Possible involvement of oxidative stress in dicyclanil-induced hepatocarcinogenesis in mice.

abstract：:Millions of tons of all kind of munitions, including mines, bombs and torpedoes have been dumped after World War II in the marine environment and do now pose a new threat to the seas worldwide. Beside the acute risk of unwanted detonation, there is a chronic risk of contamination, because the metal vessels corrode and...

journal_title：Archives of toxicology

authors： Strehse JS,Brenner M,Kisiela M,Maser E

更新日期：2020-12-01 00:00:00

abstract：:Chronic exposure to inorganic arsenic (As) [As(III) + As(V)], which affects millions of people, increases the incidence of some kinds of cancer and other non-carcinogenic pathologies. Although the oral pathway is the main form of exposure, in vivo studies have not been conducted to verify the intestinal toxicity of th...

journal_title：Archives of toxicology

authors： Chiocchetti GM,Domene A,Kühl AA,Zúñiga M,Vélez D,Devesa V,Monedero V

更新日期：2019-08-01 00:00:00

abstract：:Between 0.25-25 micrograms of an aqueous solution of either mercuric chloride or methyl mercuric acetate was injected directly into the sciatic nerve of 28 adult Wistar rats. The resultant pathological changes in the nerve were examined by teasing individual fibres and by light and electron microscopy. In most respect...

journal_title：Archives of toxicology

authors： Mitchell J,Gallagher PJ

更新日期：1980-12-01 00:00:00

abstract：:A new class of potent anticancer drugs, alkylphosphocholines has been recognized lately. Miltefosine (Hexadecylphosphochlorine, HPC) has been found to express select antineoplastic effect on human breast cancer skin metastases with simultaneous preservation of bone marrow proliferative activity and low clastogenicity....

journal_title：Archives of toxicology

authors： Martinova Y,Topashka-Ancheva M,Konstantinov S,Petkova S,Karaivanova M,Berger M

更新日期：2006-01-01 00:00:00

abstract：:N-Methyl-2-pyrrolidone (NMP) is a versatile organic solvent frequently used for surface cleaning such as paint stripping or graffiti removal. Liquid NMP is rapidly absorbed through the skin but dermal vapour phase absorption might also play an important role for the uptake of the solvent. This particular aspect was in...

journal_title：Archives of toxicology

authors： Bader M,Wrbitzky R,Blaszkewicz M,Schäper M,van Thriel C

更新日期：2008-01-01 00:00:00

abstract：:The metabolism of arsenic is generally accepted to proceed by repetitive reduction and oxidative methylation; the latter is mediated by arsenic methyltransferase (Cyt19). In human urine, the major metabolites of inorganic arsenicals such as arsenite (iAsIII) and arsenate (iAsV) are monomethylarsonic acid (MMA(V)) and ...

journal_title：Archives of toxicology

authors： Hayakawa T,Kobayashi Y,Cui X,Hirano S

更新日期：2005-04-01 00:00:00

abstract：:Pentachlorophenol (PCP) and Dichlorodiphenyltrichloroethane (DDT) are environmental contaminants found in human blood. Previous studies have shown that PCP and DDT inhibit the lytic function of highly purified human natural killer (NK) lymphocytes and decrease the expression of several surface proteins on NK cells. In...

journal_title：Archives of toxicology

authors： Martin TJ,Whalen MM

更新日期：2017-04-01 00:00:00

abstract：:Occupational and environmental asbestos exposure is the main determinant of malignant pleural mesothelioma (MPM), however, the mechanisms by which its fibres contribute to cell toxicity and transformation are not completely clear. Aberrant DNA methylation is a common event in cancer but epigenetic modifications involv...

journal_title：Archives of toxicology

authors： Casalone E,Allione A,Viberti C,Pardini B,Guarrera S,Betti M,Dianzani I,Aldieri E,Matullo G

更新日期：2018-05-01 00:00:00

abstract：:A new strategy for the evaluation of mixtures is presented. The mixture used was the organic extract of diesel exhaust particles (DEP). After extraction with dichloromethane (DCM), the crude extract was fractionated according to polarity into five fractions: aliphatic hydrocarbons, polycyclic aromatic hydrocarbons (PA...

