Formation of dichloroacetylene from trichloroethylene in the presence of alkaline material--possible cause of intoxication after abundant use of chloroethylene-containing solvents.

abstract：:Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...

journal_title：Archives of toxicology

authors： Barański B,Stetkiewicz I,Sitarek K,Szymczak W

更新日期：1983-12-01 00:00:00

abstract：:To cope with the rapid onset of the life-threatening cholinergic crisis after poisoning with organophosphorus compounds, atropine-oxime preparations should be available in autoinjectors allowing i.m. administration also in the absence of a physician. Such a scenario is conceivable in the battlefield, when nerve agents...

journal_title：Archives of toxicology

authors： Thiermann H,Radtke M,Spöhrer U,Klimmek R,Eyer P

更新日期：1996-01-01 00:00:00

abstract：:Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatm...

journal_title：Archives of toxicology

authors： Lehmann PA,Favari L

更新日期：1985-04-01 00:00:00

abstract：:The pharmacokinetics of styrene were investigated in male Sprague-Dawley rats and male B6C3F1 mice using the closed chamber technique. Animals were exposed to styrene vapors of initial concentrations ranging from 550 to 5000 ppm, or received intraperitoneal (i.p.) doses of styrene from 20 to 340 mg/kg or oral (p.o.) d...

journal_title：Archives of toxicology

authors： Filser JG,Schwegler U,Csanády GA,Greim H,Kreuzer PE,Kessler W

更新日期：1993-01-01 00:00:00

abstract：:The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The calibration curve for morphine in hair showed linear over 0.5-100 ng/mg hair. Though the limit of detection was 0.1 ng/mg hair with an S/N > 3 of the base ion(m/z 429) for morphine, the limit of confirmation by detection of thr...

journal_title：Archives of toxicology

authors： Nakahara Y,Takahashi K,Shimamine M,Saitoh A

更新日期：1992-01-01 00:00:00

abstract：:In vivo screening methods for detection of thyroid function modulators are now under development in many research laboratories. We assessed the applicability of the Hershberger assay protocol to screen for thyroid function modulators. In experiment 1, castrated male BrlHan WIST@Jcl (GALAS) rats were administered a pot...

journal_title：Archives of toxicology

authors： Noda S,Muroi T,Takakura S,Sakamoto S,Takatsuki M,Yamasaki K,Tateyama S,Yamaguchi R

更新日期：2005-11-01 00:00:00

abstract：:Humans are exposed to multiple chemicals on a daily basis instead of to just a single chemical, yet the majority of existing toxicity data comes from single-chemical exposure. Multiple factors must be considered such as the route, concentration, duration, and the timing of exposure when determining toxicity to the org...

journal_title：Archives of toxicology

authors： Hernandez AF,Buha A,Constantin C,Wallace DR,Sarigiannis D,Neagu M,Antonijevic B,Hayes AW,Wilks MF,Tsatsakis A

更新日期：2019-10-01 00:00:00

abstract：:Unfolded protein response (UPR) and endoplasmic reticulum (ER)-phagy are essential for cell homeostasis. Quantum dots (QDs), which have been widely used for biomedical applications, can accumulate in the kidney tissues and may cause renal dysfunction. However, the molecular mechanism of QDs-induced nephrotoxicity is s...

journal_title：Archives of toxicology

authors： Jiang S,Lin Y,Yao H,Yang C,Zhang L,Luo B,Lei Z,Cao L,Lin N,Liu X,Lin Z,He C

更新日期：2018-04-01 00:00:00

abstract：:DW-116, 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-l-piperazinyl)-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride, is a newly developed fluoroquinolone antibacterial. The potential of DW-116 to induce developmental toxicity was, investigated in Sprague-Dawley rats. DW-116 was administered by gavage to pre...

journal_title：Archives of toxicology

authors： Kim JC,Yun HI,Shin HC,Han SS,Chung MK

更新日期：2000-04-01 00:00:00

abstract：:Male F344/DuCrj (Fischer) rats were given bisphenol A (BPA) in the diet at levels of 0 (control), 0.25, 0.50 and 1.00%, equivalent to 0, 235, 466 and 950 mg/kg per day, respectively, for 44 days. Body weight gains were depressed dose-dependently in BPA-treated rats, and those of 0.50 and 1.00% groups were significant....

