Abstract：
:Female C57/BL/6 x DBA/2 hybrid mice were exposed to two concentrations (270 and 135 ppm) of tetrachloroethylene (PER) in inhalation chambers for 6 h/day, 5 days per week, up to 11.5 weeks (270 ppm) and 7.5 weeks (135 ppm), respectively, followed by a 3-week exposure-free period. In the peripheral blood a reduction of lymphocytes/monocytes and of neutrophils was observed with an almost complete regeneration in the exposure-free period. A reticulocytosis during and also after the exposure indicated a compensatory reaction in the erythroid cell system. Bone marrow pluripotent stem cells (CFU-S) were not affected up to 7.5 weeks. Erythroid committed cells (BFU-E and CFU-E) did react, with a reduction of CFU-E numbers at 7.5 and 11.5 weeks. A slight reduction of CFU-C numbers at 7.5 weeks indicated, in accordance with the peripheral blood data, a disturbance of the granulocytic cell series as well.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Seidel HJ,Weber L,Barthel Edoi
10.1007/BF01974021keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
228-30issue
3eissn
0340-5761issn
1432-0738journal_volume
66pub_type
杂志文章abstract：:Multiple oximes have been synthesized and evaluated for use as countermeasures against chemical warfare nerve agents. The current U.S. military and civilian oxime countermeasure, 2-[(hydroxyimino)methyl]-1-methylpyridin-1-ium chloride (2-PAM), is under consideration for replacement with a more effective acetylcholines...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0987-z
更新日期：2013-04-01 00:00:00
abstract：:The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050237
更新日期：1995-01-01 00:00:00
abstract：:To cope with the rapid onset of the life-threatening cholinergic crisis after poisoning with organophosphorus compounds, atropine-oxime preparations should be available in autoinjectors allowing i.m. administration also in the absence of a physician. Such a scenario is conceivable in the battlefield, when nerve agents...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050276
更新日期：1996-01-01 00:00:00
abstract：:Sarin, a potent organophosphate cholinesterase inhibitor, induces an array of toxic effects including convulsions. Many antidotal treatments contain anticonvulsants to block seizure activity and the ensuing brain damage. Magnesium sulfate (MGS) is used to suppress eclamptic seizures in pregnant women with hypertension...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0916-1
更新日期：2013-02-01 00:00:00
abstract：:Although the tumor-promoting effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), coplanar polychlorinated biphenyls (PCBs), and related compounds in liver tissue are primarily attributed to the activation of the aryl hydrocarbon receptor (AhR), the underlying molecular mechanisms are still unclear. Liver progenitor...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0979-z
更新日期：2013-04-01 00:00:00
abstract：:Humans are exposed to multiple chemicals on a daily basis instead of to just a single chemical, yet the majority of existing toxicity data comes from single-chemical exposure. Multiple factors must be considered such as the route, concentration, duration, and the timing of exposure when determining toxicity to the org...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02547-x
更新日期：2019-10-01 00:00:00
abstract：:The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1490-0
更新日期：2016-04-01 00:00:00
abstract：:Changes in the urinary excretion of hippuric acid (HIA) and phenaceturic acid (PUA) as well as their metabolic precursors, i.e. benzoic (BA) and phenylacetic acid (PAA), in rats housed in glass metabolic cages for 4 days were monitored using gas-liquid chromatography. The amount of HIA excreted was 128 +/- 63 mumol/kg...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00324554
更新日期：1987-01-01 00:00:00
abstract：:The hypothesis that methylmercury (MeHg) potently induces formation of reactive oxygen species (ROS) in the brain is supported by observations on the neuroprotective effects of various classes of antioxidants. Flavonoids have been reported to possess divalent metal chelating properties, antioxidant activities and to r...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-009-0482-3
更新日期：2010-02-01 00:00:00
abstract：:N-Methyl-2-pyrrolidone (NMP) is a versatile organic solvent frequently used for surface cleaning such as paint stripping or graffiti removal. Liquid NMP is rapidly absorbed through the skin but dermal vapour phase absorption might also play an important role for the uptake of the solvent. This particular aspect was in...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0230-5
更新日期：2008-01-01 00:00:00
abstract：:Dibromoacetonitrile (DBAN) is a disinfection byproduct of chlorination of drinking water. Epidemiological studies indicate that it might present a potential hazard to human health. The present work provides evidence for DBAN activation to cyanide (CN(-)) by the hypoxanthine (HX)/xanthine oxidase (XO)/iron (Fe) system ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0418-7
更新日期：2003-02-01 00:00:00
abstract：:203Pb(NO3)2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01261379
更新日期：1983-10-01 00:00:00
abstract：:Labilization of lysosomal enzymes is often associated with the general process of inflammation. The present study investigated the effect of the pneumotoxin cadmium on the release and activity of two lung lysosomal enzymes. Incubation of rat lung lysosomes with cadmium resulted in the release of beta-glucuronidase but...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050181
更新日期：1995-01-01 00:00:00
abstract：:In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca2+-binding proteins and/or Ca2+ pumps. The plasma membrane calcium pump (PMCA) maintains Ca2+ homeosta...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2031-9
更新日期：2018-01-01 00:00:00
abstract：:Since tattoos became overwhelmingly fashionable worldwide, the demand for removal has proportionally increased, Nd:YAG Q-switch laser being the most commonly used tool for the purpose. In this framework we investigated the composition and products of laser treatment of green tattoo ink, the Green Concentrate from Eter...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02790-7
