Abstract：
:The flavonol quercetin shows a wide range of effects in biological systems. We investigated whether quercetin exerts its proposed antioxidant properties via the antioxidant enzyme system. Quercetin in a concentration range from 5 to 100 microM decreased manganese superoxide dismutase, glutathione peroxidase, and copper zinc superoxide dismutase mRNA expression levels each by 30-40% in rat hepatoma H4IIE cells. Catalase mRNA expression levels increased about 30% but only with the cytotoxic concentration of 100 microM. Despite the down-regulation of antioxidant enzyme mRNA expression quercetin treatment of cells induced only a mild oxidative stress. Pretreatment of H4IIE cells with quercetin even protected against an oxidative stress resulting from hydrogen peroxide exposure. In conclusion, the antioxidant capacity of quercetin was shown not to be due to the antioxidant enzyme system.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Röhrdanz E,Bittner A,Tran-Thi QH,Kahl Rdoi
10.1007/s00204-003-0482-7keywords:
subject
Has Abstractpub_date
2003-09-01 00:00:00pages
506-10issue
9eissn
0340-5761issn
1432-0738journal_volume
77pub_type
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