：:Pentachlorophenol (PCP) and Dichlorodiphenyltrichloroethane (DDT) are environmental contaminants found in human blood. Previous studies have shown that PCP and DDT inhibit the lytic function of highly purified human natural killer (NK) lymphocytes and decrease the expression of several surface proteins on NK cells. In...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1829-1
更新日期：2017-04-01 00:00:00
abstract：:The flavonol quercetin shows a wide range of effects in biological systems. We investigated whether quercetin exerts its proposed antioxidant properties via the antioxidant enzyme system. Quercetin in a concentration range from 5 to 100 microM decreased manganese superoxide dismutase, glutathione peroxidase, and coppe...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0482-7
更新日期：2003-09-01 00:00:00
abstract：:The metabolism of arsenic is generally accepted to proceed by repetitive reduction and oxidative methylation; the latter is mediated by arsenic methyltransferase (Cyt19). In human urine, the major metabolites of inorganic arsenicals such as arsenite (iAsIII) and arsenate (iAsV) are monomethylarsonic acid (MMA(V)) and ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0620-x
更新日期：2005-04-01 00:00:00
abstract：:Aliphatic nitriles are a class of chemicals used in high volumes in the production of plastics and elastomers, in organic synthesis, and in production of a number of food packaging containers. Toxicity and metabolism of acrylonitrile (AN) are well characterized. On the other hand, minimal information is available on t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF03208340
更新日期：1994-01-01 00:00:00
abstract：:The hepatoproliferative and cytochrome P450 enzyme inducing effects of two antiestrogens, tamoxifen and toremifene, were compared in female Sprague-Dawley rats using immunohistochemical staining methods. Equimolar doses of the antiestrogens (tamoxifen 45 mg/kg and toremifene 48 mg/kg) were given by oral administration...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000116
更新日期：2000-07-01 00:00:00
abstract：:The US Environmental Protection Agency's ToxCast program has generated toxicity data for thousands of chemicals but does not adequately assess potential neurotoxicity. Networks of neurons grown on microelectrode arrays (MEAs) offer an efficient approach to screen compounds for neuroactivity and distinguish between com...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02636-x
更新日期：2020-02-01 00:00:00
abstract：:Airway smooth muscle (ASM) cell phenotypic switching played an important role in airway remodeling in asthma. In vitro platelet-derived growth factor (PDGF) induced ASM cell phenotypic switching from a mature to pro-remodeling phenotype, but the mechanism remained incompletely understood. This study was to explore the...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-1008-y
更新日期：2013-05-01 00:00:00
abstract：:Bisphenol A (BPA) is a chemical in widespread use that is under scientific discussion due to its endocrine activity. Controversies exist about how to interpret reportedly high blood concentrations measured in uncontrolled situations. Physiologically based pharmaco-/toxicokinetic modelling resulted in 10-100-fold lower...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1022-8
更新日期：2013-07-01 00:00:00
abstract：:Rodents are relatively insensitive to the neurotoxic effects of various organophosphorus compounds. The purpose of this investigation was to determine if differences in inactivation of CBDP could explain the strain differences in the sensitivity to neurotoxicity following administration of TOCP (tri-o-cresyl phosphate...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973466
更新日期：1990-01-01 00:00:00
abstract：:Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0736-8
更新日期：2012-01-01 00:00:00
abstract：:During aerobic incubation of trichloroethylene with rabbit liver microsomes and NADPH a difference absorption peak appears at 451-452 nm. Trichloroethylene does not form a ligand absorption spectrum with hepatic microsomes reduced by dithionite, or in anaerobic incubates in the presence of NADPH. Addition of trichloro...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293858
更新日期：1977-06-18 00:00:00
abstract：:Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. The microsomes themselves were not cytotoxic. P388D1 cells were more sensitive to CPA, ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000141
更新日期：2000-10-01 00:00:00
abstract：:Volunteers inhaled a constant concentration of 50 ppm trichloroethylene (Tri) for 6 hrs per day on 5 consecutive days. Simultaneous ethanol (EtOH) ingestion (blood level 0.6%) inhibits the metabolization of Tri to trichloroethanol (TCE) and trichloroacetic acid (TCA) by 40% on the average. Oxidation of Tri to TCA does...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00311271
更新日期：1975-01-01 00:00:00
abstract：:The effect of lindane and heptachlor on haem metabolism was studied with the aim to elucidate the mechanism of their porphyrinogenic action. The effects of these compounds on delta-aminolaevulinate synthase (ALA-S) and ferrochelatase were evaluated and the mechanism of increase of ALA-S activity was especially studied...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050566
更新日期：1998-11-01 00:00:00
abstract：:The effects of acetaldehyde (ACD) on dopamine (DA) and DA-derived salsolinol (SAL) levels were investigated in the striatum of freely moving rats. Dialysate levels of DA and SAL were determined using in vivo reverse microdialysis coupled with high-performance liquid chromatography with an electrochemical detector. Per...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0131-z
更新日期：2007-02-01 00:00:00
abstract：:Mouse liver tumors that harbor activating mutations in Ctnnb1, encoding β-catenin, express high levels of various cytochromes P450 (CYP), including CYP2E1 and CYP1A2. Acetaminophen (AAP) is metabolized in hepatocytes by these CYPs to the reactive intermediate N-acetyl-p-benzoquinone-imine, which is toxic to hepatocyte...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1030-8
更新日期：2013-08-01 00:00:00
abstract：:The effect of intracerebroventricular (i.c.v.) administration of cadmium or magnesium on central calcium-dependent blood pressure regulation was investigated. The systolic blood pressure of spontaneously hypertensive rats (SHR; male, 13 weeks of age) decreased following i.c.v. administration of cadmium chloride (20 nm...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050644
更新日期：2000-03-01 00:00:00
abstract：:The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological releva...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1845-1
更新日期：2016-12-01 00:00:00
abstract：:Renal papillary necrosis (RPN) was induced in Fischer 344 (F344) rats (n = 4) using 2-bromoethanamine hydrobromide (BEA) dosed at 150 mg/kg, and in multimammate desert mice (Mastomys natalensis) at 150 and 250 mg/kg (n = 4 per group). Control rats and Mastomys were dosed with 0.9% saline (n = 4 per group). Urine was c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02733668
更新日期：1995-01-01 00:00:00
