Abstract:
:A new class of potent anticancer drugs, alkylphosphocholines has been recognized lately. Miltefosine (Hexadecylphosphochlorine, HPC) has been found to express select antineoplastic effect on human breast cancer skin metastases with simultaneous preservation of bone marrow proliferative activity and low clastogenicity. In the current study, we present data about the specific effect of two widely used cytostatics Cyclophosphamide (CP) and Epirubicine (ERb) applied separately or in combination with Miltefosine. C57BL6 mice were treated per os or intraperitonieally in doses corresponding to that in clinical use. Morphological, autoradiographic, ultrastructural and cytogenetic studies on spermatogenic, thymic and bone marrow cells were performed. It is found that compared with separate application, combinations of ERb or CP with Miltefosine slightly decreases spermatogonial proliferation and exerts milder effect on the structure of germinal and thymic cells. In addition, a lot of plasmocytes showed signs of active protein (antibody) synthesis. A significant reduction of aberrant chromosomes (clastogenicity) without changes in proliferative activity of bone marrow cells were recorded. In conclusion, the combine application of Miltefosine with ERb and CP decreased the destructive cytotoxic effects of ERb and CP on mouse spermatogenic and hematopoietic cells.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Martinova Y,Topashka-Ancheva M,Konstantinov S,Petkova S,Karaivanova M,Berger Mdoi
10.1007/s00204-005-0010-zkeywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
27-33issue
1eissn
0340-5761issn
1432-0738journal_volume
80pub_type
杂志文章abstract::Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in drug discovery. Three-dimensional (3D) spheroid hepatic cultures have emerged as pr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2002-1
更新日期:2017-08-01 00:00:00
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journal_title:Archives of toxicology
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更新日期:2003-06-01 00:00:00
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journal_title:Archives of toxicology
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pub_type: 杂志文章,评审
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journal_title:Archives of toxicology
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doi:10.1007/BF00333896
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journal_title:Archives of toxicology
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doi:10.1007/s00204-004-0562-3
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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更新日期:2009-03-01 00:00:00
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更新日期:2017-05-01 00:00:00
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/BF00296984
更新日期:1987-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00292616
更新日期:1985-10-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00293571
更新日期:1976-06-08 00:00:00
abstract::A rapid gas-chromatographic method for the qualitative and quantitative measurement of various drugs in human plasma and other body fluids has been developed. The extraction procedure is done within 5 min, and gas-chromatographic measurement carried out on 2 diverse columns with detection by flame ionisation detectors...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00368231
更新日期:1978-01-25 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00295090
更新日期:1987-02-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1693-z
更新日期:2017-01-01 00:00:00
abstract::Gebel (In Arch Toxicol 87(5):923-924, 2013) replied to my Letter to the Editor (Morfeld in Arch Toxicol 87(5):921, 2013) in which I criticized the quantitative review of inhalation rat studies on the association of granular biopersistent dust exposures and lung cancer risk (Gebel in Arch Toxicol 86(7):995-1007, 2012)....
journal_title:Archives of toxicology
pub_type: 评论,信件
doi:10.1007/s00204-013-1138-x
更新日期:2013-11-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00310332
更新日期:1978-08-09 00:00:00