Role of striatal acetylcholine and free ammmonia in the central stimulatory effects of pp'DDT in rats. Protective effects of barbiturates.

Abstract:

:pp'DDT (600 mg/kg, orally) produced an increase in the level of free ammonia and a decrease of acetylcholine in the corpus striatum of rats. These effects were maximal 5 h after the administration of pp'DDT. The animals showed tremors after 2 h, mild or moderate convulsions after 3.5 h and severe convulsions 5 h after treatment with pp'DDT. The neurochemical changes and convulsions induced by pp'DDT were modified to different degrees by barbiturates. Phenobarbitone sodium abolished the convulsions while prominal reduced the severity of convulsions in pp'DDT treated animals. The level of striatal acetylcholine in pp'DDT-phenobarbitone treated animals was not significantly different from the control values. In prominal-pp'DDT treated animals, it was slightly but significantly reduced. Primidone neither changed the severity of convulsions nor the level of striatal acetylcholine in pp'DDT treated animals. Further barbiturates had no significant effect on the level of free ammonia in pp'DDT treated rats. The results suggest that changes in the level of acetylcholine are not the cause but an effect of pp'DDT induced stimulatory effects or convulsions, mediated through an increase in the level of free ammonia or some other mechanism.

journal_name

Arch Toxicol

journal_title

Archives of toxicology

authors

Matin MA,Jaffery FN,Kar PP

doi

10.1007/BF00303292

subject

Has Abstract

pub_date

1980-05-01 00:00:00

pages

29-35

issue

1

eissn

0340-5761

issn

1432-0738

journal_volume

45

pub_type

杂志文章
  • Testosterone hydroxylase in evaluating induction and suppression of murine CYP isoenzymes by fenarimol.

    abstract::This study aimed to investigate the effect of single and repeated administration of fenarimol on murine liver, kidney and lung microsomal CYP-catalyzed drug metabolism. The modulation of the regio- and stereo-selective hydroxylation of testosterone by fenarimol was considered in evaluating cocarcinogenic properties. I...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050298

    authors: Paolini M,Pozzetti L,Mesirca R,Sapone A,Cantelli-Forti G

    更新日期:1996-01-01 00:00:00

  • Comparative biological properties of the four stereoisomers of difethialone, a second-generation anticoagulant rodenticide, in rats: development of a model allowing to choose the appropriate stereoisomeric ratio.

    abstract::The current management of rodent pest populations is based on second-generation anticoagulant rodenticides (SGAR). These molecules, of which difethialone is part, are much more efficient than the first generation. Nevertheless, this efficiency comes with a major drawback, SGARs are tissue persistent that increases the...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02662-0

    authors: Lefebvre S,Fourel I,Chatron N,Caruel H,Benoit E,Lattard V

    更新日期:2020-03-01 00:00:00

  • Toxicology of organophosphorus compounds in view of an increasing terrorist threat.

    abstract::The implementation of the Chemical Weapon Convention (CWC), prohibiting the development, production, storage and use of chemical weapons by 192 nations and the ban of highly toxic OP pesticides, especially class I pesticides according to the WHO classification, by many countries constitutes a great success of the inte...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-016-1772-1

    authors: Worek F,Wille T,Koller M,Thiermann H

    更新日期:2016-09-01 00:00:00

  • In vitro activation of dibromoacetonitrile to cyanide: role of xanthine oxidase.

    abstract::Dibromoacetonitrile (DBAN) is a disinfection byproduct of chlorination of drinking water. Epidemiological studies indicate that it might present a potential hazard to human health. The present work provides evidence for DBAN activation to cyanide (CN(-)) by the hypoxanthine (HX)/xanthine oxidase (XO)/iron (Fe) system ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-002-0418-7

    authors: Mohamadin AM,Abdel-Naim AB

    更新日期:2003-02-01 00:00:00

  • The role of epoxide hydrolases in health and disease.

    abstract::Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-014-1371-y

    authors: El-Sherbeni AA,El-Kadi AO

    更新日期:2014-11-01 00:00:00

  • Host resistance to rat cytomegalovirus (RCMV) and immune function in adult PVG rats fed herring from the contaminated Baltic Sea.