journal_title：Archives of toxicology

authors： Takahashi O,Oishi S

更新日期：2001-03-01 00:00:00

abstract：:Cannabis use has become a hot topic in several countries due to the debate about its legalization for medical purposes. However, data are limited regarding adverse events, safety and potential impact on reproductive health. Cannabis consumption during pregnancy has been associated with gestational disorders such as pr...

journal_title：Archives of toxicology

authors： Maia J,Midão L,Cunha SC,Almada M,Fonseca BM,Braga J,Gonçalves D,Teixeira N,Correia-da-Silva G

更新日期：2019-03-01 00:00:00

abstract：:This study was performed to assess the relation between occupational exposure to N,N-dimethylformamide after an 8 h work shift in the acrylic fibre industry and its three biological markers N-methylformamide (NMFtotal), N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC), and N-methylcarbamoyl adduct at haemoglobin (MCVal)....

journal_title：Archives of toxicology

authors： Seitz M,Kilo S,Eckert E,Müller J,Drexler H,Göen T

更新日期：2018-07-01 00:00:00

abstract：:The assay of neurotoxic esterase (NTE) in brains taken from dosed hens enables potential neurotoxicity of organophosphate pesticides, plasticers, etc. to be assessed. The original assay [Johnson, M.K. Biochem. J. 114, 711-717 (1969)] has been simplified to eliminate centrifugation and transfer steps and both the selec...

journal_title：Archives of toxicology

authors： Johnson MK

更新日期：1977-06-18 00:00:00

abstract：:203Pb(NO3)2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. ...

journal_title：Archives of toxicology

authors： Danielsson BR,Dencker L,Lindgren A

更新日期：1983-10-01 00:00:00

abstract：:Cats were given vincristine sulfate (50 micrograms/kg i.v. every 4 days) and studied after 7-29 injections when neurological deficits became evident. The conduction velocity spectrum of individual afferent nerves from soleus muscles was shifted toward slower velocities. Relatively few functional muscle spindles or oth...

journal_title：Archives of toxicology

authors： Goldstein BD,Lowndes HE,Cho E

更新日期：1981-11-01 00:00:00

abstract：:This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a sh...

journal_title：Archives of toxicology

authors： Chuu JJ,Huang ZN,Yu HH,Chang LH,Lin-Shiau SY

更新日期：2008-06-01 00:00:00

abstract：:The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase. In vitro studies have indicated that APAP may also be cooxidized by prostaglandin H synthetase. The present experiments were designed to assess the possible contributio...

journal_title：Archives of toxicology

authors： Ben-Zvi Z,Weissman-Teitellman B,Katz S,Danon A

更新日期：1990-01-01 00:00:00

abstract：:Female wistar rats, conventional albino mice, and Chinese hamsters were given a single dose of acrylonitrile, 0.5 or 0.75 mM/kg body weight. The elimination in the urine of thiocyanate, which is the main metabolite of acrylonitrile, indicated a decreasing proportion of biotransformation after oral (over 20%), intraper...

journal_title：Archives of toxicology

authors： Gut I,Nerudová J,Kopecký J,Holecek V

更新日期：1975-02-14 00:00:00

abstract：:Sodium diethyldithiocarbamate (DETC) is the main metabolite of disulfiram. Recently, we reported that mechanism of disulfiram cytotoxicity in V79 cells might be partially connected with thiol redox-state imbalance. Here, we examined the effect of DETC on the level of intracellular glutathione (GSH), protein oxidation ...

journal_title：Archives of toxicology

authors： Rahden-Staroń I,Grosicka-Maciąg E,Kurpios-Piec D,Czeczot H,Grzela T,Szumiło M

更新日期：2012-12-01 00:00:00

abstract：:Ziram is a carbamate pesticide, which is widely used throughout the world as a fungicide in agriculture and as an accelerating agent in latex production. In the present study, we investigated the effect of ziram at 0.031-4 μM in vitro on human natural killer (NK) and lymphokine-activated killer (LAK) and murine cytoto...

journal_title：Archives of toxicology

authors： Li Q,Kobayashi M,Kawada T

更新日期：2012-03-01 00:00:00

abstract：:The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime whi...

journal_title：Archives of toxicology

authors： Clement JG

更新日期：1992-01-01 00:00:00

abstract：:The goal of the present study was to obtain an in vivo relevant prioritization method for the endocrine potencies of different polycarbonate monomers, by combining in vitro bioassay data with physiologically based kinetic (PBK) modelling. PBK models were developed for a selection of monomers, including bisphenol A (BP...

