Abstract：
:Using isolated rat hepatocytes the biochemical effects of hydrazine have been investigated using both conventional assay techniques and high resolution proton NMR. High resolution proton NMR revealed that hydrazine caused a significant increase in alanine and lactate levels in the incubation buffer, whereas levels of beta-hydroxybutyrate were decreased. NMR also detected metabolites of hydrazine notably acetylhydrazine and a cyclised hydrazone formed with alpha-ketoglutarate. Changes were detected in NADH and NADPH, ATP, succinate dehydrogenase (SDH) and total non-protein sulphydryl groups (TNPSH). However, the changes in pyridine nucleotides occurred at higher concentrations than those affecting succinate dehydrogenase and ATP. Similarly, the depletion of TNPSH occurred at a higher concentration and with a different time course to that seen with ATP depletion and inhibition of succinate dehydrogenase.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Ghatineh S,Morgan W,Preece NE,Timbrell JAdoi
10.1007/BF01981506keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
660-8issue
9eissn
0340-5761issn
1432-0738journal_volume
66pub_type
杂志文章abstract：:The present study was designed to compare the nephrotoxicity induced by the three platinum compounds cisplatin (CDDP), carboplatin (CBDCA) and transplatin (TDDP) in vitro and to obtain information to elucidate the mechanism of platinum compound-induced nephrotoxicity. Rat or rabbit renal cortical slices were incubated...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973462
更新日期：1990-01-01 00:00:00
abstract：:Melanin is a polyanionic pigment that colors, e.g., the hair, skin and eyes. The pigment neuromelanin is closely related to melanin and is mainly produced in specific neurons of the substantia nigra. Certain drugs and chemicals bind to melanin/neuromelanin and are retained in pigment cells for long periods. This speci...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1757-0
更新日期：2016-08-01 00:00:00
abstract：:Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01234482
更新日期：1983-12-01 00:00:00
abstract：:The effects of six iv infusions of an emulsion containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) on the liver and testes were investigated in 40-day-old rats. Groups of five to six animals received the emulsion every other day in doses of 0, 5, 50 or 500 mg DEHP/kg body weight. Liver effects were studied by...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00348313
更新日期：1985-12-01 00:00:00
abstract：:The comet assay is a versatile, reliable, cost-efficient, and fast technique for detecting DNA damage and repair in any tissue. It is useable in almost any cell type and applicable to both eukaryotic and prokaryotic organisms. Instead of highlighting one of the numerous specific aspects of the comet assay, the present...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1767-y
更新日期：2016-10-01 00:00:00
abstract：:Polymorphisms of the apolipoprotein E (APOE) gene differentially affect neurobiological functions and cognitive performance and confer different vulnerabilities to subclinical exposures to chlorpyrifos (CPF), a pesticide used worldwide. The data reported on this topic suggest a complex interaction between cholinergic ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02387-9
更新日期：2019-03-01 00:00:00
abstract：:Female wistar rats, conventional albino mice, and Chinese hamsters were given a single dose of acrylonitrile, 0.5 or 0.75 mM/kg body weight. The elimination in the urine of thiocyanate, which is the main metabolite of acrylonitrile, indicated a decreasing proportion of biotransformation after oral (over 20%), intraper...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00353240
更新日期：1975-02-14 00:00:00
abstract：:The effect of acetone pretreatment (5% in drinking water for 10 days on rat liver metabolism and toxicity of thiobenzamide (TB) was investigated. Hepatic microsomes from acetone-pretreated rats showed a significant increase of TB-S-oxidation rate which, on the basis of selective thermal inactivation of FAD-containing ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974397
更新日期：1990-01-01 00:00:00
abstract：:The protective effects of various chelating agents such as D-penicillamine (D-PEN), 2,3-dimercaptosuccinic acid (DMSA), 2,3-dimercaptopropane sulphonate (DMPS), and N-(2-mercapto-2-methylpropanoyl)-L-cysteine (bucillamine), on the renal damage induced by gold sodium thiomalate (AuTM) in rats were studied. Rats were in...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973712
更新日期：1991-01-01 00:00:00
abstract：:Increasing evidence suggests that free radical-mediated oxidation of biological substrates is a key feature of Alzheimer's disease (AD) pathogenesis. While it has long been established that biomarkers of lipid peroxidation (LPO) are elevated in AD brain as well as ventricular CSF postmortem, more recent studies have d...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-015-1517-6
更新日期：2015-07-01 00:00:00
abstract：:The studies presented were designed to investigate the effects of cytochrome P450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female B6C3F(1) mice. Groups of female B6C3F(1) mice were exposed to dynamic atmospheres containing tetrahydrofuran (THF) concentrations of 0, 5,400 or 15,000 mg/m(3) ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0474-7
更新日期：2003-08-01 00:00:00
abstract：:Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition of serotonin uptake and metabolism, increased serotonin synthesis and release, activation of serotonin receptors, and inhibition of cytochrome P450 oxidases. Some drug interactions involving opioids can increase intrasynaptic l...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-018-2244-6
更新日期：2018-08-01 00:00:00
abstract：:The effects of dicamba, a widely used broad-leaf herbicide, on rat liver mitochondrial bioenergetic activities were examined. The results obtained for state 4 respiration indicate not only an uncoupling effect, the result of an increase on the permeability of inner mitochondria membrane to protons, but also a strong i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0456-9
更新日期：2003-07-01 00:00:00