    abstract::The immunotoxic potential of many classes of environmental contaminants has been well established in laboratory studies, with much attention being focussed on aryl hydrocarbon (Ah)-receptor binding polychlorinated biphenyl (PCB), polychlorinated dibenzo-p-dioxin (PCDD), and polychlorinated dibenzofuran (PCDF) congener...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050326

    authors: Ross PS,Van Loveren H,de Swart RL,van der Vliet H,de Klerk A,Timmerman HH,van Binnendijk R,Brouwer A,Vos JG,Osterhaus AD

    更新日期:1996-01-01 00:00:00

  • Pneumoconiotic effects of welding-fume particles from mild and stainless steel deposited in the lung of the rat.

    abstract::Rats were exposed to single periods of inhalation of fumes generated by arc welding. Two processes were compared: either manual metal arc (MMA) using flux-coated mild steel (MS) electrodes or metal inert-gas (MIG) welding with stainless steel (SS). Widespread but small deposits of fume particles were cleared effective...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00316578

    authors: Hicks R,Lam HF,Al-Shamma KJ,Hewitt PJ

    更新日期:1984-03-01 00:00:00

  • Early morphological changes in rat cerebellum caused by a single dose of methylmercury.

    abstract::A single dose of 10 mg methylmercury chloride per kg body weight was given to 30 days old rats and to adult rats (180-200g)(. This resulted in brain levels of 1.4-2.2 micrograms Hg/g wet weight. In the young rats electron microscopic morphometry showed swelling of the granule cells. The extent of changes was more pron...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00332352

    authors: Syversen TL,Totland G,Flood PR

    更新日期:1981-04-01 00:00:00

  • Anti-apoptotic, anti-inflammatory, and immunomodulatory activities of 3,3'-diselenodipropionic acid in mice exposed to whole body γ-radiation.

    abstract::The present study was designed to evaluate the possible protective effects of 3,3'-diselenodipropionic acid (DSePA), a potent radioprotector, against oxidative organ damage induced by whole body γ-irradiation and explore its mechanistic effects. The mice were subjected to whole body γ-irradiation at 5 Gy for the detec...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-011-0687-0

    authors: Kunwar A,Bag PP,Chattopadhyay S,Jain VK,Priyadarsini KI

    更新日期:2011-11-01 00:00:00

  • NF-κB in cancer therapy.

    abstract::The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-015-1470-4

    authors: Li F,Zhang J,Arfuso F,Chinnathambi A,Zayed ME,Alharbi SA,Kumar AP,Ahn KS,Sethi G

    更新日期:2015-05-01 00:00:00

  • Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals.

    abstract::The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined. Exposure of cultured mouse hepatocytes to DDC, EDDC or griseofulvin resulted in a marked ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF01974011

    authors: Brady AM,Lock EA

    更新日期:1992-01-01 00:00:00

  • Regional blood flow during paraoxon infusion in rabbits.

    abstract::In anaesthetized and artificially ventilated rabbits an intravenous infusion of paraoxon (0.8 mg/kg) was given over 30 min. The effects on cardiac output, blood flow to various vascular beds, and on the mass discharge of the postganglionic sympathetic efferents to the spleen and kidney were monitored. Immediately foll...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00310857

    authors: Kullmann R,Reinsberg J,Amirmanssouri M

    更新日期:1982-09-01 00:00:00

  • CCR5 knockout mice with C57BL6 background are resistant to acetaminophen-mediated hepatotoxicity due to decreased macrophages migration into the liver.

    abstract::Overdose of acetaminophen (APAP) causes necrosis of centrilobular cells of the liver. Accumulating evidence suggests that innate immune system may contribute to APAP-induced hepatotoxicity. Interaction between RANTES and its receptor C-C chemokine receptor (CCR) 5 is related to recruitment of macrophages to sites of i...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-014-1253-3

    authors: Choi DY,Ban JO,Kim SC,Hong JT

    更新日期:2015-02-01 00:00:00

  • Additional oxidized and alkyl chain breakdown metabolites of the plasticizer DINCH in urine after oral dosage to human volunteers.

