Abstract：
:The effects of dicamba, a widely used broad-leaf herbicide, on rat liver mitochondrial bioenergetic activities were examined. The results obtained for state 4 respiration indicate not only an uncoupling effect, the result of an increase on the permeability of inner mitochondria membrane to protons, but also a strong inhibitory effect on the redox complexes. State 3 and respiration uncoupled by FCCP (carbonylcyanide p-trifluoromethoxyphenylhydrazone) were inhibited to approximately the same extent, i.e. by about 70%. Depression of respiratory activity is essentially mediated through partial inhibition of mitochondrial complexes II and III. ATPase activity was much less depressed by dicamba than ATP synthase activity. Therefore, a considerable part of the inhibition observed on ATP synthase is the result of an inhibition on the redox complexes. The loss of phosphorylation capacity, induced by dicamba, was in the last analysis not only the result of a direct effect of dicamba on the enzymatic complex (F(0)-F(1) ATPase) but also the result of a deleterious effect on the integrity of the mitochondrial membrane, which can promote an inhibition of the respiratory complexes and an increase of the proton permeability of the inner membrane.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Peixoto F,Vicente JA,Madeira VMdoi
10.1007/s00204-003-0456-9keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
403-9issue
7eissn
0340-5761issn
1432-0738journal_volume
77pub_type
杂志文章abstract：:O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050212
更新日期：1995-01-01 00:00:00
abstract：:Metabolic activation of the heterocyclic amine 3-amino -1,4-dimethyl-5 H-pyrido[4,3-b]indole (Trp-P-1) and 7-ethoxyresorufin O-deethylase (EROD) activity were examined in the chorioallantoic membrane (CAM) of 15-day-old chicken and 18-day-old eider duck embryos. The embryos were pretreated with an Ah receptor agonist,...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000128
更新日期：2000-08-01 00:00:00
abstract：:The oxidizing capacity of phagocytic cells is suspected to play a major role in the generation of immunogenic drug metabolites, in particular those that cause extrahepatic immunopathological lesions. In the case of the antirheumatic drug gold(I) disodium thiomalate (Na2Au(I)TM), oxidation of the Au(I) ion to Au(III) a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050198
更新日期：1995-01-01 00:00:00
abstract：:Recent work concerned with the mechanism underlying the development of organophosphorous compound-induced delayed neurotoxicity (OPIDN) is reviewed. Topics covered include the prophylaxis of OPIDN by phenylmethylsulfonyl fluoride and other agents, neurotoxic esterase (NTE) as measured using either labelled di-isopropy...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/BF00316365
更新日期：1989-01-01 00:00:00
abstract：:The genotoxicity of the sensory irritant 2-chlorobenzylidene malonitrile (CS) to V79 Chinese hamster cells was investigated using the induction of gene mutations, micronuclei and DNA repair synthesis as biological endpoints. CS efficiently induced micronuclei and mutants resistant to 6-thioguanine in these cells, but ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00278645
更新日期：1989-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974343
更新日期：1993-01-01 00:00:00
abstract：:Lead (Pb) exposure of consumers and the environment has been reduced over the past decades. Despite all measures taken, immission of Pb onto agricultural soils still occurs, with fertilizer application, lead shot from hunting activities, and Pb from air deposition representing major sources. Little is known about the ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02762-x
更新日期：2020-07-01 00:00:00
abstract：:We studied the incorporation of cocaine (COC), benzoylecgonine (BE) and ecgonine methyl ester (EME) into hair from blood. At first, the time courses of three drugs in rat plasma following i.p. administration of cocaine were investigated over 360 min. AUCs of COC, BE and EME in plasma were 14.2, 60.7 and 53.4 microgram...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02035137
更新日期：1992-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00310857
更新日期：1982-09-01 00:00:00
abstract：:The assay of neurotoxic esterase (NTE) in brains taken from dosed hens enables potential neurotoxicity of organophosphate pesticides, plasticers, etc. to be assessed. The original assay [Johnson, M.K. Biochem. J. 114, 711-717 (1969)] has been simplified to eliminate centrifugation and transfer steps and both the selec...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293860
更新日期：1977-06-18 00:00:00
abstract：:Although carbon nanotubes (CNTs) are promising nanomaterials, their potential carcinogenicity is a major concern. We previously established a genetic method of analyzing genotoxicity of chemical compounds, where we evaluated their cytotoxic effect on the DT40 lymphoid cell line comparing DNA-repair-deficient isogenic ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1084-7
更新日期：2014-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050467
更新日期：1997-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02415-8
更新日期：2019-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050001
更新日期：2000-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1042-4
更新日期：2013-10-01 00:00:00
abstract：:Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biologica...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02746-x
更新日期：2020-06-01 00:00:00