journal_title：Archives of toxicology

authors： Ostby L,Engen S,Melbye A,Eide I

更新日期：1997-01-01 00:00:00

abstract：:The in ovo carcinogenicity assessing (IOCA) assay was used to examine the morphological changes in fetal turkey livers caused by the DNA-reactive carcinogen diethylnitrosamine (DEN). Fertilized turkey eggs were allocated into 3 groups: nondosed control (NDC), vehicle (water) control (VC) and DEN-dosed. At day 0, the f...

journal_title：Archives of toxicology

authors： Williams GM,Brunnemann KD,Iatropoulos MJ,Smart DJ,Enzmann HG

更新日期：2011-06-01 00:00:00

abstract：:Inhabitants of a private home suffered from symptoms possibly due to dichloroacetylene intoxication. Subsequent anamnesis revealed that abundant amounts of trichloroethylene had been used to remove a wax coating from a concrete-lined stone floor. This prompted us to examine whether dichloroacetylene could have been fo...

journal_title：Archives of toxicology

authors： Greim H,Wolff T,Höfler M,Lahaniatis E

更新日期：1984-12-01 00:00:00

abstract：:Pregnane X receptor (PXR) is a nuclear receptor that plays a key regulatory role in xenobiotic metabolism in a ligand-dependent manner. Recently, ethanol was reported to be either an inducer or inhibitor of Cytochrome P450 (CYP) 3A expression. According to our recent microarray data, chronic ethanol upregulates the ex...

journal_title：Archives of toxicology

authors： Je YT,Sim WC,Kim DG,Jung BH,Shin HS,Lee BH

更新日期：2015-04-01 00:00:00

abstract：:Cytochrome P4502E1 (CYP2E1) gene shows genetic polymorphisms that vary markedly in frequency among different ethnic and racial groups. We studied the genotype distributions and allele frequencies of three CYP2E1 polymorphisms: CYP2E1*5B (RsaI/PstI RFLP, C-1053T/G-1293C SNP, rs2031920 /rs3813867), CYP2E1*6 (DraI RFLP, ...

journal_title：Archives of toxicology

authors： Ulusoy G,Arinç E,Adali O

更新日期：2007-10-01 00:00:00

abstract：:Single doses of procarbazine (MIH) were injected IP at 0, 50, 100, 200, and 400 mg/kg body weight to CD-1 male mice. Activities of hyaluronidase, lactate dehydrogenase isoenzyme-X, and the dehydrogenases of sorbitol, alpha-glycerophosphate, glucose-6-phosphate, malate, isocitrate, and glyceraldehyde-3-phosphate in the...

journal_title：Archives of toxicology

authors： Shen RS,Lee IP

更新日期：1984-10-01 00:00:00

abstract：:Certain populations of the mosquitofish (Gambusia affinis) are highly resistant to cyclodiene and cyclodiene-type insecticides that competitively interact with the picrotoxinin binding site of the gamma-aminobutyric acid (GABA) receptor-ionophore complex in the central nervous system. Resistance involves a reduction i...

journal_title：Archives of toxicology

authors： Bonner JC,Yarbrough JD

更新日期：1988-01-01 00:00:00

abstract：:Pathological changes induced by cadmium aerosol had features common to the changes evoked by oxidants. Female rats were exposed to fumes of lead, antimony, zinc and cadmium (15-100 nmoles/m3). One hour after termination of exposure, superoxide dismutase (SOD) activity in erythrocytes of the exposed rats lowered by 15-...

journal_title：Archives of toxicology

authors： Minami M,Koshi K,Homma K,Suzuki Y

更新日期：1982-03-01 00:00:00

abstract：:Steatosis, also known as fatty liver disease (FLD), is a disorder in which the lipid metabolism of the liver is disturbed, leading to the abnormal retention of lipids in hepatocytes. FLD can be induced by several drugs, and although it is mostly asymptomatic, it can lead to steatohepatitis, which is associated with li...

journal_title：Archives of toxicology

authors： Rodrigues RM,Branson S,De Boe V,Sachinidis A,Rogiers V,De Kock J,Vanhaecke T

更新日期：2016-03-01 00:00:00

abstract：:This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...

journal_title：Archives of toxicology

authors： Khan F,Niaz K,Ismail Hassan F,Abdollahi M

更新日期：2018-07-01 00:00:00

abstract：:The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase. In vitro studies have indicated that APAP may also be cooxidized by prostaglandin H synthetase. The present experiments were designed to assess the possible contributio...

