Regional blood flow during paraoxon infusion in rabbits.

abstract：:To clarify whether oxidative stress is involved in the development of hepatocellular preneoplastic foci induced by fenofibrate (FF), a peroxisome proliferator-activated receptor alpha agonist, male F344/N rats were fed a diet containing 6,000, 3,000, or 0 ppm of FF for 13 weeks after N-diethylnitrosamine initiation. T...

journal_title：Archives of toxicology

authors： Nishimura J,Dewa Y,Okamura T,Muguruma M,Jin M,Saegusa Y,Umemura T,Mitsumori K

更新日期：2008-09-01 00:00:00

abstract：:Garenoxacin is a des-F(6)-quinolone with a broad antibacterial spectrum, which has previously been shown to exhibit low chondrotoxicity in juvenile dogs compared with several other quinolones. A study was performed to determine whether the low chondrotoxicity observed in immature rats following garenoxacin treatment c...

journal_title：Archives of toxicology

authors： Kastner M,Rahm U,Baumann-Wilschke I,Bello A,Stahlmann R

更新日期：2004-02-01 00:00:00

abstract：:Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats we...

journal_title：Archives of toxicology

authors： Monteiro JP,Pereira CV,Silva AM,Maciel E,Baldeiras I,Peixoto F,Domingues MR,Jurado AS,Oliveira PJ

更新日期：2013-12-01 00:00:00

abstract：:Regarding the cancer risk assessment of acrylamide (AA) it is of basic interest to know, as to what amount of the absorbed AA is metabolized to glycidamide (GA) in humans, compared to what has been observed in laboratory animals. GA is suspected of being the ultimate carcinogenic metabolite of AA. From experiments wit...

journal_title：Archives of toxicology

authors： Settels E,Bernauer U,Palavinskas R,Klaffke HS,Gundert-Remy U,Appel KE

更新日期：2008-10-01 00:00:00

abstract：:Airway smooth muscle (ASM) cell phenotypic switching played an important role in airway remodeling in asthma. In vitro platelet-derived growth factor (PDGF) induced ASM cell phenotypic switching from a mature to pro-remodeling phenotype, but the mechanism remained incompletely understood. This study was to explore the...

journal_title：Archives of toxicology

authors： Ning Y,Huang H,Dong Y,Sun Q,Zhang W,Xu W,Li Q

更新日期：2013-05-01 00:00:00

abstract：:The present study was carried out to elucidate the mechanisms behind an increase in the incidence of malignant or multiple mammary tumors as a result of oral administration of rolipram in a 104-week carcinogenicity study. The organs and tissues of Sprague-Dawley (SD) rats of both sexes, which had been subjected to a 1...

journal_title：Archives of toxicology

authors： Nishiyama S,Okudaira M,Saito N

更新日期：2006-02-01 00:00:00

abstract：:Assay conditions in determining total cytochrome P-450 in four laboratories were compared. Although the determination was derived from the original Omura and Sato method in each laboratory, the four standard protocols differed slightly, resulting in considerable differences in the results. Since the cytochrome P-450 c...

journal_title：Archives of toxicology

authors： Rutten AA,Falke HE,Catsburg JF,Topp R,Blaauboer BJ,van Holsteijn I,Doorn L,van Leeuwen FX

更新日期：1987-01-01 00:00:00

abstract：:A recent intervention study demonstrated the occurrence of irilone as second most abundant isoflavone next to daidzein in human plasma after consumption of a red clover-based dietary supplement (RCDS) containing predominately formononetin ≫ biochanin A > irilone (12 % of these isoflavones). To elucidate the relevance ...

journal_title：Archives of toxicology

authors： Lutter S,Schmalbach K,Esch HL,Lehmann L

更新日期：2014-02-01 00:00:00

abstract：:Intravenous administration of lead acetate to rabbits for 10 weeks at 2 week intervals resulted in significantly elevated blood lead levels, slight anemia with marked microspherocytosis and moderate basophilic stippling, and marked depression of red cell delta-aminolevulinic acid (ALA) dehydratase activity. However th...

journal_title：Archives of toxicology

authors： Fujii H

更新日期：1979-10-01 00:00:00

abstract：:We investigated the influence of the dopamine antagonist haloperidol on the neurotransmitter content in the developing rat brain. Dopamine (DA), serotonin (5-HT) and the corresponding metabolites dopac, HVA and HIAA were determined in the corpus striatum of the rat between day 1 and day 21 pn by HPLC with electro-chem...