更新日期：2020-07-01 00:00:00
abstract：:High-dosage alcohol intoxication (i.e., binge drinking in humans) is an increasingly prevalent problem. Despite the well-known long-term consequences, the acute effects of high-dosage alcohol intoxication on cognitive control processes have not been investigated with respect to neurophysiological changes in humans. We...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1109-2
更新日期：2014-02-01 00:00:00
abstract：:The aryl hydrocarbon receptor (AHR) is known to mediate the cellular response to numerous xenobiotics including dioxin. Surprisingly AHR knockout mice provide evidence for the involvement of the AHR signalling cascade in estrogen regulated physiological functions of the female reproductive system. Several studies alre...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0870-y
更新日期：2012-10-01 00:00:00
abstract：:A study was conducted to determine the levels of cis-diamminedichloroplatinum (II) (cisplatin) in plasma proteins and hemoglobin of cancer patients after cisplatin chemotherapy. Thirty-seven cancer patients with different type of cancers (lung, esophageal, urinary tract, and testicular cancer, melanoma, osteosarcoma e...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303124
更新日期：1989-01-01 00:00:00
abstract：:Certain esterase inhibitors such as O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate (KBR-2822) and phenylmethanesulfonyl fluoride (PMSF) cause exacerbation (promotion) of toxic and traumatic axonopathies. Although these chemicals are capable of inhibiting neuropathy target esterase (NTE), whic...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050473
更新日期：1998-01-01 00:00:00
abstract：:Occupational exposure to benzene has been associated with leukemia, anemia, leukopenia, and thrombocytopenia. Genetic susceptibility to benzene toxicity in humans may be related to variations in benzene metabolizing genes. The main objective of this study was to ascertain whether polymorphism of GSTP1, GSTM1, GSTT1 an...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2104-9
更新日期：2018-06-01 00:00:00
abstract：:The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA) as well as mercuric chloride (HgCl(2)) and methylmercury chloride (MeHgCl) on gluconeogenesis was investigated in isolated rat kidney tubules. From starved rats kidney tubules were prepared and isolat...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050677
更新日期：1999-09-01 00:00:00
abstract：:The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime whi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02342509
更新日期：1992-01-01 00:00:00
abstract：:Increasing evidence suggests that free radical-mediated oxidation of biological substrates is a key feature of Alzheimer's disease (AD) pathogenesis. While it has long been established that biomarkers of lipid peroxidation (LPO) are elevated in AD brain as well as ventricular CSF postmortem, more recent studies have d...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-015-1517-6
更新日期：2015-07-01 00:00:00
abstract：:Hydrogen sulfide (H2S), the third gasotransmitter, has been shown to act as a neuroprotective factor in numerous pathological processes; however, its underlying mechanism(s) of action remain unclear. It is widely accepted that activation of moderate autophagy and the Nrf2/ARE signaling pathway play important roles in ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2208-x
更新日期：2018-06-01 00:00:00
abstract：:Melanin is a polyanionic pigment that colors, e.g., the hair, skin and eyes. The pigment neuromelanin is closely related to melanin and is mainly produced in specific neurons of the substantia nigra. Certain drugs and chemicals bind to melanin/neuromelanin and are retained in pigment cells for long periods. This speci...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1757-0
更新日期：2016-08-01 00:00:00
abstract：:A predictive test using mice for the identification of contact sensitizing chemicals was developed. Contact sensitizing activity is measured as a function of draining lymph node activation following application of test chemical. Experimental conditions for assessment of induced lymph node cell (LNC) responses have bee...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974070
更新日期：1993-01-01 00:00:00
abstract：:Teratogenic effects caused by a new nitroimidazopyridazine were examined in Wistar (WU) rats after repeated oral administration of 0, 2.5, 10, and 40 mg/kg, given on days 6-17 post coitum (p.c.) (Day of mating = Day 0) in a regular study on embryo-fetal development according to ICH S5A. At day 20 p.c., fetuses were re...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0057-5
更新日期：2006-07-01 00:00:00
abstract：:Organotin compounds such as tributyltin (TBT) and triphenyltin can induce diabetes and insulin resistance. However, the development of diabetes caused by organotins and its underlying mechanisms remain unclear. In the present study, male KM mice were orally administered with TBT (0.5, 5, and 50 μg/kg) once every 3 day...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-1961-6
更新日期：2017-10-01 00:00:00
abstract：:The development and application of high throughput in vitro assays is an important development for risk assessment in the twenty-first century. However, there are still significant challenges to incorporate in vitro assays into routine toxicity testing practices. In this paper, a robust learning approach was developed...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2260-6
更新日期：2018-09-01 00:00:00
abstract：:Adverse outcome pathways (AOPs) have been recently introduced as tools to map the mechanisms underlying toxic events relevant for chemical risk assessment. AOPs particularly depict the linkage between a molecular initiating event and an adverse outcome through a number of intermediate key events. An AOP has been previ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02691-9
更新日期：2020-04-01 00:00:00