journal_title：Archives of toxicology

authors： Ben-Zvi Z,Weissman-Teitellman B,Katz S,Danon A

更新日期：1990-01-01 00:00:00

abstract：:Trichloroethylene (TCE)-induced liver toxicity and carcinogenesis is believed to be mediated in part by activation of the peroxisome proliferator-activated receptor α (PPARα). However, the contribution of the two TCE metabolites, dichloroacetate (DCA) and trichloroacetate (TCA) to the toxicity of TCE, remains unclear....

journal_title：Archives of toxicology

authors： Fang ZZ,Krausz KW,Tanaka N,Li F,Qu A,Idle JR,Gonzalez FJ

更新日期：2013-11-01 00:00:00

abstract：:Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this...

journal_title：Archives of toxicology

authors： Luo G,Shen Y,Yang L,Lu A,Xiang Z

更新日期：2017-09-01 00:00:00

abstract：:Using the rat liver foci bioassay a dose-response relationship was evaluated for the promoting activity of the ubiquitous and persistent environmental pollutants polychlorinated biphenyls (PCBs) and chloroform. Initiation of liver foci was performed by oral administration of a single dose of 8 mg/kg body wt of diethyl...

journal_title：Archives of toxicology

authors： Deml E,Oesterle D

更新日期：1987-01-01 00:00:00

abstract：:Prudhoe Bay crude oil (PBCO) and its aliphatic, aromatic and heterocyclic fractions were tested on the developing chick embryo for (i) embryotoxicity (ii) their ability to induce hepatic and renal cytochrome P450 levels as well as hepatic, renal and pulmonary aryl hydrocarbon hydroxylase activities. On the basis of it...

journal_title：Archives of toxicology

authors： Walters P,Khan S,O'Brien PJ,Payne JF,Rahimtula AD

更新日期：1987-08-01 00:00:00

abstract：:Previous studies indicate that benzanthrone, an anthraquinone dye intermediate, caused significant depletion of ascorbic acid (AsA). In this investigation the effect of benzanthrone on the status of different forms of AsA and other bio-antioxidants such as glutathione (GSH) was studied. Oral administration of benzanth...

journal_title：Archives of toxicology

authors： Dwivedi N,Das M,Khanna SK

更新日期：2001-06-01 00:00:00

abstract：:The effect of Co(NO3)2, CdSO4, NiSO4, ZnSO4, and HgCl2 (given repeatedly in subtoxic doses in the drinking water for 30 days) on rat liver monooxygenases was studied in experiments on male Wistar rats. The salts of Co, Cd, and Zn increased the activity of benzphetamine-N-demethylase, the content of cytochrome P-450 an...

journal_title：Archives of toxicology

authors： Kadiiska M,Stoytchev T,Serbinova E

更新日期：1985-01-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent tumor promoter ever tested in rodents. Although it is known that most of the effects of TCDD are mediated by binding to the aryl hydrocarbon receptor (AhR), the mechanisms leading to tumor promotion still remain to be elucidated. Loss of contact inhibition ...

journal_title：Archives of toxicology

authors： Hoelper P,Faust D,Oesch F,Dietrich C

更新日期：2005-01-01 00:00:00

abstract：: ...

journal_title：Archives of toxicology

authors： Deng Y,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：:The present study has investigated the ability of amitraz, a widely used formamidine pesticide, to modulate serum concentrations and liver microsomal metabolism of 17beta-estradiol (E2) and testosterone in rats. Amitraz was administered intraperitoneally to male rats for 4 days and to intact female rats or ovariectomi...

journal_title：Archives of toxicology

authors： Chou CP,Lu SY,Ueng TH

更新日期：2008-10-01 00:00:00

abstract：:In this review, we introduce a new concept, precision toxicology: the mode of action of chemical- or drug-induced toxicity can be sensitively and specifically investigated by isolating a small group of cells or even a single cell with typical phenotype of interest followed by a single cell sequencing-based analysis. P...

journal_title：Archives of toxicology

authors： Zhang B,Huang K,Zhu L,Luo Y,Xu W

更新日期：2017-07-01 00:00:00

abstract：:Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition of serotonin uptake and metabolism, increased serotonin synthesis and release, activation of serotonin receptors, and inhibition of cytochrome P450 oxidases. Some drug interactions involving opioids can increase intrasynaptic l...

journal_title：Archives of toxicology

authors： Baldo BA

更新日期：2018-08-01 00:00:00