abstract：:The treatment of poisoning by highly toxic organophosphorus compounds (nerve agents) is unsatisfactory. Until now, the efficacy of new potential antidotes has primarily been evaluated in animals. However, the extrapolation of these results to humans is hampered by species differences. Since oximes are believed to act ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050495
更新日期：1998-03-01 00:00:00
abstract：:Dinitrochlorobenzene (DNCB) absorption through mouse and rat dorsal skin, pig ear skin and human abdominal skin in vitro was determined, and local metabolism to the glutathione conjugate was related to glutathione transferase activities and glutathione status in the skin. Absorption studies were conducted using skin m...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000123
更新日期：2000-09-01 00:00:00
abstract：:The possible interrelationships between the effects of dietary selenium and perfluorodecanoic acid (PFDA) on growth and lipid metabolism were studied in the male Sprague Dawley rat. Rats were divided into groups and placed on diets containing three levels of selenium (0.04, 0.2, and 1.0 ppm as sodium selenite). Two we...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973372
更新日期：1990-01-01 00:00:00
abstract：:Certain populations of the mosquitofish (Gambusia affinis) are highly resistant to cyclodiene and cyclodiene-type insecticides that competitively interact with the picrotoxinin binding site of the gamma-aminobutyric acid (GABA) receptor-ionophore complex in the central nervous system. Resistance involves a reduction i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332493
更新日期：1988-01-01 00:00:00
abstract：:The aim was to study the long-term response in the olfactory mucosa of NMRI mice after exposure to the olfactory toxicants dichlobenil (a herbicide) or methimazole (an antithyroid drug). Three and six months after exposure to dichlobenil (2x or 1 x 25 mg/kg i.p.), the dorsomedial part of the olfactory region showed a ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0321-2
更新日期：2002-03-01 00:00:00
abstract：:False-negative judgment due to poor chemical solubility is a problem with in vitro skin sensitisation tests. Water-insoluble chemicals are typically dissolved in DMSO in most sensitisation tests but precipitate when diluted with medium beyond their solubility in water. Such tests lack procedures to rule out false-nega...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02934-9
更新日期：2020-10-17 00:00:00
abstract：:The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts as a 5-hydroxyindoleacetic acid (5-HT) receptor agonist, but little is known about its pharmacological effects...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02740-3
更新日期：2020-07-01 00:00:00
abstract：:Heat shock proteins (HSPs) are a group of proteins that are rapidly induced in response to physiological stress, including hyperthermia and exposure to toxicants. Thus they may provide a useful index of toxicity in in vitro systems for screening for toxicity. We have recently developed a rat nasal explant system for i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0541-8
更新日期：2004-06-01 00:00:00
abstract：:Perfluorooctanoic acid (PFOA) has been shown to cause hepatotoxicity and other toxicological effects. Though PPARα activation by PFOA in the liver has been well accepted as an important mechanism of PFOA-induced hepatotoxicity, several pieces of evidence have shown that the hepatotoxic effects of PFOA may not be fully...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1675-1
更新日期：2017-01-01 00:00:00
abstract：:A rapid gas-chromatographic method for the qualitative and quantitative measurement of various drugs in human plasma and other body fluids has been developed. The extraction procedure is done within 5 min, and gas-chromatographic measurement carried out on 2 diverse columns with detection by flame ionisation detectors...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00368231
更新日期：1978-01-25 00:00:00
abstract：:Tea (Camellia sinensis, Theaceace), a popular beverage consumed world-wide, has been studied for its preventive effects against cancer as well as cardiovascular, neurodegenerative, and other diseases. Most of the proposed beneficial effects have been attributed to the polyphenolic compounds in tea, but the nature of t...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-008-0372-0
更新日期：2009-01-01 00:00:00
abstract：:Acute toxicity of bis (tributyltin) oxide in the sweat glands in the rat footpad was investigated by electron microscopy and an energy-dispersive X-ray microanalyzer. Male Wistar rats received an intramuscular injection of 0.5 ml/kg bis (tributyltin) oxide. After 6-8 h, swelling of mitochondria appeared in the secreto...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000174
更新日期：2000-12-01 00:00:00
abstract：:Due to its unique physical structure and chemical properties, graphene family nanomaterials (GFNs) and derived commodities have been widely used in commercial products, particularly biomedical applications, which has significantly increased the risk of human exposure. There exists significant evidence that GFNs are ac...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02717-2
更新日期：2020-06-01 00:00:00
abstract：:The goal of the present study was to obtain an in vivo relevant prioritization method for the endocrine potencies of different polycarbonate monomers, by combining in vitro bioassay data with physiologically based kinetic (PBK) modelling. PBK models were developed for a selection of monomers, including bisphenol A (BP...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02479-6
更新日期：2019-07-01 00:00:00