abstract：:Platinum coordination complexes (PtCx) are potent against several types of cancer but are often nephrotoxic. With a view to developing a PtCx nephrotoxicity model, the toxicity of cisplatin (cDDP), transplatin (tDDP) and carboplatin (CBDCA) was studied in primary cultures of rabbit proximal tubule (RPT) cells and in t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973705
更新日期：1993-01-01 00:00:00
abstract：:The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts as a 5-hydroxyindoleacetic acid (5-HT) receptor agonist, but little is known about its pharmacological effects...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02740-3
更新日期：2020-07-01 00:00:00
abstract：:Inhalation exposure to toluene diisocyanate (TDI) can result in a variety of airway diseases. Concern has been expressed that a putative carcinogenic potential of TDI exists as a result of the formation of toluenediamine (TDA) by hydrolysis of the isocyanate in the body. Results from long-term bioassays (TDI inhalatio...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050094
更新日期：1994-01-01 00:00:00
abstract：:Many carcinogens and mutagens are electrophilic in nature and will react with nucleophilic sites in protein and nucleic acid. Determination of the extent of formation of these adducts of genotoxic agents with protein provides a practical method of monitoring human exposure and of determining the possible risk associat...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00296978
更新日期：1987-01-01 00:00:00
abstract：:Free radical processes are proposed to play a crucial role in the development of procainamide adverse effects. Therefore, selenium, as a potent antioxidant, may modified procainamide toxicity. To test this hypothesis plasma and liver thiobarbituric acid-reacting substances (TBARS), plasma antioxidant activity (AOA), e...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973693
更新日期：1993-01-01 00:00:00
abstract：:Fulminant hepatitis is a serious inflammatory condition of the liver characterized by massive necrosis of liver parenchyma following excessive immune cell infiltration into the liver, and possibly causing sudden hepatic failure and medical emergency. However, the underlying mechanisms are not fully understood. Here, w...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02633-0
更新日期：2020-02-01 00:00:00
abstract：:The effect of culture medium on glutathione (GSH) dependent detoxification defence system of primary cultured hepatocyte from either male or female rats was studied. Intracellular reduced (GSH) and oxidized glutathione (GSSG), and six GSH-related enzyme activities, including GSH peroxidase (GSH Px), GSH reductase (GSH...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050345
更新日期：1996-01-01 00:00:00
abstract：:The activity of 18 vitamin D analogs on soft tissue calcification and growth impairment in neonatal rats and their effect on bone calcium mobilization, intestinal calcium absorption and binding to intestinal 1,25-dihydroxyvitamin D3 receptors in adult rats were compared. Depending on the chemical modification of the v...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303129
更新日期：1989-01-01 00:00:00
abstract：:The effects of small repeated oral doses of mono-2-cresyl diphenyl phosphate (MOCP, 2.5 mg/kg/day) on hen brain and spinal cord neurotoxic esterase (NTE) were measured. The enzyme levels were depressed to about 40% and 55% of normal respectively and maintained at that level for 8 weeks. No clinical and only doubtful h...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293807
更新日期：1980-10-01 00:00:00
abstract：:Cats were given vincristine sulfate (50 micrograms/kg i.v. every 4 days) and studied after 7-29 injections when neurological deficits became evident. The conduction velocity spectrum of individual afferent nerves from soleus muscles was shifted toward slower velocities. Relatively few functional muscle spindles or oth...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00319653
更新日期：1981-11-01 00:00:00
abstract：:Chronic exposure to carbon disulfide (CS2) can induce polyneuropathy in occupational worker and experimental animals, but underlying mechanism for CS2 neurotoxicity is currently unknown. In the present study, male Wistar rats were randomly divided into two experimental groups and one control group. The rats in two exp...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0399-2
更新日期：2009-06-01 00:00:00
abstract：:In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0078-0
更新日期：2006-09-01 00:00:00
abstract：:Increasing incidence of multidrug-resistant bacteria presents an imminent risk to global health. Polymyxins are 'last-resort' antibiotics against Gram-negative 'superbugs'; however, nephrotoxicity remains a key impediment in their clinical use. Molecular mechanisms underlying this nephrotoxicity remain poorly defined....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2192-1
更新日期：2018-07-01 00:00:00
abstract：:The circadian rhythms of HMG-CoA reductase and cholesterol-7 alpha-hydroxylase (low values, during light, rising in the evening with maximum at 12.00 p.m.) are investigated in rats under diverse conditions. Intragastral administration of cholestyramine (bile acid-absorbing resin) leads to an increased rhythm of both e...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00340534
更新日期：1976-12-17 00:00:00
abstract：:Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biologica...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02746-x
更新日期：2020-06-01 00:00:00
abstract：:Certain populations of the mosquitofish (Gambusia affinis) are highly resistant to cyclodiene and cyclodiene-type insecticides that competitively interact with the picrotoxinin binding site of the gamma-aminobutyric acid (GABA) receptor-ionophore complex in the central nervous system. Resistance involves a reduction i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332493
更新日期：1988-01-01 00:00:00
abstract：:Long-term exposure of rats to cadmium (Cd) resulted in a marked suppression of erythropoietin (Epo) mRNA expression in the kidneys and the development of severe anemia. A recent report revealed that Cd inhibited hypoxia-inducible factor 1 (HIF-1) binding activity and Epo mRNA expression and protein production. However...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0444-0
更新日期：2003-05-01 00:00:00