journal_title：Archives of toxicology

authors： Schwabe R,Thiel R,Chahoud I,Neubert D

更新日期：1992-01-01 00:00:00

abstract：:Platinum coordination complexes (PtCx) are potent against several types of cancer but are often nephrotoxic. With a view to developing a PtCx nephrotoxicity model, the toxicity of cisplatin (cDDP), transplatin (tDDP) and carboplatin (CBDCA) was studied in primary cultures of rabbit proximal tubule (RPT) cells and in t...

journal_title：Archives of toxicology

authors： Courjault F,Leroy D,Coquery L,Toutain H

更新日期：1993-01-01 00:00:00

abstract：:2C (2C-x) is the general name for the family of phenethylamines containing two methoxy groups at the 2 and 5 positions of the benzene ring. The abuse of 2C family drugs has grown rapidly, although the abuse potential and neurotoxic properties of 2C drugs have not yet been fully investigated. In this study, we investig...

journal_title：Archives of toxicology

authors： Kim YJ,Ma SX,Hur KH,Lee Y,Ko YH,Lee BR,Kim SK,Sung SJ,Kim KM,Kim HC,Lee SY,Jang CG

更新日期：2021-01-30 00:00:00

abstract：:DW-116, 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-l-piperazinyl)-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride, is a newly developed fluoroquinolone antibacterial. The potential of DW-116 to induce developmental toxicity was, investigated in Sprague-Dawley rats. DW-116 was administered by gavage to pre...

journal_title：Archives of toxicology

authors： Kim JC,Yun HI,Shin HC,Han SS,Chung MK

更新日期：2000-04-01 00:00:00

abstract：:The aim of our study was to determine the period of maximum sensitivity for the induction of characteristic malformations with thalidomide (TH) in Himalayan rabbits. TH was administered orally in different doses (50, 100, 150 and 200 mg/kg) four times at 24-h intervals starting at 192 h of gestation. The malformations...

journal_title：Archives of toxicology

authors： Sterz H,Nothdurft H,Lexa P,Ockenfels H

更新日期：1987-07-01 00:00:00

abstract：:The flavonol quercetin shows a wide range of effects in biological systems. We investigated whether quercetin exerts its proposed antioxidant properties via the antioxidant enzyme system. Quercetin in a concentration range from 5 to 100 microM decreased manganese superoxide dismutase, glutathione peroxidase, and coppe...

journal_title：Archives of toxicology

authors： Röhrdanz E,Bittner A,Tran-Thi QH,Kahl R

更新日期：2003-09-01 00:00:00

abstract：:Groups of rats were exposed simultaneously to manganese chloride (3 mg Mn2+/ml water) through drinking water and lead acetate intraperitoneally at dosages of 5.0, 8.0 and 12.0 mgPb2+/kg daily for a period of 14 days. The magnitude of changes in the behavioral pattern, contents of biogenic amines and accumulation of le...

journal_title：Archives of toxicology

authors： Chandra AV,Ali MM,Saxena DK,Murthy RC

更新日期：1981-11-01 00:00:00

abstract：:Rats were exposed to nickel sulfate (NiSO4) either by intratracheal (IT) instillation or by acute aerosol inhalation, and pulmonary clearance of Ni and pulmonary inflammatory responses were studied. The half-time of Ni in the lung (initial lung burden = 50 micrograms Ni/rat) was about 32 h in both the IT instillation ...

journal_title：Archives of toxicology

authors： Hirano S,Shimada T,Osugi J,Kodama N,Suzuki KT

更新日期：1994-01-01 00:00:00

abstract：:Cadmium (Cd), an occupational and environmental pollutant, induces nephrotoxicity by primarily damaging renal proximal tubular cells. In this study, we hypothesized that pyroptosis, a caspase-1-dependent inflammatory programmed cell death mechanism, mediates Cd-induced nephrotoxicity. Human proximal tubular epithelial...

journal_title：Archives of toxicology

authors： Chou X,Ding F,Zhang X,Ding X,Gao H,Wu Q

更新日期：2019-04-01 00:00:00

abstract：:Steatosis, also known as fatty liver disease (FLD), is a disorder in which the lipid metabolism of the liver is disturbed, leading to the abnormal retention of lipids in hepatocytes. FLD can be induced by several drugs, and although it is mostly asymptomatic, it can lead to steatohepatitis, which is associated with li...

journal_title：Archives of toxicology

authors： Rodrigues RM,Branson S,De Boe V,Sachinidis A,Rogiers V,De Kock J,Vanhaecke T