    abstract::Hexamoll® DINCH® (diisononyl-cyclohexane-1,2-dicarboxylate) is a new high molecular weight plasticizer and a non-aromatic phthalate substitute. In this follow-up study, we further investigated the extensive oxidative metabolism of Hexamoll® DINCH® after oral dosage of 50 mg to three male volunteers (0.552-0.606 mg/kg ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-016-1688-9

    authors: Schütze A,Otter R,Modick H,Langsch A,Brüning T,Koch HM

    更新日期:2017-01-01 00:00:00

  • Effect of dental materials on gluconeogenesis in rat kidney tubules.

    abstract::The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA) as well as mercuric chloride (HgCl(2)) and methylmercury chloride (MeHgCl) on gluconeogenesis was investigated in isolated rat kidney tubules. From starved rats kidney tubules were prepared and isolat...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050677

    authors: Reichl FX,Durner J,Mückter H,Elsenhans B,Forth W,Kunzelmann KH,Hickel R,Spahl W,Hume WR,Moes GW

    更新日期:1999-09-01 00:00:00

  • Changes in the excretion of endogenous glycine conjugate as a possible artifact in toxicological experiments.

    abstract::Changes in the urinary excretion of hippuric acid (HIA) and phenaceturic acid (PUA) as well as their metabolic precursors, i.e. benzoic (BA) and phenylacetic acid (PAA), in rats housed in glass metabolic cages for 4 days were monitored using gas-liquid chromatography. The amount of HIA excreted was 128 +/- 63 mumol/kg...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00324554

    authors: Linhart I,Smejkal J

    更新日期:1987-01-01 00:00:00

  • Toxicity of PCB-126 in European flounder (Platichthys flesus) with emphasis on histopathology and cytochrome P4501A induction in several organ systems.

    abstract::A series of experiments was set up to elucidate the effects of pollution on marine and estuarine fish health, since the European flounder (Platichthys flesus) has shown a relatively high prevalence of (pre)neoplastic liver lesions and lymphocystis virus disease in Dutch coastal and estuarine waters. The hypothesis of ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040100213

    authors: Grinwis GC,van den Brandhof EJ,Engelsma MY,Kuiper RV,Vaal MA,Vethaak AD,Wester PW,Vos JG

    更新日期:2001-04-01 00:00:00

  • Clinical and electrophysiological study of neuropathy after organophosphorus compounds poisoning.

    abstract::Clinical and electrophysiological examinations were performed on 12 patients with toxic neuropathy following accidental ingestion of alcohol polluted by triorthocresyl phosphate (TOCP). Concurrent PNS and CNS lesions were found in all patients. Two to three months after ingestion, five of them showed prevalent signs o...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00366186

    authors: Vasilescu C,Florescu A

    更新日期:1980-02-01 00:00:00

  • Serum carboxylesterase activity in various strains of rats: sensitivity to inhibition by CBDP (2-/o-cresyl/4H:1:3:2-benzodioxaphosphorin-2-oxide).

    abstract::Rodents are relatively insensitive to the neurotoxic effects of various organophosphorus compounds. The purpose of this investigation was to determine if differences in inactivation of CBDP could explain the strain differences in the sensitivity to neurotoxicity following administration of TOCP (tri-o-cresyl phosphate...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF01973466

    authors: Clement JG,Erhardt N

    更新日期:1990-01-01 00:00:00

  • Expressions of N-methyl-D-aspartate receptors NR2A and NR2B subunit proteins in normal and sulfite-oxidase deficient rat's hippocampus: effect of exogenous sulfite ingestion.

    abstract::Sulfites whether ingested or produced through the sulfur-containing amino acids metabolism of the animal are very active molecules and can cause cellular toxicity. Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabol...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-006-0125-x

    authors: Oztürk OH,Küçükatay V,Yönden Z,Ağar A,Bağci H,Delibaş N

    更新日期:2006-10-01 00:00:00

  • Difference in rates of the reaction of various mammalian oxyhemoglobins with phenylhydrazine.

    abstract::Second order rate constants for the initial reaction of 12 mammalian oxyhemoglobins (Hb) with equimolar phenylhydrazine (PHZ), a compound inducing Heinz body hemolytic anemia, were determined by recording continuous changes in absorbance with time at 577 nm. The rate constants were varied in a range from 43 m-1.s-1 wi...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050161

    authors: Kinuta M,Matteson JL,Itano HA

    更新日期:1995-01-01 00:00:00

  • Investigation of species differences in isobutene (2-methylpropene) metabolism between mice and rats.