journal_title：Archives of toxicology

authors： Punt A,Aartse A,Bovee TFH,Gerssen A,van Leeuwen SPJ,Hoogenboom RLAP,Peijnenburg AACM

更新日期：2019-07-01 00:00:00

abstract：:Chronic exposure to propiverine, a frequently prescribed pharmaceutical for treatment of overactive bladder and incontinence, provokes massive protein accumulation in the cytosol and nucleus of renal proximal tubule epithelial cells in rats. Previously, the accumulating protein was identified as D-amino acid oxidase (...

journal_title：Archives of toxicology

authors： Luks L,Sacchi S,Pollegioni L,Dietrich DR

更新日期：2017-01-01 00:00:00

abstract：:The toxicity of amphetamines is conditioned by a complex array of mechanisms, involving the increase of neurotransmission (e.g. leading to hyperthermia) and enzymatic and non-enzymatic oxidation of amphetamines and biogenic amines. Considering that all these processes may increase the generation of hydrogen peroxide (...

journal_title：Archives of toxicology

authors： Carvalho F,Duarte JA,Neuparth MJ,Carmo H,Fernandes E,Remião F,Bastos ML

更新日期：2001-10-01 00:00:00

abstract：:During aerobic incubation of trichloroethylene with rabbit liver microsomes and NADPH a difference absorption peak appears at 451-452 nm. Trichloroethylene does not form a ligand absorption spectrum with hepatic microsomes reduced by dithionite, or in anaerobic incubates in the presence of NADPH. Addition of trichloro...

journal_title：Archives of toxicology

authors： Uehleke H,Tabarelli-Poplawski S,Bonse G,Henschler D

更新日期：1977-06-18 00:00:00

abstract：:Acute toxicity of bis (tributyltin) oxide in the sweat glands in the rat footpad was investigated by electron microscopy and an energy-dispersive X-ray microanalyzer. Male Wistar rats received an intramuscular injection of 0.5 ml/kg bis (tributyltin) oxide. After 6-8 h, swelling of mitochondria appeared in the secreto...

journal_title：Archives of toxicology

authors： Yamamoto O,Doi Y,Kudo H,Yoshizuka M,Fujimoto S

更新日期：2000-12-01 00:00:00

abstract：:Clinical and electrophysiological examinations were performed on 12 patients with toxic neuropathy following accidental ingestion of alcohol polluted by triorthocresyl phosphate (TOCP). Concurrent PNS and CNS lesions were found in all patients. Two to three months after ingestion, five of them showed prevalent signs o...

journal_title：Archives of toxicology

authors： Vasilescu C,Florescu A

更新日期：1980-02-01 00:00:00

abstract：:There is considerable epidemiological evidence that workers exposed to carbon disulfide (CS2) develop premature atherosclerosis leading to increased rates of coronary heart disease (CHD), but mechanisms underlying this association remain obscure. The present study documents that occupational exposure to CS2 modifies t...

journal_title：Archives of toxicology

authors： Wronska-Nofer T,Chojnowska-Jezierska J,Nofer JR,Halatek T,Wisniewska-Knypl J

更新日期：2002-04-01 00:00:00

abstract：:It is estimated that only a few marketed drugs are able to directly induce liver steatosis. However, many other drugs may exacerbate or precipitate fatty liver in the presence of other risk factors or in patients prone to non-alcoholic fatty liver disease. On the other hand, current in vitro tests for drug-induced ste...

journal_title：Archives of toxicology

authors： Benet M,Moya M,Donato MT,Lahoz A,Hervás D,Guzmán C,Gómez-Lechón MJ,Castell JV,Jover R

更新日期：2014-04-01 00:00:00

abstract：:Our previous study suggested the possibilities that dicyclanil (DC), a nongenotoxic carcinogen, produces oxidative stress in the liver of the two-stage hepatocarcinogenesis model of mice and the stress induced probably causes secondary oxidative DNA damage. However, clear evidences demonstrating the relationship betwe...

journal_title：Archives of toxicology

authors： Moto M,Umemura T,Okamura M,Muguruma M,Ito T,Jin M,Kashida Y,Mitsumori K

更新日期：2006-10-01 00:00:00