更新日期：2016-03-01 00:00:00

abstract：:The nephrotoxicity of 4-amino-3-S-glutathionylphenol (PAP-GSH), a known metabolite of 4-amino-phenol (PAP), was determined in male Fischer 344 rats. Administration of a single dose of 40 or 60 mumol kg-1 caused a marked elevation in blood urea nitrogen and an increase in the urinary excretion of glucose, protein and g...

journal_title：Archives of toxicology

authors： Fowler LM,Foster JR,Lock EA

更新日期：1994-01-01 00:00:00

abstract：:Single doses of procarbazine (MIH) were injected IP at 0, 50, 100, 200, and 400 mg/kg body weight to CD-1 male mice. Activities of hyaluronidase, lactate dehydrogenase isoenzyme-X, and the dehydrogenases of sorbitol, alpha-glycerophosphate, glucose-6-phosphate, malate, isocitrate, and glyceraldehyde-3-phosphate in the...

journal_title：Archives of toxicology

authors： Shen RS,Lee IP

更新日期：1984-10-01 00:00:00

abstract：:Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatm...

journal_title：Archives of toxicology

authors： Lehmann PA,Favari L

更新日期：1985-04-01 00:00:00

abstract：:Female wistar rats, conventional albino mice, and Chinese hamsters were given a single dose of acrylonitrile, 0.5 or 0.75 mM/kg body weight. The elimination in the urine of thiocyanate, which is the main metabolite of acrylonitrile, indicated a decreasing proportion of biotransformation after oral (over 20%), intraper...

journal_title：Archives of toxicology

authors： Gut I,Nerudová J,Kopecký J,Holecek V

更新日期：1975-02-14 00:00:00

abstract：:The pregnancy outcomes of 109 women who were intoxicated during pregnancy due to excessive amounts of drugs and other agents were studied. Seventy per cent of the women attempted suicide, and the intoxication in 78% of all cases was caused by drugs. The stillbirth rate (4%) was higher than that in previous and subsequ...

journal_title：Archives of toxicology

authors： Czeizel A,Szentesi I,Szekeres I,Molnár G,Glauber A,Bucski P

更新日期：1988-08-01 00:00:00

abstract：:The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We s...

journal_title：Archives of toxicology

authors： Yang M,Ryu JH,Jeon R,Kang D,Yoo KY

更新日期：2009-03-01 00:00:00

abstract：:In the present study, spiking was used as a strategy to evaluate the mutagenicity of individual compounds in a mixture. Mutagenicity of individual polycyclic aromatic hydrocarbons (PAH) was evaluated in an organic extract of diesel exhaust particles (DEP). The particles were extracted with dichloromethane (DCM). After...

journal_title：Archives of toxicology

authors： Bostrøm E,Engen S,Eide I

更新日期：1998-10-01 00:00:00

abstract：:The present study was designed to evaluate the effects of chronic fluorosis on the dynamics (including fusion and fission proteins), fragmentation, and distribution of mitochondria in the cortical neurons of the rat brain in an attempt to elucidate molecular mechanisms underlying the brain damage associated with exces...

journal_title：Archives of toxicology

authors： Lou DD,Guan ZZ,Liu YJ,Liu YF,Zhang KL,Pan JG,Pei JJ

更新日期：2013-03-01 00:00:00

abstract：:The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The calibration curve for morphine in hair showed linear over 0.5-100 ng/mg hair. Though the limit of detection was 0.1 ng/mg hair with an S/N > 3 of the base ion(m/z 429) for morphine, the limit of confirmation by detection of thr...

journal_title：Archives of toxicology

authors： Nakahara Y,Takahashi K,Shimamine M,Saitoh A

更新日期：1992-01-01 00:00:00

abstract：:The α,β-unsaturated carbonyl group is recognized as alert for mutagenicity, attributed to (1) its direct reaction with DNA, counteractable by glutathione (GSH), and (2) oxidative stress caused indirectly by GSH depletion. Accordingly, the α,β,γ,δ-unsaturated lactone patulin (PAT), a mycotoxin detected in fruits and pr...

journal_title：Archives of toxicology

authors： Pfenning C,Esch HL,Fliege R,Lehmann L

更新日期：2016-02-01 00:00:00

abstract：:Phenethyl isothiocyanate is a chemopreventive phytochemical present in cruciferous vegetables where it exists as the glucosinolate gluconasturtiin. It is a mechanism-based inhibitor of both rat and human cytochrome P450 enzymes. The principal objective of the present study was to ascertain whether phenethyl isocyanate...

journal_title：Archives of toxicology

authors： Konsue N,Ioannides C

更新日期：2010-10-01 00:00:00