    abstract::Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340 mumol/kg/h for rats and 560 mumol/kg/h for mice. The atmospheric concentration at which Vmax/2 is reached is 1200 ppm for rats and 1800 pp...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF02034934

    authors: Csanády GA,Freise D,Denk B,Filser JG,Cornet M,Rogiers V,Laib RJ

    更新日期:1991-01-01 00:00:00

  • Formation of DNA adducts from oil-derived products analyzed by 32P-HPLC.

    abstract::The aim of this study was to investigate the genotoxic potential of DNA adducts and to compare DNA adduct levels and patterns in petroleum vacuum distillates, coal tar distillate, bitumen fume condensates, and related substances that have a wide range of boiling temperatures. An in vitro assay was used for DNA adduct ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040000172

    authors: Akkineni LK,Zeisig M,Baranczewski P,Ekström LG,Möller L

    更新日期:2001-01-01 00:00:00

  • Experimental and computational insights on the recognition mechanism between the estrogen receptor α with bisphenol compounds.

    abstract::Certain bisphenols (BPs) have been regarded as endocrine-disrupting chemicals due to their structural similarities to bisphenol A (BPA), a well-known weak estrogenic chemical. However, very limited data are currently available on the relationship between estrogenic activity and the structure of BP analogs. Therefore, ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-017-2011-0

    authors: Cao H,Wang F,Liang Y,Wang H,Zhang A,Song M

    更新日期:2017-12-01 00:00:00

  • Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors.

    abstract::The nephrotoxicity of 4-amino-3-S-glutathionylphenol (PAP-GSH), a known metabolite of 4-amino-phenol (PAP), was determined in male Fischer 344 rats. Administration of a single dose of 40 or 60 mumol kg-1 caused a marked elevation in blood urea nitrogen and an increase in the urinary excretion of glucose, protein and g...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF03035706

    authors: Fowler LM,Foster JR,Lock EA

    更新日期:1994-01-01 00:00:00

  • Determination of cis-diamminedichloroplatinum (II) in plasma proteins and hemoglobin of cancer patients.

    abstract::A study was conducted to determine the levels of cis-diamminedichloroplatinum (II) (cisplatin) in plasma proteins and hemoglobin of cancer patients after cisplatin chemotherapy. Thirty-seven cancer patients with different type of cancers (lung, esophageal, urinary tract, and testicular cancer, melanoma, osteosarcoma e...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00303124

    authors: Mustonen R,Hietanen P,Leppälä S,Takala M,Hemminki K

    更新日期:1989-01-01 00:00:00

  • Transplacental movement of inorganic lead in early and late gestation in the mouse.

    abstract::203Pb(NO3)2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF01261379

    authors: Danielsson BR,Dencker L,Lindgren A

    更新日期:1983-10-01 00:00:00

  • Determination of lorazepam in plasma by electron capture GLC.

    abstract::A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00293571

    authors: de Groot G,Maes RA,Lemmens HH

    更新日期:1976-06-08 00:00:00

  • Meso-2,3-dimercaptosuccinic acid and sodium N-benzyl-N-dithiocarboxy-D-glucamine as antagonists for cadmium intoxication.

    abstract::Orally administered meso-2,3-dimercaptosuccinic acid (DMSA) is an effective antagonist for acute oral cadmium chloride (1 mmol/kg) intoxication in mice when administered up to 8 h after cadmium ingestion. Administration of sodium N-benzyl-N-dithiocarboxy-D-glucamine (NaB) i.p. along with DMSA p.o. resulted in kidney a...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00316253

    authors: Jones MM,Basinger MA,Topping RJ,Gale GR,Jones SG,Holscher MA

    更新日期:1988-08-01 00:00:00

  • Improved assay of neurotoxic esterase for screening organophosphates for delayed neurotoxicity potential.

    abstract::The assay of neurotoxic esterase (NTE) in brains taken from dosed hens enables potential neurotoxicity of organophosphate pesticides, plasticers, etc. to be assessed. The original assay [Johnson, M.K. Biochem. J. 114, 711-717 (1969)] has been simplified to eliminate centrifugation and transfer steps and both the selec...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00293860

    authors: Johnson MK

    更新日期:1977-06-18 00:00:00