Abstract：
:Clinical and electrophysiological examinations were performed on 12 patients with toxic neuropathy following accidental ingestion of alcohol polluted by triorthocresyl phosphate (TOCP). Concurrent PNS and CNS lesions were found in all patients. Two to three months after ingestion, five of them showed prevalent signs of mixed, sensorimotor polyneuropathy, especially motor and distal, and the electrophysiological data pointed to the mixed process of axonal degeneration and secondary demyelination. In two of these five patients in whom examinations were repeated 13 years after TOCP ingestion, there was a marked clinical and electrophysiological improvement of signs of PNS lesions. Improvement of signs of CNS lesions was very poor even after 13 years. Signs of CNS lesions prevailed in the remaining seven patients. The clinical picture resembled that in amyotrophic lateral sclerosis and the electrophysiological data suggested a neuronal and axonal degeneration. Apart from the 12 cases of TOCP neuropathy, we also studied two cases of poisoning with organophosphorus insecticides, Dipterex and Divipan, in which a pure motor form of neuropathy was found.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Vasilescu C,Florescu Adoi
10.1007/BF00366186subject
Has Abstractpub_date
1980-02-01 00:00:00pages
305-15issue
4eissn
0340-5761issn
1432-0738journal_volume
43pub_type
杂志文章abstract：:Levels of glutathione and activity of glutamine synthetase were assayed in organs of rats following inhalation of a heterogeneous solvent mixture containing both aliphatic and aromatic hydrocarbons. This mixture was administered for 3 weeks (6 h daily) at two levels in the inhaled air (400 and 800 ppm) to young adult ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050192
更新日期：1995-01-01 00:00:00
abstract：:The present study was carried out to elucidate the mechanisms behind an increase in the incidence of malignant or multiple mammary tumors as a result of oral administration of rolipram in a 104-week carcinogenicity study. The organs and tissues of Sprague-Dawley (SD) rats of both sexes, which had been subjected to a 1...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0016-6
更新日期：2006-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02938-5
更新日期：2021-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02746-x
更新日期：2020-06-01 00:00:00
abstract：:Changes in the electrophysiologic activity of the rat sciatic nerve were examined after repeated dosing with either of two organophosphate insecticides, parathion, and trichlorfon. Although the parathion treated animals showed overt signs of systemic toxicity, there were no significant changes in any of the measured p...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00333896
更新日期：1983-03-01 00:00:00
abstract：:A histochemical technique for detection of the in vivo induced cellular aldehydes based on the direct Schiff's reaction is reported in this paper. CCl4-intoxicated rat liver was used as an experimental model. Fresh and non-pretreated rat liver cryostat sections fixed in 10% formol calcium solution and washed in distil...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00334622
更新日期：1988-04-01 00:00:00
abstract：:Perfluoroalkyl acids are widely used in numerous industrial and commercial applications due to their unique physical and chemical characteristics. Although perfluorooctanoic acid (PFOA) is associated with hepatomegaly through peroxisome proliferator-activated receptor α (PPARα) activation, liver fat accumulation and c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1322-7
更新日期：2015-09-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050499
更新日期：1998-04-01 00:00:00
abstract：:In vitro assays are often used for the hazard characterisation of compounds, but their application for quantitative risk assessment purposes is limited. This is because in vitro assays cannot provide a complete in vivo dose-response curve from which a point of departure (PoD) for risk assessment can be derived, like t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1107-4
更新日期：2013-09-01 00:00:00
abstract：:Organophosphate-induced delayed polyneuropathy (OPIDP) is initiated by inhibition/aging of more than 70-75% of neuropathy target esterase (NTE). Di-n-butyl-2,2-dichlorovinyl phosphate (DBDCVP) (1 mg/kg s.c.) inhibited 96%, 86% and 83% of NTE in brain, spinal cord and peripheral nerve, respectively, and induced a typic...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316450
更新日期：1989-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01981506
更新日期：1992-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1852-2
更新日期：2017-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1772-1
更新日期：2016-09-01 00:00:00
abstract：:To investigate possible persistent nephrotoxic effects of trichloroethylene (TRI), a retrospective study was carried out on 39 workers exposed to high levels of TRI from 1956 to 1975. Total protein levels in urine, as well as serum and urine creatinine and serum urea were unchanged in comparison with the control. Sodi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050613
更新日期：1999-06-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2170-7
更新日期：2018-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293687
更新日期：1988-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0063-7
更新日期：2006-07-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100264
更新日期：2001-10-01 00:00:00
abstract：:This discussion of the NEL presents some thoughts how toxicologists could be encouraged to use more sophisticated modern techniques for the study of various environmental chemicals. It is proposed to use the concept of the NEL only for data obtained by conventional techniques in routine toxicity experiments. Informati...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00695868
更新日期：1979-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303292
更新日期：1980-05-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1526-5
更新日期：2016-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974021
更新日期：1992-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02829-9
更新日期：2020-09-01 00:00:00
abstract：:HCB was detected in all preparations of human placenta, maternal blood, milk, and cord blood. It was confirmed that HCB transferred from mother to fetus through the placenta. A significant linear correlation exists between the HCB concentration in placenta and that in cord blood. Therefore, the placental concentration...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00333426
更新日期：1985-01-01 00:00:00
abstract：:Sotalol [4-(2-isopropylamino-1-hydroxyethyl)-methane-sulfonanilide hydrochloride] is a beta-adrenergic blocking agent. Despite the widespread use of these drugs, poisonings are not frequent. In this report the authors describe the first recorded case of fatal sotalol overdosage to their knowledge. The results of toxic...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00297587
更新日期：1980-01-01 00:00:00
abstract：:Monolayers of L6 rat skeletal myoblast cells formed surface binding isotherms with the purified tobacco leaf glycoprotein TGP1 and the enriched cigarette tar glycoprotein TGP2. Scatchard analysis showed that the binding in the range of the limited concentrations tested was to a single class molecule and the calculated...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050151
更新日期：1995-01-01 00:00:00
abstract：:Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions. These epoxy FAs comprise epoxyeicosatrienoic acids (EETs) and epoxy-octadeceno...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2060-4
更新日期：2017-11-01 00:00:00
abstract：:Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs i...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-013-1160-z
更新日期：2014-03-01 00:00:00
abstract：:Phytoestrogens have been described as weak estrogens, selective estrogen receptor mediators (SERMs) or to exhibit antiestrogenic properties. However, information about their activity in combination with xenoestrogens and 17beta-estradiol in vivo, is limited. Therefore, the combinatory activity of the phytoestrogen gen...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0102-4
更新日期：2006-12-01 00:00:00
abstract：:Quinacrine hydrochloride is toxic for the heart of F-344 rats. Rats treated with 500 ppm quinacrine hydrochloride in the diet all developed a high incidence of left atrial thrombosis. The lesion was associated with cardiac hypertrophy and dilatation and focal myocardial degeneration. Rats died from cardiac hypertrophy...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316350
更新日期：1984-11-01 00:00:00
